BACKGROUND Pulmonary tumorlets are nodular hyperplastic neuroendocrine cells(NECs)that extend beyond the basement membrane.They often coexist with other lung diseases such as fibrosis and bronchiectasis,but rarely acc...BACKGROUND Pulmonary tumorlets are nodular hyperplastic neuroendocrine cells(NECs)that extend beyond the basement membrane.They often coexist with other lung diseases such as fibrosis and bronchiectasis,but rarely accompanied by pulmonary sclerosing pneumocytoma(PSP),which has not been reported in the literature.CASE SUMMARY A 54-year-old woman was admitted to the hospital because she had symptoms of bloody sputum for more than 4 mo and hemoptysis for 1 wk.Computed tomography images showed atrophy accompanied by infections in the middle lobe of her right lung.Moreover,numerous nodules were identified in the middle lobe of the right lung.The patient underwent thoracoscopic pneumonectomy of the middle lobe of the right lung,and the resected mass was pathologically confirmed to have bronchiectasis,multifocal NEC hyperplasia accompanied by tumorlet,and PSP.CONCLUSION Our report presents a rare clinical case of bronchiectasis complicated with multifocal NEC hyperplasia,tumorlet,and PSP.展开更多
Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China....Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.展开更多
文摘BACKGROUND Pulmonary tumorlets are nodular hyperplastic neuroendocrine cells(NECs)that extend beyond the basement membrane.They often coexist with other lung diseases such as fibrosis and bronchiectasis,but rarely accompanied by pulmonary sclerosing pneumocytoma(PSP),which has not been reported in the literature.CASE SUMMARY A 54-year-old woman was admitted to the hospital because she had symptoms of bloody sputum for more than 4 mo and hemoptysis for 1 wk.Computed tomography images showed atrophy accompanied by infections in the middle lobe of her right lung.Moreover,numerous nodules were identified in the middle lobe of the right lung.The patient underwent thoracoscopic pneumonectomy of the middle lobe of the right lung,and the resected mass was pathologically confirmed to have bronchiectasis,multifocal NEC hyperplasia accompanied by tumorlet,and PSP.CONCLUSION Our report presents a rare clinical case of bronchiectasis complicated with multifocal NEC hyperplasia,tumorlet,and PSP.
基金National High Level Hospital Clinical Research Funding,Grant/Award Number:2022-NHLHCRF-YGJE-02Natural Science Foundation of Beijing Municipality,Grant/Award Number:7212090。
文摘Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.
