期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
ZMYND10 downregulates cyclins B1 and D1 to arrest cell cycle by trimethylating lysine 9 on histone 3
1
作者 Long-Ji Wu Xiang-Ning Zhang +5 位作者 Jian Wang Xia Kong Bi-Ying Zheng Jing Huang hong-bing yu Zhi-Wei He 《Life Research》 2021年第4期17-24,共8页
The BLU gene coding for zinc finger,MYND-type containing 10(ZMYND10)protein is mapped on chromosomal region 3p21.It is frequently lost in some kinds of cancers due to hypermethylation on its promoter region and identi... The BLU gene coding for zinc finger,MYND-type containing 10(ZMYND10)protein is mapped on chromosomal region 3p21.It is frequently lost in some kinds of cancers due to hypermethylation on its promoter region and identified as a tumour suppressor gene.The underlying mechanisms for BLU-mediated tumor suppression remain unclear.BLU has been reported to disturb cell cycle progression.The present study aims at examining whether ZMYND10 prevents progression of the cell cycle by targeting to repressive histone marks and downregulating the level of cyclins.Proteins structurally similar with ZMYND10 have been shown to recognize DNA sequence upstream of coding portion of the gene encoding cell cycle regulators.Enzymes,notably demethylases modifying the lysine residues are over-expressed line oncoproteins,and targeted in anti-cancer therapy.BLU was re-expressed in H1299 and HepG2 cells.The level of cyclin D1,cyclin B1 and trimethylate lysine 9 on histone 3(H3K9me3)and the binding of BLU with SIN3A(a component of the co-repressor)were detected.Cell cycle profile was measured.The evolutionary relationship between ZMYND10 and other ZMYND proteins was analysed by phylogenetic tree construction.We found that BLU expression induced G1 arrest in H1299 cells,and induced G1/G2 arrest in HepG2 cells.Cell cycle arrest was correlated with reduced activities and levels of cyclins;cyclin D1 was downregulated in H1299 cells;Both cyclin B1 and D1 were downregulated in HepG2 cells;and that BLU was associated with SIN3A.In both cell lines,the expression of H3K9me3 was induced.BLU was clustered with histone methyltransferase SMYD3 and SMYD1 on the same clade of the deduced phylogenetic tree.The results thus suggested that ZMYND10 encoded by BLU inhibited cyclins activity to prevent cell cycle progression through interaction with repressors and histone repressive marks to block the expression of genes coding for cyclins. 展开更多
关键词 BLU/ZMYND10 tumor suppression cell cycle arrest CYCLIN trimethylated lysine 9 on histone 3
下载PDF
Conversion of xylose and xylan into furfural in biorenewable choline chloride–oxalic acid deep eutectic solvent with the addition of metal chloride 被引量:5
2
作者 Lu-Xin Zhang Han yu +2 位作者 hong-bing yu Ze Chen Lei Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第8期1132-1136,共5页
An environmentally benign processing approach for furfural production from xylose and xylan under very mild conditions(353–373 K) was developed with the addition of metal chlorides in ChCl–oxalic acid(a deep eute... An environmentally benign processing approach for furfural production from xylose and xylan under very mild conditions(353–373 K) was developed with the addition of metal chlorides in ChCl–oxalic acid(a deep eutectic solvent(DES)) synthesized from cheap and renewable starting materials). ChCl–oxalic acid acted as both a Br?nsted acid catalyst and a reaction medium in this catalytic route. In addition, a biphasic system with methyl isobutyl ketone as an extracting reagent(DES/MIBK) to further increase furfural yield was also proposed. This processing approach for producing furfural eliminated the large energy consumption for high pressure saturated steam and the generation of acidic effluent, which was very difficult to handle. The whole catalytic system was more environmentally friendly compared with the commercial process for furfural production. 展开更多
关键词 FURFURAL XYLOSE XYLAN
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部