BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cas...BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cases,with approximately 4.5 million individuals affected by active tuberculosis.Notably,T2DM poses a significant risk factor for the development of tuberculosis,as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis(T2DMPTB),which has risen from 19.3%to 24.1%.It is evident that these two diseases are intricately interconnected and mutually reinforcing in nature.AIM To elucidate the clinical features of individuals diagnosed with both T2DM and tuberculosis(T2DM-PTB),as well as to investigate the potential risk factors associated with active tuberculosis in patients with T2DM.METHODS T2DM-PTB patients who visited our hospital between January 2020 and January 2023 were selected as the observation group,Simple DM patients presenting to our hospital in the same period were the control group,Controls and case groups were matched 1:2 according to the principle of the same sex,age difference(±3)years and disease duration difference(±5)years,patients were investigated for general demographic characteristics,diabetes-related characteristics,body immune status,lifestyle and behavioral habits,univariate and multivariate analysis of the data using conditional logistic regression,calculate the odds ratio(OR)values and 95%CI of OR values.RESULTS A total of 315 study subjects were included in this study,including 105 subjects in the observation group and 210 subjects in the control group.Comparison of the results of both anthropometric and biochemical measures showed that the constitution index,systolic blood pressure,diastolic blood pressure and lymphocyte count were significantly lower in the case group,while fasting blood glucose and high-density lipoprotein cholesterol levels were significantly higher than those in the control group.The results of univariate analysis showed that poor glucose control,hypoproteinemia,lymphopenia,TB contact history,high infection,smoking and alcohol consumption were positively associated with PTB in T2DM patients;married,history of hypertension,treatment of oral hypoglycemic drugs plus insulin,overweight,obesity and regular exercise were negatively associated with PTB in T2DM patients.Results of multivariate stepwise regression analysis found lymphopenia(OR=17.75,95%CI:3.40-92.74),smoking(OR=12.25,95%CI:2.53-59.37),history of TB contact(OR=6.56,95%CI:1.23-35.03)and poor glycemic control(OR=3.37,95%CI:1.11-10.25)was associated with an increased risk of developing PTB in patients with T2DM,While being overweight(OR=0.23,95%CI:0.08-0.72)and obesity(OR=0.11,95%CI:0.02-0.72)was associated with a reduced risk of developing PTB in patients with T2DM.CONCLUSION T2DM-PTB patients are prone to worse glycemic control,higher infection frequency,and a higher proportion of people smoking,drinking alcohol,and lack of exercise.Lymphopenia,smoking,history of TB exposure,poor glycemic control were independent risk factors for T2DM-PTB,and overweight and obesity were associated with reduced risk of concurrent PTB in patients with T2DM.展开更多
The Neogene Terror Rift in the Antarctic Victoria Land Basin(VLB)of the Ross Sea,Antarctica,is composed of the Discovery Graben and the Lee Arch.Many Neogene volcanoes are aligned in the north-south direction in the s...The Neogene Terror Rift in the Antarctic Victoria Land Basin(VLB)of the Ross Sea,Antarctica,is composed of the Discovery Graben and the Lee Arch.Many Neogene volcanoes are aligned in the north-south direction in the southern VLB,belonging to the McMurdo Volcanic Group.However,due to multiple glaciations and limited seismic data,the volcanic processes are still unclear in the northern VLB,especially in the Terror Rift.Multichannel seismic profiles were collected at the VLB from the 32nd Chinese National Antarctic Research Expedition(CHINARE).We utilized four seismic profiles from the CHINARE and additional historical profiles,along with gravity and magnetic anomalies,to analyze faults and stratigraphic characteristics in the northern Terror Rift and volcanism in the VLB.Negative flower structures found in the northern Terror Rift suggest that the Terror Rift was affected by dextral strike-slip faults extending from the northern Victoria Land(NVL).After the initial orthogonal tension,the rift transited into an oblique extension,forming a set of downward concaving normal faults and accommodation zones in the Terror Rift.On the Lee Arch,several imbricated normal faults formed and converged into a detachment fault.Under gravitational forces,the strata bent upward and formed a rollover anticline.Many deep faults and thin strata subjected to erosion facilitated volcanic activity.A brittle volcanic region in the VLB was affected by dextral strike-slip movements and east-west extension,resulting in two Neogene volcanic chains that connect three igneous provinces in the VLB:the Hallett,Melbourne,and Erebus Provinces.These two chains contain mud volcanoes with magnetic nuclei,volcanic intrusions,and late-stage volcanic eruptions.Volcanisms have brought about opposite polarities of magnetic anomalies in Antarctica,indicating the occurrence of multiple volcanic activities.展开更多
The metal oxide/nitrogen-doped carbon(NC)compounds zirconium oxide/NC(ZrO_(2)/NC)and cerium oxide/NC(CeO_(2)/NC)were synthesized via the pyrolysis of polyaniline on the metal oxide surface.The characterization of the ...The metal oxide/nitrogen-doped carbon(NC)compounds zirconium oxide/NC(ZrO_(2)/NC)and cerium oxide/NC(CeO_(2)/NC)were synthesized via the pyrolysis of polyaniline on the metal oxide surface.The characterization of the ZrO_(2)/NC and CeO_(2)/NC catalysts showed more active CO_(2) reduction reaction activity than that of NC catalyst without metal oxide.Gas chromatography analysis revealed that CO and H_(2)were the primary products,and no liquid-phase products were detected via proton nuclear magnetic resonance spectroscopy or high-performance liquid chromatography.The maximum Faraday effi ciency of ZrO_(2)/NC reached 90%at−0.73 V(vs.RHE),with the current density of CO at 5.5 mA/cm^(2);this Faraday effi ciency value was higher than that of NC(41%),with the current density of CO at 3.1 mA/cm^(2).The interaction between the metal oxide and carbon allowed the effi cient formation of defect sites,especially imine-type nitrogen,strengthening the adsorption of the key reaction intermediate CO_(2)^(•−) and thus promoting the CO_(2) reduction reaction.展开更多
文摘BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cases,with approximately 4.5 million individuals affected by active tuberculosis.Notably,T2DM poses a significant risk factor for the development of tuberculosis,as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis(T2DMPTB),which has risen from 19.3%to 24.1%.It is evident that these two diseases are intricately interconnected and mutually reinforcing in nature.AIM To elucidate the clinical features of individuals diagnosed with both T2DM and tuberculosis(T2DM-PTB),as well as to investigate the potential risk factors associated with active tuberculosis in patients with T2DM.METHODS T2DM-PTB patients who visited our hospital between January 2020 and January 2023 were selected as the observation group,Simple DM patients presenting to our hospital in the same period were the control group,Controls and case groups were matched 1:2 according to the principle of the same sex,age difference(±3)years and disease duration difference(±5)years,patients were investigated for general demographic characteristics,diabetes-related characteristics,body immune status,lifestyle and behavioral habits,univariate and multivariate analysis of the data using conditional logistic regression,calculate the odds ratio(OR)values and 95%CI of OR values.RESULTS A total of 315 study subjects were included in this study,including 105 subjects in the observation group and 210 subjects in the control group.Comparison of the results of both anthropometric and biochemical measures showed that the constitution index,systolic blood pressure,diastolic blood pressure and lymphocyte count were significantly lower in the case group,while fasting blood glucose and high-density lipoprotein cholesterol levels were significantly higher than those in the control group.The results of univariate analysis showed that poor glucose control,hypoproteinemia,lymphopenia,TB contact history,high infection,smoking and alcohol consumption were positively associated with PTB in T2DM patients;married,history of hypertension,treatment of oral hypoglycemic drugs plus insulin,overweight,obesity and regular exercise were negatively associated with PTB in T2DM patients.Results of multivariate stepwise regression analysis found lymphopenia(OR=17.75,95%CI:3.40-92.74),smoking(OR=12.25,95%CI:2.53-59.37),history of TB contact(OR=6.56,95%CI:1.23-35.03)and poor glycemic control(OR=3.37,95%CI:1.11-10.25)was associated with an increased risk of developing PTB in patients with T2DM,While being overweight(OR=0.23,95%CI:0.08-0.72)and obesity(OR=0.11,95%CI:0.02-0.72)was associated with a reduced risk of developing PTB in patients with T2DM.CONCLUSION T2DM-PTB patients are prone to worse glycemic control,higher infection frequency,and a higher proportion of people smoking,drinking alcohol,and lack of exercise.Lymphopenia,smoking,history of TB exposure,poor glycemic control were independent risk factors for T2DM-PTB,and overweight and obesity were associated with reduced risk of concurrent PTB in patients with T2DM.
基金supported by the Impact and Response of Antarctic Seas to Climate Change Project (IRASCC01-03-01)Hainan Naturtal Science Foundation Inovative Research Team Project (421CXTD441)the National Natural Science Foundation of China (Nos. 42176067, 41576069, 42176055, 41776189 and 41906197)
文摘The Neogene Terror Rift in the Antarctic Victoria Land Basin(VLB)of the Ross Sea,Antarctica,is composed of the Discovery Graben and the Lee Arch.Many Neogene volcanoes are aligned in the north-south direction in the southern VLB,belonging to the McMurdo Volcanic Group.However,due to multiple glaciations and limited seismic data,the volcanic processes are still unclear in the northern VLB,especially in the Terror Rift.Multichannel seismic profiles were collected at the VLB from the 32nd Chinese National Antarctic Research Expedition(CHINARE).We utilized four seismic profiles from the CHINARE and additional historical profiles,along with gravity and magnetic anomalies,to analyze faults and stratigraphic characteristics in the northern Terror Rift and volcanism in the VLB.Negative flower structures found in the northern Terror Rift suggest that the Terror Rift was affected by dextral strike-slip faults extending from the northern Victoria Land(NVL).After the initial orthogonal tension,the rift transited into an oblique extension,forming a set of downward concaving normal faults and accommodation zones in the Terror Rift.On the Lee Arch,several imbricated normal faults formed and converged into a detachment fault.Under gravitational forces,the strata bent upward and formed a rollover anticline.Many deep faults and thin strata subjected to erosion facilitated volcanic activity.A brittle volcanic region in the VLB was affected by dextral strike-slip movements and east-west extension,resulting in two Neogene volcanic chains that connect three igneous provinces in the VLB:the Hallett,Melbourne,and Erebus Provinces.These two chains contain mud volcanoes with magnetic nuclei,volcanic intrusions,and late-stage volcanic eruptions.Volcanisms have brought about opposite polarities of magnetic anomalies in Antarctica,indicating the occurrence of multiple volcanic activities.
基金The work was supported by the National Key R&D Program of China(No.2016YFB0600901)Changyi Hydrogen Industrial Technology Fund.
文摘The metal oxide/nitrogen-doped carbon(NC)compounds zirconium oxide/NC(ZrO_(2)/NC)and cerium oxide/NC(CeO_(2)/NC)were synthesized via the pyrolysis of polyaniline on the metal oxide surface.The characterization of the ZrO_(2)/NC and CeO_(2)/NC catalysts showed more active CO_(2) reduction reaction activity than that of NC catalyst without metal oxide.Gas chromatography analysis revealed that CO and H_(2)were the primary products,and no liquid-phase products were detected via proton nuclear magnetic resonance spectroscopy or high-performance liquid chromatography.The maximum Faraday effi ciency of ZrO_(2)/NC reached 90%at−0.73 V(vs.RHE),with the current density of CO at 5.5 mA/cm^(2);this Faraday effi ciency value was higher than that of NC(41%),with the current density of CO at 3.1 mA/cm^(2).The interaction between the metal oxide and carbon allowed the effi cient formation of defect sites,especially imine-type nitrogen,strengthening the adsorption of the key reaction intermediate CO_(2)^(•−) and thus promoting the CO_(2) reduction reaction.
基金This work was supported by the Fund for Innovative Research Group of the National Natural Science Foundation of China （No. 51421065）, by the Program for New Century Excellent Talents in University （No. NCET-12-0059）, and by the National Natural Science Foundation of China （Grant No. 41171068）, and by the Fundamental Research Funds for the Central Universities （2015KJJCA09）.
