A new quinolizidine alkaloid. 3-(4-hydroxyphenyl)-4-(3-methoxy-4-hydroxyphenyl)-3,4-dihydroquinolizidine (1). was isolated from the ethanol extract of the whole plants of Boehmeria siamensis Craib. Its structure was e...A new quinolizidine alkaloid. 3-(4-hydroxyphenyl)-4-(3-methoxy-4-hydroxyphenyl)-3,4-dihydroquinolizidine (1). was isolated from the ethanol extract of the whole plants of Boehmeria siamensis Craib. Its structure was elucidated on the analysis of ID NMR and 2D NMR spectrum.展开更多
Two new compounds, melanochromone and 2-ethoxyl-2-(4-hydroxyphenyl)ethanol. were isolated from the whole plants of Melanosoiadum pimpinelloideum II. Boiss. The known compounds isolated were 1-(4-hydroxyphenyl)-1.2etha...Two new compounds, melanochromone and 2-ethoxyl-2-(4-hydroxyphenyl)ethanol. were isolated from the whole plants of Melanosoiadum pimpinelloideum II. Boiss. The known compounds isolated were 1-(4-hydroxyphenyl)-1.2ethanediol. tymine. cimifugin, umtatin. bergenin. daucosterol and stigmasterol. Their structures were determined on the basis of spectral data.展开更多
A new monoterpene glycoside, 2,6-dimethyl-2E,6E-octadienoic acid 1,6'-lactone 8-beta-D-glucopyranoside, was isolated from Swertia punicea, accompanying with six known compounds 1-O-primeverosyl-3,7-dimethoxy-8-hyd...A new monoterpene glycoside, 2,6-dimethyl-2E,6E-octadienoic acid 1,6'-lactone 8-beta-D-glucopyranoside, was isolated from Swertia punicea, accompanying with six known compounds 1-O-primeverosyl-3,7-dimethoxy-8-hydroxyxanthone, 1-O-primeverosyl-3,7,8-tri-methoxyxan-thone, epi-eustomoside, 1-hydroxy-3,7,8-trimethoxyxanthone, 1,8-dihydroxy-3,7-dimethoxy xanthone and isovitexine. Their structures were elucidated based on spectral evidence.展开更多
Two new diphyllin glycosides, mananthoside A (1) and B (2), together with six known compounds. were isolated from the ethanolic extract of the whole plants of Mananthes patentiflora. Their structures were determined o...Two new diphyllin glycosides, mananthoside A (1) and B (2), together with six known compounds. were isolated from the ethanolic extract of the whole plants of Mananthes patentiflora. Their structures were determined on the basis of chemical and spectral evidences.展开更多
Semi-synthesis of paclitaxel was achieved in four steps from 10-deacetylbaccatin HI （10-DAB HI）. The key steps are the regioselective protection at the hydroxyl group at C-7 of 10-DAB HI, using 1,1′-thiocarbonyldii...Semi-synthesis of paclitaxel was achieved in four steps from 10-deacetylbaccatin HI （10-DAB HI）. The key steps are the regioselective protection at the hydroxyl group at C-7 of 10-DAB HI, using 1,1′-thiocarbonyldiimidazole as a selective reagent, and the deprotection of the protected paclitaxel with a mixture of p-toluenesulfonic acid and 0.1 mol/L aqueous hydrochloride.展开更多
β-Cyclodextrin/poly（γ-benzyl L-glutamate） （β-CD-PBLG） copolymers were synthesized by ring-opening polymerization of N- carboxy-γ-benzyl L-glutamate anhydride （BLG-NCA） in N,N-dimethylformamide （DMF） initia...β-Cyclodextrin/poly（γ-benzyl L-glutamate） （β-CD-PBLG） copolymers were synthesized by ring-opening polymerization of N- carboxy-γ-benzyl L-glutamate anhydride （BLG-NCA） in N,N-dimethylformamide （DMF） initiated by mono-amino-β-cyclodextrin（H2N-β-CD）. The structures of the copolymers were confirmed by IR, ^1H NMR and GPC. The fluorescence technique was used to determine the critical micelle concentrations （CMC） of copolymer micell solution, the diameter and the distribution of micelles were characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-β-CD to produce copolymer. The nanomicells were formed by these copolymers in water.展开更多
A new compound,3-butyryl-6-[rel-（1S,2S）-1,2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one（1）,was isolated from the solid fermented rice culture of Alternaria sp.CIB 108,along with three known ones,deoxyradicinin（2）,...A new compound,3-butyryl-6-[rel-（1S,2S）-1,2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one（1）,was isolated from the solid fermented rice culture of Alternaria sp.CIB 108,along with three known ones,deoxyradicinin（2）,3-epiradicinol（3）,and 3- epideoxyradicinol（4）.Their structures were elucidated on the basis of spectroscopic data.The single crystal X-ray diffraction was applied to further clarify the structure of 1.Furthermore,compounds 1-4 possessed no cytotoxicity against several cell lines（HeLa, HepG2,and Ros） and showed no antibacterial activity at 40μmol/L.展开更多
文摘A new quinolizidine alkaloid. 3-(4-hydroxyphenyl)-4-(3-methoxy-4-hydroxyphenyl)-3,4-dihydroquinolizidine (1). was isolated from the ethanol extract of the whole plants of Boehmeria siamensis Craib. Its structure was elucidated on the analysis of ID NMR and 2D NMR spectrum.
基金We are indebted to Di-Ao Science Foundation for the financial support.
文摘Two new compounds, melanochromone and 2-ethoxyl-2-(4-hydroxyphenyl)ethanol. were isolated from the whole plants of Melanosoiadum pimpinelloideum II. Boiss. The known compounds isolated were 1-(4-hydroxyphenyl)-1.2ethanediol. tymine. cimifugin, umtatin. bergenin. daucosterol and stigmasterol. Their structures were determined on the basis of spectral data.
文摘A new monoterpene glycoside, 2,6-dimethyl-2E,6E-octadienoic acid 1,6'-lactone 8-beta-D-glucopyranoside, was isolated from Swertia punicea, accompanying with six known compounds 1-O-primeverosyl-3,7-dimethoxy-8-hydroxyxanthone, 1-O-primeverosyl-3,7,8-tri-methoxyxan-thone, epi-eustomoside, 1-hydroxy-3,7,8-trimethoxyxanthone, 1,8-dihydroxy-3,7-dimethoxy xanthone and isovitexine. Their structures were elucidated based on spectral evidence.
基金the financial support of Di-Ao Science Foundation.
文摘Two new diphyllin glycosides, mananthoside A (1) and B (2), together with six known compounds. were isolated from the ethanolic extract of the whole plants of Mananthes patentiflora. Their structures were determined on the basis of chemical and spectral evidences.
文摘Semi-synthesis of paclitaxel was achieved in four steps from 10-deacetylbaccatin HI （10-DAB HI）. The key steps are the regioselective protection at the hydroxyl group at C-7 of 10-DAB HI, using 1,1′-thiocarbonyldiimidazole as a selective reagent, and the deprotection of the protected paclitaxel with a mixture of p-toluenesulfonic acid and 0.1 mol/L aqueous hydrochloride.
基金support of the Natural Science Foundation for Education Department of Liaoning Province of China(No.2007T051).
文摘β-Cyclodextrin/poly（γ-benzyl L-glutamate） （β-CD-PBLG） copolymers were synthesized by ring-opening polymerization of N- carboxy-γ-benzyl L-glutamate anhydride （BLG-NCA） in N,N-dimethylformamide （DMF） initiated by mono-amino-β-cyclodextrin（H2N-β-CD）. The structures of the copolymers were confirmed by IR, ^1H NMR and GPC. The fluorescence technique was used to determine the critical micelle concentrations （CMC） of copolymer micell solution, the diameter and the distribution of micelles were characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-β-CD to produce copolymer. The nanomicells were formed by these copolymers in water.
基金supported financially by the NSFC(No.20902089 to G.Y.Li)the Knowledge Innovation Program of the Chinese Academy of Sciences(No.KSCX2-EW-G-13-04)
文摘A new compound,3-butyryl-6-[rel-（1S,2S）-1,2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one（1）,was isolated from the solid fermented rice culture of Alternaria sp.CIB 108,along with three known ones,deoxyradicinin（2）,3-epiradicinol（3）,and 3- epideoxyradicinol（4）.Their structures were elucidated on the basis of spectroscopic data.The single crystal X-ray diffraction was applied to further clarify the structure of 1.Furthermore,compounds 1-4 possessed no cytotoxicity against several cell lines（HeLa, HepG2,and Ros） and showed no antibacterial activity at 40μmol/L.
