海洋和大气是地球气候系统关键组成部分,其相互作用对全球气候及人类生活产生深远影响。为了分析海气相互作用的研究现状与未来的发展趋势。采用文献计量分析方法,运用VOSviewer和CiteSpace工具,筛选了中国知网(China National Knowledg...海洋和大气是地球气候系统关键组成部分,其相互作用对全球气候及人类生活产生深远影响。为了分析海气相互作用的研究现状与未来的发展趋势。采用文献计量分析方法,运用VOSviewer和CiteSpace工具,筛选了中国知网(China National Knowledge Infrastructure,CNKI)和Web of Science核心合集数据库中关于海气相互作用的文献,通过分析关键词共现网络图谱、时间序列图谱、突现网络图谱以及文献的发文国家和机构分布,对1981-2021年中国在该领域的研究进展和未来发展趋势进行了综合评估。同时,本研究还选取了2001-2021年的国际文献,对全球范围内的研究进展和热点问题进行了分析。研究表明,国内外在海气相互作用领域的研究均从宏观到微观角度深入探讨,着重研究了大气和海洋的基本作用机理,并进一步分析了影响地球气候系统的多种因素,目前研究重点转向了极端天气系统的预测及其运行机制。从研究机构和国家分布来看,高校与政府机构是主要的研究主体,国内研究机构之间的合作联系较为紧密。研究关键方向和方法,从宏观层面的基础研究转向更为深入的海气通量和大尺度过程研究。这一转变反映了国际海洋发展战略的调整,同时为未来的研究方向提供了新的视角和思路。展开更多
The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault lo...The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault location and real-time monitoring.To solve the above problems,an expert experience and data-driven-based hybrid fault diagnosis method for high-speed wire rod finishing mills is proposed in this paper.First,based on its mechanical structure,time and frequency domain analysis are improved in fault feature extraction.The approach of combining virtual value,peak value with kurtosis value index,is adopted in time domain analysis.Speed adjustment and side frequency analysis are proposed in frequency domain analysis to obtain accurate component characteristic frequency and its corresponding sideband.Then,according to time and frequency domain characteristics,fault location based on expert experience is proposed to get an accurate fault result.Finally,the proposed method is implemented in the equipment intelligent diagnosis system.By taking an equipment fault on site,for example,the effectiveness of the proposed method is illustrated in the system.展开更多
Hepatocellular carcinoma(HCC)is a malignancy known for its unfavorable prognosis.The dysregulation of the tumor microenvironment(TME)can affect the sensitivity to immunotherapy or chemotherapy,leading to treatment fai...Hepatocellular carcinoma(HCC)is a malignancy known for its unfavorable prognosis.The dysregulation of the tumor microenvironment(TME)can affect the sensitivity to immunotherapy or chemotherapy,leading to treatment failure.The elucidation of PHLDA2’s involvement in HCC is imperative,and the clinical value of PHLDA2 is also underestimated.Here,bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of HCC.Then,the expression and function of PHLDA2 were examined via the qRT-PCR,Western Blot,and MTT assays.Our findings indicate a substantial upregulation of PHLDA2 in HCC,correlated with a poorer prognosis.The methylation levels of PHLDA2 were found to be lower in HCC tissues compared to normal liver tissues.Besides,noteworthy associations were observed between PHLDA2 expression and immune infiltration in HCC.In addition,PHLDA2 upregulation is closely associated with stemness features and immunotherapy or chemotherapy resistance in HCC.In vitro experiments showed that sorafenib or cisplatin significantly up-regulated PHLDA2 mRNA levels,and PHLDA2 knockdown markedly decreased the sensitivity of HCC cells to chemotherapy drugs.Meanwhile,we found that TGF-βinduced the expression of PHLDA2 in vitro.The GSEA and in vitro experiment indicated that PHLDA2 may promote the HCC progression via activating the AKT signaling pathway.Our study revealed the novel role of PHLDA2 as an independent prognostic factor,which plays an essential role in TME remodeling and treatment resistance in HCC.展开更多
文摘海洋和大气是地球气候系统关键组成部分,其相互作用对全球气候及人类生活产生深远影响。为了分析海气相互作用的研究现状与未来的发展趋势。采用文献计量分析方法,运用VOSviewer和CiteSpace工具,筛选了中国知网(China National Knowledge Infrastructure,CNKI)和Web of Science核心合集数据库中关于海气相互作用的文献,通过分析关键词共现网络图谱、时间序列图谱、突现网络图谱以及文献的发文国家和机构分布,对1981-2021年中国在该领域的研究进展和未来发展趋势进行了综合评估。同时,本研究还选取了2001-2021年的国际文献,对全球范围内的研究进展和热点问题进行了分析。研究表明,国内外在海气相互作用领域的研究均从宏观到微观角度深入探讨,着重研究了大气和海洋的基本作用机理,并进一步分析了影响地球气候系统的多种因素,目前研究重点转向了极端天气系统的预测及其运行机制。从研究机构和国家分布来看,高校与政府机构是主要的研究主体,国内研究机构之间的合作联系较为紧密。研究关键方向和方法,从宏观层面的基础研究转向更为深入的海气通量和大尺度过程研究。这一转变反映了国际海洋发展战略的调整,同时为未来的研究方向提供了新的视角和思路。
基金the National Key Research and Development Program of China under Grant 2021YFB3301300the National Natural Science Foundation of China under Grant 62203213+1 种基金the Natural Science Foundation of Jiangsu Province under Grant BK20220332the Open Project Program of Fujian Provincial Key Laboratory of Intelligent Identification and Control of Complex Dynamic System under Grant 2022A0004.
文摘The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault location and real-time monitoring.To solve the above problems,an expert experience and data-driven-based hybrid fault diagnosis method for high-speed wire rod finishing mills is proposed in this paper.First,based on its mechanical structure,time and frequency domain analysis are improved in fault feature extraction.The approach of combining virtual value,peak value with kurtosis value index,is adopted in time domain analysis.Speed adjustment and side frequency analysis are proposed in frequency domain analysis to obtain accurate component characteristic frequency and its corresponding sideband.Then,according to time and frequency domain characteristics,fault location based on expert experience is proposed to get an accurate fault result.Finally,the proposed method is implemented in the equipment intelligent diagnosis system.By taking an equipment fault on site,for example,the effectiveness of the proposed method is illustrated in the system.
基金supported by the National Natural Science Foundation of China(Nos.81872255,62141109)the Leading-Edge Technology Programme of Jiangsu Natural Science Foundation:BK20212021.
文摘Hepatocellular carcinoma(HCC)is a malignancy known for its unfavorable prognosis.The dysregulation of the tumor microenvironment(TME)can affect the sensitivity to immunotherapy or chemotherapy,leading to treatment failure.The elucidation of PHLDA2’s involvement in HCC is imperative,and the clinical value of PHLDA2 is also underestimated.Here,bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of HCC.Then,the expression and function of PHLDA2 were examined via the qRT-PCR,Western Blot,and MTT assays.Our findings indicate a substantial upregulation of PHLDA2 in HCC,correlated with a poorer prognosis.The methylation levels of PHLDA2 were found to be lower in HCC tissues compared to normal liver tissues.Besides,noteworthy associations were observed between PHLDA2 expression and immune infiltration in HCC.In addition,PHLDA2 upregulation is closely associated with stemness features and immunotherapy or chemotherapy resistance in HCC.In vitro experiments showed that sorafenib or cisplatin significantly up-regulated PHLDA2 mRNA levels,and PHLDA2 knockdown markedly decreased the sensitivity of HCC cells to chemotherapy drugs.Meanwhile,we found that TGF-βinduced the expression of PHLDA2 in vitro.The GSEA and in vitro experiment indicated that PHLDA2 may promote the HCC progression via activating the AKT signaling pathway.Our study revealed the novel role of PHLDA2 as an independent prognostic factor,which plays an essential role in TME remodeling and treatment resistance in HCC.
