中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室...中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.展开更多
目的·评价基于智能可穿戴设备BPMpathway的居家康复方案在全膝关节置换(total knee arthroplasty,TKA)术后患者中的应用效果。方法·采用方便抽样法,选取苏州大学附属第四医院(苏州市独墅湖医院)和苏州大学附属第一医院骨科202...目的·评价基于智能可穿戴设备BPMpathway的居家康复方案在全膝关节置换(total knee arthroplasty,TKA)术后患者中的应用效果。方法·采用方便抽样法,选取苏州大学附属第四医院(苏州市独墅湖医院)和苏州大学附属第一医院骨科2021年4月—2022年12月收治的膝关节骨关节炎并接受TKA术的患者作为研究对象。按照患者入院顺序,将住院号尾数为奇数的患者纳入对照组,住院号尾数为偶数的患者纳入干预组。对照组患者给予常规居家康复训练方案,干预组在对照组的基础上实施基于BPMpathway的远程居家康复训练方案。分别于基线及术后1、3、6个月采用骨科患者功能锻炼依从性量表、美国特种外科医院膝关节评分表(Hospital for Special Surgery Scale,HSS)和36项简明健康状况调查表(36-item Short Form Health Survey,SF-36)对2组患者进行测评,同时测量患者的膝关节活动度。结果·最终纳入110例患者,其中对照组56例,干预组54例。2组患者的一般资料差异无统计学意义。2组患者基线时的膝关节活动度、HSS评分、SF-36评分差异均无统计学意义。重复测量方差分析结果显示:2组患者膝关节活动度、功能锻炼依从性评分、HSS评分及SF-36评分的组间效应、时间效应及交互效应均具有统计学意义(均P<0.05)。术后1、3、6个月干预组的膝关节活动度、功能锻炼依从性评分、HSS评分及SF-36评分均高于对照组(均P<0.05)。结论·医护人员基于智能可穿戴设备BPMpathway开展的远程康复训练方案,有助于提高TKA术后患者居家康复期间功能锻炼的依从性,改善膝关节活动度,促使膝关节功能恢复,提高其生存质量,对患者预后具有积极的作用。展开更多
Obesity is associated with numerous metabolic disorders,and dietary polyphenols have been confirmed to have beneficial effects on the metabolism in obesity.However,the effect of 3-(3’,4’-dihydroxyphenyl)propanoic ac...Obesity is associated with numerous metabolic disorders,and dietary polyphenols have been confirmed to have beneficial effects on the metabolism in obesity.However,the effect of 3-(3’,4’-dihydroxyphenyl)propanoic acid(DHPA)and 3’,4’-dihydroxyphenylacetic acid(DHAA),two main metabolites of dietary polyphenols,on obesity remains poorly understood.In this study,DHPA and DHAA were found to alleviate obesity,as well as regulate insulin resistance,lipid metabolism,and oxidative stress response in high-fat diet(HFD)mice.Surprisingly,the 16S rRNA sequencing and UHPLC-Q-TOF/MS demonstrated that DHPA and DHAA only slightly disturbed the intestinal microbiome,but significantly altered the urine metabolome of HFD mice mainly by regulating pentose and glucuronate interconversion,tyrosine metabolism,pentose phosphate and tricarboxylic acid(TCA)cycle as indicated by metabolic pathway analysis based on Kyoto Encyclopedia of Genes and Genomes(KEGG)database.Correlation analysis revealed that the differential metabolites are strongly associated with body weight,blood glucose,insulin level,and superoxide dismutase(SOD)enzyme activity.Our results revealed that DHPA and DHAA exert their anti-obesity effect by regulating important metabolites in the glucose,lipid and tyrosine metabolism pathways.展开更多
BACKGROUND: Studies have demonstrated that the risk factors of vascular dementia following stroke are greatly different in region,race and other aspects. OBJECTIVE: To analyze the conditions and incidental risk factor...BACKGROUND: Studies have demonstrated that the risk factors of vascular dementia following stroke are greatly different in region,race and other aspects. OBJECTIVE: To analyze the conditions and incidental risk factors of vascular dementia in patients with acute cerebral infarction from Chongqing City. DESIGN: Case analysis. SETTING: Department of Neurology,Daping Hospital,Third Military Medical University of Chinese PLA. PARTICIPANTS: Altogether 546 inpatients with acute ischemic stroke admitted to Department of Neurology,Daping Hospital,Third Military Medical University of Chinese PLA between May 1999 and December 2002 were involved in this study. The involved patients,including 295 males and 251 females,aged 55-94 years,dwelled in Chongqing over 5 years. They were admitted to hospital within 48 hours of attack of acute ischemic stroke,and survived for over 3 months. Informed consents were obtained from all the involved subjects. METHODS: ① Following the same standard,cognitive and social function evaluations were conducted by one physician on admission and 3 months after admission. Unified questionnaire,consisting of general characteristics,vascular risk factors,stroke characteristics,neurological physical sign,and other 28 factors of involved subjects,was used in all the patients. According to the investigation results,the patients were assigned into 2 groups: dementia group and non-dementia group. ②Ischemic stroke was diagnosed according to acute ischemic brain disorder > 24 hours and CT or MRI imageology. ③ Neurophysiological examination was conducted in all the patients at 7 to 10 days after stroke (score was two SD less than or equaled to normal level was considered as abnormal). ④Diagnosis and statistics of dementia were carried out with Mini-Mental State Examination and The Diagnostic and Statistical Manual of Mental Disorders-Ⅳ (published by American Psychiatric Association) on admission and 3 months after admission. Neurologic deficit scoring was carried out with the National Institutes of Health Stroke Scale. ⑤ Chi-square test was used for categorical variable,and t test for quantitative variable between dementia group and non-dementia group. Dementia-related factors were performed multiple-factor Logistic regression model analysis. MAIN OUTCOME MEASURES: Incidence of dementia and dementia-related risk factors of patients. RESULTS: Altogether 546 patients with stroke were involved in this study,403 of them participated in the final analysis,and 143 dropped out. A total of 342 were followed-up in the hospital and 61 at home. At 3 months after cerebral infarction,vascular dementia occurred in 87 (21.6%) of 403 patients. The main risk factors were age (OR 1.179; 95%CI 1.130-1.230),low education level (OR 1.806; 95%CI 1.024-3.186),daily alcohol drinking (OR 3.447; 95%CI 1.591-7.468),stroke history (OR 2.531; 95%CI 1.419-4.512),atrial fibrilation(OR 3.475; 95%CI 1.712-7.057),dysphonia (OR 5.873; 95%CI 2.620-13.163) and left carotid artery infarction (OR 1.975; 95%CI 1.152-3.388). CONCLUSION: The incidence of vascular dementia is determined by synthetic action of multiple risk factors. Dysphonia is the most important influencing factor.展开更多
文摘中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.
文摘目的·评价基于智能可穿戴设备BPMpathway的居家康复方案在全膝关节置换(total knee arthroplasty,TKA)术后患者中的应用效果。方法·采用方便抽样法,选取苏州大学附属第四医院(苏州市独墅湖医院)和苏州大学附属第一医院骨科2021年4月—2022年12月收治的膝关节骨关节炎并接受TKA术的患者作为研究对象。按照患者入院顺序,将住院号尾数为奇数的患者纳入对照组,住院号尾数为偶数的患者纳入干预组。对照组患者给予常规居家康复训练方案,干预组在对照组的基础上实施基于BPMpathway的远程居家康复训练方案。分别于基线及术后1、3、6个月采用骨科患者功能锻炼依从性量表、美国特种外科医院膝关节评分表(Hospital for Special Surgery Scale,HSS)和36项简明健康状况调查表(36-item Short Form Health Survey,SF-36)对2组患者进行测评,同时测量患者的膝关节活动度。结果·最终纳入110例患者,其中对照组56例,干预组54例。2组患者的一般资料差异无统计学意义。2组患者基线时的膝关节活动度、HSS评分、SF-36评分差异均无统计学意义。重复测量方差分析结果显示:2组患者膝关节活动度、功能锻炼依从性评分、HSS评分及SF-36评分的组间效应、时间效应及交互效应均具有统计学意义(均P<0.05)。术后1、3、6个月干预组的膝关节活动度、功能锻炼依从性评分、HSS评分及SF-36评分均高于对照组(均P<0.05)。结论·医护人员基于智能可穿戴设备BPMpathway开展的远程康复训练方案,有助于提高TKA术后患者居家康复期间功能锻炼的依从性,改善膝关节活动度,促使膝关节功能恢复,提高其生存质量,对患者预后具有积极的作用。
基金supported by the project of the National Natural Science Foundation of China(32272331)the project of Fundamental Research Funds for the Central Universities(2662019PY034)。
文摘Obesity is associated with numerous metabolic disorders,and dietary polyphenols have been confirmed to have beneficial effects on the metabolism in obesity.However,the effect of 3-(3’,4’-dihydroxyphenyl)propanoic acid(DHPA)and 3’,4’-dihydroxyphenylacetic acid(DHAA),two main metabolites of dietary polyphenols,on obesity remains poorly understood.In this study,DHPA and DHAA were found to alleviate obesity,as well as regulate insulin resistance,lipid metabolism,and oxidative stress response in high-fat diet(HFD)mice.Surprisingly,the 16S rRNA sequencing and UHPLC-Q-TOF/MS demonstrated that DHPA and DHAA only slightly disturbed the intestinal microbiome,but significantly altered the urine metabolome of HFD mice mainly by regulating pentose and glucuronate interconversion,tyrosine metabolism,pentose phosphate and tricarboxylic acid(TCA)cycle as indicated by metabolic pathway analysis based on Kyoto Encyclopedia of Genes and Genomes(KEGG)database.Correlation analysis revealed that the differential metabolites are strongly associated with body weight,blood glucose,insulin level,and superoxide dismutase(SOD)enzyme activity.Our results revealed that DHPA and DHAA exert their anti-obesity effect by regulating important metabolites in the glucose,lipid and tyrosine metabolism pathways.
文摘BACKGROUND: Studies have demonstrated that the risk factors of vascular dementia following stroke are greatly different in region,race and other aspects. OBJECTIVE: To analyze the conditions and incidental risk factors of vascular dementia in patients with acute cerebral infarction from Chongqing City. DESIGN: Case analysis. SETTING: Department of Neurology,Daping Hospital,Third Military Medical University of Chinese PLA. PARTICIPANTS: Altogether 546 inpatients with acute ischemic stroke admitted to Department of Neurology,Daping Hospital,Third Military Medical University of Chinese PLA between May 1999 and December 2002 were involved in this study. The involved patients,including 295 males and 251 females,aged 55-94 years,dwelled in Chongqing over 5 years. They were admitted to hospital within 48 hours of attack of acute ischemic stroke,and survived for over 3 months. Informed consents were obtained from all the involved subjects. METHODS: ① Following the same standard,cognitive and social function evaluations were conducted by one physician on admission and 3 months after admission. Unified questionnaire,consisting of general characteristics,vascular risk factors,stroke characteristics,neurological physical sign,and other 28 factors of involved subjects,was used in all the patients. According to the investigation results,the patients were assigned into 2 groups: dementia group and non-dementia group. ②Ischemic stroke was diagnosed according to acute ischemic brain disorder > 24 hours and CT or MRI imageology. ③ Neurophysiological examination was conducted in all the patients at 7 to 10 days after stroke (score was two SD less than or equaled to normal level was considered as abnormal). ④Diagnosis and statistics of dementia were carried out with Mini-Mental State Examination and The Diagnostic and Statistical Manual of Mental Disorders-Ⅳ (published by American Psychiatric Association) on admission and 3 months after admission. Neurologic deficit scoring was carried out with the National Institutes of Health Stroke Scale. ⑤ Chi-square test was used for categorical variable,and t test for quantitative variable between dementia group and non-dementia group. Dementia-related factors were performed multiple-factor Logistic regression model analysis. MAIN OUTCOME MEASURES: Incidence of dementia and dementia-related risk factors of patients. RESULTS: Altogether 546 patients with stroke were involved in this study,403 of them participated in the final analysis,and 143 dropped out. A total of 342 were followed-up in the hospital and 61 at home. At 3 months after cerebral infarction,vascular dementia occurred in 87 (21.6%) of 403 patients. The main risk factors were age (OR 1.179; 95%CI 1.130-1.230),low education level (OR 1.806; 95%CI 1.024-3.186),daily alcohol drinking (OR 3.447; 95%CI 1.591-7.468),stroke history (OR 2.531; 95%CI 1.419-4.512),atrial fibrilation(OR 3.475; 95%CI 1.712-7.057),dysphonia (OR 5.873; 95%CI 2.620-13.163) and left carotid artery infarction (OR 1.975; 95%CI 1.152-3.388). CONCLUSION: The incidence of vascular dementia is determined by synthetic action of multiple risk factors. Dysphonia is the most important influencing factor.
