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煤层底板含水层区域注浆改造浆液扩散范围现场示踪试验
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作者 郭艳 桂和荣 +10 位作者 洪荒 陈永青 孙晓宇 胡荣杰 郭祥东 赵群 戴亚男 余浩 李俊 孙亮 高川 《煤炭学报》 EI CAS CSCD 北大核心 2024年第4期2045-2056,共12页
近年来,为解放底板高承压灰岩水上煤炭资源,华北煤田普遍采用地面定向钻技术,对太原组薄层灰岩进行区域性注浆加固改造(习称“底板区域治理”),以全面封堵灰岩岩溶裂隙并阻断垂向导水通道。该技术中,与浆液扩散范围(半径)密切相关的“... 近年来,为解放底板高承压灰岩水上煤炭资源,华北煤田普遍采用地面定向钻技术,对太原组薄层灰岩进行区域性注浆加固改造(习称“底板区域治理”),以全面封堵灰岩岩溶裂隙并阻断垂向导水通道。该技术中,与浆液扩散范围(半径)密切相关的“水平分支孔”孔间距设计问题,一直备受学界和业界的广泛关注。皖北矿区底板区域注浆工程量大,特别是深部资源开采,将有数十亿元的注浆工程,有必要查清浆液扩散范围真实数据。为此,以皖北矿区恒源煤矿为研究基地,依托Ⅱ63采区底板区域治理工程,设计并实施浆液扩散范围示踪试验,在中间的水平分支孔(Z8-7)投放荧光剂(示踪剂),在两侧的水平分支孔(Z8-6、Z8-8)以及交叉分支检测孔(Z8JC)取岩屑样鉴别荧光水泥,以获得浆液扩散范围,进而在浆液扩散影响因素分析基础上,构建恒源煤矿底板区域注浆治理浆液扩散范围计算公式。结果表明:①综合岩屑现场及室内鉴别结果分析,获得恒源煤矿Ⅱ63采区底板区域注浆浆液扩散范围为38.3~44.0 m,且水泥分布密集区在水平分支孔浆液扩散范围30 m以内,该区域内注浆效果最佳。②通过现场岩屑快速鉴别与室内岩屑精准鉴别,取得的浆液扩散范围基本一致,证明了荧光示踪浆液扩散范围的有效性。③通过对比分析,认为在计算参数、边界约束等符合实际注浆工况条件下,浆液扩散范围理论计算和数值模拟结果,与现场示踪试验实测结果较为接近。④利用示踪试验过程中的压水试验及注浆参数、钻遇构造及水文地质响应等数据,考虑重力、构造、地下水径流等因素影响,借助SPSS非线性拟合软件,得到恒源煤矿Ⅱ63采区底板区域注浆浆液扩散范围计算公式。⑤基于恒源煤矿受注层实际地质、水文地质条件,利用拟合的浆液扩散范围计算公式得出Ⅱ63采区Z8场地浆液扩散范围为37.8~42.9 m,与浆液扩散范围示踪试验实测结果相近,计算公式可在类似条件下推广应用。本次煤矿底板区域注浆浆液扩散范围现场示踪工程试验,不仅取得了浆液扩散范围的真实数据,而且阐明了浆液扩散与多种地质、水文地质因素之间的内在联系,揭示了超深、超长定向钻注浆浆液扩散机理,构建了浆液扩散范围计算公式,为类似条件下底板区域治理工程水平分支孔孔间距的合理设计提供了参考依据。 展开更多
关键词 底板区域治理 浆液扩散范围 示踪试验 浆液扩散计算公式 皖北矿区恒源煤矿
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基于PI3K/Akt/mTOR信号通路探讨乌苏酸对结肠癌细胞的影响
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作者 陈科科 洪滉 +1 位作者 刘长宝 曹伟兰 《温州医科大学学报》 CAS 2024年第5期396-400,共5页
目的:探讨乌苏酸(UA)对结肠癌细胞的影响及其作用机制。方法:设立空白对照组及不同浓度UA给药组,采用CCK-8法测定各组细胞的增殖活力,通过细胞划痕实验测定各组细胞的迁移能力及通过Western blot法测定UA对PI3K/Akt/mTOR信号通路的影响... 目的:探讨乌苏酸(UA)对结肠癌细胞的影响及其作用机制。方法:设立空白对照组及不同浓度UA给药组,采用CCK-8法测定各组细胞的增殖活力,通过细胞划痕实验测定各组细胞的迁移能力及通过Western blot法测定UA对PI3K/Akt/mTOR信号通路的影响。结果:CCK-8实验表明UA能明显降低SW480及LOVO结肠癌细胞生存率,且随着药物浓度的升高,细胞的生存率显著降低(P<0.05)。细胞划痕实验表明,与对照组相比,低浓度的UA处理的细胞愈合率降低不明显(P>0.05),而高浓度的UA处理的细胞的愈合率明显降低(P<0.05)。Western blot实验结果显示,UA处理过的细胞p-PI3K、p-Akt、p-mTOR蛋白表达量明显下降(P<0.05)。结论:UA可通过抑制PI3K/Akt/mTOR信号通路的表达,从而抑制结肠癌细胞增殖、迁移,具有明确的抗肿瘤性。 展开更多
关键词 乌苏酸 PI3K/Akt/mTOR信号通路 结肠癌 作用机制
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Track-Pattern-Based Characteristics of Extratropical Transitioning Tropical Cyclones in the Western North Pacific
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作者 hong huang Dan WU +2 位作者 Yuan WANG Zhen WANG Yu LIU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第6期1251-1263,共13页
Based on the Regional Specialized Meteorological Center(RSMC)Tokyo-Typhoon Center best-track data and the NCEP-NCAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETCs)over the western North Pacif... Based on the Regional Specialized Meteorological Center(RSMC)Tokyo-Typhoon Center best-track data and the NCEP-NCAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETCs)over the western North Pacific(WNP)during 1951–2021 are classified into six clusters using the fuzzy c-means clustering method(FCM)according to their track patterns.The characteristics of the six hard-clustered ETCs with the highest membership coefficient are shown.Most tropical cyclones(TCs)that were assigned to clusters C2,C5,and C6 made landfall over eastern Asian countries,which severely threatened these regions.Among landfalling TCs,93.2%completed their ET after landfall,whereas 39.8%of ETCs completed their transition within one day.The frequency of ETCs over the WNP has decreased in the past four decades,wherein cluster C5 demonstrated a significant decrease on both interannual and interdecadal timescales with the expansion and intensification of the western Pacific subtropical high(WPSH).This large-scale circulation pattern is favorable for C2 and causes it to become the dominant track pattern,owning to it containing the largest number of intensifying ETCs among the six clusters,a number that has increased insignificantly over the past four decades.The surface roughness variation and three-dimensional background circulation led to C5 containing the maximum number of landfalling TCs and a minimum number of intensifying ETCs.Our results will facilitate a better understanding of the spatiotemporal distributions of ET events and associated environment background fields,which will benefit the effective monitoring of these events over the WNP. 展开更多
关键词 Western North Pacific tropical cyclone extratropical transition fuzzy c-means clustering method
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A Gaussian Noise-Based Algorithm for Enhancing Backdoor Attacks
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作者 hong huang Yunfei Wang +1 位作者 Guotao Yuan Xin Li 《Computers, Materials & Continua》 SCIE EI 2024年第7期361-387,共27页
Deep Neural Networks(DNNs)are integral to various aspects of modern life,enhancing work efficiency.Nonethe-less,their susceptibility to diverse attack methods,including backdoor attacks,raises security concerns.We aim... Deep Neural Networks(DNNs)are integral to various aspects of modern life,enhancing work efficiency.Nonethe-less,their susceptibility to diverse attack methods,including backdoor attacks,raises security concerns.We aim to investigate backdoor attack methods for image categorization tasks,to promote the development of DNN towards higher security.Research on backdoor attacks currently faces significant challenges due to the distinct and abnormal data patterns of malicious samples,and the meticulous data screening by developers,hindering practical attack implementation.To overcome these challenges,this study proposes a Gaussian Noise-Targeted Universal Adversarial Perturbation(GN-TUAP)algorithm.This approach restricts the direction of perturbations and normalizes abnormal pixel values,ensuring that perturbations progress as much as possible in a direction perpendicular to the decision hyperplane in linear problems.This limits anomalies within the perturbations improves their visual stealthiness,and makes them more challenging for defense methods to detect.To verify the effectiveness,stealthiness,and robustness of GN-TUAP,we proposed a comprehensive threat model.Based on this model,extensive experiments were conducted using the CIFAR-10,CIFAR-100,GTSRB,and MNIST datasets,comparing our method with existing state-of-the-art attack methods.We also tested our perturbation triggers using various defense methods and further experimented on the robustness of the triggers against noise filtering techniques.The experimental outcomes demonstrate that backdoor attacks leveraging perturbations generated via our algorithm exhibit cross-model attack effectiveness and superior stealthiness.Furthermore,they possess robust anti-detection capabilities and maintain commendable performance when subjected to noise-filtering methods. 展开更多
关键词 Image classification model backdoor attack gaussian distribution Artificial Intelligence(AI)security
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BSTFNet:An Encrypted Malicious Traffic Classification Method Integrating Global Semantic and Spatiotemporal Features
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作者 hong huang Xingxing Zhang +2 位作者 Ye Lu Ze Li Shaohua Zhou 《Computers, Materials & Continua》 SCIE EI 2024年第3期3929-3951,共23页
While encryption technology safeguards the security of network communications,malicious traffic also uses encryption protocols to obscure its malicious behavior.To address the issues of traditional machine learning me... While encryption technology safeguards the security of network communications,malicious traffic also uses encryption protocols to obscure its malicious behavior.To address the issues of traditional machine learning methods relying on expert experience and the insufficient representation capabilities of existing deep learning methods for encrypted malicious traffic,we propose an encrypted malicious traffic classification method that integrates global semantic features with local spatiotemporal features,called BERT-based Spatio-Temporal Features Network(BSTFNet).At the packet-level granularity,the model captures the global semantic features of packets through the attention mechanism of the Bidirectional Encoder Representations from Transformers(BERT)model.At the byte-level granularity,we initially employ the Bidirectional Gated Recurrent Unit(BiGRU)model to extract temporal features from bytes,followed by the utilization of the Text Convolutional Neural Network(TextCNN)model with multi-sized convolution kernels to extract local multi-receptive field spatial features.The fusion of features from both granularities serves as the ultimate multidimensional representation of malicious traffic.Our approach achieves accuracy and F1-score of 99.39%and 99.40%,respectively,on the publicly available USTC-TFC2016 dataset,and effectively reduces sample confusion within the Neris and Virut categories.The experimental results demonstrate that our method has outstanding representation and classification capabilities for encrypted malicious traffic. 展开更多
关键词 Encrypted malicious traffic classification bidirectional encoder representations from transformers text convolutional neural network bidirectional gated recurrent unit
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Inhibition of the NF-κB Signaling Pathway Improves Cigarette Mainstream Smoke-Induced Lung Injury and Gut Microbiota Disturbance
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作者 hong huang Shengjie Li +6 位作者 Lifang Zeng Yan Zhang Ying Chen Yanbing Ma Jing Wei Changwei Zou Tingtao Chen 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第6期676-681,共6页
Currently,cigarette smoke(CS)remains a major contributor to disease morbidity and mortality.CS can be divided into cigarette mainstream smoke(CMS)and side-stream smoke,depending on where it is produced by burning toba... Currently,cigarette smoke(CS)remains a major contributor to disease morbidity and mortality.CS can be divided into cigarette mainstream smoke(CMS)and side-stream smoke,depending on where it is produced by burning tobacco^([1]).CMS is inhaled by smokers from the filter end during cigarette combustion and is strongly associated with the development of several diseases^([2-4]). 展开更多
关键词 SMOKE CMS CIGARETTE
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Explosion of research on psychopathology and social media use after COVID-19:A scientometric study
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作者 Meng-Di Zhang Rong-Quan He +7 位作者 Jia-Yuan Luo Wan-Ying huang Jing-Yu Wei Jian Dai hong huang Zhen Yang Jin-Liang Kong Gang Chen 《World Journal of Psychiatry》 SCIE 2024年第5期742-759,共18页
BACKGROUND Despite advances in research on psychopathology and social media use,no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus dise... BACKGROUND Despite advances in research on psychopathology and social media use,no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus disease 2019(COVID-19)outbreak.AIM To explore the status of research on psychopathology and social media use before and after the COVID-19 outbreak.METHODS We used Bibliometrix(an R software package)to conduct a scientometric analysis of 4588 relevant studies drawn from the Web of Science Core Collection,PubMed,and Scopus databases.RESULTS Such research output was scarce before COVID-19,but exploded after the pandemic with the publication of a number of high-impact articles.Key authors and institutions,located primarily in developed countries,maintained their core positions,largely uninfluenced by COVID-19;however,research production and collaboration in developing countries increased significantly after COVID-19.Through the analysis of keywords,we identified commonly used methods in this field,together with specific populations,psychopathological conditions,and clinical treatments.Researchers have devoted increasing attention to gender differences in psychopathological states and linked COVID-19 strongly to depression,with depression detection becoming a new trend.Developments in research on psychopathology and social media use are unbalanced and uncoordinated across countries/regions,and more indepth clinical studies should be conducted in the future.CONCLUSION After COVID-19,there was an increased level of concern about mental health issues and a changing emphasis on social media use and the impact of public health emergencies. 展开更多
关键词 PSYCHOPATHOLOGY Social media BIBLIOMETRICS Web of Science PUBMED SCOPUS
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What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years
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作者 Yi Chen Xiao-Song Chen +10 位作者 Rong-Quan He Zhi-Guang huang Hui-Ping Lu hong huang Da-Ping Yang Zhong-Qing Tang Xia Yang Han-Jie Zhang Ning Qv Jin-Liang Kong Gang Chen 《World Journal of Clinical Oncology》 2024年第6期765-782,共18页
BACKGROUND Lung cancer bone metastasis(LCBM)is a disease with a poor prognosis,high risk and large patient population.Although considerable scientific output has accumulated on LCBM,problems have emerged,such as confu... BACKGROUND Lung cancer bone metastasis(LCBM)is a disease with a poor prognosis,high risk and large patient population.Although considerable scientific output has accumulated on LCBM,problems have emerged,such as confusing research structures.AIM To organize the research frontiers and body of knowledge of the studies on LCBM from the last 22 years according to their basic research and translation,clinical treatment,and clinical diagnosis to provide a reference for the development of new LCBM clinical and basic research.METHODS We used tools,including R,VOSviewer and CiteSpace software,to measure and visualize the keywords and other metrics of 1903 articles from the Web of Science Core Collection.We also performed enrichment and proteinprotein interaction analyses of gene expression datasets from LCBM cases worldwide.RESULTS Research on LCBM has received extensive attention from scholars worldwide over the last 20 years.Targeted therapies and immunotherapies have evolved into the mainstream basic and clinical research directions.The basic aspects of drug resistance mechanisms and parathyroid hormone-related protein may provide new ideas for mechanistic study and improvements in LCBM prognosis.The produced molecular map showed that ribosomes and focal adhesion are possible pathways that promote LCBM occurrence.CONCLUSION Novel therapies for LCBM face animal testing and drug resistance issues.Future focus should centre on advancing clinical therapies and researching drug resistance mechanisms and ribosome-related pathways. 展开更多
关键词 Lung cancer Bone metastasis BIBLIOMETRICS Targeted therapy IMMUNOTHERAPY Enrichment analysis
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区域注浆影响下煤层底板太原组灰岩水水文地球化学演化规律 被引量:4
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作者 郭艳 桂和荣 +7 位作者 魏久传 庞迎春 胡满聪 郭祥东 洪荒 聂锋 崔亚利 叶爽 《煤炭学报》 EI CAS CSCD 北大核心 2023年第8期3204-3217,共14页
淮北煤田下组煤开采,主要威胁水源是煤层底板灰岩水(包括石炭系太原组及奥陶系灰岩水),淹井事故时有发生。针对底板灰岩水害治理,目前多采用地面定向钻高压注浆技术,对煤层底板太原组第3层薄层灰岩(简称“三灰”)进行区域性加固改造,以... 淮北煤田下组煤开采,主要威胁水源是煤层底板灰岩水(包括石炭系太原组及奥陶系灰岩水),淹井事故时有发生。针对底板灰岩水害治理,目前多采用地面定向钻高压注浆技术,对煤层底板太原组第3层薄层灰岩(简称“三灰”)进行区域性加固改造,以封堵三灰岩溶裂隙并阻断穿过三灰的垂向导水通道。但大规模高压注浆工程的实施,受注含水层地下水流场会受到干扰,在大量浆液析出水的耦合作用下,地下水化学场必然会受到严重扰动。以淮北煤田桃园煤矿太原组灰岩含水层(简称“太灰水”)为研究对象,基于常量组分监测数据统计、Piper图、离子组合比及饱和指数分析,开展了区域注浆前-注浆期间-注浆结束后(即区域注浆前-中-后“三时段”)太灰水水文地球化学演化规律研究。结果表明:(1)三时段太灰水中Na^(+)+K^(+)、HCO_(3)^(-)、Cl^(−)先减小后增大,Ca2+、SO_(4)^(2-)和pH先增大后减小,Mg2+、TDS则整体减小。注浆治理区域Ca2+、SO_(4)^(2-)相对较高,碱度较大,而Na^(+)+K^(+)、HCO_(3)^(-)含量相对较低。注浆前以SO_(4)·Cl^(−)Na和SO_(4)·Cl^(−)Na·Ca(混合型)为主,区域注浆“中-后”时段,太灰水则以SO_(4)·Cl^(−)Na·Ca和SO_(4)·Cl^(−)Na型居多,混合型水占比增大。(2)注浆期间,太灰水中碳酸盐、硫酸盐溶解作用、脱硫酸作用和阳离子交换作用减弱,方解石、白云石的溶解作用增强,同时浆液析出水的混合影响作用明显。注浆结束后,碳酸盐、硫酸盐溶解作用、脱硫酸作用和阳离子交换作用逐渐增强,方解石、白云石的溶解作用逐渐减弱,浆液析出水的混合影响作用减弱。注浆结束1 a后水化学作用逐渐向注浆前状态恢复,但仍未恢复至注浆前状态,可知区域注浆治理对太灰水化学场扰动影响比较明显。(3)太灰水中白云石、方解石饱和指数较大,多呈现沉淀状态;石膏、岩盐饱和指数较小,多以溶蚀状态存在。三时段太灰水中方解石、白云石和石膏3种矿物饱和指数均呈先增加后降低趋势,其中白云石表现较为明显,而岩盐饱和指数变化不明显。多数矿物饱和指数与pH呈较强的正相关性,而石膏饱和指数则与TDS呈较强正相关性。(4)由于高pH的注浆浆液析出水的混扰,原来离子间平衡被打破,从而导致区域注浆以来太灰水常量指标相关性降低,且注浆结束后比注浆期间相关性更低。 展开更多
关键词 区域注浆扰动 太灰水 水岩作用 淮北煤田
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煤层底板区域注浆浆液扩散数值模拟及影响因素分析 被引量:3
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作者 郭艳 桂和荣 +5 位作者 魏久传 洪荒 郭祥东 崔亚利 叶爽 李俊 《煤田地质与勘探》 EI CAS CSCD 北大核心 2023年第6期30-39,共10页
地面高压超前区域注浆已成为煤矿水害防治的首选工程方法,注浆浆液扩散机理受到普遍关注,且分支孔间距设计多依赖现场经验,具有一定的盲目性,制约着工程效果及效益。基于淮北煤田恒源煤矿注浆现场实际工况,利用COMSOL Multiphysics软件... 地面高压超前区域注浆已成为煤矿水害防治的首选工程方法,注浆浆液扩散机理受到普遍关注,且分支孔间距设计多依赖现场经验,具有一定的盲目性,制约着工程效果及效益。基于淮北煤田恒源煤矿注浆现场实际工况,利用COMSOL Multiphysics软件,开展地面定向钻煤层底板区域高压注浆浆液扩散数值模拟研究及浆液扩散影响因素分析,探讨地面高压注浆浆液扩散机理。结果如下:(1)煤层底板石炭系太原组第三薄层灰岩(简称三灰)裂隙发育,通过模拟发现,8~12 MPa高压注浆时很可能发生劈裂作用,期间渗透系数增大4~5个数量级。(2)不考虑重力影响时,以分支孔为中心,浆液向周边扩散距离相等,且在分支孔附近,浆液浓度较大,体积分数达20%以上;考虑重力作用时,水平向浆液扩散范围相对增大,垂向上浆液主要向下扩散,表现为“上短下长”。(3)浆液扩散模拟得出,扩散范围为41.2 m;浆液扩散范围现场实测显示,扩散范围为38.3~44.0 m,浆液扩散现场实测验证了扩散模型的正确性。(4)浆液扩散范围与浆液相对密度、静水压力、浆液动力黏度、浆液屈服强度及孔隙率呈负相关,与裂隙隙宽、渗透系数呈正相关。其中浆液相对密度越小,其扩散范围响应越明显;随动力黏度增加,扩散范围减小得越来越慢。研究成果可为煤系底板水害区域注浆治理工程合理设计提供参考,具有较好的参考应用价值。 展开更多
关键词 定向钻 高压注浆 浆液扩散范围 浆液扩散机理
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Analysis of Characteristic and Causes of a Strong Cooling Process in China in the Early Winter of 2020/2021
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作者 Ju WANG Tianju WANG +2 位作者 hong huang Banghui HU Xuezhong WANG 《Meteorological and Environmental Research》 CAS 2023年第1期7-14,20,共9页
The characteristics and causes of a drop in temperature during a cold wave process in the early winter of 2020/2021 were analyzed.The results show that the air temperature at 700-600 hPa over China was firstly and mos... The characteristics and causes of a drop in temperature during a cold wave process in the early winter of 2020/2021 were analyzed.The results show that the air temperature at 700-600 hPa over China was firstly and mostly influenced by the cold wave process,and then the cold air gradually extended to the lower layer,causing the most severe cooling in North China and its nearby areas.During the cold wave,the longitude of the upper-level jet over the Chinese mainland was larger;the Ural blocking high and the East Asian trough were stronger,so that the geopotential height gradient between the two was also significantly larger;the meridional air flow was abnormally strong,which was conducive to the southward transport of cold air from the middle and high latitudes.Results of the diagnostic analysis further show that the outbreak of the cold wave and the negative temperature tendency anomaly in the key area were mainly caused by the meridional temperature horizontal advection anomaly,while the temperature rise accompanied by abnormal air subsidence compensated for the abnormal decrease in temperature,which was conducive to the gradual rise of temperature in the key area. 展开更多
关键词 Cold wave Strong cooling process Diagnostic analysis Temperature tendency equation
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Application of Weighted Cross-Entropy Loss Function in Intrusion Detection 被引量:2
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作者 Ziyun Zhou hong huang Binhao Fang 《Journal of Computer and Communications》 2021年第11期1-21,共21页
The deep learning model is overfitted and the accuracy of the test set is reduced when the deep learning model is trained in the network intrusion detection parameters, due to the traditional loss function convergence... The deep learning model is overfitted and the accuracy of the test set is reduced when the deep learning model is trained in the network intrusion detection parameters, due to the traditional loss function convergence problem. Firstly, we utilize a network model architecture combining Gelu activation function and deep neural network;Secondly, the cross-entropy loss function is improved to a weighted cross entropy loss function, and at last it is applied to intrusion detection to improve the accuracy of intrusion detection. In order to compare the effect of the experiment, the KDDcup99 data set, which is commonly used in intrusion detection, is selected as the experimental data and use accuracy, precision, recall and F1-score as evaluation parameters. The experimental results show that the model using the weighted cross-entropy loss function combined with the Gelu activation function under the deep neural network architecture improves the evaluation parameters by about 2% compared with the ordinary cross-entropy loss function model. Experiments prove that the weighted cross-entropy loss function can enhance the model’s ability to discriminate samples. 展开更多
关键词 Cross-Entropy Loss Function Visualization Analysis Intrusion Detection KDD Data Set ACCURACY
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淮北煤田宿临矿区中层水水文地球化学演化特征 被引量:3
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作者 邱慧丽 桂和荣 +2 位作者 崔琳 洪荒 崔亚利 《地下空间与工程学报》 CSCD 北大核心 2021年第6期2021-2029,共9页
为了解淮北煤田中层水化学演化过程,选择淮北煤田较具代表性的宿临矿区为研究基地,以历史监测水质数据为基础,采用离子组合比以及主成分分析等方法,分时段开展中层水水文地球化学时空演化特征分析。研究结果表明,宿临矿区中层水水化学... 为了解淮北煤田中层水化学演化过程,选择淮北煤田较具代表性的宿临矿区为研究基地,以历史监测水质数据为基础,采用离子组合比以及主成分分析等方法,分时段开展中层水水文地球化学时空演化特征分析。研究结果表明,宿临矿区中层水水化学类型主要是HCO_(3)·SO_(4)—Na·Mg型和HCO_(3)—Na·Mg型,短期内无明显变化。离子组合比和主成分分析结果显示,中层水常规离子组分主要受硅酸盐风化作用的影响,也伴有离子交换作用。主成分得分等值线图显示整个研究区中层水浓缩作用和阳离子交替吸附作用较稳定。中层水TDS等值线分析表明西部中层水相对东部而言,水流速度较快,滞留时间长。研究结果为矿区水源地实现科学管理提供一定的参考。 展开更多
关键词 淮北煤田 中层水 地球化学演化特征 主成分分析
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GST-π、Ki-67的表达与体质量指数在直肠癌预后中的临床意义 被引量:2
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作者 黄崇杰 洪滉 +3 位作者 刘长宝 曹伟兰 黄颖鹏 王中林 《温州医科大学学报》 2021年第11期873-880,共8页
目的:探讨直肠癌组织GST-π、Ki-67的表达及患者体质量指数(BMI)与患者临床生物学特征的相关性及临床意义。方法:收集温州医科大学附属第二医院2010年1月至2013年1月共308例直肠癌患者的临床资料、术后病理及5年生存率。分析BMI及肿瘤指... 目的:探讨直肠癌组织GST-π、Ki-67的表达及患者体质量指数(BMI)与患者临床生物学特征的相关性及临床意义。方法:收集温州医科大学附属第二医院2010年1月至2013年1月共308例直肠癌患者的临床资料、术后病理及5年生存率。分析BMI及肿瘤指标(GST-π、Ki-67)的表达与患者临床及病理特征的相关性,进一步分析BMI与GST-π、Ki-67表达之间的相关性及临床意义。分析Ki-67高阳性患者5年生存率与BMI的关系。结果:肿瘤组织Ki-67的高表达与TNM分期、组织浸润深度及术后5年生存率低相关(P<0.05)。与正常BMI组相比,消瘦组且Ki-67的表达高阳性患者5年生存率偏低(P<0.05)。GST-π的阳性表达与消瘦、肿瘤位置低、淋巴结转移及较高的TNM分期显著相关(P<0.05)。结论:结合分析BMI与GST-π、Ki-67的表达水平及相关性,对评估肿瘤的恶性度、预后情况起到重要作用。 展开更多
关键词 直肠癌 体质量指数 KI-67 GST-Π
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Let-7a过表达对结肠黏液腺癌细胞LS-174T增殖及侵袭性的影响 被引量:1
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作者 黄崇杰 曹伟兰 +2 位作者 洪滉 刘鹏鹏 刘长宝 《温州医科大学学报》 CAS 2019年第10期724-729,共6页
目的:研究let-7a过表达对结肠黏液腺癌LS-174T细胞增殖及侵袭性的影响。方法:构建let-7a过表达慢病毒载体并感染结肠黏液腺癌LS-174T细胞,设立空白对照组(A组,不进行病毒转染);转染空病毒组(B组,只含有EGFP,浓度1×10^7 TU/L);C1转... 目的:研究let-7a过表达对结肠黏液腺癌LS-174T细胞增殖及侵袭性的影响。方法:构建let-7a过表达慢病毒载体并感染结肠黏液腺癌LS-174T细胞,设立空白对照组(A组,不进行病毒转染);转染空病毒组(B组,只含有EGFP,浓度1×10^7 TU/L);C1转染组(C1组,浓度1×10^6 TU/L):转染hsa-Let-7a(含let-7a病毒和EGFP);C2转染组(C2组,浓度1×10^7 TU/L);C3转染组(C3组,浓度1×10^8 TU/L)。通过倒置荧光显微镜观察各组感染效率;RT-qPCR检测各组细胞中let-7a基因表达水平;MTT法检测各组细胞增殖活力;Transwell侵袭和划痕实验测评估细胞的侵袭和迁移能力;RT-qPCR和Western blot分析TGF-β1 mRNA和蛋白水平的表达。结果:倒置荧光显微镜观察各组细胞48 h绿色荧光表达情况,C3组荧光表达最强,感染效率可达90%以上,与初始病毒浓度成正相关(P<0.05);MTT检测结果显示各组OD值均随时间延长而增高,在第0、第1天,5组OD值差异无统计学意义(P>0.05),第2、第3、第4天,与A组比,C组的OD值增幅明显降低(P<0.05);各组细胞let-7a基因表达水平行RT-q PCR检测结果显示,与A组比,C组let-7a的基因表达水平显著升高,且转染细胞let-7a的表达水平与含let-7a的慢病毒浓度梯度呈正相关(P<0.05),而RT-qPCR及Western blot检测显示let-7a过表达后TGF-β1 mRNA和蛋白水平逐渐降低(P<0.05)。侵袭和划痕实验结果表明,let-7a的过表达降低了LS-174T细胞的侵袭和迁移能力,且与初始病毒浓度成负相关(P<0.05)。结论:Let-7a过表达对LS-174T细胞增殖活力有明显抑制作用,可通过下调TGF-β1含量而抑制细胞的侵袭和转移。 展开更多
关键词 Let-7a 侵袭转移 上皮-间质转化 结肠黏液腺癌
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The Method of Data Access for Nuclear Instrument Based on Linked List
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作者 Zhi Liu Rui Li +2 位作者 hong huang Yi Cheng Xiaoping Yu 《Journal of Computer and Communications》 2016年第7期1-6,共6页
A new method of data access which can effectively resolve the problem of high speed and real time reading data of nuclear instrument in small storage space is introduced. This method applies the data storage mode of ... A new method of data access which can effectively resolve the problem of high speed and real time reading data of nuclear instrument in small storage space is introduced. This method applies the data storage mode of “linked list” to the system of Micro Control Unit (MCU), and realizes the pointer access of nuclear data on the small storage space of MCU. Experimental results show that this method can solve some problems of traditional data storage method, which has the advantages of simple program design, stable performance, accurate data, strong repeatability, saving storage space and so on. 展开更多
关键词 Linked List Data Storage Method Nuclear Instrument
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注浆工程扰动下煤系砂岩含水层水岩作用机理——以桃园煤矿为例 被引量:3
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作者 郭艳 桂和荣 +11 位作者 魏久传 倪建明 成荣发 庞迎春 张治 洪荒 胡满聪 崔亚利 梁展 李俊 陈家玉 李晨 《煤田地质与勘探》 CAS CSCD 北大核心 2021年第1期232-240,共9页
煤系砂岩裂隙水是煤矿重要的充水水源之一,以淮北煤田桃园煤矿二叠纪煤系为研究对象,在分析该矿水害注浆治理以来煤系水水化学特征的基础上,阐明了地下水水文地球化学作用机理及其控制因素。结果表明:注浆治理期间,煤系水中主要阳离子为... 煤系砂岩裂隙水是煤矿重要的充水水源之一,以淮北煤田桃园煤矿二叠纪煤系为研究对象,在分析该矿水害注浆治理以来煤系水水化学特征的基础上,阐明了地下水水文地球化学作用机理及其控制因素。结果表明:注浆治理期间,煤系水中主要阳离子为Na^(+),主要阴离子为SO4^(2-);阳离子质量浓度由大到小为Na^(+)、Ca^(2+)、Mg^(2+),阴离子质量浓度由大到小为SO4^(2-)、HCO3^(-)、Cl^(-);通过Durov水化学图分析,注浆治理期间煤系水化学类型以Na-SO_(4)和Na-HCO_(3)为主;煤系水中存在黄铁矿氧化或碳酸盐、硫酸盐溶解作用,并伴随着一定程度的阳离子交换作用与脱硫酸作用,特别是在注浆治理工程实施期间,阳离子交换作用增强;大型突水、注浆治理防治水工程、地质构造背景及采矿活动等均不同程度地影响了煤系水水岩作用,且随注浆治理范围增大,影响程度增大。该研究成果对于煤矿涌(突)水水源识别及水害防治具有重要意义,为类似条件下的其他煤矿(区)在突水或注浆治理扰动下的地下水水文地球化学研究及应用提供参考。 展开更多
关键词 煤系水 水化学类型 水化学演化 水岩作用与控制因素 淮北桃园煤矿
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Alterations in enterocyte mitochondrial respiratory function and enzyme activities in gastrointestinal dysfunction following brain injury 被引量:11
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作者 Ke-Jun Zhu hong huang +2 位作者 Hui Chu Hang Yu Shi-Ming Zhang 《World Journal of Gastroenterology》 SCIE CAS 2014年第28期9585-9591,共7页
AIM: To determine the alterations in rat enterocyte mitochondrial respiratory function and enzyme activities following traumatic brain injury (TBI).
关键词 MITOCHONDRIA Brain injury ENTEROCYTE Rats Malate dehydrogenase
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采动影响下皖北恒源煤矿八含水化学特征研究
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作者 施亚丽 吴基文 +3 位作者 翟晓荣 王广涛 洪荒 毕尧山 《安徽理工大学学报(自然科学版)》 CAS 2021年第1期31-40,共10页
为研究矿井开采活动对含水层的扰动影响,以皖北恒源煤矿八含为研究对象,收集了1988a~2019a共61个八含水样的水质数据,运用聚类分析方法将所采水样分成3个不同开采阶段的数据组,通过分析不同开采阶段的八含水化学特征,从时间维度上研究... 为研究矿井开采活动对含水层的扰动影响,以皖北恒源煤矿八含为研究对象,收集了1988a~2019a共61个八含水样的水质数据,运用聚类分析方法将所采水样分成3个不同开采阶段的数据组,通过分析不同开采阶段的八含水化学特征,从时间维度上研究了采矿活动对八含水质的扰动影响,并通过建立不同开采阶段八含水质和太灰水质的偏最小二乘判别(PLS-DA)模型讨论了八含水与太灰水之间的水力联系。结果表明:(1)随着开采活动的进行,八含水的水化学特征发生了明显变化;(2)对比不同开采阶段的八含水质与太灰水质,显示开采初期八含水水质与太灰水水质迥异,但随着采矿活动的进行,开采Ⅲ阶段的八含水水质趋近于太灰水水质;(3)不同开采阶段八含水质具有明显的聚类效应,部分开采Ⅲ阶段的八含水样水质呈现出太灰水与八含水的混合水水质特征,验证了八含水在采动影响下与太灰水发生水力联系的结果。研究成果可为矿井水害防治以及水资源的开发利用提供科学依据。 展开更多
关键词 水化学特征变化 水力联系 聚类分析 PLS-DA 采动影响
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A Numerical Study of Mesoscale Vortex Formation in the Midlatitudes:The Role of Moist Processes 被引量:5
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作者 Yongqiang JIANG Yuan WANG +2 位作者 Chaohui CHEN hongrang HE hong huang 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2019年第1期65-78,共14页
In this study, a three-dimensional mesoscale model was used to numerically simulate the well-known "98.7" heavy rainfall event that affected the Yangtze Valley in July 1998. Two experiments were conducted to... In this study, a three-dimensional mesoscale model was used to numerically simulate the well-known "98.7" heavy rainfall event that affected the Yangtze Valley in July 1998. Two experiments were conducted to analyze the impact of moist processes on the development of meso-β scale vortices(MβV) and their triggering by mesoscale wind perturbation(MWP). In the experiment in which the latent heat feedback(LHF) scheme was switched off, a stable low-level col field(i.e., saddle field—a region between two lows and two highs in the isobaric surface) formed, and the MWP triggered a weak MβV. However, when the LHF scheme was switched on as the MWP was introduced into the model, the MβV developed quickly and intense rainfall and a mesoscale low-level jet(mLLJ) were generated. The thickness of the air column and average temperature between 400 and 700 hPa decreased without the feedback of latent heat, whereas they increased quickly when the LHF scheme was switched on, with the air pressure falling at low levels but rising at upper levels. A schematic representation of the positive feedbacks among the mesoscale vortex, rainfall, and mLLJ shows that in the initial stage of the MβV, the MWP triggers light rainfall and the latent heat occurs at low levels, which leads to weak convergence and ageostrophic winds. In the mature stage of the MβV, convection extends to the middle-to-upper levels, resulting in an increase in the average temperature and a stretching of the air column. A low-level cyclonic circulation forms under the effect of Coriolis torque, and the m LLJ forms to the southeast of the MβV. 展开更多
关键词 moist process latent heat feedback mesoscale vortex col field
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