We build a high-resolution early aftershock catalog for the 2023 SE Türkiye seismic sequence with PALM,a seamless workflow that sequentially performs phase picking,association,location,and matched filter for cont...We build a high-resolution early aftershock catalog for the 2023 SE Türkiye seismic sequence with PALM,a seamless workflow that sequentially performs phase picking,association,location,and matched filter for continuous data.The catalog contains 29,519 well-located events in the two mainshocks rupture region during 2023-02-01–2023-02-28,which significantly improves the detection completeness and relocation precision compared to the public routine catalog.Employing the new PALM catalog,we analyze the structure of the seismogenic fault system.We find that the Eastern Anatolian Fault(EAF)that generated the first M_(W)7.9 mainshock is overall near-vertical,whereas complexities are revealed in a small-scale,such as subparallel subfaults,unmapped branches,and stepovers.The seismicity on EAF is shallow(<15 km)and concentrated in depth distribution,indicating a clear lock-creep transition.In contrast,the SürgüFault(SF)that is responsible for the second M_(W)7.8 mainshock is shovel-shaped for the nucleation segment and has overall low dip angles(~40°–80°).Aftershocks on the SF distribute in a broad range of depth,extending down to~35 km.We also analyze the temporal behavior of seismicity,discovering no immediate foreshocks within~5 days preceding the first mainshock,and no seismic activity on the SF before the second mainshock.展开更多
Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.Although daily foods can provide PS to human body,the amount is very limited...Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.Although daily foods can provide PS to human body,the amount is very limited due to its poverty in most foods.To overcome the issue,numerous studies based on PS have been reported to develop PS-related supplements.In this review,PS was comprehensively and critically reviewed from the view of resources,functions,processing techniques,patents,and prospects.For resources,animal,plant,and microorganism origins were all covered with their differences in composition profiles.For functions,benefits regarding memory,cognitive enhancement,exercise performance,reducing Alzheimer’s disease,and attention-deficit hyperactivity disorder symptoms were covered as well as the functional differences among animal-,plant-,and microorganism-based PS-related supplements.For processing techniques,traditional extracting methods from animal,plant,and microorganism tissues were comparatively discussed with enzymatic synthesis based on different reaction systems.Finally,patents of PS-related supplements were evaluated as well as their applications.This review could provide scientific and valuable support for PS industry.展开更多
Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and th...Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell(NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells(iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis(EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs.展开更多
基金jointly supported by the National Key R&D Program (No.2022YFF0800601)the Istanbul Technical University Research Fund (ITU-BAP)+1 种基金the Alexander von Humboldt Foundation Research Fellowship Award for providing computing facilities through the Humboldt-Stiftung Follow-Up Programthe University of California,Riverside。
文摘We build a high-resolution early aftershock catalog for the 2023 SE Türkiye seismic sequence with PALM,a seamless workflow that sequentially performs phase picking,association,location,and matched filter for continuous data.The catalog contains 29,519 well-located events in the two mainshocks rupture region during 2023-02-01–2023-02-28,which significantly improves the detection completeness and relocation precision compared to the public routine catalog.Employing the new PALM catalog,we analyze the structure of the seismogenic fault system.We find that the Eastern Anatolian Fault(EAF)that generated the first M_(W)7.9 mainshock is overall near-vertical,whereas complexities are revealed in a small-scale,such as subparallel subfaults,unmapped branches,and stepovers.The seismicity on EAF is shallow(<15 km)and concentrated in depth distribution,indicating a clear lock-creep transition.In contrast,the SürgüFault(SF)that is responsible for the second M_(W)7.8 mainshock is shovel-shaped for the nucleation segment and has overall low dip angles(~40°–80°).Aftershocks on the SF distribute in a broad range of depth,extending down to~35 km.We also analyze the temporal behavior of seismicity,discovering no immediate foreshocks within~5 days preceding the first mainshock,and no seismic activity on the SF before the second mainshock.
基金financially supported by the Innovative Funds Plan of Henan University of Technology(2020ZKCJ10)Cultivation Programme for Young Backbone Teachers in Henan University of Technology.
文摘Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.Although daily foods can provide PS to human body,the amount is very limited due to its poverty in most foods.To overcome the issue,numerous studies based on PS have been reported to develop PS-related supplements.In this review,PS was comprehensively and critically reviewed from the view of resources,functions,processing techniques,patents,and prospects.For resources,animal,plant,and microorganism origins were all covered with their differences in composition profiles.For functions,benefits regarding memory,cognitive enhancement,exercise performance,reducing Alzheimer’s disease,and attention-deficit hyperactivity disorder symptoms were covered as well as the functional differences among animal-,plant-,and microorganism-based PS-related supplements.For processing techniques,traditional extracting methods from animal,plant,and microorganism tissues were comparatively discussed with enzymatic synthesis based on different reaction systems.Finally,patents of PS-related supplements were evaluated as well as their applications.This review could provide scientific and valuable support for PS industry.
基金supported by the China National Basic Research Program(2013CB966901,2012CBA01303)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01040108)+1 种基金National Thousand Young Talents Program to Tongbiao Zhaothe National Natural Science Foundation of China Program((31271592,31570995)to Tongbiao Zhao,(31400831)to Jiani Cao)
文摘Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell(NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells(iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis(EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs.
