BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation...BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.展开更多
To estimate the cancer incidences and mortalities in China in 2010, the National Central Cancer Registry(NCCR) of China evaluated data for the year of 2010 from 145 qualified cancer registries covering 158,403,248 peo...To estimate the cancer incidences and mortalities in China in 2010, the National Central Cancer Registry(NCCR) of China evaluated data for the year of 2010 from 145 qualified cancer registries covering 158,403,248 people(92,433,739 in urban areas and 65,969,509 in rural areas). The estimates of new cancer cases and cancer deaths were 3,093,039 and 1,956,622 in 2010, respectively. The percentage of morphologically verified cases were 67.11%; 2.99% of incident cases were identified through death certification only, with the mortality to incidence ratio of 0.61. The crude incidence was 235.23/100,000(268.65/100,000 in males and 200.21/100,000 in females). The age-standardized rates by Chinese standard population(ASR China) and by world standard population(ASR world) were 184.58/100,000 and 181.49/100,000, respectively, with a cumulative incidence(0-74 years old) of 21.11%. The crude cancer mortality was 148.81/100,000(186.37/100,000 in males and 109.42/100,000 in females). The ASR China and ASR world were 113.92/100,000 and 112.86/100,000, respectively, with a cumulative mortality of 12.78%. Lung, breast, gastric, liver, esophageal, colorectal, and cervical cancers were the most common cancers. Lung, liver, gastric, esophageal, colorectal, breast, and pancreatic cancers were the leading causes of cancer deaths. The coverage of cancer registration has rapidly increased in China in recent years and may reflect more accurate cancer burdens among populations living in different areas. Given the increasing cancer burden in the past decades, China should strengthen its cancer prevention and control.展开更多
Objective:Cancer incidence and mortality data collected from population-based cancer registries were analyzed to present the overall cancer statistics in Chinese registration areas by age,sex and geographic area in 20...Objective:Cancer incidence and mortality data collected from population-based cancer registries were analyzed to present the overall cancer statistics in Chinese registration areas by age,sex and geographic area in 2007.Methods:In 2010,48 cancer registries reported cancer incidence and mortality data of 2007 to National Central Cancer Registry of China.Of them,38 registries' data met the national criteria.Incidence and mortality were calculated by cancer sites,age,gender,and area.Age-standardized rates were described by China and World population.Results:The crude incidence rate for all cancers was 276.16/100,000(305.22/100,000 for male and 246.46/100,000 for female;284.71/100,000 in urban and 251.07/100,000 in rural).Age-standardized incidence rates by China and World population were 145.39/100,000 and 189.46/100,000 respectively.The crude mortality rate for all cancers was 177.09/100,000(219.15/100,000 for male and 134.10/100,000 for female;173.55/100,000 in urban and 187.49/100,000 in rural).Age-standardized mortality rates by China and World population were 86.06/100,000 and 116.46/100,000,respectively.The top 10 most frequently common cancer sites were the lung,stomach,colon and rectum,liver,breast,esophagus,pancreas,bladder,brain and lymphoma,accounting for 76.12% of the total cancer cases.The top 10 causes of cancer death were cancers of the lung,liver,stomach,esophagus,colon and rectum,pancreas,breast,leukemia,brain and lymphoma,accounting for 84.37% of the total cancer deaths.Conclusion: Cancer remains a major disease threatening people's health in China. Prevention and control should be enhanced, especially for the main cancers.展开更多
Background: Liver cancer is a common cancer with poor prognosis in China. In this study, the national population?based cancer registration data were used to evaluate and analyze liver cancer incidence and mortality in...Background: Liver cancer is a common cancer with poor prognosis in China. In this study, the national population?based cancer registration data were used to evaluate and analyze liver cancer incidence and mortality in China in 2011 and provide a reference for liver cancer prevention and control.Methods: We collected and evaluated the incidence and mortality data of liver cancer in 2011 from 177 cancer registries with qualiied data. These data were used in the inal analysis including calculating crude, standardized, and truncated incidences and mortalities, and estimated new liver cancer cases and deaths using age?speciic rates and the corresponding populations. The national census in 2000 and Segi's population were used for age?standardized rates.Results: The estimates of new liver cancer cases and deaths were 355,595 and 322,416, respectively, in China in 2011. The crude incidence, age?standardized rate of incidence by Chinese standard population(ASRIC), and age?stand?ardized rate of incidence by world standard population(ASRIW) of liver cancer were 26.39/100,000, 19.48/100,000, and 19.10/100,000, respectively; the crude mortality, age?standardized rate of mortality by Chinese standard popula?tion(ASRMC), and age?standardized rate of mortality by world standard population(ASRMW) of liver cancer were 23.93/100,000,17.48/100,000, and 17.17/100,000, respectively. The incidence and mortality were higher in rural areas than in urban areas and higher in males than in females. The age?speciic incidence and mortality of liver cancer increased greatly with age, particularly after 30 years and peaked at 80–84 or 85+ years.Conclusions: Liver cancer is a common cancer in China, particularly for males and residents in rural areas. Targeted prevention, early detection, and treatment programs should be carried out.展开更多
Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer’s disease.However,it is not yet possible to easily detect these abnormalities using head computed tomography in the early s...Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer’s disease.However,it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease.In this review,we evaluated the ways in which modern imaging techniques such as positron emission computed tomography,single photon emission tomography,magnetic resonance spectrum imaging,structural magnetic resonance imaging,magnetic resonance diffusion tensor imaging,magnetic resonance perfusion weighted imaging,magnetic resonance sensitive weighted imaging,and functional magnetic resonance imaging have revealed specific changes not only in brain structure,but also in brain function in Alzheimer’s disease patients.The reviewed literature indicated that decreased fluorodeoxyglucose metabolism in the temporal and parietal lobes of Alzheimer’s disease patients is frequently observed via positron emission computed tomography.Furthermore,patients with Alzheimer’s disease often show a decreased N-acetylaspartic acid/creatine ratio and an increased myoinositol/creatine ratio revealed via magnetic resonance imaging.Atrophy of the entorhinal cortex,hippocampus,and posterior cingulate gyrus can be detected early using structural magnetic resonance imaging.Magnetic resonance sensitive weighted imaging can show small bleeds and abnormal iron metabolism.Task-related functional magnetic resonance imaging can display brain function activity through cerebral blood oxygenation.Resting functional magnetic resonance imaging can display the functional connection between brain neural networks.These are helpful for the differential diagnosis and experimental study of Alzheimer’s disease,and are valuable for exploring the pathogenesis of Alzheimer’s disease.展开更多
基金Supported by the National Natural Science Foundation of China,No.3206080019 and No.32060182Science and Technology Support Plan of Guizhou Province in China,No.[2020]4Y129Qiannan Prefecture Science and Technology Plan Project,No.[2022]01.
文摘BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.
文摘To estimate the cancer incidences and mortalities in China in 2010, the National Central Cancer Registry(NCCR) of China evaluated data for the year of 2010 from 145 qualified cancer registries covering 158,403,248 people(92,433,739 in urban areas and 65,969,509 in rural areas). The estimates of new cancer cases and cancer deaths were 3,093,039 and 1,956,622 in 2010, respectively. The percentage of morphologically verified cases were 67.11%; 2.99% of incident cases were identified through death certification only, with the mortality to incidence ratio of 0.61. The crude incidence was 235.23/100,000(268.65/100,000 in males and 200.21/100,000 in females). The age-standardized rates by Chinese standard population(ASR China) and by world standard population(ASR world) were 184.58/100,000 and 181.49/100,000, respectively, with a cumulative incidence(0-74 years old) of 21.11%. The crude cancer mortality was 148.81/100,000(186.37/100,000 in males and 109.42/100,000 in females). The ASR China and ASR world were 113.92/100,000 and 112.86/100,000, respectively, with a cumulative mortality of 12.78%. Lung, breast, gastric, liver, esophageal, colorectal, and cervical cancers were the most common cancers. Lung, liver, gastric, esophageal, colorectal, breast, and pancreatic cancers were the leading causes of cancer deaths. The coverage of cancer registration has rapidly increased in China in recent years and may reflect more accurate cancer burdens among populations living in different areas. Given the increasing cancer burden in the past decades, China should strengthen its cancer prevention and control.
文摘Objective:Cancer incidence and mortality data collected from population-based cancer registries were analyzed to present the overall cancer statistics in Chinese registration areas by age,sex and geographic area in 2007.Methods:In 2010,48 cancer registries reported cancer incidence and mortality data of 2007 to National Central Cancer Registry of China.Of them,38 registries' data met the national criteria.Incidence and mortality were calculated by cancer sites,age,gender,and area.Age-standardized rates were described by China and World population.Results:The crude incidence rate for all cancers was 276.16/100,000(305.22/100,000 for male and 246.46/100,000 for female;284.71/100,000 in urban and 251.07/100,000 in rural).Age-standardized incidence rates by China and World population were 145.39/100,000 and 189.46/100,000 respectively.The crude mortality rate for all cancers was 177.09/100,000(219.15/100,000 for male and 134.10/100,000 for female;173.55/100,000 in urban and 187.49/100,000 in rural).Age-standardized mortality rates by China and World population were 86.06/100,000 and 116.46/100,000,respectively.The top 10 most frequently common cancer sites were the lung,stomach,colon and rectum,liver,breast,esophagus,pancreas,bladder,brain and lymphoma,accounting for 76.12% of the total cancer cases.The top 10 causes of cancer death were cancers of the lung,liver,stomach,esophagus,colon and rectum,pancreas,breast,leukemia,brain and lymphoma,accounting for 84.37% of the total cancer deaths.Conclusion: Cancer remains a major disease threatening people's health in China. Prevention and control should be enhanced, especially for the main cancers.
文摘Background: Liver cancer is a common cancer with poor prognosis in China. In this study, the national population?based cancer registration data were used to evaluate and analyze liver cancer incidence and mortality in China in 2011 and provide a reference for liver cancer prevention and control.Methods: We collected and evaluated the incidence and mortality data of liver cancer in 2011 from 177 cancer registries with qualiied data. These data were used in the inal analysis including calculating crude, standardized, and truncated incidences and mortalities, and estimated new liver cancer cases and deaths using age?speciic rates and the corresponding populations. The national census in 2000 and Segi's population were used for age?standardized rates.Results: The estimates of new liver cancer cases and deaths were 355,595 and 322,416, respectively, in China in 2011. The crude incidence, age?standardized rate of incidence by Chinese standard population(ASRIC), and age?stand?ardized rate of incidence by world standard population(ASRIW) of liver cancer were 26.39/100,000, 19.48/100,000, and 19.10/100,000, respectively; the crude mortality, age?standardized rate of mortality by Chinese standard popula?tion(ASRMC), and age?standardized rate of mortality by world standard population(ASRMW) of liver cancer were 23.93/100,000,17.48/100,000, and 17.17/100,000, respectively. The incidence and mortality were higher in rural areas than in urban areas and higher in males than in females. The age?speciic incidence and mortality of liver cancer increased greatly with age, particularly after 30 years and peaked at 80–84 or 85+ years.Conclusions: Liver cancer is a common cancer in China, particularly for males and residents in rural areas. Targeted prevention, early detection, and treatment programs should be carried out.
基金This work was supported by the Science and Technology Support Plan of Guizhou Province of China,No.QianKeHe-Zhicheng[2020]4Y129(to HB)the Scientific Research Foundation of Guizhou Health Committee of China,No.gzwkj2017-1-022(to HB)the Scientific Research Project of Guizhou Traditional Chinese Medicine Bureau of China,No.QZYY-2018-044(to HB).
文摘Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer’s disease.However,it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease.In this review,we evaluated the ways in which modern imaging techniques such as positron emission computed tomography,single photon emission tomography,magnetic resonance spectrum imaging,structural magnetic resonance imaging,magnetic resonance diffusion tensor imaging,magnetic resonance perfusion weighted imaging,magnetic resonance sensitive weighted imaging,and functional magnetic resonance imaging have revealed specific changes not only in brain structure,but also in brain function in Alzheimer’s disease patients.The reviewed literature indicated that decreased fluorodeoxyglucose metabolism in the temporal and parietal lobes of Alzheimer’s disease patients is frequently observed via positron emission computed tomography.Furthermore,patients with Alzheimer’s disease often show a decreased N-acetylaspartic acid/creatine ratio and an increased myoinositol/creatine ratio revealed via magnetic resonance imaging.Atrophy of the entorhinal cortex,hippocampus,and posterior cingulate gyrus can be detected early using structural magnetic resonance imaging.Magnetic resonance sensitive weighted imaging can show small bleeds and abnormal iron metabolism.Task-related functional magnetic resonance imaging can display brain function activity through cerebral blood oxygenation.Resting functional magnetic resonance imaging can display the functional connection between brain neural networks.These are helpful for the differential diagnosis and experimental study of Alzheimer’s disease,and are valuable for exploring the pathogenesis of Alzheimer’s disease.
基金supported by a grant from the Program of National Natural Science Foundation of China(No.30772515)the National"863"High-Tech Res & Dev Program of China(No.2006A A02A402)
