BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and stroke.The composite dietary antioxidant index(CDAI),wh...BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and stroke.The composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this relationship.Although previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular events.AIM To investigate the association between CDAI and stroke risk in individuals with diabetes.METHODS Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with diabetes.The CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and E;carotenoids;selenium;and zinc.Multivariate logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke risk.RESULTS The participant cohort,with an average age of 59.5 years and a slight male majority,reflected the broader demographic characteristics of individuals with diabetes.The analysis revealed a strong inverse relationship between CDAI levels and stroke risk.Remarkably,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adjustments for various confounders.This finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with diabetes.CONCLUSION Our findings suggested that CDAI was inversely associated with stroke prevalence among patients with diabetes.These results suggest incorporating antioxidant-rich foods into dietary regimens as a potential strategy for stroke prevention.展开更多
BACKGROUND The glycemic control of children with type 1 diabetes(T1D)may be influenced by the economic status of their parents.AIM To investigate the association between parental economic status and blood glucose leve...BACKGROUND The glycemic control of children with type 1 diabetes(T1D)may be influenced by the economic status of their parents.AIM To investigate the association between parental economic status and blood glucose levels of children with T1D using a mobile health application.METHODS Data from children with T1D in China's largest T1D online community,Tang-TangQuan■.Blood glucose levels were uploaded every three months and parental economic status was evaluated based on annual household income.Children were divided into three groups:Low-income(<30000 Yuan),middle-income(30000-100000 Yuan),and high-income(>100000 yuan)(1 Yuan=0.145 United States Dollar approximately).Blood glucose levels were compared among the groups and associations were explored using Spearman’s correlation analysis and multivariable logistic regression.RESULTS From September 2015 to August 2022,1406 eligible children with T1D were included(779 female,55.4%).Median age was 8.1 years(Q1-Q3:4.6-11.6)and duration of T1D was 0.06 years(0.02-0.44).Participants were divided into three groups:Low-income(n=320),middle-income(n=724),and high-income(n=362).Baseline hemoglobin A1c(HbA1c)levels were comparable among the three groups(P=0.072).However,at month 36,the low-income group had the highest HbA1c levels(P=0.036).Within three years after registration,glucose levels increased significantly in the low-income group but not in the middle-income and high-income groups.Parental economic status was negatively correlated with pre-dinner glucose(r=-0.272,P=0.012).After adjustment for confounders,parental economic status remained a significant factor related to pre-dinner glucose levels(odds ratio=13.02,95%CI:1.99 to 126.05,P=0.002).CONCLUSION The blood glucose levels of children with T1D were negatively associated with parental economic status.It is suggested that parental economic status should be taken into consideration in the management of T1D for children.展开更多
The novel Ni-based brazing filler was used to join C/C composites.When brazing temperature increased from 1080 to 1100°C,the wetting angle decreased from 23°to 14°,and the brazing filler had good wettab...The novel Ni-based brazing filler was used to join C/C composites.When brazing temperature increased from 1080 to 1100°C,the wetting angle decreased from 23°to 14°,and the brazing filler had good wettability on the surface of C/C composites.The brazing seam of the brazed joint consisted of Ni(s,s)and Cr_(3)C_(2) phases.As brazing temperature increased,lots of Cr_(3)C_(2) phases were generated at the bonding interface,and the thick reaction layer was formed.When brazing temperature was 1120°C,the shear strength of C/C joint reached the maximum value of 31.5 MPa.The fracture path extended in the C/C matrix close to the bonding interface.展开更多
BACKGROUND PD-1 inhibitors in combination with fruquintinib have not previously been reported as neoadjuvant therapy for patients with colorectal cancer.In this case report,the combination of a PD-1 inhibitor and fruq...BACKGROUND PD-1 inhibitors in combination with fruquintinib have not previously been reported as neoadjuvant therapy for patients with colorectal cancer.In this case report,the combination of a PD-1 inhibitor and fruquintinib demonstrated good efficacy in patients with MSI-H colorectal cancer.CASE SUMMARY The patient was a young man in his 30s who had MSI-H type colon cancer.The patient underwent four cycles of neoadjuvant therapy with a PD-1 inhibitor combined with fruquintinib before surgery,resulting in regression of the mass and a successful surgery.CONCLUSION Some patients with colorectal cancer have the MSI-H type,and the first-line chemotherapy regimen is not effective.However,PD-1 monoclonal antibody immunotherapy has a good therapeutic effect,which can be improved by combination therapy with fruquintinib.We recommend that patients with a history of colon or rectal cancer receive universal MSI testing;then,neoadjuvant therapy should be used.展开更多
Lithium metal batteries(LMBs) with a high theoretical capacity are seen as a type of the most potential energy storage system.Unfortunately,the growth of lithium dendrite,the irreversible side reactions,and the infini...Lithium metal batteries(LMBs) with a high theoretical capacity are seen as a type of the most potential energy storage system.Unfortunately,the growth of lithium dendrite,the irreversible side reactions,and the infinite volume alteration still curb the practical utilization of lithium metal anodes,resulting in low Coulombic efficiency(CE) and safety problems,etc.Herein,we synthesize a lithiophilic 3D copper foam host with uniformly distributed nano-flower-like ZnO particles(CuF/ZnO) and obtain the composite lithium metal anode containing the Li_(2)O,LiZn alloy,and pure Li by the infusion of molten Li(CuF/Li_(2)O-LiZn@Li).Benefitting from the advantages of the 3D structure of copper foam and the lithiophilicity of ZnO sites,the composite lithium metal anode can restrain the volume alternation and regulate the uniform deposition of lithium.The symmetrical cells of the composite lithium metal anode have a 1600 h long cycle life with a low polarization voltage of 15 mV,and the Coulombic efficiency can maintain about 97.8% at 1.0 mA·cm^(-2),1.0mAh·cm^(-2).展开更多
The nano-Ag paste consisted of Ag nanoparticles and organic solvents.These organics would be removed by evaporation or decomposition during sintering.When the sintering temperature was 300℃,the resistivity of sintere...The nano-Ag paste consisted of Ag nanoparticles and organic solvents.These organics would be removed by evaporation or decomposition during sintering.When the sintering temperature was 300℃,the resistivity of sintered bulk was 8.35×10^-6Ωcm,and its thermal conductivity was 247 W m^-1 K^-1.The Si/SiC chips and direct bonding copper(DBC)substrates could be bonded by this nano-Ag paste at low temperature.The bonding interface,sintered microstructure and shear strength of Si/SiC chip attachment were investigated by scanning electron microscopy,transmission electron microscopy and shear tests.Results showed that the sintered Ag layer was porous structure and tightly adhered to the electroless nickel immersion gold surface of DBC substrate and formed the continuous Ag–Au interdiffusion layer.The shear strength of Si and SiC chip attachments was higher than 35 MPa when the sintering pressure was 10 MPa.The fracture occurred inside the sintered Ag layer,and the fracture surface had obvious plastic deformation.展开更多
In the prevailing incineration processes of municipal solid waste,the presence of polyvinyl chloride(PVC)may cause environmental problems.The energy-intensive ironmaking sector in the iron and steel industry operates ...In the prevailing incineration processes of municipal solid waste,the presence of polyvinyl chloride(PVC)may cause environmental problems.The energy-intensive ironmaking sector in the iron and steel industry operates at high temperature and under high reduction potential with the function of energy conversion,which can provide a potential path for the collaborative utilization of waste plastics in large quantities and low cost.The gasification of the char formed from PVC when processed in the ironmaking sector is significant for the development of the related technologies.Thus,the gasification experiment of PVC char and traditional carbonaceous materials was performed by thermogravimetric analysis.The results indicated that the gasification ability decreased in the sequence of PVC char>anthracite coal>coke>graphite.Then,kinetics were also analyzed by Coats-Redfern and Doyle approximations.The PVC char showed the best gasification ability with the smallest activation energy,ranging from 87.18 to 117.52 kJ/mol,and the smaller graphitization degree of PVC char compared with other carbonaceous materials should be the main reason for its excellent gasification reactivity.展开更多
基金Supported by Strategic Priority Research Program of Chinese Academy of Sciences,No.XDB38010100Construction and Validation of an Early Identification System for Cardiovascular Disease Associated with Glucose Metabolism Disorders,No.202204295107020026Science and Technology Projects in Guangzhou,No.2023A04J1087.
文摘BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and stroke.The composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this relationship.Although previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular events.AIM To investigate the association between CDAI and stroke risk in individuals with diabetes.METHODS Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with diabetes.The CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and E;carotenoids;selenium;and zinc.Multivariate logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke risk.RESULTS The participant cohort,with an average age of 59.5 years and a slight male majority,reflected the broader demographic characteristics of individuals with diabetes.The analysis revealed a strong inverse relationship between CDAI levels and stroke risk.Remarkably,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adjustments for various confounders.This finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with diabetes.CONCLUSION Our findings suggested that CDAI was inversely associated with stroke prevalence among patients with diabetes.These results suggest incorporating antioxidant-rich foods into dietary regimens as a potential strategy for stroke prevention.
基金Supported by the Strategic Priority Research Program of Chinese Academy of Sciences,No.XDB38010100the Natural Science Research Project of Anhui Educational Committee,No.2023AH040398+1 种基金Emergency Technological Research Project for COVID-19Science and Technology Projects in Guangzhou,No.2023A04J1087.
文摘BACKGROUND The glycemic control of children with type 1 diabetes(T1D)may be influenced by the economic status of their parents.AIM To investigate the association between parental economic status and blood glucose levels of children with T1D using a mobile health application.METHODS Data from children with T1D in China's largest T1D online community,Tang-TangQuan■.Blood glucose levels were uploaded every three months and parental economic status was evaluated based on annual household income.Children were divided into three groups:Low-income(<30000 Yuan),middle-income(30000-100000 Yuan),and high-income(>100000 yuan)(1 Yuan=0.145 United States Dollar approximately).Blood glucose levels were compared among the groups and associations were explored using Spearman’s correlation analysis and multivariable logistic regression.RESULTS From September 2015 to August 2022,1406 eligible children with T1D were included(779 female,55.4%).Median age was 8.1 years(Q1-Q3:4.6-11.6)and duration of T1D was 0.06 years(0.02-0.44).Participants were divided into three groups:Low-income(n=320),middle-income(n=724),and high-income(n=362).Baseline hemoglobin A1c(HbA1c)levels were comparable among the three groups(P=0.072).However,at month 36,the low-income group had the highest HbA1c levels(P=0.036).Within three years after registration,glucose levels increased significantly in the low-income group but not in the middle-income and high-income groups.Parental economic status was negatively correlated with pre-dinner glucose(r=-0.272,P=0.012).After adjustment for confounders,parental economic status remained a significant factor related to pre-dinner glucose levels(odds ratio=13.02,95%CI:1.99 to 126.05,P=0.002).CONCLUSION The blood glucose levels of children with T1D were negatively associated with parental economic status.It is suggested that parental economic status should be taken into consideration in the management of T1D for children.
基金the financial support from the National Natural Science Foundation of China (Nos. 51675030, 51871010, 52005022)Shanghai Aerospace Scienceand Technology Innovation Fund, China (No. SAST2020-117)。
文摘The novel Ni-based brazing filler was used to join C/C composites.When brazing temperature increased from 1080 to 1100°C,the wetting angle decreased from 23°to 14°,and the brazing filler had good wettability on the surface of C/C composites.The brazing seam of the brazed joint consisted of Ni(s,s)and Cr_(3)C_(2) phases.As brazing temperature increased,lots of Cr_(3)C_(2) phases were generated at the bonding interface,and the thick reaction layer was formed.When brazing temperature was 1120°C,the shear strength of C/C joint reached the maximum value of 31.5 MPa.The fracture path extended in the C/C matrix close to the bonding interface.
文摘BACKGROUND PD-1 inhibitors in combination with fruquintinib have not previously been reported as neoadjuvant therapy for patients with colorectal cancer.In this case report,the combination of a PD-1 inhibitor and fruquintinib demonstrated good efficacy in patients with MSI-H colorectal cancer.CASE SUMMARY The patient was a young man in his 30s who had MSI-H type colon cancer.The patient underwent four cycles of neoadjuvant therapy with a PD-1 inhibitor combined with fruquintinib before surgery,resulting in regression of the mass and a successful surgery.CONCLUSION Some patients with colorectal cancer have the MSI-H type,and the first-line chemotherapy regimen is not effective.However,PD-1 monoclonal antibody immunotherapy has a good therapeutic effect,which can be improved by combination therapy with fruquintinib.We recommend that patients with a history of colon or rectal cancer receive universal MSI testing;then,neoadjuvant therapy should be used.
基金financially supported by the School Research Startup Expenses of Harbin Institute of Technology (Shenzhen) (Nos.DD29100027 and DD45001022)the National Natural Science Foundation of China (No.52002094)+4 种基金Guangdong Basic and Applied Basic Research Foundation (No. 2019A1515110756)Shenzhen Science and Technology Program (Nos.JCYJ20210324121411031,JSGG202108021253804014 and RCBS20210706092218040)the Open Fund of Guangdong Provincial Key Laboratory of Advanced Energy Storage materials (No. asem202107)the Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering (No.2022-K16)Shenzhen Steady Support Plan (No. GXWD20201230155427003-20200824103000001)。
文摘Lithium metal batteries(LMBs) with a high theoretical capacity are seen as a type of the most potential energy storage system.Unfortunately,the growth of lithium dendrite,the irreversible side reactions,and the infinite volume alteration still curb the practical utilization of lithium metal anodes,resulting in low Coulombic efficiency(CE) and safety problems,etc.Herein,we synthesize a lithiophilic 3D copper foam host with uniformly distributed nano-flower-like ZnO particles(CuF/ZnO) and obtain the composite lithium metal anode containing the Li_(2)O,LiZn alloy,and pure Li by the infusion of molten Li(CuF/Li_(2)O-LiZn@Li).Benefitting from the advantages of the 3D structure of copper foam and the lithiophilicity of ZnO sites,the composite lithium metal anode can restrain the volume alternation and regulate the uniform deposition of lithium.The symmetrical cells of the composite lithium metal anode have a 1600 h long cycle life with a low polarization voltage of 15 mV,and the Coulombic efficiency can maintain about 97.8% at 1.0 mA·cm^(-2),1.0mAh·cm^(-2).
基金financially supported by the National Key Research and Development Program of China(No.2017YFB1104900)the China Postdoctoral Science Foundation(No.2019M650425)。
文摘The nano-Ag paste consisted of Ag nanoparticles and organic solvents.These organics would be removed by evaporation or decomposition during sintering.When the sintering temperature was 300℃,the resistivity of sintered bulk was 8.35×10^-6Ωcm,and its thermal conductivity was 247 W m^-1 K^-1.The Si/SiC chips and direct bonding copper(DBC)substrates could be bonded by this nano-Ag paste at low temperature.The bonding interface,sintered microstructure and shear strength of Si/SiC chip attachment were investigated by scanning electron microscopy,transmission electron microscopy and shear tests.Results showed that the sintered Ag layer was porous structure and tightly adhered to the electroless nickel immersion gold surface of DBC substrate and formed the continuous Ag–Au interdiffusion layer.The shear strength of Si and SiC chip attachments was higher than 35 MPa when the sintering pressure was 10 MPa.The fracture occurred inside the sintered Ag layer,and the fracture surface had obvious plastic deformation.
基金The work was supported by the National Natural Science Foundation of China(Nos.51804024 and U1960205)the Fundamental Research Funds for the Central Universities(No.FRF-IC-20-09)The authors also thank for the financial support from the State Key Laboratory of Advanced Metallurgy,University of Science and Technology Beijing,China(No.41621002).
文摘In the prevailing incineration processes of municipal solid waste,the presence of polyvinyl chloride(PVC)may cause environmental problems.The energy-intensive ironmaking sector in the iron and steel industry operates at high temperature and under high reduction potential with the function of energy conversion,which can provide a potential path for the collaborative utilization of waste plastics in large quantities and low cost.The gasification of the char formed from PVC when processed in the ironmaking sector is significant for the development of the related technologies.Thus,the gasification experiment of PVC char and traditional carbonaceous materials was performed by thermogravimetric analysis.The results indicated that the gasification ability decreased in the sequence of PVC char>anthracite coal>coke>graphite.Then,kinetics were also analyzed by Coats-Redfern and Doyle approximations.The PVC char showed the best gasification ability with the smallest activation energy,ranging from 87.18 to 117.52 kJ/mol,and the smaller graphitization degree of PVC char compared with other carbonaceous materials should be the main reason for its excellent gasification reactivity.
