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肿瘤相关巨噬细胞:调节肿瘤微环境的新靶点
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作者 周银雪 任敦强 +4 位作者 毕焕焕 易冰倩 张彩 王红梅 孙家兴 《中国肺癌杂志》 CAS CSCD 北大核心 2024年第3期231-240,共10页
肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)在肺癌免疫微环境中扮演着重要的角色。它们通过自身的表型和吞噬功能的变化,在肺癌的发生和进展中发挥作用,通过促进肺癌免疫抑制型微环境的形成和肿瘤异常血管的生长加速肺癌的侵... 肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)在肺癌免疫微环境中扮演着重要的角色。它们通过自身的表型和吞噬功能的变化,在肺癌的发生和进展中发挥作用,通过促进肺癌免疫抑制型微环境的形成和肿瘤异常血管的生长加速肺癌的侵袭和扩散。巨噬细胞在应对不同刺激时,可以极化为具有不同功能和特征的亚型,分为抗肿瘤M1型和促肿瘤的M2型。在肿瘤组织中,TAM通常极化为交替活化型的M2表型,表现出对肿瘤免疫的抑制作用。本文综述了抗血管生成药物在调节TAM表型方面的作用,它们可以通过将M2型TAM重编程为M1型来发挥抗肿瘤作用。同时,TAM的功能改变在抗血管生成治疗和免疫治疗策略中也起到重要作用。研究证实,TAM通过极化及功能改变可能成为调节肿瘤微环境的新靶点,开辟肺癌治疗的新途径。 展开更多
关键词 肿瘤相关巨噬细胞 极化 抗血管生成治疗 肺肿瘤
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HUID:DBN-Based Fingerprint Localization and Tracking System with Hybrid UWB and IMU 被引量:1
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作者 Junchang Sun Rongyan Gu +4 位作者 Shiyin Li Shuai Ma hongmei wang Zongyan Li Weizhou Feng 《China Communications》 SCIE CSCD 2023年第2期139-154,共16页
High-precision localization technology is attracting widespread attention in harsh indoor environments.In this paper,we present a fingerprint localization and tracking system to estimate the locations of the tag based... High-precision localization technology is attracting widespread attention in harsh indoor environments.In this paper,we present a fingerprint localization and tracking system to estimate the locations of the tag based on a deep belief network(DBN).In this system,we propose using coefficients as fingerprints to combine the ultra-wideband(UWB)and inertial measurement unit(IMU)estimation linearly,termed as a HUID system.In particular,the fingerprints are trained by a DBN and estimated by a radial basis function(RBF).However,UWB-based estimation via a trilateral method is severely affected by the non-line-of-sight(NLoS)problem,which limits the localization precision.To tackle this problem,we adopt the random forest classifier to identify line-of-sight(LoS)and NLoS conditions.Then,we adopt the random forest regressor to mitigate ranging errors based on the identification results for improving UWB localization precision.The experimental results show that the mean square error(MSE)of the localization error for the proposed HUID system reduces by 12.96%,50.16%,and 64.92%compared with that of the existing extended Kalman filter(EKF),single UWB,and single IMU estimation methods,respectively. 展开更多
关键词 Ultra-wideband(UWB) inertial measurement unit(IMU) fingerprints positioning NLoS identification estimated errors mitigation deep belief network(DBN) radial basis function(RBF)
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老年期痴呆的中医手法治疗效果初探
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作者 李宗民 刘勇泼 +10 位作者 刘洪旺 杜宁 张守字 丁全茂 王红梅 扈盛 王凯鹏 王锡宁 赵祥麟 陈凌霜 陈宏图 《阿尔茨海默病及相关病杂志》 2023年第1期64-68,共5页
目的:对老年期痴呆患者提供中医传统手法治疗并对此疗法在减轻患者精神行为问题和提高日常生活机能与认知功能方面的疗效进行评价,为该病的精神行为症状的治疗和缓解提供新思路。方法:总共71名受试者来自中国十个省市的14个中医院和养老... 目的:对老年期痴呆患者提供中医传统手法治疗并对此疗法在减轻患者精神行为问题和提高日常生活机能与认知功能方面的疗效进行评价,为该病的精神行为症状的治疗和缓解提供新思路。方法:总共71名受试者来自中国十个省市的14个中医院和养老院,为50岁以上中老年人(其中50~60岁2人,60~70岁16人,70~80岁23人,80~90岁25人,90以上5人),患有不同程度的认知功能障碍。所有病人得到为期为6个月,每周3次,每次40~60分钟的统一规程的中医手法推拿按摩治疗。使用单组治疗前后对照研究,全部参加者在入组时先做基线测查,治疗中期(3个月)和治疗结束(6个月)时再做一次同样的测查。结果:认知功能(MMSE)三月追踪和基线无显著性统计变化,但六月追踪与基线相比有显著性提高(t=2.71;p <0.01)。精神行为问题(NPI)三月追踪(t=-3.15;p <0.01)和六月追踪(t=-4.43;p <0.001)都相对基线有显著性降低。日常生活机能(ADL)三月追踪(t=3.75;p <0.001)和六月追踪(t=6.17;p <0.001)相对基线有显著性提高。这些结果表明,这些患者在接受传统中医手法治疗三个月后,在降低精神与行为问题方面有明显好转,在日常生活机能方面也有明显提高。在连续接受治疗六个月,患者的认知功能还表现出明显的好转。结论:初步证据表明传统中医手法对老年期痴呆患者有明显治疗效果。中医手法操作简单易学,在老年期痴呆患者照护实践中有很强的可行性和广泛接受性,值得进一步研究和推广。 展开更多
关键词 中医手法治疗 老年期痴呆 疗效评价
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Advantages and Development Prospects of Building Information Modelling(BIM)Technology Application in Highway Engineering
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作者 hongmei wang Ying Lin Xiaolin Gan 《Journal of Architectural Research and Development》 2023年第6期1-5,共5页
Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the applica... Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the application of BIM technology in practice,and approaches from the integration of BIM design-construction.This paper also puts forward the integration of cross-stage information based on the BIM+Geographic Information System(GIS)construction information management system to realize the BIM whole life cycle management,and provides directional support for the continuous and efficient application of BIM technology in engineering practice. 展开更多
关键词 BIM technology Highway engineering Application advantages Development prospects
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Mercury Speciation of Flue Gas Desulphurization By-Products in Coal-Fired Power Plants in China
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作者 Gang Tian Hongyan Long +7 位作者 Yu Liu Chen Zhang Fan Zhang Hongchang wang Jinwei Zhu Yanping Zhang hongmei wang Fan wang 《Journal of Power and Energy Engineering》 2020年第11期1-11,共11页
The aim of this study was to develop and examine the morphology and distribution of mercury (Hg) in flue gas desulfurization (FGD) by-product.</span></span><span><span><span style="font... The aim of this study was to develop and examine the morphology and distribution of mercury (Hg) in flue gas desulfurization (FGD) by-product.</span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Mercury in the coal of coal-fired power plants is concentrated in the by-products of desulfurization process, and it is widely used as an additive in cement, building materials and other industries. Due to the different stability of various forms of mercury in the environment, subsequent use of products containing desulfurization by-product additives will continue to be released into the environment, endangering human health. Therefore, it is very necessary to study the form and distribution of mercury in the by-products of desulfurization in coal-fired power plants to provide a theoretical basis for subsequent harmless treatment.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">For content and morphology of mercury analysis, 1 sample of dry FGD ash and 6 samples of wet FGD gypsum were analyzed. The total 7 samples were extracted using a modification of sequential chemical extractions (SCE) method, which was employed for the partitioning Hg into four fractions: water soluble, acid soluble, H<sub>2</sub>O<sub>2</sub> soluble, and residual. The Hg analysis was done with United States Environmental Protection Agency (USEPA) method</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">7471B. Comparing with the wet FGD gypsums of coal-fired boilers, the total Hg content in the dry FGD by-product was as high as</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">1.22 mg/kg, while the total Hg content in the FGD gypsum is 0.23</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">0.74 mg/kg, which was 2 times over the wet FGD gypsum. The concentration of water soluble Hg in the dry FGD by-product was the highest amount (0.72 mg/kg), accounting for 59.02% of the total mercury. While residual Hg content was 0.16 mg/kg, only about 13.11% of the total mercury. Mercury content in FGD gypsum was expressed in the form of <i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(residual Hg) ></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(H</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;"> soluble Hg)</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(water soluble Hg)</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(acid soluble Hg). The morphology and distribution of mercury in FGD by-products is supposed to be analyzed before utilization, and the impact of mercury on the environment should be considered. 展开更多
关键词 MERCURY Mercury Speciation Flue Gas DESULPHURIZATION BY-PRODUCT Sequential Chemical Extractions Morphology and Distribution GYPSUM
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The Prevention and Control Measures of COVID-19 in the People’s Hospital of Pingchang County
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作者 Xiaofang Li Xiaoxiao Yang +4 位作者 Yu Zhang Lin Zhang hongmei wang Ziyan Zhang Fangqiong Dong 《Natural Science》 CAS 2022年第10期421-423,共3页
COVID-19 (COVID-19) or COVID-19 is pneumonia caused by the novel coronavirus infection in patients in 2019. COVID-19 pneumonia epidemic is widespread, wide, and deep. To effectively combat the further spread of COVID-... COVID-19 (COVID-19) or COVID-19 is pneumonia caused by the novel coronavirus infection in patients in 2019. COVID-19 pneumonia epidemic is widespread, wide, and deep. To effectively combat the further spread of COVID-19: the overall protocol of the hospital: “three lines of defense” of community prevention and control, fever clinic and face-to-face treatment;grasp the good three-time limits: “2 hours, 12 hours and 24 hours”;do a good job of three key points: key areas and places and groups;carry out four early prevention and control measures: early detection, early reporting, early isolation and early treatment;management of confirmed, suspected, fever, close contact “four types of personnel”;implement l responsibility system;doing all receivable, should be treated, should be checked, should be separated by “four should be”;do investigation, control, supervision, education, and care “five in place”. Through the above methods, the People’s Hospital of Pingchang County has effectively controlled COVID-19. 展开更多
关键词 Medical Institutions COVID-19 Prevention Measures Health Services MANAGEMENT
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The Trend of the Multidrug Resistance of Helicobacter pylori Strains Isolated in Chengdu
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作者 Xiaofang Li Xiaoxiao Yang +4 位作者 Lin Zhang Yu Zhang hongmei wang Ziyan Zhang Fangqiong Dong 《Natural Science》 CAS 2022年第12期517-523,共7页
Background: The treatment of Hp infection has been the most popular topic of the most attention and research by gastrointestinal disease workers, and the biggest problem in the treatment of Hp infection is Hp drug res... Background: The treatment of Hp infection has been the most popular topic of the most attention and research by gastrointestinal disease workers, and the biggest problem in the treatment of Hp infection is Hp drug resistance to antibiotics, and Hp drug resistance is the main cause of Hp eradication failure. It is severe for the multidrug resistance of Hp. Objective: To investigate the changing trend of Helicobacter pylori (Hp) resistance to metronidazole, clarithromycin and amoxicillin in children and adults in Chengdu. Methods: The Hp strain determined the minimum antibacterial concentration (MIC) from 585 patients with upper gastrointestinal symptoms, metronidazole, clarithromycin and amoxicillin was measured by the E-test. Clinically isolated Hp strains were obtained by microaerobic condition culture as the diagnostic standard. Results: The Hp resistance to metronidazole and clarithromycin in children in Chengdu were: 17.65% (27/153) and 18.06 (78/432) in adults. The Hp resistance to metronidazole and amoxicillin in children in Chengdu were: 11.76% (18/153) and 13.19 (57/432) in adults. The Hp resistance to metronidazole, clarithromycin and amoxicillin in children in Chengdu were: 3.92% (6/153) and 10.41 (45/432) in adults. There were 76.92% of the strains which were resistant to metronidazole, 24.11% to clarithromycin, and 18.46% to amoxicillin. The drug resistance rate of Hp has increased year by year from 2017 to 2021 year, especially the drug resistance rate of Hp to clarithromycin and metronidazole has generally increased. Conclusions: The drug resistance rate of Hp has increased year by year from 2017 to 2021 year. 展开更多
关键词 Multidrug Resistance Helicobacter pylori Strains ADULTS Children
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白蛋白结合型紫杉醇在局部晚期/晚期头颈部肿瘤治疗中的研究进展及展望 被引量:17
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作者 何芳 王红梅 +2 位作者 贾保昌 王雪军 张伟军 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第20期1061-1066,共6页
化疗在局部晚期/晚期头颈部肿瘤的治疗中发挥重要作用,对提高肿瘤局部控制率、延缓肿瘤进展、减少远处转移及延长患者生存时间有重要的意义。TP(紫杉醇类加铂类)和TPF(紫杉醇类、顺铂及5-氟尿嘧啶)方案是头颈部肿瘤的经典有效化疗方案,... 化疗在局部晚期/晚期头颈部肿瘤的治疗中发挥重要作用,对提高肿瘤局部控制率、延缓肿瘤进展、减少远处转移及延长患者生存时间有重要的意义。TP(紫杉醇类加铂类)和TPF(紫杉醇类、顺铂及5-氟尿嘧啶)方案是头颈部肿瘤的经典有效化疗方案,故紫杉醇类(如紫杉醇和多西他赛)是头颈部肿瘤常用的化疗药物。白蛋白结合型紫杉醇作为一种新型紫杉醇类药物,以其独特剂型优势,已在多个临床试验中显示出良好的疗效及安全性。本文总结了以白蛋白结合型紫杉醇为基础分别联合其他不同化疗药物方案治疗局部晚期/晚期头颈部肿瘤的安全性及有效性,对白蛋白结合型紫杉醇在局部晚期/晚期头颈部肿瘤中应用的最新临床研究作一综述,并对未来该药治疗局部晚期/晚期头颈部肿瘤进行展望。 展开更多
关键词 白蛋白结合型紫杉醇 局部晚期/晚期头颈部肿瘤 头颈部鳞癌 鼻咽癌 化疗
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Variation of culturable bacteria along depth in the East Rongbuk ice core,Mt.Everest 被引量:7
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作者 Liang Shen Tandong Yao +5 位作者 Baiqing Xu hongmei wang Nianzhi Jiao Shichang Kang Xiaobo Liu Yongqin Liu 《Geoscience Frontiers》 SCIE CAS 2012年第3期327-334,共8页
冰从从东方 Rongbuk 冰河被钻的 22.27 m 冰核心融化水,埃韦雷斯特山是以二个孵化方法的孵化:板直接融化水并且丰富融化水优先的板分别地。许多可耕种的细菌与 1385 的一个总数在二孵化从 0295 CFU mL1 到 01720 CFU mL1 孤立获得。... 冰从从东方 Rongbuk 冰河被钻的 22.27 m 冰核心融化水,埃韦雷斯特山是以二个孵化方法的孵化:板直接融化水并且丰富融化水优先的板分别地。许多可耕种的细菌与 1385 的一个总数在二孵化从 0295 CFU mL1 到 01720 CFU mL1 孤立获得。比较指导耕作,丰富耕作恢复了更多的细菌。生产颜料的细菌说明了因为 84.9% 总数的一般水准孤立。如此的高百分比建议那颜料生产可以是为在冰核心的细菌的一个适应生理的特征在冰河上应付强壮的紫外放射。许多可耕种的细菌并且生产颜料孤立沿着深度同时地变化了:在中间的更高的丰富并且在顶和底部更低。它显示冰核心的中间的部分为微生物引起的幸存是好客的。基于殖民地的生理的性质, 89 孤立为种系发生的分析被选择。获得的 16S rRNA 基因序列掉进四个组:Firmicutes, Alpha-Proteobacteria, Gamma-Proteobacteria,和 Actinobacteria,与是主导的 Firmicutes。微生物引起的作文源于直接并且丰富耕作没被重叠。我们建议探索 culturable 是一个更好的方法在由联合途径的冰核心的微生物引起的差异直接并且丰富耕作。 展开更多
关键词 东绒布冰芯 富集培养 珠穆朗玛峰 细菌 微生物多样性 RRNA基因序列 生产菌株 系统发育分析
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Catalytic reduction of NO_x by biomass-derived activated carbon supported metals 被引量:5
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作者 Yun Shu Fan Zhang +1 位作者 Fan wang hongmei wang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第10期2077-2083,共7页
In this study,to prepare a series of activated carbon-supported metals for the catalytic reduction of NO_x to N_2 in excess O_2,activated carbons derived from lignocellulosic and herbaceous biomasses were selected as ... In this study,to prepare a series of activated carbon-supported metals for the catalytic reduction of NO_x to N_2 in excess O_2,activated carbons derived from lignocellulosic and herbaceous biomasses were selected as the reducing agents,and alkali and transition metals were used as the catalytic active phases.The effects of the type of biomass,carbonization temperature and catalyst composition on NO_x reduction efficiency were analyzed in a fixed-bed flow reactor.The results showed that two temperature regimes are present for the NO_x-carbon reaction:at temperatures below 250°C,the NO_x adsorption process on the carbon surface was predominant,whereas true NO_x reduction by carbon occurred at temperatures above 250°C,producing N_2,CO_2 and CO.The influence of the carbonization temperature on carbon reactivity depended on the effect of the carbonization temperature on the carbon surface area and the reduction of the metal species on carbon.All studied metals catalyzed both NO_xand O_2reduction by carbon,and potassium could strongly enhance the C-NO_x reaction without substantial carbon consumption by O_2.Moreover,the potassium supported by sawdust-derived activated carbon exhibited higher selectivity and capacity towards NO_x reduction than did its previously reported coal-derived counterparts.These properties were ascribed to the high dispersion of the active potassium species on the carbon surface,as observed through the comparison of X-ray photoelectron spectroscopy and powder X-ray diffraction results for the carbons made from biomass and coal-based precursors. 展开更多
关键词 碳化温度 生物资源 催化剂 激活 金属 NOx 代理人
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The return and loss of litter phosphorus in different types of sand dunes in Horqin Sandy Land,northeastern China 被引量:3
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作者 QuanLai ZHOU DeMing JIANG +4 位作者 ZhiMin LIU Alamusa XueHua LI YongMing LUO hongmei wang 《Journal of Arid Land》 SCIE 2012年第4期431-440,共10页
Litter phosphorus(P) return is important to maintain the P cycle and balance in the sandy land of arid areas.In this study,we determined the loss and return of litter P in sand dune areas and elucidated their relation... Litter phosphorus(P) return is important to maintain the P cycle and balance in the sandy land of arid areas.In this study,we determined the loss and return of litter P in sand dune areas and elucidated their relationship.We investigated litter production and litter P amount,and simulated leaf litter moving dynamics to understand the relationships between the loss of litter P and the total litter P,and between the return of litter P and the total litter P in active(AD),semi-stabilized(SSD) and stabilized(SD) dunes in Inner Mongolia,northeastern China.The vegetation litter P was 12.6,94.5,and 201.6 mg P/m2 in AD,SSD,and SD,respectively.A significant movement and loss of leaf litter P with time occurred on the three types of sand dunes.As a result,the loss of P was 7.4,46.9,and 69.8 mg P/m2 and the return of P was 5.5,47.6,and 131.8 mg P/m2 in AD,SSD,and SD,respectively.The relationship between both loss and return of P and total litter P in AD,SSD,and SD was revealed by linear regression.The slope of the regression line indicated the rate of loss or return of litter P.From AD to SD,the loss rate showed a declining slope(0.52,0.32,and 0.17 for AD,SSD,and SD,respectively),and the return rate showed a rising slope(0.48,0.67,and 0.83 for AD,SSD,and SD,respectively).The loss of litter P should be regarded in the local management of vegetation and land in sand dune areas.Improved vegetation restoration measures are necessary to decrease litter P loss to maintain the stability of ecosystems in sand dune areas. 展开更多
关键词 中国东北地区 科尔沁沙地 损失率 凋落物 沙丘地 磷流失 类型 SSD
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Validation and Spatiotemporal Distribution of GEOS-5-Based Planetary Boundary Layer Height and Relative Humidity in China 被引量:2
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作者 Yidan SI Shenshen LI +4 位作者 Liangfu CHEN Chao YU Zifeng wang Yang wang hongmei wang 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2018年第4期479-492,共14页
Few studies have specifically focused on the validation and spatiotemporal distribution of planetary boundary layer height(PBLH) and relative humidity(RH) data in China. In this analysis, continuous PBLH and surface-l... Few studies have specifically focused on the validation and spatiotemporal distribution of planetary boundary layer height(PBLH) and relative humidity(RH) data in China. In this analysis, continuous PBLH and surface-level RH data simulated from GEOS-5 between 2004 and 2012, were validated against ground-based observations. Overall, the simulated RH was consistent with the statistical data from meteorological stations, with a correlation coefficient of 0.78 and a slope of 0.9. However, the simulated PBLH was underestimated compared to LIDAR data by a factor of approximately two,which was primarily because of poor simulation in late summer and early autumn. We further examined the spatiotemporal distribution characteristics of two factors in four regions—North China, South China, Northwest China, and the Tibetan Plateau. The results showed that the annual PBLH trends in all regions were fairly moderate but sensitive to solar radiation and precipitation, which explains why the PBLH values were ranked in order from largest to smallest as follows: Tibetan Plateau, Northwest China, North China, and South China. Strong seasonal variation of the PBLH exhibited high values in summer and low values in winter, which was also consistent with the turbulent vertical exchange. Not surprisingly, the highest RH in South China and the lowest RH in desert areas of Northwest China(less than 30%). Seasonally, South China exhibited little variation, whereas Northwest China exhibited its highest humidity in winter and lowest humidity in spring,the maximum values in the other regions were obtained from July to September. 展开更多
关键词 边界层高度 相对湿度 中国 分发 时间 空间 行星 数据一致
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Synthesis and Optimization of TiO_2/Graphene with Exposed {001} Facets Based on Response Surface Methodology and Evaluation of Enhanced Photocatalytic Activity 被引量:2
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作者 Yifei wang Zhiyang Zhang +2 位作者 Qianqian Shang Xin Tan hongmei wang 《Transactions of Tianjin University》 EI CAS 2018年第5期415-423,共9页
Response surface methodology(RSM) was employed to optimize the control parameters of TiO_2/graphene with exposed {001} facets during synthesis, and its enhanced photocatalytic activities were evaluated in the photodeg... Response surface methodology(RSM) was employed to optimize the control parameters of TiO_2/graphene with exposed {001} facets during synthesis, and its enhanced photocatalytic activities were evaluated in the photodegradation of toluene. Experimental results were in good agreement with the predicted results obtained using RSM with a correlation coefficient(R^2) of 0.9345. When 22.06 mg of graphite oxide(GO) and 2.09 mL of hydrofluoric acid(HF) were added and a hydrothermal time of 28 h was used, a maximum efficiency in the degradation of toluene was achieved. X-ray diffraction(XRD), transmission electron microscopy(TEM), and scanning electron microscopy(SEM) were employed to characterize the obtained hybrid photocatalyst. The electron transferred between Ti and C retarded the combination of electron–hole pairs and hastened the transferring of electrons, which enhanced the photocatalytic activity. 展开更多
关键词 TiO2/graphene Exposed{001}facets SYNTHESIS Response surface METHODOLOGY
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洛铂联合依托泊苷与顺铂联合依托泊苷一线治疗广泛期小细胞肺癌随机对照临床研究(英文) 被引量:2
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作者 Wanfeng Guo Guoqing Liao +6 位作者 Hongjun Gao hongmei wang Chuanhao Tang Haifeng Qin Jianjie Li Xiaoyan Li Xiaoqing Liu 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第8期365-368,共4页
Objective: To compare the efficacy and safety of Lobaplatin plus Etoposide (EL) and Cisplatin plus Etoposide (EP) regimens in chemonaive with extensive-stage small-cell lung cancer (SCLC). Methods: Between July 2010 a... Objective: To compare the efficacy and safety of Lobaplatin plus Etoposide (EL) and Cisplatin plus Etoposide (EP) regimens in chemonaive with extensive-stage small-cell lung cancer (SCLC). Methods: Between July 2010 and July 2011, a total of 62 patients with extensive-stage small-cell lung cancer who received initial treatment in our hospital and 309 hospital of PLA. 31 patients were randomly assigned to the EL Group: Lobaplatin was given intravenously at a dose of 30 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. Another 31 patients were assigned to the EP Group: Cisplatin was given intravenously at a dose of 75 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. We evaluated the efficacy, overall response rate (ORR), disease control rate (DCR), the progression-free survival (PFS) and toxicity between the patients of the two groups. Results: All 62 patients were eligible. In the EL group, 2 (6.5%) patients had complete response, 20 (64.5%) patients had partial response, 5 (16.1%) patients had stable disease and 4 (12.9%) patients had progress disease. In the EP group, 2 (6.5%) patients had complete response, 22 (70.9%) patients had partial response, 4 (12.9%) patients had stable disease and 3 (9.7%) patients had progress disease. The ORR of EL and EP group were 70.9% and 77.4%, respectively, showing no significant difference (P = 0.562). The DCR of both groups were 87% and 90%, respectively, showing no significant difference (P = 0.688). Median PFS of patients with EL and EP regimens were 5.5 months and 5 months, respectively, showing no significant difference (P = 0.637). Adverse events were observed in all 62 patients. Grade 1 to 4 anemia was higher in the EP group than in EL group, showing significant difference (P = 0.02). Grade 3 and 4 thrombocytopenia was seen in 4 patients (12.9%) in EL group and 1 patient (3.2%) in EP group. Although one patient had platelet transfusion owing to Grade 4 thrombocytopenia in EL group, no significant difference (P = 0.637) were shown. The incidence of nausea/vomiting was higher in the EP group than in the EL group (96.7% vs 51.6%, P = 0.00). Conclusion: The EL regimen is an effective and low-toxicity chemotherapy and no inferior to EP regimen in treatment response, therefore, EL regimen maybe is a good choice for patients with extensive-stage SCLC. 展开更多
关键词 患者 顺铂 肺癌 细胞 足叶乙甙 随机比较 化疗 血小板减少
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The effects of coloring therapy on patients with generalized anxiety disorder 被引量:2
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作者 Bosomtwe Samuel hongmei wang +4 位作者 Chengdong Shi Yongliang Pan Yuzi Yu Weiyu Zhu Zhou Jing 《Animal Models and Experimental Medicine》 CAS CSCD 2022年第6期502-512,共11页
Generalized anxiety disorder(GAD)has harmful effects on physical and mental health and quality of life.Coloring therapy has been reported to have a positive effect on improving patient anxiety and depression.But there... Generalized anxiety disorder(GAD)has harmful effects on physical and mental health and quality of life.Coloring therapy has been reported to have a positive effect on improving patient anxiety and depression.But there are no reported clinical trials examining their effectiveness as a treatment for GAD.This study was planned to evaluate the effectiveness of coloring therapy combined with conventional therapy in improving anxiety,depression,and positive and negative emotions with GAD.This randomized controlled study comprising 88 GAD patients was selected for intervention in different wards.The control group(n=45)was given conventional antianxiety medication and physical therapy,and the experimental group(n=43)received coloring therapy combined with conventional therapy.The Self-Rating Depression Scale,Self-Rating Anxiety Scale(SAS),Hamilton Depression Scale,Hamilton Anxiety Scale(HAMA),and Positive and Negative Affect Scale were assessed in both groups before and 3 weeks after the intervention.After the intervention,there were statistical differences in intra-and inter-group comparisons of anxiety,depression,and positive and negative mood scales in the experimental and control groups(p<.05).The minus in anxiety/positive emotions pre-and postintervention in the experimental group was statistically significant compared to that in anxiety/positive emotions pre-and postintervention in the control group(HAMA:d=1.45,95%confidence interval[CI](0.34,2.57),p=.011;SAS:d=3.87,95%CI(1.73,6.00),p=.001;positive:d=1.76,95%CI(0.17,3.34),p=.030).The minus in depressive/negative emotions pre-and postintervention in the experimental group was not statistically significant compared with that in depressive/negative emotions pre-and postintervention in the control group(p>.05).For GAD patients,adding coloring therapy based on conventional drug therapy and physical therapy can not only reduce depression and negative emotions but also have better effects on reducing anxiety and improving positive emotions than conventional therapy. 展开更多
关键词 ANXIETY coloring therapy DEPRESSION generalized anxiety disorder
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Genetic variation of height growth rhythm between clones of Larix kaempferi × L. gmelini based on logistic models 被引量:1
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作者 Chunming Li Hui Xia +4 位作者 Hui Bai hongmei wang Yajuan Xing Xiyang Zhao Xiaomei Sun 《Journal of Forestry Research》 SCIE CAS CSCD 2018年第5期1387-1394,共8页
Fifty-three larch interspecific hybrid clones(Larix kaempferi × L.gmelini) and their parent clones were used for growth curve analysis of height variations.The growth curves of the 55 clones were 'S'-shap... Fifty-three larch interspecific hybrid clones(Larix kaempferi × L.gmelini) and their parent clones were used for growth curve analysis of height variations.The growth curves of the 55 clones were 'S'-shaped and 36 exhibited similar curves as the male parent.The coefficients of the logistic models were higher than 0.943,indicating that our results were effective in the simulation of the growth curves.ANOVA analysis showed significant differences in height of different clones (P\0.01).Average date of maximum height growth was Day 173,and average duration of rapid growth lasted for 50 days.Annual average increase in height was 9.7cm d^(-1) and daily average increase was 0.2 cm.The ratio of GR to the total annual increase in height ranged from 51.2 to 68.8%,with the average being 59.8%.There was a positive correlation between k values and plant heights which benefited from the evaluation of early plant height.There was also a positive correlation between GR(growth stage),GD(plant height) and annual increase in height.These results are informative to the evaluation of the elite clone selection and provide a theoretical basis for breeding and management. 展开更多
关键词 生长曲线分析 逻辑模型 克隆 基因变化 节奏 混血儿 落叶松 显示
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Study of 2-Propanol Photocatalytic Degradation on Surface of Phase-Ratio-Controlled TiO_2 Nanoparticles 被引量:1
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作者 Yifei wang hongmei wang Xin Tan 《Transactions of Tianjin University》 EI CAS 2018年第1期1-7,共7页
The crystal form of TiO_2 is a crucial focus of research on the photocatalytic degradation of gaseous pollutants by TiO_2-based composite photocatalysts. To explore the synergistic effect of mixed crystalline TiO_2 on... The crystal form of TiO_2 is a crucial focus of research on the photocatalytic degradation of gaseous pollutants by TiO_2-based composite photocatalysts. To explore the synergistic effect of mixed crystalline TiO_2 on gaseous organic-pollutant photocatalytic degradation, we synthesized a series of TiO_2 nanoparticles with controllable phase ratios. We explored the role of the TiO_2 phase ratio on the photocatalytic activity and degradation pathway in the photodegradation of 2-propanol(IPA). We estimated the crystallite size and crystal proportions of anatase and rutile by X-ray diffraction. We used the Brunauer-Emmett-Teller method to calculate the specific surface area and Fourier transform infrared spectroscopy to characterize the surface chemistry of the samples. Our results show the photocatalytic activities of pure anatase and the sample with 8.6% rutile to be much better than those of the samples with a phase junction and pure rutile. As such, anatase is the better option for the study of photodegradation design and preparation of gas-phase organic pollutants. 展开更多
关键词 MIXED-PHASE TiO2 PHASE JUNCTIONS PHOTOCATALYTIC degradation 2-Propanol
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Investigation on process mechanism of a novel energy-saving synthesis for high performance Li_(4)Ti_(5)O_(12) anode material 被引量:1
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作者 Guochuan wang hongmei wang +8 位作者 Guangqiang Ma Xinhe Du Liyu Du Peng Jing Yanqing wang Kaipeng Wu Hao Wu Qian wang Yun Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第7期266-275,I0008,共11页
Li_(4)Ti_(5)O_(12)(LTO) anode material demonstrates superior cycling performance due to its stable spinel structure and high lithiation/de-lithiation potential.Herein,a novel energy-saving solid-phase synthesis route ... Li_(4)Ti_(5)O_(12)(LTO) anode material demonstrates superior cycling performance due to its stable spinel structure and high lithiation/de-lithiation potential.Herein,a novel energy-saving solid-phase synthesis route for LTO has been successfully designed,employing the cheap industrial intermediate product of metatitanic acid (HTO) as titanium source.Through the in-situ Fourier transform infrared spectroscopy (FTIR)and ex-situ X-ray diffraction (XRD),it is revealed for the first time that the amorphous crystal structure of HTO is more conducive for the Li+insertion,making it possible to prepare LTO at a relatively lower sintering temperature.Utilizing the dehydration carbonization reaction between glucose and sulfuric acid,an ingenious strategy of glucose pre-coating is adopted to avoid the generation of Li_(2)SO_(4) impurity caused by the residual sulfuric acid on the surface of HTO,which meanwhile enhances the conductivity and inhibits the particle growth of LTO.The obtained ALTO@C anode material consequently exhibits excellent electrochemical performance that 132.0 m Ah g^(-1)is remained even at 20 C,and ultra low decay rate of 0.015% per cycle is achieved during 1000 cycles at 2 C.Remarkably,LiCoO_(2)//ALTO@C full cell delivers conspicuous low-temperature property (130.7 m Ah g^(-1)at 0.5 C and almost no attenuation after 300 cycles under-20℃). 展开更多
关键词 Metatitanic acid Carbonization promoted by sulfuric acid ENERGY-SAVING Low temperature performance Lithium titanate anode
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Effects of Vibration Characteristics on the Atomization Performance in the Medical Piezoelectric Atomization Device Induced by Intra-Hole Fluctuation 被引量:1
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作者 Qiufeng Yan Wanting Sun +2 位作者 Lei Zhang hongmei wang Jianhui Zhang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2021年第6期331-339,共9页
Oral inhalation of aerosolized drugs has be widely applied in healing the affected body organs including lesions of the throat and lungs and it is more effiicient than those conventional therapies,such as intravenous ... Oral inhalation of aerosolized drugs has be widely applied in healing the affected body organs including lesions of the throat and lungs and it is more effiicient than those conventional therapies,such as intravenous drip,intramuscular injection and external topical administration in the aspects of the dosage reduction and side effects of drugs.Never-theless,the traditional atomization devices always exhibit many drawbacks.For example,non-uniformed atomization particle distribution,the instability of transient atomization quantity and difficulties in precise energy control would seriously restrict an extensive use of atomization inhalation therapy.In this study,the principle of intra-hole fluctua-tion phenomenon occurred in the hole is fully explained,and the produced volume change is also estimated.Addi-tionally,the mathematical expression of the atomization rate of the atomizing device is well established.The mecha-nism of the micro-pump is further clarified,and the influence of the vibration characteristics of the atomizing film on the atomization behavior is analyzed theoretically.The curves of sweep frequency against the velocity and amplitude of the piezoelectric vibrator are obtained by the Doppler laser vibrometer,and the corresponding mode shapes of the resonance point are achieved.The influence of vibration characteristics on atomization rate,atomization height and atomization particle size are also verified by experiments,respectively.Both the experimental results and theoretical calculation are expected to provide a guidance for the design of this kind of atomization device in the future. 展开更多
关键词 PIEZOELECTRIC Intra-hole fluctuation Vibration characteristics ATOMIZATION
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生物发酵饲料在无抗养猪生产上的应用研究进展 被引量:14
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作者 张遨然 魏明 +6 位作者 王红梅 尹望 周航 郭建强 蔡熙姮 李敬先 周桂莲 《猪业科学》 2021年第1期42-46,共5页
生物发酵饲料作为"第四代活的饲料",近年来备受畜牧行业的关注,也是国家实行饲料全面禁抗后的替抗研究手段之一。生物发酵饲料立足于去除原料抗营养因子、改善饲料营养价值、提高饲料养分消化利用率、产生有益微生物代谢产物... 生物发酵饲料作为"第四代活的饲料",近年来备受畜牧行业的关注,也是国家实行饲料全面禁抗后的替抗研究手段之一。生物发酵饲料立足于去除原料抗营养因子、改善饲料营养价值、提高饲料养分消化利用率、产生有益微生物代谢产物,达到维护动物肠道健康、提升动物机体免疫力、促进动物生产性能、减少动物粪污排放和环保健康养殖的目的。生物饲料在养猪生产上应用最早、也最为广泛,从早年欧洲家庭农场的液体发酵饲喂,到近年来发酵原料、益生活菌及其代谢产物在猪饲料上的使用,都取得了成功实践。文章就生物发酵饲料的概述、其替抗的作用机理及其在生猪养殖上的研究进展进行综述,为生物发酵饲料的广泛应用提供参考依据。 展开更多
关键词 生物发酵饲料 猪生产 无抗
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