Here we present zircon U–Pb–Hf and wholerock major and trace element studies of eastern Ningzhen W-Mo-ore-related magmatic rocks,Yushan and Longwangshan granitic rocks,to constrain their form timing,magma sources,an...Here we present zircon U–Pb–Hf and wholerock major and trace element studies of eastern Ningzhen W-Mo-ore-related magmatic rocks,Yushan and Longwangshan granitic rocks,to constrain their form timing,magma sources,and tectonic settings.The results showed that the two plutons were formed in the Early Cretaceous with;Pb/;U ages of 107.8±1.2 and 105.2±1.5 Ma(;Pb/;U),respectively.The trapped/residual zircons are mainly distributed in 2.0–2.5 Ga.The two intrusions are characterized by high silicon(68.60–73.99%),high aluminum(13.56–15.02%),high Mg#(47–55),high Sr,Sr/Y,LaN/YN,and low Yb,falling into high Mg#adakitic rock region.The zirconεHf(t)values of the two intrusions range from-24.8 to-13.2,indicating an ancient continental crust in their magma sources.The average Ti-inzircon temperature is 689°C,slightly higher than those of other high-Mg adakitic rocks in the lower Yangtze River belt,but lower than those of high-Mg adakitic rocks in the Southern Tanlu Fault(STLF).Zircon Ce;/Ce;show low oxygen fugacity(LWS-1:3–400,average 92;sample ZYS-4:9–382,average 93).These geochemical features indicate a thickened lower continental crust in the Eastern Ningzhen region in a subduction setting.Comparing the geochemical characteristics of the eastern Ningzhen to the western Ningzhen and other areas in the Lower Yangtze River Metallogenic Belt(LYRMB)and the high-Mg ore-barren adakitic rocks of the STLF,we propose that the magmatic rocks from eastern Ningzhen may be mainly from a thickened lower continental crust that hybridized with a very small part of mantle sources,while the west Ningzhen magmatic rocks may have experienced a higher degree of mantle contaminations in their source.The metallogenic differences between the eastern(W–Mo)and western(Cu–Fe–Pb–Zn)parts of Ningzhen also indicate different proportions of crustal materials in their magma source.展开更多
Background: Compound Salvia Pellet (T89), consisting of Danshen (salvia miltiorrhiza), Sanqi (panax notoginseng), and Borneol (Cinnamomum camphora), has been used worldwide for 14 years for chronic angina treatment. P...Background: Compound Salvia Pellet (T89), consisting of Danshen (salvia miltiorrhiza), Sanqi (panax notoginseng), and Borneol (Cinnamomum camphora), has been used worldwide for 14 years for chronic angina treatment. Purpose: A dose escalation study to determine the maximum tolerance dose (MTD) in Chinese population to support a proposed dose regimen change. Methods: Forty-six participants (age 18 to 45 yrs, male to female ratio = 1:1) were divided into a series of 6 patients cohorts, and sequentially assigned into one of the escalating dose groups, starting from 540 mg, the clinical doses, until 4 out of 6 subjects experience clinical Adverse Events (AEs) or when the pre-defined 3510 mg dose level is reached and completed. All doses were given orally as a single dose 2 hours after breakfast. Adverse events, vital signs, 12-lead ECG, clinical and laboratory parameters and medical evaluation were conducted as outcome measures. Results: Study completed at the highest pre-defined dose level of 3510 mg dose as never had 4/6 of subject experience AEs in any dose levels studied. All participants completed the study and data were included in the safety analysis. The only moderate AE observation (muscle damage) was observed at 2970 mg dose and was recovered without any medical treatment, and all other AEs (ECG, dizziness, muscle damage) were mild and may (5 cases) or may not (9 cases) be related to testing drug and were all self-resolved within 30 min after dose. Conclusion: Given as single oral dose, Compound Salvia Pellet is safe and well-tolerated up to the 3510 mg studied. The MTD value of Compound Salvia Pellet is unknown from this trial and must be higher than 3510 mg, 13 times higher than its current clinical dose.展开更多
Objective:To evaluate the value of 3D printing assisted pedicle screw placement in the treatment of thoracolumbar spinal fractures.Methods: 56 cases of thoracolumbar spinal fractures patients underwent 3D printing ass...Objective:To evaluate the value of 3D printing assisted pedicle screw placement in the treatment of thoracolumbar spinal fractures.Methods: 56 cases of thoracolumbar spinal fractures patients underwent 3D printing assisted pedicle screw placement (study group) and another 56 cases of thoracolumbar spinal fractures patients underwent conventional screw placement (control group) in our department from February 2016 to September 2017 were selected. Then the surgical related indicators, JOA score, the reduction of injured vertebrae and complications were recorded and compared between groups at different time points, including, before operation (T0), postoperative 1mon (T1), postoperative 6mon (T2) and postoperative 12mon (T3).Results: The operation time, intraoperative X-ray fluoroscopy frequency and intraoperative blood loss in the study group were significantly lower than those in the control group (P<0.05), meanwhile the accuracy rate of screw placement was significantly higher than that of the control group (P<0.05). JOA scores at T1, T2 and T3 in both groups were significantly higher than those at T0 (P<0.05), and JOA scores at all postoperative time points in the study group were significantly higher than those in the control group (P<0.05). Compared with T0, the ratio of the anterior and posterior border height of injured vertebrae in the two groups at T2 was significantly increased (P<0.05), while the Cobb Angle of sagittal kyphoid significantly was decreased (P<0.05). Meanwhile, the reduction of injured vertebrae in the study group was significantly better than that the control group at T2 (P<0.05). The incidence of complications in the study group was significantly lower than that in the control group (P<0.05).Conclusion: The application of 3D printing assisted pedicle screw placement in the treatment has the advantages of less injury to patients, good prognosis and high safety, which is worthy of clinical application.展开更多
Highly conductive polymer composites(CPCs) with excellent mechanical flexibility are ideal materials for designing excellent electromagnetic interference(EMI) shielding materials,which can be used for the electromagne...Highly conductive polymer composites(CPCs) with excellent mechanical flexibility are ideal materials for designing excellent electromagnetic interference(EMI) shielding materials,which can be used for the electromagnetic interference protection of flexible electronic devices.It is extremely urgent to fabricate ultra-strong EMI shielding CPCs with efficient conductive networks.In this paper,a novel silver-plated polylactide short fiber(Ag@PL ASF,AAF) was fabricated and was integrated with carbon nanotubes(CNT) to construct a multi-scale conductive network in polydimethylsiloxane(PDMS) matrix.The multi-scale conductive network endowed the flexible PDMS/AAF/CNT composite with excellent electrical conductivity of 440 S m-1and ultra-strong EMI shielding effectiveness(EMI SE) of up to 113 dB,containing only 5.0 vol% of AAF and 3.0 vol% of CNT(11.1wt% conductive filler content).Due to its excellent flexibility,the composite still showed 94% and 90% retention rates of EMI SE even after subjected to a simulated aging strategy(60℃ for 7 days) and 10,000 bending-releasing cycles.This strategy provides an important guidance for designing excellent EMI shielding materials to protect the workspace,environment and sensitive circuits against radiation for flexible electronic devices.展开更多
Ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC–Q-TOF/MS) was developed to identify the absorbed parent components and metabolites in rat bile, plasma and ...Ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC–Q-TOF/MS) was developed to identify the absorbed parent components and metabolites in rat bile, plasma and urine after oral administration of Radix Paeoniae Alba extract(RPAE).A total of 65 compounds were detected in rat bile, plasma and urine samples, including 11 parent compounds and 54 metabolites. The results indicated that glucuronidation, hydroxylation and methylation were the major metabolic pathways of the components of RPAE. Furthermore, the results of this work demonstrated that UPLC–Q-TOF/MS combined with MetaboLynx?software and mass defect filtering(MDF) could provide unique high throughput capabilities for drug metabolism study, with excellent MS mass accuracy and enhanced MSEdata acquisition. With the MSEtechnique, both precursor and fragment mass spectra can be simultaneously acquired by alternating between high and low collision energy during a single chromatographic run.展开更多
基金fundamentally supported by the National Key R&D Program of China (Grant No. 2016YFC0600404 and2016YFC0600206)Natural Science Foundation of China (Grant No.41873034)the Fundamental Research Funds for the Central Universities (Grant No. PA2018GDQT0020)
文摘Here we present zircon U–Pb–Hf and wholerock major and trace element studies of eastern Ningzhen W-Mo-ore-related magmatic rocks,Yushan and Longwangshan granitic rocks,to constrain their form timing,magma sources,and tectonic settings.The results showed that the two plutons were formed in the Early Cretaceous with;Pb/;U ages of 107.8±1.2 and 105.2±1.5 Ma(;Pb/;U),respectively.The trapped/residual zircons are mainly distributed in 2.0–2.5 Ga.The two intrusions are characterized by high silicon(68.60–73.99%),high aluminum(13.56–15.02%),high Mg#(47–55),high Sr,Sr/Y,LaN/YN,and low Yb,falling into high Mg#adakitic rock region.The zirconεHf(t)values of the two intrusions range from-24.8 to-13.2,indicating an ancient continental crust in their magma sources.The average Ti-inzircon temperature is 689°C,slightly higher than those of other high-Mg adakitic rocks in the lower Yangtze River belt,but lower than those of high-Mg adakitic rocks in the Southern Tanlu Fault(STLF).Zircon Ce;/Ce;show low oxygen fugacity(LWS-1:3–400,average 92;sample ZYS-4:9–382,average 93).These geochemical features indicate a thickened lower continental crust in the Eastern Ningzhen region in a subduction setting.Comparing the geochemical characteristics of the eastern Ningzhen to the western Ningzhen and other areas in the Lower Yangtze River Metallogenic Belt(LYRMB)and the high-Mg ore-barren adakitic rocks of the STLF,we propose that the magmatic rocks from eastern Ningzhen may be mainly from a thickened lower continental crust that hybridized with a very small part of mantle sources,while the west Ningzhen magmatic rocks may have experienced a higher degree of mantle contaminations in their source.The metallogenic differences between the eastern(W–Mo)and western(Cu–Fe–Pb–Zn)parts of Ningzhen also indicate different proportions of crustal materials in their magma source.
文摘Background: Compound Salvia Pellet (T89), consisting of Danshen (salvia miltiorrhiza), Sanqi (panax notoginseng), and Borneol (Cinnamomum camphora), has been used worldwide for 14 years for chronic angina treatment. Purpose: A dose escalation study to determine the maximum tolerance dose (MTD) in Chinese population to support a proposed dose regimen change. Methods: Forty-six participants (age 18 to 45 yrs, male to female ratio = 1:1) were divided into a series of 6 patients cohorts, and sequentially assigned into one of the escalating dose groups, starting from 540 mg, the clinical doses, until 4 out of 6 subjects experience clinical Adverse Events (AEs) or when the pre-defined 3510 mg dose level is reached and completed. All doses were given orally as a single dose 2 hours after breakfast. Adverse events, vital signs, 12-lead ECG, clinical and laboratory parameters and medical evaluation were conducted as outcome measures. Results: Study completed at the highest pre-defined dose level of 3510 mg dose as never had 4/6 of subject experience AEs in any dose levels studied. All participants completed the study and data were included in the safety analysis. The only moderate AE observation (muscle damage) was observed at 2970 mg dose and was recovered without any medical treatment, and all other AEs (ECG, dizziness, muscle damage) were mild and may (5 cases) or may not (9 cases) be related to testing drug and were all self-resolved within 30 min after dose. Conclusion: Given as single oral dose, Compound Salvia Pellet is safe and well-tolerated up to the 3510 mg studied. The MTD value of Compound Salvia Pellet is unknown from this trial and must be higher than 3510 mg, 13 times higher than its current clinical dose.
文摘Objective:To evaluate the value of 3D printing assisted pedicle screw placement in the treatment of thoracolumbar spinal fractures.Methods: 56 cases of thoracolumbar spinal fractures patients underwent 3D printing assisted pedicle screw placement (study group) and another 56 cases of thoracolumbar spinal fractures patients underwent conventional screw placement (control group) in our department from February 2016 to September 2017 were selected. Then the surgical related indicators, JOA score, the reduction of injured vertebrae and complications were recorded and compared between groups at different time points, including, before operation (T0), postoperative 1mon (T1), postoperative 6mon (T2) and postoperative 12mon (T3).Results: The operation time, intraoperative X-ray fluoroscopy frequency and intraoperative blood loss in the study group were significantly lower than those in the control group (P<0.05), meanwhile the accuracy rate of screw placement was significantly higher than that of the control group (P<0.05). JOA scores at T1, T2 and T3 in both groups were significantly higher than those at T0 (P<0.05), and JOA scores at all postoperative time points in the study group were significantly higher than those in the control group (P<0.05). Compared with T0, the ratio of the anterior and posterior border height of injured vertebrae in the two groups at T2 was significantly increased (P<0.05), while the Cobb Angle of sagittal kyphoid significantly was decreased (P<0.05). Meanwhile, the reduction of injured vertebrae in the study group was significantly better than that the control group at T2 (P<0.05). The incidence of complications in the study group was significantly lower than that in the control group (P<0.05).Conclusion: The application of 3D printing assisted pedicle screw placement in the treatment has the advantages of less injury to patients, good prognosis and high safety, which is worthy of clinical application.
基金supported by the National Natural Science Foundation of China(Nos.51973142,52033005,52003169).
文摘Highly conductive polymer composites(CPCs) with excellent mechanical flexibility are ideal materials for designing excellent electromagnetic interference(EMI) shielding materials,which can be used for the electromagnetic interference protection of flexible electronic devices.It is extremely urgent to fabricate ultra-strong EMI shielding CPCs with efficient conductive networks.In this paper,a novel silver-plated polylactide short fiber(Ag@PL ASF,AAF) was fabricated and was integrated with carbon nanotubes(CNT) to construct a multi-scale conductive network in polydimethylsiloxane(PDMS) matrix.The multi-scale conductive network endowed the flexible PDMS/AAF/CNT composite with excellent electrical conductivity of 440 S m-1and ultra-strong EMI shielding effectiveness(EMI SE) of up to 113 dB,containing only 5.0 vol% of AAF and 3.0 vol% of CNT(11.1wt% conductive filler content).Due to its excellent flexibility,the composite still showed 94% and 90% retention rates of EMI SE even after subjected to a simulated aging strategy(60℃ for 7 days) and 10,000 bending-releasing cycles.This strategy provides an important guidance for designing excellent EMI shielding materials to protect the workspace,environment and sensitive circuits against radiation for flexible electronic devices.
文摘Ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC–Q-TOF/MS) was developed to identify the absorbed parent components and metabolites in rat bile, plasma and urine after oral administration of Radix Paeoniae Alba extract(RPAE).A total of 65 compounds were detected in rat bile, plasma and urine samples, including 11 parent compounds and 54 metabolites. The results indicated that glucuronidation, hydroxylation and methylation were the major metabolic pathways of the components of RPAE. Furthermore, the results of this work demonstrated that UPLC–Q-TOF/MS combined with MetaboLynx?software and mass defect filtering(MDF) could provide unique high throughput capabilities for drug metabolism study, with excellent MS mass accuracy and enhanced MSEdata acquisition. With the MSEtechnique, both precursor and fragment mass spectra can be simultaneously acquired by alternating between high and low collision energy during a single chromatographic run.
基金Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Prof Jian Wang （Shanghai University, Shanghai） for his valuable revision and discussion. This work was supported by grants from the National Natural Science Foundation of China （30700411）, Shenzhen Bureau of Science Technology and Information （SZKJ-2006018, SZKJ-2007012）, Shenzhen Nanshan Bureau of Science Technology and Information （2008036） and Shenzhen Key Laboratory Advancement Scheme.
