Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment.In this work,a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid wa...Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment.In this work,a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed.Carbon dots(CDs),from folic acid as the raw material,were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles(MSNs–NH2) via a microwave-assisted solvothermal reaction.The as-prepared nanohybrid(designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of MSNs(e.g.,mesoporous structure,large specific surface area,and good biocompatibility),demonstrating a potential capability for fluorescence imagingguided drug delivery.More interestingly,the MSNs–CDs nanohybrid was able to selectively target folate receptor-overexpressing cancer cells(e.g.,HeLa),indicating that folic acid still retained its function even after undergoing the solvothermal reaction.Benefited by these excellent properties,the fluorescent MSNs–CDs nanohybrid can be employed as a fluorescence-guided nanocarrier for the targeted deliveryof anticancer drugs(e.g.,doxorubicin),thereby enhancing chemotherapeutic efficacy and reducing side effects.Our studies may provide a facile strategy for the fabrication of multifunctional MSN-based theranostic platforms,which is beneficial in the diagnosis and therapy of cancers in future.展开更多
Near-infrared(NIR),particularly NIR-containing dual-/multimode afterglow,is very attractive in many fields of application,but it is still a great challenge to achieve such property of materials. Herein,we report a fac...Near-infrared(NIR),particularly NIR-containing dual-/multimode afterglow,is very attractive in many fields of application,but it is still a great challenge to achieve such property of materials. Herein,we report a facile method to prepare green and NIR dual-mode afterglow of carbon dots(CDs) through in situ embedding o-CDs(being prepared from o-phenylenediamine) into cyanuric acid(CA) matrix(named o-CDs@CA). Further studies reveal that the green and NIR afterglows of o-CDs@CA originate from thermal activated delayed fluorescence(TADF) and room temperature phosphorescence(RTP) of o-CDs,respectively. In addition,the formation of covalent bonds between o-CDs and CA,and the presence of multiple fixation and rigid e ects to the triplet states of o-CDs are confirmed to be critical for activating the observed dual-mode afterglow. Due to the shorter lifetime and insensitiveness to human vision of the NIR RTP of o-CDs@CA,it is completely covered by the green TADF during directly observing. The NIR RTP signal,however,can be readily captured if an optical filter(cut-o wavelength of 600 nm) being used. By utilizing these unique features,the applications of o-CDs@CA in anti-counterfeiting and information encryption have been demonstrated with great confidentiality. Finally,the as-developed method was confirmed to be applicable to many other kinds of CDs for achieving or enhancing their afterglow performances.展开更多
The first carbon dot(CD)-based organic long persistent luminescence(OLPL)system exhibiting more than 1 h of duration was developed.In contrast to the established OLPL systems,herein,the reported CDs-based system(named...The first carbon dot(CD)-based organic long persistent luminescence(OLPL)system exhibiting more than 1 h of duration was developed.In contrast to the established OLPL systems,herein,the reported CDs-based system(named m-CDs@CA)can be facilely and effectively fabricated using a household microwave oven,and more impressively,its LPL can be observed under ambient conditions and even in aqueous media.XRD and TEM characterizations,afterglow decay,time-resolved spectroscopy,and ESR analysis were performed,showing the successful composition of CDs and.CA,the formation of exciplexes and long-lived charged-separated states.Further studies suggest that the production of covalent bonds between CA and CDs plays pivotal roles in activating LPL and preventing its quenching from oxygen and water.To the best of our knowledge,this is a very rare example of an OLPL system that exhibits hourlevel afterglow under ambient conditions.Finally,applications of m-CDs@C.A in glow-in-the-dark paints for emergency signs and multicolored luminous pearls were preliminarily demonstrated.This work may provide new insights for the development of rare earth-free and robust OLPL materials.展开更多
Extensive research have been devoted to the exploration of multifunctional theranostic agents for cancer,but the poor tumor specificity and unsatisfactory treatment efficacy are some of the critical obstacles for thei...Extensive research have been devoted to the exploration of multifunctional theranostic agents for cancer,but the poor tumor specificity and unsatisfactory treatment efficacy are some of the critical obstacles for their clinical translations.Herein,ferrocene-carbon dot-crosslinked nanoparticles(Fc-CD NPs)were designed and fabricated for achieving highly specific and photothermal-augmented chemodynamic therapy(CDT).The Fc-CD NPs were found not only to inherit the immanent fluorescence,photoacoustic,and photothermal properties of carbon dots(CDs),but also be endowed with CDT that could occur selectively in tumor microenvironment(TME)due to the presence of Fc for triggering Fenton reaction.Moreover,the enlarged particle size of Fc-CD NPs facilitated their effective accumulation at tumor sites,thus realizing great improvement for antitumor treatment outcomes.Once docking at tumor and being exposed to 660 nm laser irradiation,significantly amplified CDT effect of Fc-CD NPs was observed due to heataccelerating generation of reactive oxygen species(ROS).More interestingly,since the produced ROS could in turn alleviate the thermal-resistance of photothermal therapy(PTT),the therapeutic efficiency of integrated PTT and CDT was synergized to the maximum extent.This study on the one hand provides a facile approach to fabricate CDs-based multifunctional theranostic nanoplatform with enhanced tumor accumulation and specificity,on the other hand emphasizes the merits of synergizing mutually beneficial therapeutic modalities for more efficient cancer therapy.展开更多
Materials with controllable luminescence colors are highly desirable for numerous promising applications, however, the preparation of such materials, particularly with color-controllable room-temperature phosphorescen...Materials with controllable luminescence colors are highly desirable for numerous promising applications, however, the preparation of such materials, particularly with color-controllable room-temperature phosphorescence(RTP), remains a formidable challenge. In this work, we reported on a facile strategy to prepare color-controllable RTP materials via the pyrolysis of a mixture containing 1-(2-hydroxyethyl)-urea(H-urea) and boric acid(BA). By controlling the pyrolysis temperatures, the as-prepared materials exhibited ultralong RTP with emission colors ranging from cyan, green, to yellow. Further studies revealed that multiple luminescent centers formed from H-urea, which were in-situ embedded in the B2O3matrix(produced from BA) during the pyrolysis process. The contents of the different luminescent centers could be regulated by the pyrolysis temperatures, resulting in color-tunable RTP. Significantly, the luminescent center engineering and in-situ immobilization strategy not only provided a facile method for conveniently preparing color-controllable RTP materials, but also endowed the materials prepared at relatively lower temperatures with color-changeable RTP features under thermal stimulus. Considering their unique properties, the potential applications of the as-obtained materials for advanced anti-counterfeiting and information encryption were preliminarily demonstrated.展开更多
Carbon dots(CDs), as a new member of carbon nanostructures, have been widely applied in extensive fields due to their exceptional physicochemical properties. While, the emissions of most reported CDs are located in th...Carbon dots(CDs), as a new member of carbon nanostructures, have been widely applied in extensive fields due to their exceptional physicochemical properties. While, the emissions of most reported CDs are located in the blue to green range under the excitation of ultraviolet or blue light, which severely limits their practical applications, especially in photovoltaic and biological fields. Studies that focused on synthesizing CDs with long-wavelength(red to near-infrared) emission/excitation features(simply named L-w CDs) and exploring their potential applications have been frequently reported in recent years. In this review, we analyzed the key influence factors for the synthesis of CDs with long wavelength and multicolor(containing long wavelength) emissive properties, discussed possible fluorescence mechanism,and summarized their applications in sensing and cancer theranostics. Finally, the existing challenges and potential opportunities of L-w CDs are presented.展开更多
Recently,multidimensional(or multi-channel)sensing methodology has attracted broad attention in the field of analytical chemistry due to its fascinating merits.A variety of multidimensional sensors based on sensor arr...Recently,multidimensional(or multi-channel)sensing methodology has attracted broad attention in the field of analytical chemistry due to its fascinating merits.A variety of multidimensional sensors based on sensor arrays,lab-on-a-molecule/nanoparticle and smart chip strategies have been designed to differentiate chemical structure and property similar analytes and complex samples.Pattern recognition algorithms are usually used and allow these sensors to fulfill such proposes.In this review,the recent advances of multidimensional sensor devices were firstly summarized,and particularly focused on their design strategies and applications in monitoring of biological active molecules,biomarkers,microbes,foods and beverages,etc.Then,some limitations and possible solutions of multidimensional sensors were discussed.And finally,potential applications of this technique in the future were proposed.This review would help the readers who are interested in multidimensional sensing methodology to understand the research progresses and trends.展开更多
基金the financial support from the National Natural Science Foundation of China(51872300 and U1832110)Ningbo Science and Technology Bureau(2016C50009)the W.C.Wong Education Foundation(rczx0800)
文摘Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment.In this work,a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed.Carbon dots(CDs),from folic acid as the raw material,were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles(MSNs–NH2) via a microwave-assisted solvothermal reaction.The as-prepared nanohybrid(designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of MSNs(e.g.,mesoporous structure,large specific surface area,and good biocompatibility),demonstrating a potential capability for fluorescence imagingguided drug delivery.More interestingly,the MSNs–CDs nanohybrid was able to selectively target folate receptor-overexpressing cancer cells(e.g.,HeLa),indicating that folic acid still retained its function even after undergoing the solvothermal reaction.Benefited by these excellent properties,the fluorescent MSNs–CDs nanohybrid can be employed as a fluorescence-guided nanocarrier for the targeted deliveryof anticancer drugs(e.g.,doxorubicin),thereby enhancing chemotherapeutic efficacy and reducing side effects.Our studies may provide a facile strategy for the fabrication of multifunctional MSN-based theranostic platforms,which is beneficial in the diagnosis and therapy of cancers in future.
基金the National Natural Science Foundation of China (52003284,51872300 and U1832110)the China Postdoctoral Science Foundation (BX20190338)S&T Innovation 2025 Major Special Program of Ningbo (2018B10054) for financially supporting this work。
文摘Near-infrared(NIR),particularly NIR-containing dual-/multimode afterglow,is very attractive in many fields of application,but it is still a great challenge to achieve such property of materials. Herein,we report a facile method to prepare green and NIR dual-mode afterglow of carbon dots(CDs) through in situ embedding o-CDs(being prepared from o-phenylenediamine) into cyanuric acid(CA) matrix(named o-CDs@CA). Further studies reveal that the green and NIR afterglows of o-CDs@CA originate from thermal activated delayed fluorescence(TADF) and room temperature phosphorescence(RTP) of o-CDs,respectively. In addition,the formation of covalent bonds between o-CDs and CA,and the presence of multiple fixation and rigid e ects to the triplet states of o-CDs are confirmed to be critical for activating the observed dual-mode afterglow. Due to the shorter lifetime and insensitiveness to human vision of the NIR RTP of o-CDs@CA,it is completely covered by the green TADF during directly observing. The NIR RTP signal,however,can be readily captured if an optical filter(cut-o wavelength of 600 nm) being used. By utilizing these unique features,the applications of o-CDs@CA in anti-counterfeiting and information encryption have been demonstrated with great confidentiality. Finally,the as-developed method was confirmed to be applicable to many other kinds of CDs for achieving or enhancing their afterglow performances.
基金the National Natural Science Foundation of China(52003284,51872300,and U1832110)the China Postdoctoral Science Foundation(BX20190338)the S&T Innovation 2025 Major Special Programme of Ningbo(2018B10054)for financially supporting this work.
文摘The first carbon dot(CD)-based organic long persistent luminescence(OLPL)system exhibiting more than 1 h of duration was developed.In contrast to the established OLPL systems,herein,the reported CDs-based system(named m-CDs@CA)can be facilely and effectively fabricated using a household microwave oven,and more impressively,its LPL can be observed under ambient conditions and even in aqueous media.XRD and TEM characterizations,afterglow decay,time-resolved spectroscopy,and ESR analysis were performed,showing the successful composition of CDs and.CA,the formation of exciplexes and long-lived charged-separated states.Further studies suggest that the production of covalent bonds between CA and CDs plays pivotal roles in activating LPL and preventing its quenching from oxygen and water.To the best of our knowledge,this is a very rare example of an OLPL system that exhibits hourlevel afterglow under ambient conditions.Finally,applications of m-CDs@C.A in glow-in-the-dark paints for emergency signs and multicolored luminous pearls were preliminarily demonstrated.This work may provide new insights for the development of rare earth-free and robust OLPL materials.
基金the National Natural Science Foundation of China(Nos.52173126,51902323,51872300,32101142,and U1832110).
文摘Extensive research have been devoted to the exploration of multifunctional theranostic agents for cancer,but the poor tumor specificity and unsatisfactory treatment efficacy are some of the critical obstacles for their clinical translations.Herein,ferrocene-carbon dot-crosslinked nanoparticles(Fc-CD NPs)were designed and fabricated for achieving highly specific and photothermal-augmented chemodynamic therapy(CDT).The Fc-CD NPs were found not only to inherit the immanent fluorescence,photoacoustic,and photothermal properties of carbon dots(CDs),but also be endowed with CDT that could occur selectively in tumor microenvironment(TME)due to the presence of Fc for triggering Fenton reaction.Moreover,the enlarged particle size of Fc-CD NPs facilitated their effective accumulation at tumor sites,thus realizing great improvement for antitumor treatment outcomes.Once docking at tumor and being exposed to 660 nm laser irradiation,significantly amplified CDT effect of Fc-CD NPs was observed due to heataccelerating generation of reactive oxygen species(ROS).More interestingly,since the produced ROS could in turn alleviate the thermal-resistance of photothermal therapy(PTT),the therapeutic efficiency of integrated PTT and CDT was synergized to the maximum extent.This study on the one hand provides a facile approach to fabricate CDs-based multifunctional theranostic nanoplatform with enhanced tumor accumulation and specificity,on the other hand emphasizes the merits of synergizing mutually beneficial therapeutic modalities for more efficient cancer therapy.
基金supported by the National Natural Science Foundation of China(32101142)the Natural Science Foundation of Jiangsu Province(BK20221532)the Fundamental Research Funds for the Central Universities(JUSRP622037)。
基金the National Natural Science Foundation of China (Nos. 51872300 and 52003284)the Natural Science Foundation of Jiangsu Province (No. BK20210481)the Fundamental Research Fund of Jiangnan University (No. JUSRP122015) for financially supporting this work。
文摘Materials with controllable luminescence colors are highly desirable for numerous promising applications, however, the preparation of such materials, particularly with color-controllable room-temperature phosphorescence(RTP), remains a formidable challenge. In this work, we reported on a facile strategy to prepare color-controllable RTP materials via the pyrolysis of a mixture containing 1-(2-hydroxyethyl)-urea(H-urea) and boric acid(BA). By controlling the pyrolysis temperatures, the as-prepared materials exhibited ultralong RTP with emission colors ranging from cyan, green, to yellow. Further studies revealed that multiple luminescent centers formed from H-urea, which were in-situ embedded in the B2O3matrix(produced from BA) during the pyrolysis process. The contents of the different luminescent centers could be regulated by the pyrolysis temperatures, resulting in color-tunable RTP. Significantly, the luminescent center engineering and in-situ immobilization strategy not only provided a facile method for conveniently preparing color-controllable RTP materials, but also endowed the materials prepared at relatively lower temperatures with color-changeable RTP features under thermal stimulus. Considering their unique properties, the potential applications of the as-obtained materials for advanced anti-counterfeiting and information encryption were preliminarily demonstrated.
基金the financial support from the National Natural Science Foundation of China(Nos.51902323,51872300 and U1832110)Postdoctoral Science Foundation of China(No.2020M671831)+1 种基金S&T Innovation 2025 Major Special Program of Ningbo(No.2018B10054)Zhejiang Provincial Natural Science Foundation of China(No.LY20B050003)。
文摘Carbon dots(CDs), as a new member of carbon nanostructures, have been widely applied in extensive fields due to their exceptional physicochemical properties. While, the emissions of most reported CDs are located in the blue to green range under the excitation of ultraviolet or blue light, which severely limits their practical applications, especially in photovoltaic and biological fields. Studies that focused on synthesizing CDs with long-wavelength(red to near-infrared) emission/excitation features(simply named L-w CDs) and exploring their potential applications have been frequently reported in recent years. In this review, we analyzed the key influence factors for the synthesis of CDs with long wavelength and multicolor(containing long wavelength) emissive properties, discussed possible fluorescence mechanism,and summarized their applications in sensing and cancer theranostics. Finally, the existing challenges and potential opportunities of L-w CDs are presented.
基金supported by the National Natural Science Foundation of China (21607160, 51872300, U1832110)the Zhejiang Provincial Natural Science Foundation of China (LY16B050005)+1 种基金Ningbo Science and Technology Bureau (2016C50009)the W. C. Wong Education Foundation (rczx0800)
文摘Recently,multidimensional(or multi-channel)sensing methodology has attracted broad attention in the field of analytical chemistry due to its fascinating merits.A variety of multidimensional sensors based on sensor arrays,lab-on-a-molecule/nanoparticle and smart chip strategies have been designed to differentiate chemical structure and property similar analytes and complex samples.Pattern recognition algorithms are usually used and allow these sensors to fulfill such proposes.In this review,the recent advances of multidimensional sensor devices were firstly summarized,and particularly focused on their design strategies and applications in monitoring of biological active molecules,biomarkers,microbes,foods and beverages,etc.Then,some limitations and possible solutions of multidimensional sensors were discussed.And finally,potential applications of this technique in the future were proposed.This review would help the readers who are interested in multidimensional sensing methodology to understand the research progresses and trends.
