Background Coronary artery calcification(CAC)is common in end-stage renal disease(ESRD)patients,and the extent of CAC is closely related to cardiovascular outcomes in ESRD patients.Cartilage oligomeric matrix protein(...Background Coronary artery calcification(CAC)is common in end-stage renal disease(ESRD)patients,and the extent of CAC is closely related to cardiovascular outcomes in ESRD patients.Cartilage oligomeric matrix protein(COMP),as a component of the vascular matrix,has been found to be an inhibitor of arterial calcification in basic studies.However,there is no clinical research on the correlation between COMP and CAC in maintenance hemodialysis(MHD)patients.The aim of this study was to explore the relationship between serum COMP levels and CAC and cardiovascular events in MHD patients.Methods Serum COMP levels were compared between 54 MHD patients and 66 healthy people.MHD patients were then divided into three groups according to the tertiles of the concentration of COMP level and were followed up for major adverse cardiac events(MACEs),which were defined as a combined end point of new onset angina pectoris,nonfatal myocardial infarction,heart failure,coronary artery revascularization,hospitalization due to angina pectoris and all-cause deaths.The CAC score was calculated based on computed tomography scans.Results The serum COMP level in MHD patients was significantly higher than that in the general population[984.23(248.43-1902.61)ng/mL vs.219.01(97.26-821.92)ng/mL,P<0.01].Serum COMP levels were positively correlated with CAC(r=0.313,P=0.021)and serum parathyroid hormone in MHD patients(r=0.359,P<0.01).Linear regression suggested that after adjusting for age,fasting blood glucose(Glu)and glycosylated hemoglobin(HbAlc),CAC score was an independent predictor in the final model for COMP level(β=0.424,t=3.130,P<0.01).The receiver operating characteristic(ROC)curve showed that COMP≥994 mg/mL had 68.0%sensitivity and 72.4%specificity for the prediction of severe CAC[area under the curve(AUC):0.674,P=0.030,95%CI:0.526-0.882].After a median follow-up of 16 months(8-24 months),there was no difference in the incidence rate of MACEs between the upper,middle and lower serum COMP groups.Conclusions Our study found that MHD patients have higher levels of circulating COMP than controls.The serum COMP level is positively correlated with CAC score and could be used as a biomarker of severe CAC in MHD patients.However,there is no obvious correlation between serum COMP levels and the incidence of cardiovascular events.展开更多
Mercury emission has become a great environmental concern because of its high toxicity,bioaccumulation,and persistence.Adsorption is an effective method to remove Hg^(0)from coal-fired flue gas,with adsorbents playing...Mercury emission has become a great environmental concern because of its high toxicity,bioaccumulation,and persistence.Adsorption is an effective method to remove Hg^(0)from coal-fired flue gas,with adsorbents playing a dominant role.Extensive investigations have been conducted on the use of CuO-based materials for Hg^(0)removal,and some fruitful results have been obtained.In this review,we summarize advances in the application of CuO-based materials for Hg^(0)capture.Firstly,the fundamentals of CuO,including its crystal information and synthesis methods,are introduced.Then,the Hg^(0)removal capability of some typical CuO-based adsorbents is discussed.Considering that coal-fired flue gas also contains a certain amount of NO,SO_(2),H_(2)O,NH_(3),and HCl,the impacts of these species on adsorbent Hg^(0)removal efficiency are summarized next.By generalizing the mechanisms dominating the Hg^(0)removal process,the rate-determining step and the key intermediates can be discovered.Apart from Hg^(0),some other air pollutants,such as CO,NOx,and volatile organic compounds(VOCs),account for a certain portion of flue gas.In view of their similar abatement mechanisms,simultaneous removal of Hg^(0)and other air pollutants has become a hot topic in the environmental field.Considering the Hg^(0)re-emission phenomena in wet flue gas desulfurization(WFGD),mercury capture performance under different conditions in this device is discussed.Finally,we conclude that new adsorbents suitable for long-term operation in coal-fired flue gas should be developed to realize the effective reduction of mercury emissions.展开更多
基金supported by the National Natural Science Foundation of China(81400262)the Backbone Fund of Peking University Third Hospital(Y72497-04)
文摘Background Coronary artery calcification(CAC)is common in end-stage renal disease(ESRD)patients,and the extent of CAC is closely related to cardiovascular outcomes in ESRD patients.Cartilage oligomeric matrix protein(COMP),as a component of the vascular matrix,has been found to be an inhibitor of arterial calcification in basic studies.However,there is no clinical research on the correlation between COMP and CAC in maintenance hemodialysis(MHD)patients.The aim of this study was to explore the relationship between serum COMP levels and CAC and cardiovascular events in MHD patients.Methods Serum COMP levels were compared between 54 MHD patients and 66 healthy people.MHD patients were then divided into three groups according to the tertiles of the concentration of COMP level and were followed up for major adverse cardiac events(MACEs),which were defined as a combined end point of new onset angina pectoris,nonfatal myocardial infarction,heart failure,coronary artery revascularization,hospitalization due to angina pectoris and all-cause deaths.The CAC score was calculated based on computed tomography scans.Results The serum COMP level in MHD patients was significantly higher than that in the general population[984.23(248.43-1902.61)ng/mL vs.219.01(97.26-821.92)ng/mL,P<0.01].Serum COMP levels were positively correlated with CAC(r=0.313,P=0.021)and serum parathyroid hormone in MHD patients(r=0.359,P<0.01).Linear regression suggested that after adjusting for age,fasting blood glucose(Glu)and glycosylated hemoglobin(HbAlc),CAC score was an independent predictor in the final model for COMP level(β=0.424,t=3.130,P<0.01).The receiver operating characteristic(ROC)curve showed that COMP≥994 mg/mL had 68.0%sensitivity and 72.4%specificity for the prediction of severe CAC[area under the curve(AUC):0.674,P=0.030,95%CI:0.526-0.882].After a median follow-up of 16 months(8-24 months),there was no difference in the incidence rate of MACEs between the upper,middle and lower serum COMP groups.Conclusions Our study found that MHD patients have higher levels of circulating COMP than controls.The serum COMP level is positively correlated with CAC score and could be used as a biomarker of severe CAC in MHD patients.However,there is no obvious correlation between serum COMP levels and the incidence of cardiovascular events.
基金This work is supported by the Scientific Research Foundation of China Jiliang Universitythe Zhejiang Provincial Natural Science Foundation of China(Nos.LQ22E060003 and LY22E040001).
文摘Mercury emission has become a great environmental concern because of its high toxicity,bioaccumulation,and persistence.Adsorption is an effective method to remove Hg^(0)from coal-fired flue gas,with adsorbents playing a dominant role.Extensive investigations have been conducted on the use of CuO-based materials for Hg^(0)removal,and some fruitful results have been obtained.In this review,we summarize advances in the application of CuO-based materials for Hg^(0)capture.Firstly,the fundamentals of CuO,including its crystal information and synthesis methods,are introduced.Then,the Hg^(0)removal capability of some typical CuO-based adsorbents is discussed.Considering that coal-fired flue gas also contains a certain amount of NO,SO_(2),H_(2)O,NH_(3),and HCl,the impacts of these species on adsorbent Hg^(0)removal efficiency are summarized next.By generalizing the mechanisms dominating the Hg^(0)removal process,the rate-determining step and the key intermediates can be discovered.Apart from Hg^(0),some other air pollutants,such as CO,NOx,and volatile organic compounds(VOCs),account for a certain portion of flue gas.In view of their similar abatement mechanisms,simultaneous removal of Hg^(0)and other air pollutants has become a hot topic in the environmental field.Considering the Hg^(0)re-emission phenomena in wet flue gas desulfurization(WFGD),mercury capture performance under different conditions in this device is discussed.Finally,we conclude that new adsorbents suitable for long-term operation in coal-fired flue gas should be developed to realize the effective reduction of mercury emissions.
