The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great sign...The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great significance to study the ecological risk and the accumulation trends of heavy metals in the soil of mining areas for scientific prevention and control of heavy metal pollution.Taking the Taowanbeigou River Basin in the mine concentration area as the research object,the ecological pollution risk and cumulative effect of heavy metals in the soil of the basin were studied by using the comprehensive pollution index method,potential ecological risk assessment method and geoaccumulation index method.On this basis,the cumulative exceeding years of specific heavy metals were predicted by using the early warning model.The comprehensive potential ecological risk of heavy metals in the soil near the Luanchuan mine concentration area is moderate,and the single element Cd is the main ecological risk factor,with a contribution rate of 53.6%.The overall cumulative degrees of Cu and Pb in the soil are“none-moderate”,Zn and Cd are moderate,Mo has reached an extremely strong cumulative level,Hg,As and Cr risks are not obvious,and the overall cumulative risks order is Mo>Cd>Zn>Cu>Pb>Hg.According to the current accumulation rate and taking the risk screening values for soil contamination of agricultural land as the reference standard,the locations over standard rates of Cu,Zn and Cd will exceed 78%in 90years,and the over standard rate of Pb will reach approximately 57%in 200 years.The cumulative exceeding standard periods of As,Cr and Hg are generally long,which basically indicates that these elements do not pose a significant potential threat to the ecological environment.Mining activities will accelerate the accumulation of heavy metals in soil.With the continuous development of mining activities,the potential pollution risk of heavy metals in the soil of mining areas will also increase.展开更多
BACKGROUND Pancreaticobiliary maljunction(PBM) is an uncommon congenital anomaly of the pancreatic and biliary ductal system, defined as a union of the pancreatic and biliary ducts located outside the duodenal wall. A...BACKGROUND Pancreaticobiliary maljunction(PBM) is an uncommon congenital anomaly of the pancreatic and biliary ductal system, defined as a union of the pancreatic and biliary ducts located outside the duodenal wall. According to the Komi classification of PBM, the common bile duct(CBD) directly fuses with the ventral pancreatic duct in all types. Pancreas divisum(PD) occurs when the ventral and dorsal ducts of the embryonic pancreas fail to fuse during the second month of fetal development. The coexistence of PBM and PD is an infrequent condition.Here, we report an unusual variant of PBM associated with PD in a pediatric patient, in whom an anomalous communication existed between the CBD and dorsal pancreatic duct.CASE SUMMARY A boy aged 4 years and 2 mo was hospitalized for abdominal pain with nausea and jaundice for 5 d. Abdominal ultrasound showed cholecystitis with cholestasis in the gallbladder, dilated middle-upper CBD, and a strong echo in the lower CBD, indicating biliary stones. The diagnosis was extrahepatic biliary obstruction caused by biliary stones, which is an indication for endoscopic retrograde cholangiopancreatography(ERCP). ERCP was performed to remove biliary stones. During the ERCP, we found a rare communication between the CBD and dorsal pancreatic duct. After clearing the CBD with a balloon, an 8.5 Fr 4-cm pigtail plastic pancreatic stent was placed in the biliary duct through the major papilla. Six months later, his biliary stent was removed after he had no symptoms and normal laboratory tests. In the following 4-year period, the child grew up normally with no more attacks of abdominal pain.CONCLUSION We consider that ERCP is effective and safe in pediatric patients with PBM combined with PD, and can be the initial therapy to manage such cases,especially when it is combined with aberrant communication between the CBD and dorsal pancreatic duct.展开更多
Background: New-onset hyperglycemia(NOH) is a common phenomenon after liver transplantation(LT),but its impact on clinical outcomes has not yet been fully assessed. We aimed to evaluate the etiology and prognosis of N...Background: New-onset hyperglycemia(NOH) is a common phenomenon after liver transplantation(LT),but its impact on clinical outcomes has not yet been fully assessed. We aimed to evaluate the etiology and prognosis of NOH within 1 month after LT.Methods: The data of 3339 adult patients who underwent primary LT from donation after citizen death between January 2010 and June 2016 were extracted from China Liver Transplant Registry database and analyzed. NOH was defined as fasting blood glucose ≥7.0 mmol/L confirmed on at least two occasions within the first post-transplant month with or without hypoglycemic agent.Results: Of 3339 liver recipients, 1416(42.4%) developed NOH. Recipients with NOH had higher incidence of post-transplant complications such as graft and kidney failure, infection, biliary stricture, cholangitis,and tumor recurrence in a glucose concentration-dependent manner as compared to non-NOH recipients(P < 0.05). The independent risk factors of NOH were donor warm ischemic time >10 min, cold ischemic time >10 h, anhepatic time >60 min, recipient model for end-stage liver disease score >30, moderate ascites and corticosteroid usage(P < 0.05). Liver enzymes(alanine aminotransferase and gammaglutamyltranspeptidase) on post-transplant day 7 significantly correlated with NOH(P < 0.001).Conclusions: NOH leads to increased morbidity and mortality in liver recipients. Close surveillance and tight control of blood glucose are desiderated immediately following LT particularly in those with delayed graft function and receiving corticosteroid. Strategic targeting graft ischemic injury may help maintain glucose homeostasis.展开更多
BACKGROUND Post-transplant dyslipidemia(PTDL)is a common complication in liver recipients and can cause morbidity and threaten graft function.The crosstalk between metabolic inflammation and dyslipidemia has been rece...BACKGROUND Post-transplant dyslipidemia(PTDL)is a common complication in liver recipients and can cause morbidity and threaten graft function.The crosstalk between metabolic inflammation and dyslipidemia has been recently revealed.However,the role of grafts’and recipients’metabolic status in the development of PTDL has not been evaluated.AIM To investigate the association of recipients’metabolic inflammation status with PTDL and construct a predictive model.METHODS A total of 396 adult patients who received primary liver transplantation between 2015 and 2017 were enrolled.Metabolomics and cytokines were analyzed using recipients’pre-transplant peripheral blood in a training set(n=72).An integrated prediction model was established according to the clinical risk factors and metabolic inflammation compounds and further verified in a validation set(n=144).RESULTS The serum lipid profile took 3 mo to reach homeostasis after liver transplantation.A total of 278(70.2%)liver recipients developed PTDL during a follow-up period of 1.78(1.00,2.97)years.The PTDL group showed a significantly lower tumorfree survival and overall survival than the non-PTDL group in patients with hepatocellular carcinoma(n=169).The metabolomic analysis showed that metabolic features discriminating between the PTDL and non-PTDL groups were associated with lipid and glucose metabolism-associated pathways.Among metabolites and cytokines differentially expressed between the two groups,interleukin-12(p70)showed the best diagnostic accuracy and significantly increased the predictive value when it was incorporated into the clinical model in both training and validation sets.CONCLUSION Recipients’pre-transplant serum interleukin-12(p70)level is associated with the risk of PTDL and has potential clinical value for predicting PTDL.展开更多
Intrapancreatic accessory spleen(IPAS)is a rare differential diagnosis of a solitary hypervascular lesion.It is not uncommon to misdiagnose IPAS as pancreatic tumors since no specific imaging has been developed for th...Intrapancreatic accessory spleen(IPAS)is a rare differential diagnosis of a solitary hypervascular lesion.It is not uncommon to misdiagnose IPAS as pancreatic tumors since no specific imaging has been developed for the differential diagnosis.We described a rare case of a male patient with a unilateral accessory nipple and a solitary hypervascular lesion in the pancreas.The patient underwent a distal pancreaticosplenectomy,and IPAS was finally diagnosed.展开更多
In order to reveal the cold resistant mechanism of tea plant,two varieties with different cold resistances were studied.The activities of catalase(CAT),peroxidase(POD),superoxide dismutase(SOD) and polyphenol oxidase(...In order to reveal the cold resistant mechanism of tea plant,two varieties with different cold resistances were studied.The activities of catalase(CAT),peroxidase(POD),superoxide dismutase(SOD) and polyphenol oxidase(PPO) were investigated,and the contents of soluble protein,sugar and malondialdehyde(MDA) were determined in fresh tea leaves in the autumn.The results showed that the activities of POD and the content of soluble sugar were both much higher in the variety with strong cold resistance,and the content of soluble protein was associated with the cold resistance,while the cold resistance of the plant was not related with the activities of the CAT,SOD and PPO,and the content of MDA.It is considered that the activity of POD and contents of soluble sugar could be used as indicators to identify the cold resistance of tea varieties.展开更多
Developing new saturable absorbers for use in the mid-infrared region has practical significance for short-pulsed lasers and related scientific and industrial applications.The performance of gold nanorods(GNRs)as satu...Developing new saturable absorbers for use in the mid-infrared region has practical significance for short-pulsed lasers and related scientific and industrial applications.The performance of gold nanorods(GNRs)as saturable absorbers at novel mid-infrared wavelengths needs to be evaluated even though these benefit from ultrafast nonlinear responses and broadband saturable absorption.Passive Q-switching of an LD-pumped 2.3μm Tm:YLF laser using GNRs was successfully realized in this study.Pulses with an 843 ns pulse width and a 6.67 kHz repetition rate were achieved using this Q-switched laser.Results showed that GNRs provide promising passive Q-switches for 2.3μm Tm-doped lasers.展开更多
基金supported by the Science and Technology Research Project to Henan Provincial Department of Natural Resources(Henan Natural Resources Letter[2019]373–10)。
文摘The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great significance to study the ecological risk and the accumulation trends of heavy metals in the soil of mining areas for scientific prevention and control of heavy metal pollution.Taking the Taowanbeigou River Basin in the mine concentration area as the research object,the ecological pollution risk and cumulative effect of heavy metals in the soil of the basin were studied by using the comprehensive pollution index method,potential ecological risk assessment method and geoaccumulation index method.On this basis,the cumulative exceeding years of specific heavy metals were predicted by using the early warning model.The comprehensive potential ecological risk of heavy metals in the soil near the Luanchuan mine concentration area is moderate,and the single element Cd is the main ecological risk factor,with a contribution rate of 53.6%.The overall cumulative degrees of Cu and Pb in the soil are“none-moderate”,Zn and Cd are moderate,Mo has reached an extremely strong cumulative level,Hg,As and Cr risks are not obvious,and the overall cumulative risks order is Mo>Cd>Zn>Cu>Pb>Hg.According to the current accumulation rate and taking the risk screening values for soil contamination of agricultural land as the reference standard,the locations over standard rates of Cu,Zn and Cd will exceed 78%in 90years,and the over standard rate of Pb will reach approximately 57%in 200 years.The cumulative exceeding standard periods of As,Cr and Hg are generally long,which basically indicates that these elements do not pose a significant potential threat to the ecological environment.Mining activities will accelerate the accumulation of heavy metals in soil.With the continuous development of mining activities,the potential pollution risk of heavy metals in the soil of mining areas will also increase.
文摘BACKGROUND Pancreaticobiliary maljunction(PBM) is an uncommon congenital anomaly of the pancreatic and biliary ductal system, defined as a union of the pancreatic and biliary ducts located outside the duodenal wall. According to the Komi classification of PBM, the common bile duct(CBD) directly fuses with the ventral pancreatic duct in all types. Pancreas divisum(PD) occurs when the ventral and dorsal ducts of the embryonic pancreas fail to fuse during the second month of fetal development. The coexistence of PBM and PD is an infrequent condition.Here, we report an unusual variant of PBM associated with PD in a pediatric patient, in whom an anomalous communication existed between the CBD and dorsal pancreatic duct.CASE SUMMARY A boy aged 4 years and 2 mo was hospitalized for abdominal pain with nausea and jaundice for 5 d. Abdominal ultrasound showed cholecystitis with cholestasis in the gallbladder, dilated middle-upper CBD, and a strong echo in the lower CBD, indicating biliary stones. The diagnosis was extrahepatic biliary obstruction caused by biliary stones, which is an indication for endoscopic retrograde cholangiopancreatography(ERCP). ERCP was performed to remove biliary stones. During the ERCP, we found a rare communication between the CBD and dorsal pancreatic duct. After clearing the CBD with a balloon, an 8.5 Fr 4-cm pigtail plastic pancreatic stent was placed in the biliary duct through the major papilla. Six months later, his biliary stent was removed after he had no symptoms and normal laboratory tests. In the following 4-year period, the child grew up normally with no more attacks of abdominal pain.CONCLUSION We consider that ERCP is effective and safe in pediatric patients with PBM combined with PD, and can be the initial therapy to manage such cases,especially when it is combined with aberrant communication between the CBD and dorsal pancreatic duct.
基金supported by grants from the National Natural Science Foundation of China(81771713,81470892,and 81570589)Zhejiang Natural Science Foundation(LY17H100003)Zhejiang Science and Technology Key Research and Development Project(2018C04010)
文摘Background: New-onset hyperglycemia(NOH) is a common phenomenon after liver transplantation(LT),but its impact on clinical outcomes has not yet been fully assessed. We aimed to evaluate the etiology and prognosis of NOH within 1 month after LT.Methods: The data of 3339 adult patients who underwent primary LT from donation after citizen death between January 2010 and June 2016 were extracted from China Liver Transplant Registry database and analyzed. NOH was defined as fasting blood glucose ≥7.0 mmol/L confirmed on at least two occasions within the first post-transplant month with or without hypoglycemic agent.Results: Of 3339 liver recipients, 1416(42.4%) developed NOH. Recipients with NOH had higher incidence of post-transplant complications such as graft and kidney failure, infection, biliary stricture, cholangitis,and tumor recurrence in a glucose concentration-dependent manner as compared to non-NOH recipients(P < 0.05). The independent risk factors of NOH were donor warm ischemic time >10 min, cold ischemic time >10 h, anhepatic time >60 min, recipient model for end-stage liver disease score >30, moderate ascites and corticosteroid usage(P < 0.05). Liver enzymes(alanine aminotransferase and gammaglutamyltranspeptidase) on post-transplant day 7 significantly correlated with NOH(P < 0.001).Conclusions: NOH leads to increased morbidity and mortality in liver recipients. Close surveillance and tight control of blood glucose are desiderated immediately following LT particularly in those with delayed graft function and receiving corticosteroid. Strategic targeting graft ischemic injury may help maintain glucose homeostasis.
基金Supported by the National Natural Science Foundation of China,No.81771713Zhejiang Provincial Natural Science Foundation of China,No.LR18H030001.
文摘BACKGROUND Post-transplant dyslipidemia(PTDL)is a common complication in liver recipients and can cause morbidity and threaten graft function.The crosstalk between metabolic inflammation and dyslipidemia has been recently revealed.However,the role of grafts’and recipients’metabolic status in the development of PTDL has not been evaluated.AIM To investigate the association of recipients’metabolic inflammation status with PTDL and construct a predictive model.METHODS A total of 396 adult patients who received primary liver transplantation between 2015 and 2017 were enrolled.Metabolomics and cytokines were analyzed using recipients’pre-transplant peripheral blood in a training set(n=72).An integrated prediction model was established according to the clinical risk factors and metabolic inflammation compounds and further verified in a validation set(n=144).RESULTS The serum lipid profile took 3 mo to reach homeostasis after liver transplantation.A total of 278(70.2%)liver recipients developed PTDL during a follow-up period of 1.78(1.00,2.97)years.The PTDL group showed a significantly lower tumorfree survival and overall survival than the non-PTDL group in patients with hepatocellular carcinoma(n=169).The metabolomic analysis showed that metabolic features discriminating between the PTDL and non-PTDL groups were associated with lipid and glucose metabolism-associated pathways.Among metabolites and cytokines differentially expressed between the two groups,interleukin-12(p70)showed the best diagnostic accuracy and significantly increased the predictive value when it was incorporated into the clinical model in both training and validation sets.CONCLUSION Recipients’pre-transplant serum interleukin-12(p70)level is associated with the risk of PTDL and has potential clinical value for predicting PTDL.
文摘Intrapancreatic accessory spleen(IPAS)is a rare differential diagnosis of a solitary hypervascular lesion.It is not uncommon to misdiagnose IPAS as pancreatic tumors since no specific imaging has been developed for the differential diagnosis.We described a rare case of a male patient with a unilateral accessory nipple and a solitary hypervascular lesion in the pancreas.The patient underwent a distal pancreaticosplenectomy,and IPAS was finally diagnosed.
文摘In order to reveal the cold resistant mechanism of tea plant,two varieties with different cold resistances were studied.The activities of catalase(CAT),peroxidase(POD),superoxide dismutase(SOD) and polyphenol oxidase(PPO) were investigated,and the contents of soluble protein,sugar and malondialdehyde(MDA) were determined in fresh tea leaves in the autumn.The results showed that the activities of POD and the content of soluble sugar were both much higher in the variety with strong cold resistance,and the content of soluble protein was associated with the cold resistance,while the cold resistance of the plant was not related with the activities of the CAT,SOD and PPO,and the content of MDA.It is considered that the activity of POD and contents of soluble sugar could be used as indicators to identify the cold resistance of tea varieties.
基金Project supported by the National Natural Science Foundation of China(Nos.61875077 and 61911530131)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.18KJA510001)。
文摘Developing new saturable absorbers for use in the mid-infrared region has practical significance for short-pulsed lasers and related scientific and industrial applications.The performance of gold nanorods(GNRs)as saturable absorbers at novel mid-infrared wavelengths needs to be evaluated even though these benefit from ultrafast nonlinear responses and broadband saturable absorption.Passive Q-switching of an LD-pumped 2.3μm Tm:YLF laser using GNRs was successfully realized in this study.Pulses with an 843 ns pulse width and a 6.67 kHz repetition rate were achieved using this Q-switched laser.Results showed that GNRs provide promising passive Q-switches for 2.3μm Tm-doped lasers.
