Background:Guben Zhike decoction(GBZKD)is derived from the experience of Professor Enxiang Chao,an esteemed master of Chinese medicine,while treating chronic obstructive pulmonary disease(COPD).GBZKD reinforces the he...Background:Guben Zhike decoction(GBZKD)is derived from the experience of Professor Enxiang Chao,an esteemed master of Chinese medicine,while treating chronic obstructive pulmonary disease(COPD).GBZKD reinforces the healthy qi and consolidates defensive qi.This study explored the efficacy and potential mechanism of action of GBZKD in a COPD mouse model using proteomics.Methods:A COPD mouse model was established through cigarette smoke exposure and intranasal lipopolysaccharide administration.The model was verified through lung function test and lung histopathological observation.Label-free quantitative proteomics was used to detect the lung tissue proteins of mice from the GBZKD,COPD,and control groups.Results:GBZKD markedly improved the lung function and associated pathological conditions in the COPD mouse model.Proteomic analysis identified 4316 proteins,of which 3696 were quantitative proteins.We highlighted 287 and 184 proteins with significant regulatory roles in the lung tissues of COPD mice and GBZKD-treated mice,respectively.These proteins participated in multiple functions,including complement/coagulation cascade,immune response,and metabolic pathways.Conclusion:GBZKD exhibits multitarget and multipathway therapeutic effects in a COPD mouse model.展开更多
Photoresponsive supramolecular systems have merited extensive attention for their applications in materials science and life science.Here,we synthesized a water-soluble stiff-stilbene molecular photoswitch,exhibiting ...Photoresponsive supramolecular systems have merited extensive attention for their applications in materials science and life science.Here,we synthesized a water-soluble stiff-stilbene molecular photoswitch,exhibiting outstanding photoisomerization reaction between its(E)-and(Z)-configurations upon irradiation at distinct light.The photoswitch can assemble with cucurbit[7]uril(CB[7])to form a superior fluorescent supramolecular complex(compared to the only guest)with excellent water solubility,which manifested dramatic photoluminescence enhancement caused by restriction of intramolecular rotation and remained good photochromic characteristics.Furthermore,introduction of CB[7]influence photoreaction quantum yield(Φ)of the stiff-stilbene,leading to reduction ofΦ_(E→Z) and increase ofΦ_(Z→E) of the stiff-stilbene.Importantly,the photoadjustable supramolecular assembly can act as a fluorescence switch,and the phototunable guest further selectively modulate G-quadruplex structure of Tel22 upon light irradiation or with addition of CB[7].The study provides a new simple way for accurately regulating photochromic properties of molecular switches and developing smart materials with potential applications in controlled modulation of G-quadruplex,targeted biological imaging and so on.展开更多
Three discrete tetrahedral metallo-supramolecular cages were designed and constructed using truxenepended base ligands.Owing to the synergistic rigidifying effect of unsymmetric cyano-substituted oligo(pphenylene-viny...Three discrete tetrahedral metallo-supramolecular cages were designed and constructed using truxenepended base ligands.Owing to the synergistic rigidifying effect of unsymmetric cyano-substituted oligo(pphenylene-vinylene)(u-COPV)suspended by the truxene skeleton,the resulting supramolecular cages were confirmed to exhibit significant aggregation-induced emission(AIE)accompanied by an interesting solvatochromic fluorescent behavior as well as a porous honeycomb-like state during aggregation.In particular,the anti-counterfeiting performance and emission behaviors of the cages in the solid state under external hydrostatic pressure were investigated.展开更多
A new class of near-infrared(NIR)fluorescent organoboron AIEgens was successfully developed for latent fingerprints(LFPs)imaging.They exhibit real-time and in situ high-resolution imaging performance at 1-3 levels of ...A new class of near-infrared(NIR)fluorescent organoboron AIEgens was successfully developed for latent fingerprints(LFPs)imaging.They exhibit real-time and in situ high-resolution imaging performance at 1-3 levels of LFPs by spraying method.In addition,we systematically elucidate the fingerprint imaging mechanism of these AIEgens.Significantly,the excellent level 3 structural imaging capabilities enable the application of them for analyzing incomplete LFPs and identifying individuals in different scenarios.展开更多
The molecular assembling properties can be dramatically improved using redox-responsive nanoplatforms, which can bring quite different aggregation modes and binding behaviors in the redox states. In this work, we fabr...The molecular assembling properties can be dramatically improved using redox-responsive nanoplatforms, which can bring quite different aggregation modes and binding behaviors in the redox states. In this work, we fabricated a redox-responsive system based on the host–guest complexation of b-cyclodextrin(b-CD) with ferrocene-modified diphenylalanine(Fc-FF). The morphological conversion of Fc-FF can be easily achieved from nanofibers to nanospheres in the presence of b-CD, and the supramolecular nanospheres can be reversibly assembled and disassembled by the chemical redox of ferrocenyl groups in the Fc-FF&b-CD nanoassemblies. These results demonstrate that the incorporation of stimuli-switchable components with macrocyclic receptors may become a promising approach to the construction of smart peptide-involved supramolecular assemblies.展开更多
Conformational regulation among two or more distant sites is not only one of the main pathways to accomplish multiple tasks in complex biological systems but also represents a powerful strategy to obtain stimuli-respo...Conformational regulation among two or more distant sites is not only one of the main pathways to accomplish multiple tasks in complex biological systems but also represents a powerful strategy to obtain stimuli-responsive supramolecular nanoconstructs with tailored physicochemical performance.We herein report the fabrication of a photochromic supramolecular assembly,which can be synergistically activated by the conformational regulation with bis(4,8-disulfonato-1,5-naphtho)-32-crown-8 and then reversibly switched by the through-space communication between restricted stilbazolium salt and photochromic dithienylethene.This work demonstrates that the synergistic conformational modulation via intra-and intermolecular interactions can be developed as a generalizable approach to construct more advanced biomimetic nanomaterials.展开更多
A metal-organic photoinduced electron transfer(PET) supramolecular nanoarchitecture comprised of Ru(Ⅱ) bis(terpyridine)-modified pillar[5]arene(electron acceptor) and triazole triphenylamine amyl cyanide(electron don...A metal-organic photoinduced electron transfer(PET) supramolecular nanoarchitecture comprised of Ru(Ⅱ) bis(terpyridine)-modified pillar[5]arene(electron acceptor) and triazole triphenylamine amyl cyanide(electron donor) has been designed and constructed.Through the comparison of diverse solvents and acceptors,the two conditions,i.e.,modification of pillar[5]arene to donor and weak polar solvent are benefit for the occurrence of "efficient PET" because of shorter D-A distance in the presence of pillar[5]arene.Crucially,the fluorescence and PET process of the supramolecular assembly could be further modulated by solvent conversion and another competitive guest.The study provides a supramolecular method to design and construct tunable PET systems and PET-based smart materials.展开更多
基金This study was supported by the National Natural Science Foundation of China(82074367).
文摘Background:Guben Zhike decoction(GBZKD)is derived from the experience of Professor Enxiang Chao,an esteemed master of Chinese medicine,while treating chronic obstructive pulmonary disease(COPD).GBZKD reinforces the healthy qi and consolidates defensive qi.This study explored the efficacy and potential mechanism of action of GBZKD in a COPD mouse model using proteomics.Methods:A COPD mouse model was established through cigarette smoke exposure and intranasal lipopolysaccharide administration.The model was verified through lung function test and lung histopathological observation.Label-free quantitative proteomics was used to detect the lung tissue proteins of mice from the GBZKD,COPD,and control groups.Results:GBZKD markedly improved the lung function and associated pathological conditions in the COPD mouse model.Proteomic analysis identified 4316 proteins,of which 3696 were quantitative proteins.We highlighted 287 and 184 proteins with significant regulatory roles in the lung tissues of COPD mice and GBZKD-treated mice,respectively.These proteins participated in multiple functions,including complement/coagulation cascade,immune response,and metabolic pathways.Conclusion:GBZKD exhibits multitarget and multipathway therapeutic effects in a COPD mouse model.
基金We thank Top-Notch Talents Program of Henan Agricultural University(No.30501049)Project supported by the Science and Technology Department of Henan Province(No.212102310332)the Merit Funding for the Oversea Staff of Henan Province for financial support.
文摘Photoresponsive supramolecular systems have merited extensive attention for their applications in materials science and life science.Here,we synthesized a water-soluble stiff-stilbene molecular photoswitch,exhibiting outstanding photoisomerization reaction between its(E)-and(Z)-configurations upon irradiation at distinct light.The photoswitch can assemble with cucurbit[7]uril(CB[7])to form a superior fluorescent supramolecular complex(compared to the only guest)with excellent water solubility,which manifested dramatic photoluminescence enhancement caused by restriction of intramolecular rotation and remained good photochromic characteristics.Furthermore,introduction of CB[7]influence photoreaction quantum yield(Φ)of the stiff-stilbene,leading to reduction ofΦ_(E→Z) and increase ofΦ_(Z→E) of the stiff-stilbene.Importantly,the photoadjustable supramolecular assembly can act as a fluorescence switch,and the phototunable guest further selectively modulate G-quadruplex structure of Tel22 upon light irradiation or with addition of CB[7].The study provides a new simple way for accurately regulating photochromic properties of molecular switches and developing smart materials with potential applications in controlled modulation of G-quadruplex,targeted biological imaging and so on.
基金the National Natural Science Foundation of China(Nos.22101267,21672192,21803059,U2004191,U1904212,21801063)for financial support。
文摘Three discrete tetrahedral metallo-supramolecular cages were designed and constructed using truxenepended base ligands.Owing to the synergistic rigidifying effect of unsymmetric cyano-substituted oligo(pphenylene-vinylene)(u-COPV)suspended by the truxene skeleton,the resulting supramolecular cages were confirmed to exhibit significant aggregation-induced emission(AIE)accompanied by an interesting solvatochromic fluorescent behavior as well as a porous honeycomb-like state during aggregation.In particular,the anti-counterfeiting performance and emission behaviors of the cages in the solid state under external hydrostatic pressure were investigated.
基金supported by the Topnotch Talents Program of Henan Agricultural University(30501032)the National Natural Science Foundation of China(52003228 and 52273197)+2 种基金the Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ2021324134613038)the Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001)Shenzhen Peacock Team Project(KQTD20210811090142053).
文摘A new class of near-infrared(NIR)fluorescent organoboron AIEgens was successfully developed for latent fingerprints(LFPs)imaging.They exhibit real-time and in situ high-resolution imaging performance at 1-3 levels of LFPs by spraying method.In addition,we systematically elucidate the fingerprint imaging mechanism of these AIEgens.Significantly,the excellent level 3 structural imaging capabilities enable the application of them for analyzing incomplete LFPs and identifying individuals in different scenarios.
基金National Natural Science Foundation of China (Nos. 21432004, 21472100, 21772099 and 91527301) for financial support
文摘The molecular assembling properties can be dramatically improved using redox-responsive nanoplatforms, which can bring quite different aggregation modes and binding behaviors in the redox states. In this work, we fabricated a redox-responsive system based on the host–guest complexation of b-cyclodextrin(b-CD) with ferrocene-modified diphenylalanine(Fc-FF). The morphological conversion of Fc-FF can be easily achieved from nanofibers to nanospheres in the presence of b-CD, and the supramolecular nanospheres can be reversibly assembled and disassembled by the chemical redox of ferrocenyl groups in the Fc-FF&b-CD nanoassemblies. These results demonstrate that the incorporation of stimuli-switchable components with macrocyclic receptors may become a promising approach to the construction of smart peptide-involved supramolecular assemblies.
基金supported by the National Natural Science Foundation of China(Nos.21871154,21772099,21861132001,and 21873051)the Fundamental Research Funds for the Central Universities,Nankai University。
文摘Conformational regulation among two or more distant sites is not only one of the main pathways to accomplish multiple tasks in complex biological systems but also represents a powerful strategy to obtain stimuli-responsive supramolecular nanoconstructs with tailored physicochemical performance.We herein report the fabrication of a photochromic supramolecular assembly,which can be synergistically activated by the conformational regulation with bis(4,8-disulfonato-1,5-naphtho)-32-crown-8 and then reversibly switched by the through-space communication between restricted stilbazolium salt and photochromic dithienylethene.This work demonstrates that the synergistic conformational modulation via intra-and intermolecular interactions can be developed as a generalizable approach to construct more advanced biomimetic nanomaterials.
基金the National Natural Science Foundation of China(Nos.21801063,21672192,21803059 and 21929101)China Postdoctoral Science Foundation(No.2018M642767)+4 种基金Ph.D.Foundation of Henan University of Technology,China(No.2017BS020)the Science and Technology Foundation of Henan Province(No.192102210039)the Colleges and Universities Key Research Program Foundation of Henan Province(No.19A150022)Fundation of Henan University of Technology(No.2018QNJH14)the Natural Science Foundation of Henan Province(No.182300410255)for financial support。
文摘A metal-organic photoinduced electron transfer(PET) supramolecular nanoarchitecture comprised of Ru(Ⅱ) bis(terpyridine)-modified pillar[5]arene(electron acceptor) and triazole triphenylamine amyl cyanide(electron donor) has been designed and constructed.Through the comparison of diverse solvents and acceptors,the two conditions,i.e.,modification of pillar[5]arene to donor and weak polar solvent are benefit for the occurrence of "efficient PET" because of shorter D-A distance in the presence of pillar[5]arene.Crucially,the fluorescence and PET process of the supramolecular assembly could be further modulated by solvent conversion and another competitive guest.The study provides a supramolecular method to design and construct tunable PET systems and PET-based smart materials.
