In order to deeply understand the status of ideological and political research on experimental courses in colleges and universities,the relevant literature collected by China National Knowledge Infrastructure(CNKI)was...In order to deeply understand the status of ideological and political research on experimental courses in colleges and universities,the relevant literature collected by China National Knowledge Infrastructure(CNKI)was taken as the research object,and the analysis was carried out by using CiteSpace software.The results show that research authors of ideological and political education in experimental courses have not yet formed cross-regional cooperation,and there is no core author.The ideological and political construction of experimental courses mainly focuses on experimental courses such as medicine,chemistry,and physics.The research focus on ideological and political education in experimental courses focuses on the concept of educating people,the construction of teaching systems,teaching modes,and the combination of new experimental teaching methods and ideological and political elements.The ideological and political education of experimental courses needs more attention and support from colleges and universities.展开更多
Henoch-Schnlein purpura(HSP) is a small-vessel vasculitis mediated by IgA-immune complex deposition.It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura,abdominal pain,arthritis and re...Henoch-Schnlein purpura(HSP) is a small-vessel vasculitis mediated by IgA-immune complex deposition.It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura,abdominal pain,arthritis and renal involvement.The diagnosis of HSP is difficult,especially when abdominal symptoms precede cutaneous lesions.We report a rare case of paroxysmal drastic abdominal pain with gastrointestinal bleeding presented in HSP.The diagnosis was verified by renal damage and the occurrence of purpura.展开更多
BACKGROUND Irritable bowel syndrome(IBS)is a common digestive system disease with a high incidence rate and is common in women.The cause of IBS remains unclear.Some studies have shown that mental and psychological dis...BACKGROUND Irritable bowel syndrome(IBS)is a common digestive system disease with a high incidence rate and is common in women.The cause of IBS remains unclear.Some studies have shown that mental and psychological diseases are independent risk factors for IBS.At present,the treatment of IBS is mainly symptomatic treatment.Clinically,doctors also use cognitive behavioral therapy to improve patients'cognitive ability to diseases and clinical symptoms.In recent years,exercise therapy has attracted more and more attention from scholars.Improving the symptoms of IBS patients through psychosomatic treatment strategy may be a good treatment method.AIM To explore the effects of an intervention of cognitive behavioral therapy combined with exercise(CBT+E)on the cognitive bias and coping styles of patients with diarrhea-predominant irritable bowel syndrome(IBS-D);and to provide a theoretical reference for the management of IBS.METHODS Sixty IBS-D patients and thirty healthy subjects were selected.The 60 IBS-D patients were randomly divided into experimental and control groups.The experimental group was treated with the CBT+E intervention,while the control group was treated with conventional drugs without any additional intervention.The cognitive bias and coping styles of the participants were evaluated at baseline and after 6 wk,12 wk and 24 wk using the Automatic Thoughts Questionnaire(ATQ),Dysfunctional Attitudes Scale(DAS)and Pain Coping Style Questionnaire(CSQ)instruments,and the intervention effect was analyzed using SPSS 17.0 statistical software.RESULTS At baseline,the scores on the various scales showed that all subjects had cognitive bias and adverse coping styles.The IBS Symptom Severity Scale(IBSSSS)scores,ATQ total scores,DAS scores and CSQ scores of the two groups were not significantly different(P>0.05).Compared with baseline,after 6 wk of the CBT+E intervention,there were significant differences in the ATQ scores,the dependence and total scores on the DAS,and the catastrophization,distraction and prayer scores on the CSQ(P<0.05).After 12 wk,there were significant differences in the scores for perfectionism on the DAS and in the scores for reinterpretation,neglect and pain behavior on the CSQ in the experimental group(P<0.05).After 24 wk,there were significant differences in the vulnerability,dependence,perfectionism,and total scores on the DAS and in the catastrophization,distraction and prayer scores on the CSQ in the experimental group(P<0.01).The IBS-SSS scores were negatively correlated with the ATQ and DAS total scores(P<0.05)but were positively correlated with the CSQ total score(P<0.05).CONCLUSION Intervention consisting of CBT+E can correct the cognitive bias of IBS-D patients and eliminate their adverse coping conditions.CBT+E should be promoted for IBS and psychosomatic diseases.展开更多
[Objective]The research aimed to study climatic characteristics of hail and risk zoning of its disaster factor in Anhui Province.[Method]Based on the hail-day records from 82 weather stations in Anhui Province,Chinese...[Objective]The research aimed to study climatic characteristics of hail and risk zoning of its disaster factor in Anhui Province.[Method]Based on the hail-day records from 82 weather stations in Anhui Province,Chinese Meteorological Disaster Dictionary(1951 to 2005)and The Yearbook of Meteorological Disaster in Anhui Province(2006 to 2009),we discussed the climatic characteristic and risk zoning of hail disaster in Anhui Province.[Result]The hail days exhibited significant interdecadal variability,and it had a significant negative correlation with annual mean minimum temperature.The hail usually occurred from March to August,most frequently in June but less in autumn and winter.It most likely took place from afternoon to sunset.The spatial distribution showed that the hail occurred more in northeast of Huaibei,south of Dabie Mountain and some areas of Huangshan Mountain,but less in Jianghuai region.The index of hail intensity was defined by three factors,the diameter,duration and gust grade,and the percentile method was used to grade the intensity of the hail disaster.This work provided a possibility for quantitative assessment of the intensity of hail disaster.The results of hail disaster risk zoning in Anhui Province showed that high risk zones were concentrated in northeast of Huaibei,and low risk zones were mainly in south of Huaihe River.Finally,verified by historic disaster,it showed that the results of risk zoning had a certain rationality and feasibility.[Conclusion]The research could provide reference basis for hail disaster defense and assessment.展开更多
Angioimmunoblastic T-cell lymphoma(AITL)is a unique type of peripheral T-cell lymphoma with a constellation of clinical symptoms and signs,including weight loss,fever,chills,anemia,skin rash,hepatosplenomegaly,lymphad...Angioimmunoblastic T-cell lymphoma(AITL)is a unique type of peripheral T-cell lymphoma with a constellation of clinical symptoms and signs,including weight loss,fever,chills,anemia,skin rash,hepatosplenomegaly,lymphadenopathy,thrombocytopenia and polyclonal hypergammaglobulinemia.The histological features of AITL are also distinctive.Pure red cell aplasia is a bone marrow failure characterized by progressive normocytic anemia and reticulocytopenia without leucopenia or thrombocytopenia.However,AITL with abdominal pain and pure red cell aplasia has rarely been reported.Here,we report a rare case of AITL-associated pure red cell aplasia with abdominal pain.The diagnosis was verified by a biopsy of the enlarged abdominal lymph nodes with immunohistochemical staining.展开更多
Glioma is one of the lethal central nervous system tumors.The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues,resulting in inevitable recurrenc...Glioma is one of the lethal central nervous system tumors.The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues,resulting in inevitable recurrence after surgery operation.Gliomas do not metastasize,so to prevent the residual tumor from proliferating or invading is a key challenge.Previous report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’activities.Using a hypotaurine synthesis deficient U251 cell line,we proved that the cells invasion ability was impaired.Gene expression profile analysis exhibited that knocking down one of the key enzymes of hypotaurine synthesis,2-aminoethanethiol dioxygenase(ADO),significantly affected the extracellular matrix-receptor process.Of that process,Wnt5a expression was severely upregulated by decreased intracellular ADO expression.Cells cultured at the presence of hypotaurine showed a decrease in intracellular Wnt5a protein and mRNA levels.This phenotype was due to hypermethylation of Wnt5a promoter,which was most likely the result of hypotaurine’s inhibiting demethylases activities.Collectively,this study demonstrated that hypotaurine synthesis deficient U251 cells were prone to epigenetic modification and Wnt5a seemed to be a tumor suppressor under that circumstance.This tumor suppression effect is warranted to be reevaluated in real tumor samples and the relevant evidence might contribute to develop new glioma interference strategies.展开更多
In the present paper, we answer the question: for 0a what are the greatest value p(a) and the least value q(a) such that the double inequality Jp(a,b)aA(a,b)+ (1-a)G(a,b)Jq(a,b) holds for all a,b>0 with a is not eq...In the present paper, we answer the question: for 0a what are the greatest value p(a) and the least value q(a) such that the double inequality Jp(a,b)aA(a,b)+ (1-a)G(a,b)Jq(a,b) holds for all a,b>0 with a is not equal to?b ?展开更多
基金2019 Laboratory Research Project of Beijing Institute of Technology(2019BITSYA27)。
文摘In order to deeply understand the status of ideological and political research on experimental courses in colleges and universities,the relevant literature collected by China National Knowledge Infrastructure(CNKI)was taken as the research object,and the analysis was carried out by using CiteSpace software.The results show that research authors of ideological and political education in experimental courses have not yet formed cross-regional cooperation,and there is no core author.The ideological and political construction of experimental courses mainly focuses on experimental courses such as medicine,chemistry,and physics.The research focus on ideological and political education in experimental courses focuses on the concept of educating people,the construction of teaching systems,teaching modes,and the combination of new experimental teaching methods and ideological and political elements.The ideological and political education of experimental courses needs more attention and support from colleges and universities.
基金grants from the SciTechnical Development Project of Shaanxi Province, China （2005K15-G2） Traditional Chinese Project of Shaanxi Province, China （2005024） Natural Science Foundation of Xi＇ an Jiaotong University （573026）.
文摘瞄准：在成年老鼠的睾丸由 FA 对氧化损坏在睾丸和维生素Ｅ(VE ) 的保护的效果上调查甲醛(FA ) 的效果。方法：三十只老鼠随机被划分成三个组：(1 ) 控制；(2 ) FA 处理组织(脂肪) ；并且(3 ) 胖 + VE 组织。胖、胖的 + VE 组被吸入在 10 mg/m (3 ) 的集中暴露于 FA 2 个星期。另外，胖 + VE 组在 2 星期的 FA 处理期间是口头上地管理的 VE。在精子的处理，在睾丸的组织病理学说、生物化学的变化，以及数量和质量以后，被观察。结果：精子的阴囊的重量，数量和质量，超级氧化物歧化酶(草皮)的活动，而 malondialdehyde ( MDA )的水平显著地在控制组与那些相比在胖组在老鼠的睾丸被增加，谷胱甘肽过氧化物酶( GSH-Px )和谷胱甘肽( GSH )显著地被减少。VE 处理在胖 + VE 组恢复了这些参数。另外，有 hematoxylin 曙红的显微镜学(他) 染色证明细精管萎缩的、生精的上皮细胞瓦解了，在在胖组和 VE 处理的老鼠的 shed 显著地在胖 + VE 改进了阴囊的结构组。结论：在由导致氧化应力的成年老鼠的阴囊的结构和功能，和这损坏能部分是的 FA 破坏由 VE 逆行。
基金Supported by The Major Projects Incubator Program of Sun Yat-Sen University,No.10ykjc25One Hundred Talents Program of Sun Yat-Sen University,No.82000-3171310+1 种基金Guangdong Science and Technology Program,No.2009B060300001National Natural Science Foundation of China,No.30971357
文摘Henoch-Schnlein purpura(HSP) is a small-vessel vasculitis mediated by IgA-immune complex deposition.It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura,abdominal pain,arthritis and renal involvement.The diagnosis of HSP is difficult,especially when abdominal symptoms precede cutaneous lesions.We report a rare case of paroxysmal drastic abdominal pain with gastrointestinal bleeding presented in HSP.The diagnosis was verified by renal damage and the occurrence of purpura.
基金Acknowledgment We thank the laboratory, clinical and paramedical staff of the center of Reproductive Medicine, and the Departmerit of Forensic Medicine, Pathology for their assistance. We especially thank Dr Sheng-Bin Li for practical support. This study was supported by National Natural Science Foundation of China （No. 30471735） and Science ＆ Technique Research Intensive Project of Education Ministry of China （No.105157） and Sci-Technical Development Project of Shaanxi Province, China （2005K15-G2, 2006K15-G4）.
文摘瞄准：在 ubiquitin 特定的朊酶学习单个核苷酸多型性的发生 26 (USP26 ) 在在中国的自发的男不孕的基因和它的参与。方法：平淡的精液分析被执行。不孕因素象免疫学的那样，传染、生物化学的混乱被检验与自发的不孕选择病人。DNA 从选择病人和控制人口的外部血被孤立，它用聚合酶链反应单人赛海滨符合构造多型性分析为变化被检验。而且，核苷酸序列在一些病人和控制被定序。结果：41 个不肥沃的人， 9 (22.0% ， P = 0.01 ) 在 X 染色体上的 USP26 基因的有的变化。一个复合变化(364insACA；460G → A ) 在 8 个病人被检测(19.5% ， P = 0.01 ) 并且 1044T → A 替换在 1 个病人被发现(2.4% ， P 】
0.05 ) 。所有三个变化在编码氨基酸导致了变化。二替换预言一些变化：460G → A 把缬氨酸变成异白氨酸，并且 1044T → A 用白氨酸代替本氨基丙酸。三核苷酸 ACA 的另一插入引起 threonine 的插入。没有另外的变化在留下的病人和肥沃的控制被发现。结论：USP26 基因可能具有在男复制的重要性。在这基因的变化可能与男不孕被联系，并且可能否定地影响阴囊的功能。关于这个问题的进一步的研究在进行中。
基金Supported by the National Nature Science Foundation of China,No.81572243Scientific Research Funds Project of Liaoning Education Department,No.LJC2019ST02
文摘BACKGROUND Irritable bowel syndrome(IBS)is a common digestive system disease with a high incidence rate and is common in women.The cause of IBS remains unclear.Some studies have shown that mental and psychological diseases are independent risk factors for IBS.At present,the treatment of IBS is mainly symptomatic treatment.Clinically,doctors also use cognitive behavioral therapy to improve patients'cognitive ability to diseases and clinical symptoms.In recent years,exercise therapy has attracted more and more attention from scholars.Improving the symptoms of IBS patients through psychosomatic treatment strategy may be a good treatment method.AIM To explore the effects of an intervention of cognitive behavioral therapy combined with exercise(CBT+E)on the cognitive bias and coping styles of patients with diarrhea-predominant irritable bowel syndrome(IBS-D);and to provide a theoretical reference for the management of IBS.METHODS Sixty IBS-D patients and thirty healthy subjects were selected.The 60 IBS-D patients were randomly divided into experimental and control groups.The experimental group was treated with the CBT+E intervention,while the control group was treated with conventional drugs without any additional intervention.The cognitive bias and coping styles of the participants were evaluated at baseline and after 6 wk,12 wk and 24 wk using the Automatic Thoughts Questionnaire(ATQ),Dysfunctional Attitudes Scale(DAS)and Pain Coping Style Questionnaire(CSQ)instruments,and the intervention effect was analyzed using SPSS 17.0 statistical software.RESULTS At baseline,the scores on the various scales showed that all subjects had cognitive bias and adverse coping styles.The IBS Symptom Severity Scale(IBSSSS)scores,ATQ total scores,DAS scores and CSQ scores of the two groups were not significantly different(P>0.05).Compared with baseline,after 6 wk of the CBT+E intervention,there were significant differences in the ATQ scores,the dependence and total scores on the DAS,and the catastrophization,distraction and prayer scores on the CSQ(P<0.05).After 12 wk,there were significant differences in the scores for perfectionism on the DAS and in the scores for reinterpretation,neglect and pain behavior on the CSQ in the experimental group(P<0.05).After 24 wk,there were significant differences in the vulnerability,dependence,perfectionism,and total scores on the DAS and in the catastrophization,distraction and prayer scores on the CSQ in the experimental group(P<0.01).The IBS-SSS scores were negatively correlated with the ATQ and DAS total scores(P<0.05)but were positively correlated with the CSQ total score(P<0.05).CONCLUSION Intervention consisting of CBT+E can correct the cognitive bias of IBS-D patients and eliminate their adverse coping conditions.CBT+E should be promoted for IBS and psychosomatic diseases.
基金Supported by Special Project of Science Research in Public ServiceIndustry(Meteorology),China(GYHY200906019)
文摘[Objective]The research aimed to study climatic characteristics of hail and risk zoning of its disaster factor in Anhui Province.[Method]Based on the hail-day records from 82 weather stations in Anhui Province,Chinese Meteorological Disaster Dictionary(1951 to 2005)and The Yearbook of Meteorological Disaster in Anhui Province(2006 to 2009),we discussed the climatic characteristic and risk zoning of hail disaster in Anhui Province.[Result]The hail days exhibited significant interdecadal variability,and it had a significant negative correlation with annual mean minimum temperature.The hail usually occurred from March to August,most frequently in June but less in autumn and winter.It most likely took place from afternoon to sunset.The spatial distribution showed that the hail occurred more in northeast of Huaibei,south of Dabie Mountain and some areas of Huangshan Mountain,but less in Jianghuai region.The index of hail intensity was defined by three factors,the diameter,duration and gust grade,and the percentile method was used to grade the intensity of the hail disaster.This work provided a possibility for quantitative assessment of the intensity of hail disaster.The results of hail disaster risk zoning in Anhui Province showed that high risk zones were concentrated in northeast of Huaibei,and low risk zones were mainly in south of Huaihe River.Finally,verified by historic disaster,it showed that the results of risk zoning had a certain rationality and feasibility.[Conclusion]The research could provide reference basis for hail disaster defense and assessment.
基金Acknowledgment We thank the laboratory, clinical and paramedical staff of the center of Reproductive Medicine, and the Department of Pathology for their assistance. This study was supported by the National Natural Science Foundation of China （30471735 and 30700654） and the Sci-Technical Development Project of Shanxi Province, China （2006K 15-G4）.
文摘Angioimmunoblastic T-cell lymphoma(AITL)is a unique type of peripheral T-cell lymphoma with a constellation of clinical symptoms and signs,including weight loss,fever,chills,anemia,skin rash,hepatosplenomegaly,lymphadenopathy,thrombocytopenia and polyclonal hypergammaglobulinemia.The histological features of AITL are also distinctive.Pure red cell aplasia is a bone marrow failure characterized by progressive normocytic anemia and reticulocytopenia without leucopenia or thrombocytopenia.However,AITL with abdominal pain and pure red cell aplasia has rarely been reported.Here,we report a rare case of AITL-associated pure red cell aplasia with abdominal pain.The diagnosis was verified by a biopsy of the enlarged abdominal lymph nodes with immunohistochemical staining.
基金supported by New and Old Energy Conversion Project of Jining City(2017ZDGH031)Guiding funds for the development of local science and technology by the Central government(2017106014)Natural Science Foundation of Liaoning Province(L2015317).
文摘Glioma is one of the lethal central nervous system tumors.The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues,resulting in inevitable recurrence after surgery operation.Gliomas do not metastasize,so to prevent the residual tumor from proliferating or invading is a key challenge.Previous report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’activities.Using a hypotaurine synthesis deficient U251 cell line,we proved that the cells invasion ability was impaired.Gene expression profile analysis exhibited that knocking down one of the key enzymes of hypotaurine synthesis,2-aminoethanethiol dioxygenase(ADO),significantly affected the extracellular matrix-receptor process.Of that process,Wnt5a expression was severely upregulated by decreased intracellular ADO expression.Cells cultured at the presence of hypotaurine showed a decrease in intracellular Wnt5a protein and mRNA levels.This phenotype was due to hypermethylation of Wnt5a promoter,which was most likely the result of hypotaurine’s inhibiting demethylases activities.Collectively,this study demonstrated that hypotaurine synthesis deficient U251 cells were prone to epigenetic modification and Wnt5a seemed to be a tumor suppressor under that circumstance.This tumor suppression effect is warranted to be reevaluated in real tumor samples and the relevant evidence might contribute to develop new glioma interference strategies.
文摘In the present paper, we answer the question: for 0a what are the greatest value p(a) and the least value q(a) such that the double inequality Jp(a,b)aA(a,b)+ (1-a)G(a,b)Jq(a,b) holds for all a,b>0 with a is not equal to?b ?
基金The financial support from the National Nature Science Foundation of China （No. 10835008） and State Key Laboratory of Coal Conversion （SKLCC） in-house project （No. 2008BWZ011） were highly acknowledged.
