Broadband electroluminescence based on environment-friendly emitters is promising for healthy lighting yet remains an unprecedented challenge to progress.The copper halide-based emitters are competitive candidates for...Broadband electroluminescence based on environment-friendly emitters is promising for healthy lighting yet remains an unprecedented challenge to progress.The copper halide-based emitters are competitive candidates for broadband emission,but their high-performance electroluminescence shows inadequate broad emission bandwidth of less than 90 nm.Here,we demonstrate efficient ultra-broadband electroluminescence from a copper halide(CuI)nanocluster single emitter prepared by a one-step solution synthesis-deposition process,through dedicated design of ligands and subtle selection of solvents.The CuI nanocluster exhibits high rigidity in the excitation state as well as dual-emissive modes of phosphorescence and temperature-activated delayed fluorescence,enabling the uniform cluster-composed film to show excellent stability and high photoluminescent efficiency.In consequence,ultra-broadband light-emitting diodes(LEDs)present nearly identical performance in an inert or air atmosphere without encapsulation and outstanding high-temperature operation performance,reaching an emission full width at half maximum(FWHM)of~120 nm,a peak external quantum efficiency of 13%,a record maximum luminance of~50,000 cd m^(−2),and an operating half-lifetime of 137 h at 100 cd m^(−2).The results highlight the potential of copper halide nanoclusters for next-generation healthy lighting.展开更多
Depression is not only a major global public health concern,but also a common comorbidity among patients who experience chronic diseases,such as cancer,stroke,heart disease,diabetes,and chronic obstructive pulmonary d...Depression is not only a major global public health concern,but also a common comorbidity among patients who experience chronic diseases,such as cancer,stroke,heart disease,diabetes,and chronic obstructive pulmonary disease.Yet the recognition and treatment varies widely around the world.This study(1)provides an integrated review of the literature on the prevalence of depression among patients with chronic diseases in China and the United States and its relationship to poorer health outcomes and(2)compares the differences in the percentages of patients receiving treatments for depression between the United States and China.Given the current situation,we recommended that primary care and specialty providers should be knowledgeable and alert regarding the signs of depression.Efforts should be directed to further implement integrated care based interventions to manage depression and improve quality of life among patients suffering chronic diseases in both China and the United States.展开更多
Psoriasis is a common chronic inflammatory skin disease driven by the aberrant activation of dendritic cells(DCs)and T cells,ultimately leading to increased production of cytokines such as interleukin(IL)-23 and IL-17...Psoriasis is a common chronic inflammatory skin disease driven by the aberrant activation of dendritic cells(DCs)and T cells,ultimately leading to increased production of cytokines such as interleukin(IL)-23 and IL-17A.It is established that the cGAS-STING pathway is essential for psoriatic inflammation,however,the specific role of cGAS-STING signaling in DCs within this context remains unclear.In this study,we demonstrated the upregulation of cGAS-STING signaling in psoriatic lesions by analyzing samples from both clinical patients and imiquimod(IMQ)-treated mice.Using a conditional Sting-knockout transgenic mouse model,we elucidated the impact of cGAS-STING signaling in DCs on the activation of IL-17-and IFN-γ-producing T cells in psoriatic inflammation.Ablation of the Sting hampers DC activation leads to decreased numbers of IL-17-producing T cells and Th1 cells,and thus subsequently attenuates psoriatic inflammation in the IMQ-induced mouse model.Furthermore,we explored the therapeutic potential of the STING inhibitor C-176,which reduces psoriatic inflammation and enhances the anti-IL-17A therapeutic response.Our results underscore the critical role of cGAS-STING signaling in DCs in driving psoriatic inflammation and highlight a promising psoriasis treatment.展开更多
In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor prot...In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor proteolytical stability and low intracellular delivery efficiency of peptide inhibitors limit their clinical application. Here, we designed and synthesized the bicyclic stapled peptides based on p53 by combining all-hydrocarbon stapling and lactam stapling strategies. We demonstrated that bicyclic stapled peptide p53-16 significantly improved α-helicity and proteolytic stability. Especially, p53-16showed nanomolar binding affinity for MDM2 and MDMX. In addition, p53-16 could penetrate the cell membrane, and selectively inhibited the activity of tumor cells via activating p53 pathway in vitro. Our data suggest that p53-16 is a potential dual inhibitor of MDM2 and MDMX interactions. The bicyclic stapling strategy is a promising drug design strategy for protein–protein interactions inhibitors.展开更多
China's financial market has undergone significant changes since financial deleveraging commenced and regulatory supervision was tightened in 2017.Intensifying China-US trade tensions have further increased the un...China's financial market has undergone significant changes since financial deleveraging commenced and regulatory supervision was tightened in 2017.Intensifying China-US trade tensions have further increased the uncertainties of external environments.In this article,we use a Bayesian approach instead of the standard maximum likelihood estimation in the Laubach-Williams model to estimate the natural interest rate by considering financial factors and open conditions,and analyze the relationships among the natural interest rate,economic activities and monetary policies.We find that technological and demographic factors are the main drivers of natural interest rates,while financial factors and open conditions also play important roles.In particular,shocks in the financial markets and the external economic environment in recent years are important reasons for the decline of China's natural interest rate.Therefore,it is necessary to strengthen research on the estimation of the natural interest rate to ensure China's transformation into more price-based monetary policy and high-quality development.展开更多
Dendritic cells(DCs)play a critical role in controlling T helper 2(Th2)cell-dependent diseases,but the signaling mechanism that triggers this function is not fully understood.We showed that p38αactivity in DCs was de...Dendritic cells(DCs)play a critical role in controlling T helper 2(Th2)cell-dependent diseases,but the signaling mechanism that triggers this function is not fully understood.We showed that p38αactivity in DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals and Th2-instructive cytokines.p38α-specific deletion in cDC1s but not in cDC2s or macrophages promoted Th2 responses under HDM stimulation.Further study showed that p38αin cDC1s regulated Th2-cell differentiation by modulating the MK2−c-FOS−IL-12 axis.Importantly,crosstalk between p38α-dependent DCs and Th2 cells occurred during the sensitization phase,not the effector phase,and was conserved between mice and humans.Our results identify p38αsignaling as a central pathway in DCs that integrates allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment to regulate Th2-cell differentiation and function,and this finding may offer a novel strategy for the treatment of allergic diseases and parasitic infection.展开更多
基金the Fundamental Research Funds for the Central Universities(17241022301)the National Natural Science Foundation of China(52102188)+3 种基金the Key Research and Development Program of Zhejiang Province(2021C01030)Natural Science Foundation of Zhejiang Province(LQ21F040005)Science and Technology projects of the Institute of Wenzhou,Zhejiang University(XMGL-KJZX-202302)Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2022SZ-TD004)。
文摘Broadband electroluminescence based on environment-friendly emitters is promising for healthy lighting yet remains an unprecedented challenge to progress.The copper halide-based emitters are competitive candidates for broadband emission,but their high-performance electroluminescence shows inadequate broad emission bandwidth of less than 90 nm.Here,we demonstrate efficient ultra-broadband electroluminescence from a copper halide(CuI)nanocluster single emitter prepared by a one-step solution synthesis-deposition process,through dedicated design of ligands and subtle selection of solvents.The CuI nanocluster exhibits high rigidity in the excitation state as well as dual-emissive modes of phosphorescence and temperature-activated delayed fluorescence,enabling the uniform cluster-composed film to show excellent stability and high photoluminescent efficiency.In consequence,ultra-broadband light-emitting diodes(LEDs)present nearly identical performance in an inert or air atmosphere without encapsulation and outstanding high-temperature operation performance,reaching an emission full width at half maximum(FWHM)of~120 nm,a peak external quantum efficiency of 13%,a record maximum luminance of~50,000 cd m^(−2),and an operating half-lifetime of 137 h at 100 cd m^(−2).The results highlight the potential of copper halide nanoclusters for next-generation healthy lighting.
基金This research received no specific grant from any funding agency in the public,commercial or not-for-profit sectors
文摘Depression is not only a major global public health concern,but also a common comorbidity among patients who experience chronic diseases,such as cancer,stroke,heart disease,diabetes,and chronic obstructive pulmonary disease.Yet the recognition and treatment varies widely around the world.This study(1)provides an integrated review of the literature on the prevalence of depression among patients with chronic diseases in China and the United States and its relationship to poorer health outcomes and(2)compares the differences in the percentages of patients receiving treatments for depression between the United States and China.Given the current situation,we recommended that primary care and specialty providers should be knowledgeable and alert regarding the signs of depression.Efforts should be directed to further implement integrated care based interventions to manage depression and improve quality of life among patients suffering chronic diseases in both China and the United States.
基金supported by China National Natural Science Foundation(grant nos.82374445,82303061,82305233 and 82373179)Shanghai Shuguang Scholar(grant no.22SG42)+3 种基金Scientific research project of Shanghai Municipal Health Commission(grant no.20224Z0019)Key Discipline Construction Project of Shanghai Three Year Action Plan for Strengthening the Construction of Public Health System(grant no.GWVI-11.1-24)High-level Chinese Medicine Key Discipline Construction Project(Integrative Chinese and Western Medicine Clinic)of National Administration of TCM(grant no.zyyzdxk-2023065)Evidence-based dermatology base sponsored by state Administration of Traditional Chinese medicine.
文摘Psoriasis is a common chronic inflammatory skin disease driven by the aberrant activation of dendritic cells(DCs)and T cells,ultimately leading to increased production of cytokines such as interleukin(IL)-23 and IL-17A.It is established that the cGAS-STING pathway is essential for psoriatic inflammation,however,the specific role of cGAS-STING signaling in DCs within this context remains unclear.In this study,we demonstrated the upregulation of cGAS-STING signaling in psoriatic lesions by analyzing samples from both clinical patients and imiquimod(IMQ)-treated mice.Using a conditional Sting-knockout transgenic mouse model,we elucidated the impact of cGAS-STING signaling in DCs on the activation of IL-17-and IFN-γ-producing T cells in psoriatic inflammation.Ablation of the Sting hampers DC activation leads to decreased numbers of IL-17-producing T cells and Th1 cells,and thus subsequently attenuates psoriatic inflammation in the IMQ-induced mouse model.Furthermore,we explored the therapeutic potential of the STING inhibitor C-176,which reduces psoriatic inflammation and enhances the anti-IL-17A therapeutic response.Our results underscore the critical role of cGAS-STING signaling in DCs in driving psoriatic inflammation and highlight a promising psoriasis treatment.
基金supported by National Natural Science Foundation of China-Shandong Joint Fund (No. U1606403)Innovation Project of Qingdao National Laboratory for Marine Science and Technology (No. 2015ASKJ02)。
文摘In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor proteolytical stability and low intracellular delivery efficiency of peptide inhibitors limit their clinical application. Here, we designed and synthesized the bicyclic stapled peptides based on p53 by combining all-hydrocarbon stapling and lactam stapling strategies. We demonstrated that bicyclic stapled peptide p53-16 significantly improved α-helicity and proteolytic stability. Especially, p53-16showed nanomolar binding affinity for MDM2 and MDMX. In addition, p53-16 could penetrate the cell membrane, and selectively inhibited the activity of tumor cells via activating p53 pathway in vitro. Our data suggest that p53-16 is a potential dual inhibitor of MDM2 and MDMX interactions. The bicyclic stapling strategy is a promising drug design strategy for protein–protein interactions inhibitors.
文摘China's financial market has undergone significant changes since financial deleveraging commenced and regulatory supervision was tightened in 2017.Intensifying China-US trade tensions have further increased the uncertainties of external environments.In this article,we use a Bayesian approach instead of the standard maximum likelihood estimation in the Laubach-Williams model to estimate the natural interest rate by considering financial factors and open conditions,and analyze the relationships among the natural interest rate,economic activities and monetary policies.We find that technological and demographic factors are the main drivers of natural interest rates,while financial factors and open conditions also play important roles.In particular,shocks in the financial markets and the external economic environment in recent years are important reasons for the decline of China's natural interest rate.Therefore,it is necessary to strengthen research on the estimation of the natural interest rate to ensure China's transformation into more price-based monetary policy and high-quality development.
基金This work was supported by the National Natural Science Foundation of China(91642104,31670897,and 81471528 to GH81600788 to MH,81671399 and 81971329 to XL,81725004 to HBL,82001702 to TZ)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(2021B1515130004 to GH2021B1515140021 to YYW)the National Key R&D Program of China(2018YFC0115900 to GH)。
文摘Dendritic cells(DCs)play a critical role in controlling T helper 2(Th2)cell-dependent diseases,but the signaling mechanism that triggers this function is not fully understood.We showed that p38αactivity in DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals and Th2-instructive cytokines.p38α-specific deletion in cDC1s but not in cDC2s or macrophages promoted Th2 responses under HDM stimulation.Further study showed that p38αin cDC1s regulated Th2-cell differentiation by modulating the MK2−c-FOS−IL-12 axis.Importantly,crosstalk between p38α-dependent DCs and Th2 cells occurred during the sensitization phase,not the effector phase,and was conserved between mice and humans.Our results identify p38αsignaling as a central pathway in DCs that integrates allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment to regulate Th2-cell differentiation and function,and this finding may offer a novel strategy for the treatment of allergic diseases and parasitic infection.
