<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Malignant gliomas refer to grade III or IV brain tumors de</span><...<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Malignant gliomas refer to grade III or IV brain tumors de</span><span style="font-family:Verdana;">fined according to the World Health Organization (WHO) classification.</span><span style="font-family:Verdana;"> They </span><span style="font-family:Verdana;">are a heterogeneous group of pathologies and represent a serious health</span><span style="font-family:Verdana;"> problem by their frequency, severity and treatment difficulties. The prognosis of malignant gliomas remains poor despite all the medical advances. </span><b><span style="font-family:Verdana;">Materials</span></b> <b><span style="font-family:Verdana;">and</span></b> <b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> It is a retrospective study included 20 cases of malignant glial </span><span style="font-family:Verdana;">tumors treated at the medical oncology department, Fattouma Bourguiba</span><span style="font-family:Verdana;"> hospital in Monastir between 2012 and 2016, according to the STUPP protocol. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> These were 12 men and 8 women with a median age of 43. Clinical signs were not very specific, dominated by intracranial hypertension and </span><span style="font-family:Verdana;">deficit signs. Imagery referred to the diagnosis of malignant gliomas in 1s</span><span style="font-family:Verdana;">t intention. Surgery consisted of a macroscopically complete exeresis in (15%) cases, a partial exeresis in (50%), the rest of the patients had a stereotactic biopsy. Histology found GBM in 16 patients (80%), 2 cases of Grade III anaplastic astrocytoma (10%), 1 case of anaplastic oligodendroglioma (5%), and 1 case of Grade III anaplastic eppendymoma (5%). Most of our patients received concurrent radio-chemotherapy and adjuvant TMZ chemotherapy was administered in 15 patients, 7 of whom received the full 6 scheduled cures. A relapse treatment was decided in only one of the 12 patients who relapsed. 6 patients are still alive. The median survival is 11.27 months. In our series, overall survival was related to histological type (p = 0.006) and neurological status assessed at the end of RT-CT (p = 0.001). While age, general condition score, type of surgery, and post-therapeutic development did not</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">show </span><span style="font-family:Verdana;">a</span><span style="font-family:""> </span><a name="OLE_LINK16"></a><a name="OLE_LINK15"></a><span style="font-family:Verdana;"><span style="font-family:Verdana;">stat</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">istically</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">significant relationship, although survival rates were consistent with</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">the criteria assessed. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Malignant gliomas are rare tumors, bad</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> prognosis, aggravated in Tunisia by a diagnostic delay. The creation of a multidisciplinary neuro-oncology group can help to improve management.</span></span></span>展开更多
Synovial sarcoma originating from the kidney is extremely rare. A 13-year-old</span><span style="font-family:Verdana;"> girl presented with a mild left flank pain of one-week duration, with no as...Synovial sarcoma originating from the kidney is extremely rare. A 13-year-old</span><span style="font-family:Verdana;"> girl presented with a mild left flank pain of one-week duration, with no associated history of hematuria or any other systemic symptoms. Computed tomography (CT) demonstrated a 6 × 13 × 9 cm mass in the left kidney. No soft tissue or extrarenal masses were identified. The patient received a combined of treatment with doxorubicin and ifosfamide. A radical nephrectomy was performed in the left kidney with no complications. Postoperative pathology revealed post-chemotherapy residue of monophasic spindle cell synovialosarcoma of the left kidney. She received a combined treatment with doxorubicin and ifosfamide in concomittance with external radiation therapy. The patient was re-examined 4 months after surgery. An abdominal and pulmonary CT found no recurrence or metastasis.展开更多
文摘<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Malignant gliomas refer to grade III or IV brain tumors de</span><span style="font-family:Verdana;">fined according to the World Health Organization (WHO) classification.</span><span style="font-family:Verdana;"> They </span><span style="font-family:Verdana;">are a heterogeneous group of pathologies and represent a serious health</span><span style="font-family:Verdana;"> problem by their frequency, severity and treatment difficulties. The prognosis of malignant gliomas remains poor despite all the medical advances. </span><b><span style="font-family:Verdana;">Materials</span></b> <b><span style="font-family:Verdana;">and</span></b> <b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> It is a retrospective study included 20 cases of malignant glial </span><span style="font-family:Verdana;">tumors treated at the medical oncology department, Fattouma Bourguiba</span><span style="font-family:Verdana;"> hospital in Monastir between 2012 and 2016, according to the STUPP protocol. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> These were 12 men and 8 women with a median age of 43. Clinical signs were not very specific, dominated by intracranial hypertension and </span><span style="font-family:Verdana;">deficit signs. Imagery referred to the diagnosis of malignant gliomas in 1s</span><span style="font-family:Verdana;">t intention. Surgery consisted of a macroscopically complete exeresis in (15%) cases, a partial exeresis in (50%), the rest of the patients had a stereotactic biopsy. Histology found GBM in 16 patients (80%), 2 cases of Grade III anaplastic astrocytoma (10%), 1 case of anaplastic oligodendroglioma (5%), and 1 case of Grade III anaplastic eppendymoma (5%). Most of our patients received concurrent radio-chemotherapy and adjuvant TMZ chemotherapy was administered in 15 patients, 7 of whom received the full 6 scheduled cures. A relapse treatment was decided in only one of the 12 patients who relapsed. 6 patients are still alive. The median survival is 11.27 months. In our series, overall survival was related to histological type (p = 0.006) and neurological status assessed at the end of RT-CT (p = 0.001). While age, general condition score, type of surgery, and post-therapeutic development did not</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">show </span><span style="font-family:Verdana;">a</span><span style="font-family:""> </span><a name="OLE_LINK16"></a><a name="OLE_LINK15"></a><span style="font-family:Verdana;"><span style="font-family:Verdana;">stat</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">istically</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">significant relationship, although survival rates were consistent with</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">the criteria assessed. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Malignant gliomas are rare tumors, bad</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> prognosis, aggravated in Tunisia by a diagnostic delay. The creation of a multidisciplinary neuro-oncology group can help to improve management.</span></span></span>
文摘Synovial sarcoma originating from the kidney is extremely rare. A 13-year-old</span><span style="font-family:Verdana;"> girl presented with a mild left flank pain of one-week duration, with no associated history of hematuria or any other systemic symptoms. Computed tomography (CT) demonstrated a 6 × 13 × 9 cm mass in the left kidney. No soft tissue or extrarenal masses were identified. The patient received a combined of treatment with doxorubicin and ifosfamide. A radical nephrectomy was performed in the left kidney with no complications. Postoperative pathology revealed post-chemotherapy residue of monophasic spindle cell synovialosarcoma of the left kidney. She received a combined treatment with doxorubicin and ifosfamide in concomittance with external radiation therapy. The patient was re-examined 4 months after surgery. An abdominal and pulmonary CT found no recurrence or metastasis.
