Epilepsy is a common yet complex neurological disorder.Historically,antiseizure medications(ASMs)have faced challenges in crossing the blood-brain barrier(BBB)and targeting the epileptogenic zone,creating a bottleneck...Epilepsy is a common yet complex neurological disorder.Historically,antiseizure medications(ASMs)have faced challenges in crossing the blood-brain barrier(BBB)and targeting the epileptogenic zone,creating a bottleneck in seizure management.Certain nanomaterials can facilitate drug penetration through the BBB and enable stimulus-responsive drug release,thereby enhancing targeted and efficient drug utilization while reducing adverse reactions in other brain tissues and peripherally.This article reviews the current researches on stimulus-responsive nanosystems applicable in antiepileptic therapy,as well as nanotechnology applications that improve the brain delivery of ASMs.展开更多
基金National Natural Science Foundation of China[81971598,82071456]Shanghai Academic Research Leader Program[21XD1420900]Shanghai Municipal Commission of Health Program[20224Z0002].
文摘Epilepsy is a common yet complex neurological disorder.Historically,antiseizure medications(ASMs)have faced challenges in crossing the blood-brain barrier(BBB)and targeting the epileptogenic zone,creating a bottleneck in seizure management.Certain nanomaterials can facilitate drug penetration through the BBB and enable stimulus-responsive drug release,thereby enhancing targeted and efficient drug utilization while reducing adverse reactions in other brain tissues and peripherally.This article reviews the current researches on stimulus-responsive nanosystems applicable in antiepileptic therapy,as well as nanotechnology applications that improve the brain delivery of ASMs.
