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Utilizing auxin dwarf genes to optimize seed yield and lodging resistance in rapeseed
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作者 hongxiang lou Yan Peng +10 位作者 Chunyun Wang Zongkai Wang Bowen Zhao Ali Mahmoud El-Badri Maria Batool Bo Wang Jing Wang Zhenghua Xu Jie Zhao Jie Kuai Guangsheng Zhou 《The Crop Journal》 SCIE CSCD 2024年第4期1208-1221,共14页
Direct-seeding rapeseed production at high plant density raises the risk of lodging.We investigated the use of dwarf genes to improve rapeseed plant architecture to balance yield and lodging.Three genotypes with diffe... Direct-seeding rapeseed production at high plant density raises the risk of lodging.We investigated the use of dwarf genes to improve rapeseed plant architecture to balance yield and lodging.Three genotypes with different plant architectures(dwarf sca^(HS5),semi-dwarf+/sca^(HS5),and tall ^(HS5))were evaluated under varying nitrogen rates(N1,N2,and N3:120,240,and 360 kg N ha^(-1))and plant densities(D1,D2,and D3:15,45,and 75 plants m^(-2))from 2019 to 2022.The results showed that increasing N rate positively influenced yield while decreasing lodging resistance in all genotypes.Increasing plant density(D2-D3)enhanced lodging resistance and yield in sca^(HS5) and+/sca^(HS5),but reduced yield in ^(HS5).Compared to the two parents,+/sca^(HS5) exhibited moderate expressions of IAA3,GH3.15,and SAUR30 in stems under N2D3,resulting in reduced plant height and increased compactness.Additionally,+/sca^(HS5) had a thicker silique layer than ^(HS5) by 14.7%,and it had a significant correlation between branch height/angle and yield.Increasing N rate led to increased lignin and pectin contents,while cellulose content decreased.Increasing plant density resulted in greater stem cellulose content and CSLA3/7 expression in sca^(HS5) and+/sca^(HS5),but decreased in ^(HS5).Compared to ^(HS5),+/sca^(HS5) exhibited higher expressions of ARAD1 and GAUT4,along with a 51.1%increase in pectin content,leading to improved lodging resistance under N2D3.Consequently,+/sca^(HS5) showed a 46.4%higher yield and 38.9%lodging resistance than ^(HS5) under N2D3,while sca^(HS5) demonstrated strong lodging resistance but lower yield potential.Overall,this study underscores the potential of utilizing auxin dwarf genes to optimize the trade-off between yield and lodging resistance in rapeseed and the possibility of maximizing yield potential by optimizing the plant architecture of+/sca^(HS5) through nitrogen reduction and dense planting. 展开更多
关键词 RAPESEED Plant density NITROGEN LODGING AUXIN
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Rearranged 19-nor-7,8-seco-labdane diterpenoids and Diels-Alder cycloadducts from the Chinese liverwort Pallavicinia ambigua:Structural elucidation,photoinduced rearrangement,and cytotoxic activity
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作者 Chunyang Zhang Yuelan Li +8 位作者 Zhaojun Chu Shuangzhi Yuan Yanan Qiao Jiaozhen Zhang Lin Li Yueqing Zhang Ruifeng Tian Yajie Tang hongxiang lou 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第3期415-418,共4页
Two distinctive rearranged 19-nor-7,8-seco-labdane diterpenoids(1 and 2)with a novel tetracyclo[5.2.1.0^(2,5.)0^(4,10)]decane skeleton,a derivative of the open tetrahydrofuran ring(7),three dimeric compounds(8-10),and... Two distinctive rearranged 19-nor-7,8-seco-labdane diterpenoids(1 and 2)with a novel tetracyclo[5.2.1.0^(2,5.)0^(4,10)]decane skeleton,a derivative of the open tetrahydrofuran ring(7),three dimeric compounds(8-10),and four revised homologs(3-6)were obtained from Chinese liverwort Pallavicinia ambigua.Their structures were identified via combined analysis of their spectroscopic data,single-crystal X-ray diffraction patterns,and ECD calculations.The light-driven conversion of compound 5 to compounds 1-4 demonstrated that photochemically induced postmodification involved in biosynthesis is an important way to diversify natural structures.A preliminary cytotoxicity assay revealed that compound 5 showed significant inhibition in the human prostate cancer(PC-3)cell line via an apoptotic pathway. 展开更多
关键词 LIVERWORT Pallavicinia ambigua 19-nor-7 8-seco-Labdan diterpenoid Photoinduced rearrangement Cytotoxic activity
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The PI3K/AKT Pathway and Renal Cell Carcinoma 被引量:48
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作者 Huifang Guo Peter German +8 位作者 Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi hongxiang lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2015年第7期343-353,共11页
The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway, and thus is frequently activated as a c... The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway, and thus is frequently activated as a cancer driver. More importantly, the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades, providing many potential targets for cancer therapy. Renal cell carcinoma (RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies. The PI3K/AKT pathway is modestly mutated but highly activated in RCC, representing a promising drug target. Indeed, PI3K pathway inhibitors of the rapalog family are approved for use in RCC. Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC, reiterating the critical role of the PI3K/AKT pathway in this cancer. In this review, we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data, as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. 展开更多
关键词 PI3K AKT MTOR Renal cell carcinoma Targeted therapy
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Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion 被引量:4
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作者 Huanmin Niu Lilin Qian +8 位作者 Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa hongxiang lou Huiqing Yuan 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2019年第5期923-936,共14页
It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that mar... It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. 展开更多
关键词 SASP Marchantin M TFEB NF-KB Drug resistance
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A new pimarane-type diterpenoid from moss Pseudoleskeella papillosa (Lindb.)Kindb 被引量:1
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作者 Na Liu Song Wang hongxiang lou 《Acta Pharmaceutica Sinica B》 SCIE CAS 2012年第3期256-259,共4页
A new pimarane-type diterpenoid,momilactone C(1),together with one known compound,momilactone A(2),was isolated from moss Pseudoleskeella papillosa by column chromatography on silica gel,Sephadex LH-20 and semi-prepar... A new pimarane-type diterpenoid,momilactone C(1),together with one known compound,momilactone A(2),was isolated from moss Pseudoleskeella papillosa by column chromatography on silica gel,Sephadex LH-20 and semi-preparative HPLC.Their structures were established on the basis of HR-ESI-MS,ID and 2D NMR spectroscopic methods.Allelopathic test showed that the two diterpenoids inhibited germination of the Arabidopsis thaliana seeds. 展开更多
关键词 MOSS Pseudoleskeella papillosa(Lindb.)Kindb Pimarane-type diterpenoid
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Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes 被引量:1
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作者 Ping Lin Xue Li +3 位作者 Yuchen Xin Hongying Li Gang Li hongxiang lou 《Engineering Microbiology》 2022年第3期37-46,共10页
Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse fam-ily of polycyclic polyphenols.Some of them are consequently suggested as lead structures for drug developm... Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse fam-ily of polycyclic polyphenols.Some of them are consequently suggested as lead structures for drug development.Among them,rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannu-lated[5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin unit.This type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities,includ-ing antimicrobial,anticancer,and enzyme inhibition activity.The unique structures,intriguing biosynthesis,and marked bioactivities of rubromycins have drawn considerable attention from several chemists and biologists.This review covers the isolation,characterization,biosynthesis,and biological studies of these structurally diverse and complex rubromycins. 展开更多
关键词 Natural products Rubromycins SPIROKETAL BIOSYNTHESIS Bioactivity
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Targeting of VPS 18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance
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作者 Huanmin Niu Lilin Qian +7 位作者 Yanhai Luo Fang Wang Hongbo Zheng Yanhui Gao Hanbo Wang Xuelei Hu Huiqing Yuan hongxiang lou 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第7期1979-1981,共3页
Dear Editor,Multidrug resistance(MDR)is still a major challenge for successful cancer treatments.Numerous mechanisms that confer therapy-induced drug resistance have been extensively investigated to explore how to com... Dear Editor,Multidrug resistance(MDR)is still a major challenge for successful cancer treatments.Numerous mechanisms that confer therapy-induced drug resistance have been extensively investigated to explore how to combat the MDR.In this regard,lysosomal sequestration has demonstrated to be a mechanism contributing to drug resistance via an/,off-target,/effect in which hydrophobic and weakly basic chemotherapeutic agents are trapped in lysosomes,sequestering them from their targets. 展开更多
关键词 DRUG resistance AGENT
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