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Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice 被引量:15
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作者 Zhi-Jun Zang hong-feng tang +4 位作者 Ying Tuo Wei-Jie Xing Su-Yun Ji Yong Gao Chun-Hua Deng 《Asian Journal of Andrology》 SCIE CAS CSCD 2016年第4期613-619,共7页
Twenty-four-month-old male C57BU6 mice with low serum testosterone levels were used as a late-onset hypogonadism (LOH) animal model for examining the effects of velvet antler polypeptide (VAP) on sexual function a... Twenty-four-month-old male C57BU6 mice with low serum testosterone levels were used as a late-onset hypogonadism (LOH) animal model for examining the effects of velvet antler polypeptide (VAP) on sexual function and testosterone synthesis. These mice received VAP for 5 consecutive weeks by daily gavage at doses of 100, 200, or 300 mg kg-1 body weight per day (n = 10 mice per dose). Control animals (n = 10) received the same weight-based volume of vehicle. Sexual behavior and testosterone levels in serum and interstitial tissue of testis were measured after the last administration of VAP. Furthermore, to investigate the mechanisms of how VAP affects sexual behavior and testosterone synthesis in vivo, the expression of steroidogenic acute regulatory protein (STAR), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc), and 3β-hydroxysteroid dehydrogenase (3βHSD) in Leydig cells was also measured by immunofluorescence staining and quantitative real-time PCR. As a result, VAP produced a significant improvement in the sexual function of these aging male mice. Serum testosterone level and intratesticular testosterone (ITT) concentration also increased in the VAP-treated groups. The expression of STAR, P450scc, and 3β-HSD was also found to be enhanced in the VAP-treated groups compared with the control group. Our results suggested that VAP was effective in improving sexual function in aging male mice. The effect of velvet antler on sexual function was due to the increased expression of several rate-limiting enzymes of testosterone synthesis (STAR, P450scc, and 3β-HSD) and the following promotion of testosterone syothesis in vivo. 展开更多
关键词 aged male hypogonadism mouse sexual behavior testosterone synthesis velvet antler polypeptide
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