An electrochemical biosensing platform was developed based on glucose oxidase(GOx)/Fe3O4-reduced graphene oxide(Fe3O4-RGO) nanosheets loaded on the magnetic glassy carbon electrode(MGCE).With the advantages of the mag...An electrochemical biosensing platform was developed based on glucose oxidase(GOx)/Fe3O4-reduced graphene oxide(Fe3O4-RGO) nanosheets loaded on the magnetic glassy carbon electrode(MGCE).With the advantages of the magnetism, conductivity and biocompatibility of the Fe3O4-RGO nanosheets, the nanocomposites could be facilely adhered to the electrode surface by magnetically controllable assembling and beneficial to achieve the direct redox reactions and electrocatalytic behaviors of GOx immobilized into the nanocomposites. The biosensor exhibited good electrocatalytic activity, high sensitivity and stability. The current response is linear over glucose concentration ranging from 0.05 to 1.5 m M with a low detection limit of0.15 μM. Meanwhile, validation of the applicability of the biosensor was carried out by determining glucose in serum samples. The proposed protocol is simple, inexpensive and convenient, which shows great potential in biosensing application.展开更多
Facing the trend of increasing population,how to increase maize grain yield is a very important issue to ensure food security.In this study,28 nationally approved maize hybrids were evaluated across 24 different clima...Facing the trend of increasing population,how to increase maize grain yield is a very important issue to ensure food security.In this study,28 nationally approved maize hybrids were evaluated across 24 different climatic conditions for two consecutive years(2018-2019).The purpose of this study was to select high-yield with stable genotypes and identify important agronomic traits for maize breeding program improvement.The results of this study showed that the genotypeenvironment interaction effects of the 12 evaluated agronomic traits was highly significant(P<0.001).We introduced a novel multi-trait genotype-ideotype distance index(MGIDI)to select genotypes based on multiple agronomic traits.The selection process exhibited by this method is unique and easy to understand,so the MGIDI index will have more and more important applications in future multi-environment trials(METs)research.The genotypes selected by the MGIDI index were G22,G10,G12 and G1 as the high yielding and stable genotypes.The parents of these selected genotypes have the ability to play a greater role as the basic germplasm in the breeding process.A new form of genotype(G)main effects and genotype(G)-by-environment(E)interaction(GGE)technician,genotypeyieldtrait(GYT)biplot,based on multiple traits for genotypes selection was also applied in this study.The GYT biplot ranked genotypes by combining grain yield with other evaluated agronomic traits,and displayed the distribution of their traits,namely strengths and weaknesses.展开更多
The rapid development of micro-electronics raises the demand of their power sources to be simplified,miniaturized and highly integratable with other electronics on a chip.In-plane Micro-sized energy storage devices(ME...The rapid development of micro-electronics raises the demand of their power sources to be simplified,miniaturized and highly integratable with other electronics on a chip.In-plane Micro-sized energy storage devices(MESDs),which are composed of interdigitated electrodes on a single chip,have aroused particular attentions since they could be easily integrated with other miniaturized electronics,reducing the complexity of overall chip design via removing complex interconnections with bulky power sources.This review highlights the achievements in the device fabrication of in-plane MESDs,as well as their integration and intelligent designs.We also discussed the current challenges and future perspectives for the development of in-plane MESDs.展开更多
Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome ...Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome radioresistance due to the feedback mechanisms initiated by tumor cells under radiotherapy.Therefore,we herein developed an engineering biomimetic nanosystem(M@HHPt)masked with tumor cell membranes and loaded with a hybridized protein-based nanoparticle carrying oxygens(O_(2))and cisplatin prodrugs(Pt(Ⅳ))to target multiple tumor radioresistance hallmarks for enhanced radiotherapy.After administration,M@HHPt actively targeted and smoothly accumulated in tumor cells by virtue of its innate homing abilities to realize efficient co-delivery of O_(2)and Pt(Ⅳ).O_(2)introduction induced hypoxia alleviation cooperated with Pt(Ⅳ)reduction caused glutathione consumption greatly amplified radiotherapy-ignited cellular oxidative stress.Moreover,the released cisplatin effectively hindered DNA damage repair by crosslinking with radiotherapy-produced DNA fragments.Consequently,M@HHPt-sensitized radiotherapy significantly suppressed the proliferation of lung cancer H1975 cells with an extremely high sensitizer enhancement ratio of 1.91 and the progression of H1975 tumor models with an excellent tumor inhibition rate of 94.7%.Overall,this work provided a feasible strategy for tumor radiosensitization by overcoming multiple radioresistance mechanisms.展开更多
.In this paper,we prove the global existence and uniqueness of so-lutions for the inhomogeneous Navier-Stokes equations with the initial data(ρ_(0),u_(0))∈L^(∞)×H^(s) _(0),s>1/2 and ||u_(0)||H^(s)_(0)≤ε0 ....In this paper,we prove the global existence and uniqueness of so-lutions for the inhomogeneous Navier-Stokes equations with the initial data(ρ_(0),u_(0))∈L^(∞)×H^(s) _(0),s>1/2 and ||u_(0)||H^(s)_(0)≤ε0 in bounded domain Ω■R^(3),in which the density is assumed to be nonnegative.The regularity of initial data is weaker than the previous(ρ_(0),u_(0))∈(W^(1)γ∩L^(∞)×H^(1)_(0) in [13] and(ρ_(0),u_(0))∈L^(∞)×H^(1)_(0) in[7],which constitutes a positive answer to the question raised by Danchin and Mucha in[7].The methods used in this paper are mainly the classical time weighted energy estimate and Lagrangian approach,and the continuity argu-ment and shift of integrability method are applied to complete our proof.展开更多
Synchronously reducing/self-assembling strategy on Zn substrate was designed to fabricate large-area cation-doped hydrated V_(2)O_(5)/multi-walled carbon nanotube(D-HVO/MWCNT)composite films.Interestingly,the Zn^(2+)i...Synchronously reducing/self-assembling strategy on Zn substrate was designed to fabricate large-area cation-doped hydrated V_(2)O_(5)/multi-walled carbon nanotube(D-HVO/MWCNT)composite films.Interestingly,the Zn^(2+)ions are simultaneously doped in hydrated V_(2)O_(5) during the assembly process,which will be beneficial to the high electrochemical performance of hydrated V_(2)O_(5).By further combining 3D conductive MWCNT network,the freestanding D-HVO/MWCNT composite films display high capacity,excellent rate capability,and remarkable long-term cycling performance(up to 10,000 cycles with a high capacity retention of 98.5%).Moreover,owing to the high conductivity and flexibility of the D-HVO/MWCNT composite films,the softpackaged aqueous zinc-ion batteries(ZIBs)were constructed based on such composite films.The devices exhibit stable electrochemical performance even under different bending states.Therefore,such a strategy provides a promising route to achieve large-area carbon and metal oxides-based composite films with high performance and good flexibility.展开更多
基金supported by the National Natural Science Foundation of China (21373138)Shanghai Sci. & Tech. Committee (12JC1407200)Program for Changjiang Scholars and Innovative Research Team in University (IRT1269)
文摘An electrochemical biosensing platform was developed based on glucose oxidase(GOx)/Fe3O4-reduced graphene oxide(Fe3O4-RGO) nanosheets loaded on the magnetic glassy carbon electrode(MGCE).With the advantages of the magnetism, conductivity and biocompatibility of the Fe3O4-RGO nanosheets, the nanocomposites could be facilely adhered to the electrode surface by magnetically controllable assembling and beneficial to achieve the direct redox reactions and electrocatalytic behaviors of GOx immobilized into the nanocomposites. The biosensor exhibited good electrocatalytic activity, high sensitivity and stability. The current response is linear over glucose concentration ranging from 0.05 to 1.5 m M with a low detection limit of0.15 μM. Meanwhile, validation of the applicability of the biosensor was carried out by determining glucose in serum samples. The proposed protocol is simple, inexpensive and convenient, which shows great potential in biosensing application.
基金This research was funded by the Key Research&Development Projects of Hebei Province(20326305D)Key Research and Development Program of Hengshui City(2020014005C)+1 种基金Demonstration and Transformation of Major Achievements of Hebei Academy of Agriculture and Forestry Sciences in 2020,Innovative Project funded by Hebei Academy of Agriculture and Forestry Sciences,Special Fund for National System(Maize)of Modern Industrial Technology(CARS-02)the Science and Technology Support Program of Hebei Province(16226323D-X).
文摘Facing the trend of increasing population,how to increase maize grain yield is a very important issue to ensure food security.In this study,28 nationally approved maize hybrids were evaluated across 24 different climatic conditions for two consecutive years(2018-2019).The purpose of this study was to select high-yield with stable genotypes and identify important agronomic traits for maize breeding program improvement.The results of this study showed that the genotypeenvironment interaction effects of the 12 evaluated agronomic traits was highly significant(P<0.001).We introduced a novel multi-trait genotype-ideotype distance index(MGIDI)to select genotypes based on multiple agronomic traits.The selection process exhibited by this method is unique and easy to understand,so the MGIDI index will have more and more important applications in future multi-environment trials(METs)research.The genotypes selected by the MGIDI index were G22,G10,G12 and G1 as the high yielding and stable genotypes.The parents of these selected genotypes have the ability to play a greater role as the basic germplasm in the breeding process.A new form of genotype(G)main effects and genotype(G)-by-environment(E)interaction(GGE)technician,genotypeyieldtrait(GYT)biplot,based on multiple traits for genotypes selection was also applied in this study.The GYT biplot ranked genotypes by combining grain yield with other evaluated agronomic traits,and displayed the distribution of their traits,namely strengths and weaknesses.
基金supported by the Ministry of Science and Technology of China(Grant No.2019YFA0705600)the National Natural Science Foundation of China(Grant Nos.51822205,21875121)+2 种基金the Natural Science Foundation of Tianjin(Grant Nos.18JCJQJC46300,19JCZDJC31900)the Ministry of Education of China(Grant No.B12015)the “Frontiers Science Center for New Organic Matter”,Nankai University(Grant No.63181206)。
文摘The rapid development of micro-electronics raises the demand of their power sources to be simplified,miniaturized and highly integratable with other electronics on a chip.In-plane Micro-sized energy storage devices(MESDs),which are composed of interdigitated electrodes on a single chip,have aroused particular attentions since they could be easily integrated with other miniaturized electronics,reducing the complexity of overall chip design via removing complex interconnections with bulky power sources.This review highlights the achievements in the device fabrication of in-plane MESDs,as well as their integration and intelligent designs.We also discussed the current challenges and future perspectives for the development of in-plane MESDs.
基金supported by the National Science Fund for Distinguished Young Scholars of China(82225026)the National Natural Science Foundation of China(82172082)CAMS Innovation Fund for Medical Sciences(2021-I2M-1-042,2023-I2M-QJ-016)。
文摘Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome radioresistance due to the feedback mechanisms initiated by tumor cells under radiotherapy.Therefore,we herein developed an engineering biomimetic nanosystem(M@HHPt)masked with tumor cell membranes and loaded with a hybridized protein-based nanoparticle carrying oxygens(O_(2))and cisplatin prodrugs(Pt(Ⅳ))to target multiple tumor radioresistance hallmarks for enhanced radiotherapy.After administration,M@HHPt actively targeted and smoothly accumulated in tumor cells by virtue of its innate homing abilities to realize efficient co-delivery of O_(2)and Pt(Ⅳ).O_(2)introduction induced hypoxia alleviation cooperated with Pt(Ⅳ)reduction caused glutathione consumption greatly amplified radiotherapy-ignited cellular oxidative stress.Moreover,the released cisplatin effectively hindered DNA damage repair by crosslinking with radiotherapy-produced DNA fragments.Consequently,M@HHPt-sensitized radiotherapy significantly suppressed the proliferation of lung cancer H1975 cells with an extremely high sensitizer enhancement ratio of 1.91 and the progression of H1975 tumor models with an excellent tumor inhibition rate of 94.7%.Overall,this work provided a feasible strategy for tumor radiosensitization by overcoming multiple radioresistance mechanisms.
基金The second author(H.Cao)is supported by the National Natural Science Foundation of China(No.12001269)the Fundamental Research Funds for the Central Universities of China.
文摘.In this paper,we prove the global existence and uniqueness of so-lutions for the inhomogeneous Navier-Stokes equations with the initial data(ρ_(0),u_(0))∈L^(∞)×H^(s) _(0),s>1/2 and ||u_(0)||H^(s)_(0)≤ε0 in bounded domain Ω■R^(3),in which the density is assumed to be nonnegative.The regularity of initial data is weaker than the previous(ρ_(0),u_(0))∈(W^(1)γ∩L^(∞)×H^(1)_(0) in [13] and(ρ_(0),u_(0))∈L^(∞)×H^(1)_(0) in[7],which constitutes a positive answer to the question raised by Danchin and Mucha in[7].The methods used in this paper are mainly the classical time weighted energy estimate and Lagrangian approach,and the continuity argu-ment and shift of integrability method are applied to complete our proof.
基金supported by the Natural Science Foundation of Tianjin(18JCJQJC46300,19JCZDJC31900)the National Natural Science Foundation of China(51972231)。
文摘Synchronously reducing/self-assembling strategy on Zn substrate was designed to fabricate large-area cation-doped hydrated V_(2)O_(5)/multi-walled carbon nanotube(D-HVO/MWCNT)composite films.Interestingly,the Zn^(2+)ions are simultaneously doped in hydrated V_(2)O_(5) during the assembly process,which will be beneficial to the high electrochemical performance of hydrated V_(2)O_(5).By further combining 3D conductive MWCNT network,the freestanding D-HVO/MWCNT composite films display high capacity,excellent rate capability,and remarkable long-term cycling performance(up to 10,000 cycles with a high capacity retention of 98.5%).Moreover,owing to the high conductivity and flexibility of the D-HVO/MWCNT composite films,the softpackaged aqueous zinc-ion batteries(ZIBs)were constructed based on such composite films.The devices exhibit stable electrochemical performance even under different bending states.Therefore,such a strategy provides a promising route to achieve large-area carbon and metal oxides-based composite films with high performance and good flexibility.
