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Investigate Evaluation of Oxidative Stress and Lipid Profile in STZ-Induced Rats Treated with Antioxidant Vitamin 被引量:1
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作者 Abdella Emam Abdella Baragob Waleed hassan AlMalki +3 位作者 hassan elsiddig hassan farag alla Asim Ibrahim Salwa Khojali Muhammed Samia Abdella 《Pharmacology & Pharmacy》 2014年第3期272-279,共8页
The objective of this study was designed to investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by showing significant changes in blood glucose, water, food intake, lipid profil... The objective of this study was designed to investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by showing significant changes in blood glucose, water, food intake, lipid profile, serum urea and ceratinine level, and antioxidant enzyme parameters activity. Streptozotocin (STZ)-induced toxicity was studied in male Waster rats;each divided into four groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ-induced diabetic rats (GIII), and STZ-induced diabetic rats treated with vitamin E (G1V). Moreover, vitamin E reduced (p < 0.05) blood glucose and urea, thus, our study improved the lipid profile (reduced the serum levels of amount of total cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV). Vitamin prevented modification in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSX-Px) and in the concentration of the lipid hydroperoxide. Finally the study suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. 展开更多
关键词 INVESTIGATE LIPID Profile STZ OXIDATIVE Stress VITAMIN E
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