Irreversible electroporation(IRE) employs the use of an electric field to cause irreversible permeability of the cell membrane, inducing apoptosis. The use of IRE for locally advanced pancreatic cancer(LAPC) was first...Irreversible electroporation(IRE) employs the use of an electric field to cause irreversible permeability of the cell membrane, inducing apoptosis. The use of IRE for locally advanced pancreatic cancer(LAPC) was first described in 2012. The crucial advantage of IRE compared with other devices employing thermal ablation is the safety around vital structures such as vessels and ducts. This makes it an attractive option for use in the pancreas due to the close proximity of multiple major vascular structures, biliary ducts, and adjacent gastrointestinal organs. Over the past decade, IRE has established itself as a useful treatment adjunct and may soon become the standard of care, particularly for LAPC. This article will explore the current evidence and provide a concise summary of pertinent issues, including patient selection, preoperative management, clinical outcomes, radiological response and future prospects of IRE in pancreatic cancer.展开更多
Hepatocellular carcinoma(HCC)is the second most lethal tumour,with therapies broadly divided into curative and palliative intent.Unfortunately,the majority of HCCs were found to be unresectable at diagnosis.Advances i...Hepatocellular carcinoma(HCC)is the second most lethal tumour,with therapies broadly divided into curative and palliative intent.Unfortunately,the majority of HCCs were found to be unresectable at diagnosis.Advances in novel loco-regional therapies have given patients with unresectable HCC a vital chance for disease control and survival.However,the COVID-19 pandemic has greatly shaped and impacted treatment protocols and delivery for HCC patients.This review article aims to describe the impact of the COVID-19 pandemic on the delivery of locoregional treatment modalities for HCC and compare treatment trends between the pre-pandemic and pandemic eras.Treatment of HCC involves complex collaboration between clinical professionals within their local and global healthcare institutions.The COVID-19 pandemic has had a profound impact on the treatment of HCC.The delivery of loco-regional treatment for HCC will need to adapt to each healthcare system’s unique structure.展开更多
文摘Irreversible electroporation(IRE) employs the use of an electric field to cause irreversible permeability of the cell membrane, inducing apoptosis. The use of IRE for locally advanced pancreatic cancer(LAPC) was first described in 2012. The crucial advantage of IRE compared with other devices employing thermal ablation is the safety around vital structures such as vessels and ducts. This makes it an attractive option for use in the pancreas due to the close proximity of multiple major vascular structures, biliary ducts, and adjacent gastrointestinal organs. Over the past decade, IRE has established itself as a useful treatment adjunct and may soon become the standard of care, particularly for LAPC. This article will explore the current evidence and provide a concise summary of pertinent issues, including patient selection, preoperative management, clinical outcomes, radiological response and future prospects of IRE in pancreatic cancer.
文摘Hepatocellular carcinoma(HCC)is the second most lethal tumour,with therapies broadly divided into curative and palliative intent.Unfortunately,the majority of HCCs were found to be unresectable at diagnosis.Advances in novel loco-regional therapies have given patients with unresectable HCC a vital chance for disease control and survival.However,the COVID-19 pandemic has greatly shaped and impacted treatment protocols and delivery for HCC patients.This review article aims to describe the impact of the COVID-19 pandemic on the delivery of locoregional treatment modalities for HCC and compare treatment trends between the pre-pandemic and pandemic eras.Treatment of HCC involves complex collaboration between clinical professionals within their local and global healthcare institutions.The COVID-19 pandemic has had a profound impact on the treatment of HCC.The delivery of loco-regional treatment for HCC will need to adapt to each healthcare system’s unique structure.
