Objectives: To explore the relationship between thrombin-antithrombin complex (TAT), plasmin—α plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator/plasminogen activator inhibitor-1 com...Objectives: To explore the relationship between thrombin-antithrombin complex (TAT), plasmin—α plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator/plasminogen activator inhibitor-1 complex (t-PAIC) and Gastric cancer. Methods: The plasma levels of TAT, TM, t-PAIC and PIC in patients with gastric cancer (40 in the initial diagnosis group and 35 in the post-treatment group) and 40 healthy controls were measured by chemiluminescent enzyme immunoassay. Then analyze the differences between these indicators in different stages of gastric cancer patients and healthy controls. Results: 1) The plasma levels of TAT, TM, t-PAIC and PIC in the newly diagnosed gastric cancer group were higher than those in the control group and the post-treatment group (P 0.05). 2) The plasma levels of TAT, TM, t-PAIC and PIC were not significantly different among the effective treatment group, the ineffective treatment group and the healthy control group. Conclusion: The changes of TAT, TM, t-PAIC and PIC levels are closely related to the development of patients with gastric cancer, and their increase may indicate that patients have a high risk of thrombosis.展开更多
BACKGROUND Capecitabine(CAP)is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation(LT)in clinical studies.Our previous study showed that metronomic CAP can cause the ...BACKGROUND Capecitabine(CAP)is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation(LT)in clinical studies.Our previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress in healthy mice.Ferroptosis,a newly defined non-apoptotic cell death that occurs in response to iron overload and lethal levels of lipid peroxidation,is an important mechanism by which CAP induces cell death.Therefore,ferroptosis may also play an important role in CAP-induced T cell death and play an immunosuppressive role in acute rejection after transplantation.AIM To investigate the functions and underlying mechanisms of antirejection effects of metronomic CAP.METHODS A rat LT model of acute rejection was established,and the effect of metronomic CAP on splenic hematopoietic function and acute graft rejection was evaluated 7 d after LT.In vitro,primary CD3+T cells were sorted from rat spleens and human peripheral blood,and co-cultured with or without 5-fluorouracil(5-FU)(active agent of CAP).The levels of ferroptosis-related proteins,ferrous ion concentration,and oxidative stress-related indicators were observed.The changes in mitochondrial structure were observed using electron microscopy.RESULTS With no significant myelotoxicity,metronomic CAP alleviated graft injury(Banff score 9 vs 7.333,P<0.001),prolonged the survival time of the recipient rats(11.5 d vs 16 d,P<0.01),and reduced the infiltration rate of CD3+T cells in peripheral blood(6.859 vs 3.735,P<0.001),liver graft(7.459 vs 3.432,P<0.001),and spleen(26.92 vs 12.9,P<0.001),thereby inhibiting acute rejection after LT.In vitro,5-FU,an end product of CAP metabolism,induced the degradation of the ferritin heavy chain by upregulating nuclear receptor coactivator 4,which caused the accumulation of ferrous ions.It also inhibited nuclear erythroid 2 p45-related factor 2,heme oxygenase-1,and glutathione peroxidase 4,eventually leading to oxidative damage and ferroptosis of T cells.CONCLUSION Metronomic CAP can suppress acute allograft rejection in rats by triggering CD3+T cell ferroptosis,which makes it an effective immunosuppressive agent after LT.展开更多
The authenticity identification of anti-counterfeiting codes based on mobile phone platforms is affected by lighting environment,photographing habits,camera resolution and other factors,resulting in poor collection qu...The authenticity identification of anti-counterfeiting codes based on mobile phone platforms is affected by lighting environment,photographing habits,camera resolution and other factors,resulting in poor collection quality of anti-counterfeiting codes and weak differentiation of anti-counterfeiting codes for high-quality counterfeits.Developing an anticounterfeiting code authentication algorithm based on mobile phones is of great commercial value.Although the existing algorithms developed based on special equipment can effectively identify forged anti-counterfeiting codes,the anti-counterfeiting code identification scheme based on mobile phones is still in its infancy.To address the small differences in texture features,low response speed and excessively large deep learning models used in mobile phone anti-counterfeiting and identification scenarios,we propose a feature-guided double pool attention network(FG-DPANet)to solve the reprinting forgery problem of printing anti-counterfeiting codes.To address the slight differences in texture features in high-quality reprinted anti-counterfeiting codes,we propose a feature guidance algorithm that creatively combines the texture features and the inherent noise feature of the scanner and printer introduced in the reprinting process to identify anti-counterfeiting code authenticity.The introduction of noise features effectively makes up for the small texture difference of high-quality anti-counterfeiting codes.The double pool attention network(DPANet)is a lightweight double pool attention residual network.Under the condition of ensuring detection accuracy,DPANet can simplify the network structure as much as possible,improve the network reasoning speed,and run better on mobile devices with low computing power.We conducted a series of experiments to evaluate the FG-DPANet proposed in this paper.Experimental results show that the proposed FG-DPANet can resist highquality and small-size anti-counterfeiting code reprint forgery.By comparing with the existing algorithm based on texture,it is shown that the proposed method has a higher authentication accuracy.Last but not least,the proposed scheme has been evaluated in the anti-counterfeiting code blurring scene,and the results show that our proposed method can well resist slight blurring of anti-counterfeiting images.展开更多
BACKGROUND Lung endometriosis is an extremely rare gynecological disease.Current literature reports suggest that the majority of patients will present with only generic symptoms,such as hemoptysis,pneumothorax,and hem...BACKGROUND Lung endometriosis is an extremely rare gynecological disease.Current literature reports suggest that the majority of patients will present with only generic symptoms,such as hemoptysis,pneumothorax,and hemopneumothorax,which often leads to misdiagnosis.To date,there are 18 case reports of lung endometriosis that describe the clinical manifestation,imaging changes,treatment,and prognosis of the disease.To provide further insights into this rare disease,we present a new case report and a brief review of pulmonary endometriosis.CASE SUMMARY We report here about a 19-year-old woman who was admitted to the hospital for repeated catamenial hemoptysis over a 3-mo period.computed tomography(CT)imaging during menstruation revealed patchy high-density shadows,approximately 0.5 cm3 in size,in the right middle lobe of the lung.The patient’s hemoptysis and changes in the CT scans resolved after menstruation.Thoracoscopic right middle lobectomy,right lower lung repair,and closed thoracic drainage were performed.Postoperative histopathology confirmed lung endometriosis.There was no recurrence of symptoms at the 6 mo follow-up.CONCLUSION We propose diagnosing lung endometriosis by thoroughly taking reproductive history,clinical details,imaging,and histopathology followed by treatment with surgical resection.展开更多
In this paper, according to G-Brownian motion and other related concepts and properties, we define multiple Itôintegrals driven by G-Brownian motion and G-Lévy process. By using the G-Itôformula...In this paper, according to G-Brownian motion and other related concepts and properties, we define multiple Itôintegrals driven by G-Brownian motion and G-Lévy process. By using the G-Itôformula and the properties of G-expectation, two main theorems about Itôintegral are obtained and proved. These two theorems provide powerful help for the subsequent research on jump process.展开更多
文摘Objectives: To explore the relationship between thrombin-antithrombin complex (TAT), plasmin—α plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator/plasminogen activator inhibitor-1 complex (t-PAIC) and Gastric cancer. Methods: The plasma levels of TAT, TM, t-PAIC and PIC in patients with gastric cancer (40 in the initial diagnosis group and 35 in the post-treatment group) and 40 healthy controls were measured by chemiluminescent enzyme immunoassay. Then analyze the differences between these indicators in different stages of gastric cancer patients and healthy controls. Results: 1) The plasma levels of TAT, TM, t-PAIC and PIC in the newly diagnosed gastric cancer group were higher than those in the control group and the post-treatment group (P 0.05). 2) The plasma levels of TAT, TM, t-PAIC and PIC were not significantly different among the effective treatment group, the ineffective treatment group and the healthy control group. Conclusion: The changes of TAT, TM, t-PAIC and PIC levels are closely related to the development of patients with gastric cancer, and their increase may indicate that patients have a high risk of thrombosis.
基金Supported by National Key Research and Development Program of China,No.2020YFA0710802The Youth Science Fund of the Nature Science Foundation of Tianjin,No.20JCQNJC01370+1 种基金The Key Projects of Tianjin Science and Technology Project,No.21JCZDJC00160The Science Foundation of Tianjin Health Commission,No.ZC20065 and No.ZC20089.
文摘BACKGROUND Capecitabine(CAP)is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation(LT)in clinical studies.Our previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress in healthy mice.Ferroptosis,a newly defined non-apoptotic cell death that occurs in response to iron overload and lethal levels of lipid peroxidation,is an important mechanism by which CAP induces cell death.Therefore,ferroptosis may also play an important role in CAP-induced T cell death and play an immunosuppressive role in acute rejection after transplantation.AIM To investigate the functions and underlying mechanisms of antirejection effects of metronomic CAP.METHODS A rat LT model of acute rejection was established,and the effect of metronomic CAP on splenic hematopoietic function and acute graft rejection was evaluated 7 d after LT.In vitro,primary CD3+T cells were sorted from rat spleens and human peripheral blood,and co-cultured with or without 5-fluorouracil(5-FU)(active agent of CAP).The levels of ferroptosis-related proteins,ferrous ion concentration,and oxidative stress-related indicators were observed.The changes in mitochondrial structure were observed using electron microscopy.RESULTS With no significant myelotoxicity,metronomic CAP alleviated graft injury(Banff score 9 vs 7.333,P<0.001),prolonged the survival time of the recipient rats(11.5 d vs 16 d,P<0.01),and reduced the infiltration rate of CD3+T cells in peripheral blood(6.859 vs 3.735,P<0.001),liver graft(7.459 vs 3.432,P<0.001),and spleen(26.92 vs 12.9,P<0.001),thereby inhibiting acute rejection after LT.In vitro,5-FU,an end product of CAP metabolism,induced the degradation of the ferritin heavy chain by upregulating nuclear receptor coactivator 4,which caused the accumulation of ferrous ions.It also inhibited nuclear erythroid 2 p45-related factor 2,heme oxygenase-1,and glutathione peroxidase 4,eventually leading to oxidative damage and ferroptosis of T cells.CONCLUSION Metronomic CAP can suppress acute allograft rejection in rats by triggering CD3+T cell ferroptosis,which makes it an effective immunosuppressive agent after LT.
基金This work is supported by Supported by the National Key Research and Development Program of China under Grant No.2020YFF0304902the Science and Technology Research Project of Jiangxi Provincial Department of Education under Grant No.GJJ202511。
文摘The authenticity identification of anti-counterfeiting codes based on mobile phone platforms is affected by lighting environment,photographing habits,camera resolution and other factors,resulting in poor collection quality of anti-counterfeiting codes and weak differentiation of anti-counterfeiting codes for high-quality counterfeits.Developing an anticounterfeiting code authentication algorithm based on mobile phones is of great commercial value.Although the existing algorithms developed based on special equipment can effectively identify forged anti-counterfeiting codes,the anti-counterfeiting code identification scheme based on mobile phones is still in its infancy.To address the small differences in texture features,low response speed and excessively large deep learning models used in mobile phone anti-counterfeiting and identification scenarios,we propose a feature-guided double pool attention network(FG-DPANet)to solve the reprinting forgery problem of printing anti-counterfeiting codes.To address the slight differences in texture features in high-quality reprinted anti-counterfeiting codes,we propose a feature guidance algorithm that creatively combines the texture features and the inherent noise feature of the scanner and printer introduced in the reprinting process to identify anti-counterfeiting code authenticity.The introduction of noise features effectively makes up for the small texture difference of high-quality anti-counterfeiting codes.The double pool attention network(DPANet)is a lightweight double pool attention residual network.Under the condition of ensuring detection accuracy,DPANet can simplify the network structure as much as possible,improve the network reasoning speed,and run better on mobile devices with low computing power.We conducted a series of experiments to evaluate the FG-DPANet proposed in this paper.Experimental results show that the proposed FG-DPANet can resist highquality and small-size anti-counterfeiting code reprint forgery.By comparing with the existing algorithm based on texture,it is shown that the proposed method has a higher authentication accuracy.Last but not least,the proposed scheme has been evaluated in the anti-counterfeiting code blurring scene,and the results show that our proposed method can well resist slight blurring of anti-counterfeiting images.
文摘BACKGROUND Lung endometriosis is an extremely rare gynecological disease.Current literature reports suggest that the majority of patients will present with only generic symptoms,such as hemoptysis,pneumothorax,and hemopneumothorax,which often leads to misdiagnosis.To date,there are 18 case reports of lung endometriosis that describe the clinical manifestation,imaging changes,treatment,and prognosis of the disease.To provide further insights into this rare disease,we present a new case report and a brief review of pulmonary endometriosis.CASE SUMMARY We report here about a 19-year-old woman who was admitted to the hospital for repeated catamenial hemoptysis over a 3-mo period.computed tomography(CT)imaging during menstruation revealed patchy high-density shadows,approximately 0.5 cm3 in size,in the right middle lobe of the lung.The patient’s hemoptysis and changes in the CT scans resolved after menstruation.Thoracoscopic right middle lobectomy,right lower lung repair,and closed thoracic drainage were performed.Postoperative histopathology confirmed lung endometriosis.There was no recurrence of symptoms at the 6 mo follow-up.CONCLUSION We propose diagnosing lung endometriosis by thoroughly taking reproductive history,clinical details,imaging,and histopathology followed by treatment with surgical resection.
文摘In this paper, according to G-Brownian motion and other related concepts and properties, we define multiple Itôintegrals driven by G-Brownian motion and G-Lévy process. By using the G-Itôformula and the properties of G-expectation, two main theorems about Itôintegral are obtained and proved. These two theorems provide powerful help for the subsequent research on jump process.
