Ecological livability is one of the important tasks and objectives of the rural revitalization strategy proposed at the 19 th National Congress of the CPC.The most precious wealth of the countryside is the excellent e...Ecological livability is one of the important tasks and objectives of the rural revitalization strategy proposed at the 19 th National Congress of the CPC.The most precious wealth of the countryside is the excellent ecological environment,and China must unswervingly follow the route of green agricultural development.Based on current research on the relationship between ecological livable and agricultural green development,comprehensive policy documents,journal literature and related reports,this paper explored the background and connotation of ecological livable,the current situation of agricultural green development and existing problems,and profoundly analyzed ecological livable and the internal connection between agricultural green development,aiming to provide theoretical reference and scientific reference for the final realization of ecological livable goal.展开更多
<strong>Objective:</strong> To investigate the value of the number of circulating tumor cells (CTC) in peripheral blood in the prognosis and coagulation-related indicators of patients with renal cancer. &l...<strong>Objective:</strong> To investigate the value of the number of circulating tumor cells (CTC) in peripheral blood in the prognosis and coagulation-related indicators of patients with renal cancer. <strong>Methods:</strong> 65 patients with renal cell carcinoma (RCC) confirmed pathologically were divided into CTC positive group and CTC negative group according to the CTC count (5 pcs/3.5 ml). Compare the age, gender, tumor location, TNM (clinical stage), pathological grade, tissue type, lymph node metastasis, distant metastasis, prognosis and prothrombin time (PT), fibrinogen (FIB), partial coagulation of the two groups of patients The correlation between the results of zymogen time (APTT) and D-dimer (DD) and the number of CTC. <strong>Results:</strong> There were significant differences in TNM, lymph node metastasis, and distant metastasis between the two groups (P < 0.05). The number of CTC in patients was correlated with FIB and D-D levels (P < 0.05). <strong>Conclusion:</strong> The number of CTC in patients with renal cell carcinoma is correlated with some clinical phenotypes (TNM, lymph node metastasis, distant metastasis) and some coagulation indexes (FIB, D-D), and can jointly predict the prognosis of renal cancer.展开更多
</span><b><span style="font-family:Verdana;">Objective</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Ve...</span><b><span style="font-family:Verdana;">Objective</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> To investigate the value of CTC clinical features and blood-related test indicators in renal cancer patients by detecting the number of circulating tumor cells (CTC) in patients with renal cancer. <b></span><b><span style="font-family:Verdana;">Methods</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> To analyze 59 patients with renal cell carcinoma (RCC) admitted to the Department of Urology, Affiliated Hospital of Chengde Medical College from May 2018 to October 2019. According to the CTC count (5 pcs/3.5</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ml), they were divided into CTC positive group and CTC negative group. The age, gender, tumor location, tumor size, hematuria, CEC (circulating endothelial cells), CTC Cluster (aggregate), gene mutation, platelet (PLT), albumin (ALB), hemoglobin (HB), alkaline phosphatase (AKP), lactate dehydrogenase (LDH) were compared between the two groups of patients and the correlation of the number of CTCs.</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><b></span><b><span style="font-family:Verdana;">Results</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> There were significant differences in tumor size, CEC, and gene mutations between the two groups (P</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">< 0.05). The number of CTC in patients was correlated with the levels of HB, PLT and LDH (P</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">< 0.05). </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><b></span><b><span style="font-family:Verdana;">C</span><span style="font-family:Verdana;">onclusion</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> The number of CTC in RCC patients is correlated with some clinical features (tumor size, CEC, gene mutation) and some related test indicators (HB, PLT, LDH), and can be combined with the above related indicators to predict the occurrence, metastasis and prognosis of renal cancer.展开更多
In this paper,a new parallel controller is developed for continuous-time linear systems.The main contribution of the method is to establish a new parallel control law,where both state and control are considered as the...In this paper,a new parallel controller is developed for continuous-time linear systems.The main contribution of the method is to establish a new parallel control law,where both state and control are considered as the input.The structure of the parallel control is provided,and the relationship between the parallel control and traditional feedback controls is presented.Considering the situations that the systems are controllable and incompletely controllable,the properties of the parallel control law are analyzed.The parallel controller design algorithms are given under the conditions that the systems are controllable and incompletely controllable.Finally,numerical simulations are carried out to demonstrate the effectiveness and applicability of the present method.Index Terms-Continuous-time linear systems,digital twin,parallel controller,parallel intelligence,parallel systems.展开更多
Nature education is the trend of the current social development.By gradually improving the awareness of ecological civilization among the whole people,the achievements in ecological civilization are jointly built and ...Nature education is the trend of the current social development.By gradually improving the awareness of ecological civilization among the whole people,the achievements in ecological civilization are jointly built and shared by the whole people.Yancheng Yellow Sea Wetland is a characteristic natural resource and the name card of Yancheng City,and also an important part of the natural education of teenagers in Yancheng.As one of the main resources of nature education in Yancheng,the Yellow Sea Wetland World Natural Heritage resources play a more important role in the cultivation of youth ecological civilization values and legal awareness of environmental protection.Based on the protection and utilization of the Yellow Sea Wetland World Natural Heritage resources,this paper explores the methods and approaches of nature education for teenagers in Yancheng.展开更多
<strong>Objective:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> T</span></span&...<strong>Objective:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> T</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">he </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">objective </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">is to </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">explore the effects of different surgical methods-retroperitoneal</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> laparoscopic radical nephrectomy (RLRN) and open radical </span><span><span style="font-family:Verdana;">nephrectomy (ORN) on the number of circulating tumor cells (CTC) in the peripheral blood of patients with renal cancer. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The clinical data of</span></span><span style="font-family:Verdana;"> 63 patients in the Department of Urology, Affiliated Hospital of Chengde Medical College who underwent radical surgery for renal cancer were divided into CTC positive group (18 cases of open surgery and 16 cases of minimally invasive surgery) and CTC negative group (14 cases of open surgery), 15 cases of minimally invasive surgery), overall group (32 cases of open surgery, 31 cases of minimally invasive surgery). Observe the changes in the number of CTC 1 week before operation and 1 week after operation. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> In the positive group, whether it was open surgery or minimally invasive surgery, the postoperative CTC level of patients was significantly reduced (P < 0.05). In the negative group, the CTC decreased significantly after open surgery (P > 0.05), and the CTC level decreased significantly after minimally invasive surgery (P < 0.01). In the overall group, both open and minimally invasive surgery CTC decreased significantly, and the difference was statistically significant (P < 0.05). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The two different surgical methods can reduce the level of CTC, but compared with ORN, RLRN can significantly reduce the number of postoperative CTC. Patients in the CTC-negative group may be less suitable for open surgery. CTC levels have certain potential in the selection and guidance of treatment modes for patients with renal cell carcinoma (RCC).</span></span></span></span>展开更多
With the rapid increase of water contamination,membrane separation technology and their corresponding molecular weight cut-off(MWCO) evaluation method become more necessary.In this study,Panax notoginseng saponins was...With the rapid increase of water contamination,membrane separation technology and their corresponding molecular weight cut-off(MWCO) evaluation method become more necessary.In this study,Panax notoginseng saponins was used as a new standard marker to determinate ultrafiltration(UF) membrane MWCOs,series of Millipore membranes were selected as control group to analyze and calculate the relationship between retention rate and MWCOs with exponential or logarithmic equation.A new and convenient method was provided for determining the membrane MWCO by modeling analysis retention rate with MWCOs,and the regression coefficients >0.990.The feasibility and practicability of established method was verified by different manufactures' membrane and dextrans.In the detection progress,as the main ingredient of Panax notoginseng saponins,Notoginsenoside R_1,Ginsenoside Rg_1,Ginsenoside Rb_1 and Ginsenoside Rd with different surface activity,the MWCO range of UF membranes can be divided into two zones mainly due to the retention rate difference among Notoginsenoside R_1,Ginsenoside Rg_1,Ginsenoside Rb_1 and Ginsenoside Rd.Zone 1,1000-10000;and Zone II,10000-100000.Thus,the new method would be helpful to improve the applicability of UF membrane in separation technology.展开更多
Purpose:.To analyze clinical features and main causes of multiple sclerosis-related optic neuritis(MS-ON), providing evidence for the differential diagnosis of MS-ON.Methods: Clinical data were collected from 527 pati...Purpose:.To analyze clinical features and main causes of multiple sclerosis-related optic neuritis(MS-ON), providing evidence for the differential diagnosis of MS-ON.Methods: Clinical data were collected from 527 patients, 123 males and 404 females, diagnosed with MS-ON between June2008 and June 2013. Visual acuity, optometry, visual field,slit-lamp microscopy, indirect ophthalmoscopy(20D), optical coherence tomography(OCT) and magnetic resonance imaging(MRI) were performed. Venous blood was sampled for detection of autoimmune antibodies and Aquaporin(AQP-4).Results:.Fifty nine cases were diagnosed with neuromyelitis optica-related optic neuritis.(NMO-ON),.27 Sjogren's syndrome-related optic neuropathy,.22 tumors,.21 anterior ischemic optic neuropathy, 15 radiation-induced optic neuropathy, 14 optic neuropathy-related infection, 17 genetic eye diseases and 10 open angle glaucoma. Among168 MS-ON patients undergoing optic nerve MRI,90 cases(53.57%) had a lesion < 15 mm in size, 15-30 mm in 76(45.24%) and > 30 mm in two(1.19%).Conclusion:.MS-ON is more commonly misdiagnosed with NMO-ON and Sjogren's syndrome, when compared to optic neuropathy, tumors and ischemic optic neuropathy.展开更多
We numerically demonstrate a photo-excited plasmon-induced transparency(PIT)effect in hybrid terahertz(THz)metamaterials.The proposed metamaterials are regular arrays of hybrid unit cells composed of a metallic cut wi...We numerically demonstrate a photo-excited plasmon-induced transparency(PIT)effect in hybrid terahertz(THz)metamaterials.The proposed metamaterials are regular arrays of hybrid unit cells composed of a metallic cut wire and four metallic split-ring resonators(SRRs)whose gaps are filled with photosensitive semiconductor gallium arsenide(GaAs)patches.We simulate the PIT effect controlled by external infrared light intensity to change the conductivity of GaAs.In the absence of photo excitation,the conductivity of Ga As is 0,thus the SRR gaps are disconnected,and the PIT effect is not observed since the dark resonator(supported by the hybrid SRRs)cannot be stimulated.When the conductivity of GaAs is increased via photo excitation,the conductivity of Ga As can increase rapidly from 0 S/m to 1×10^(6)S/m and GaAs can connect the metal aluminum SRR gaps,and the dark resonator is excited through coupling with the bright resonator(supported by the cut wire),which leads to the PIT effect.Therefore,the PIT effect can be dynamically tuned between the on and off states by controlling the intensity of the external infrared light.We also discuss couplings between one bright mode(CW)and several dark modes(SRRs)with different sizes.The interference analytically described by the coupled Lorentz oscillator model elucidates the coupling mechanism between one bright mode and two dark modes.The phenomenon can be considered the result of linear superposition of the coupling between the bright mode and each dark mode.The proposed metamaterials are promising for application in the fields of THz communications,optical storage,optical display,and imaging.展开更多
Human adipose stem cells(hADSCs)are reliable sources for cell therapy.However,the clinical applications are limited by the decrease in activity during in vitro culture.We used a knockout serum replacement(KSR)medium,E...Human adipose stem cells(hADSCs)are reliable sources for cell therapy.However,the clinical applications are limited by the decrease in activity during in vitro culture.We used a knockout serum replacement(KSR)medium,Eppendorf(EP)tube culture,and a simulated microgravity(SMG)culture system to establish hADSC spheroids.We found that hADSCs aggregated and formed spheroids in the KSR culture medium.The EP tube culture method revealed many biological cell characteristics,such as good cell viabilities,rough surfaces,polar growth,fusion phenomenon,and injectability.The findings show its advantages for hADSCs spherical cultures.When cultured in SMG,hADSC spheroids produced large-scale spheroids.Additionally,confocal examination and viability assays revealed that SMG-cultured hADSC spheroids had higher cell viabilities and looser spherical structures,relative to those cultured in EP tubes.hADSC spheroids in static EP tube culture had tighter structures and more dead cells with rough and irregular surfaces,while hADSC spheroids in dynamic SMG condition exhibited looser structures and better cell viabilities with flat and regular surfaces.Therefore,the KSR media promotes spherical formation by hADSCs,which showed polar growth,fusion,and injectability in vitro.The dynamic SMG culture enhances the formation of a looser structure and better cell viabilities for hADSC spheroids.展开更多
The origin,introduction,cultivation,active ingredients,use and advances in propagation methods of Adansonia digitata are reviewed in this paper,with focus on the rapid propagation techniques of plant tissues,to provid...The origin,introduction,cultivation,active ingredients,use and advances in propagation methods of Adansonia digitata are reviewed in this paper,with focus on the rapid propagation techniques of plant tissues,to provide theoretical basis for seedling breeding and promotion of A.digitata.展开更多
The influence of loading path on tube hydroforming process is discussed in this paper with finiteelement simulation. Four different loading paths are utilized in simulating the forming process of square tubular compon...The influence of loading path on tube hydroforming process is discussed in this paper with finiteelement simulation. Four different loading paths are utilized in simulating the forming process of square tubular component with hydroforming and the result of different loading path is presented. Among the result. the thickness distribution of bilinear loading path is the most uniform one. It shows that the increase of punch displacement in the stage of high pressure is beneficial to the forming of component for optimized Stress condition.展开更多
Herein, a bidirectional polarization strategy is proposed for hosting efficient and durable lithium-sulfur battery(Li-S) electrochemistry. By co-doping electronegative N and electropositive B in graphene matrix(BNrGO)...Herein, a bidirectional polarization strategy is proposed for hosting efficient and durable lithium-sulfur battery(Li-S) electrochemistry. By co-doping electronegative N and electropositive B in graphene matrix(BNrGO), the bidirectional electron redistribution enables a higher polysulfide affinity over its monodoped counterparts, contributing to strong sulfur immobilization and fast conversion kinetics. As a result,BNrGO as the cathode host matrix realizes excellent cycling stability over 1000 cycles with a minimum capacity fading of 0.027% per cycle, and superb rate capability up to 10 C. Meanwhile, decent areal capacity(6.46 m Ah/cm^(2)) and cyclability(300 cycles) are also achievable under high sulfur loading and limited electrolyte. This work provides instructive insights into the interaction between doping engineering and sulfur electrochemistry for pursuing superior Li-S batteries.展开更多
New helium isotopic data of ores and rocks from the Altay orogenic zone, Xinjiang,China are reported, which show that the pegmatites from No. 3 vein in the Keketuohai area have high <sup>3</sup>He/<sup&...New helium isotopic data of ores and rocks from the Altay orogenic zone, Xinjiang,China are reported, which show that the pegmatites from No. 3 vein in the Keketuohai area have high <sup>3</sup>He/<sup>4</sup>He ratios up to 1 .795 x 10<sup>-6</sup> and 2.54 x 10<sup>-6</sup>. Such a result suggests that the metallogenic process of rare metal deposits in the Altay orogenic zone might be related to mantle degassing.展开更多
Material genetic engineering can significantly accelerate the development of new materials.As an important topic in material science and condensed matter physics,the development of metallic glasses(MGs)with specific p...Material genetic engineering can significantly accelerate the development of new materials.As an important topic in material science and condensed matter physics,the development of metallic glasses(MGs)with specific properties has largely been the result of trial and error since their discovery in 1960.Yet,property design based on the physical parameters of constituent elements of MGs remains a huge challenge owing to the lack of an understanding of the property inheritance from constitute elements to the resultant alloys.In this work,we report the inherent relationships of the yield strengthσ_(y),Young’s modulus E,and shear Modulus G with the valence electron density.More importantly,we reveal that the electronic density of states(EDOSs)at the Fermi surface(E_(F))is an inheritance factor for the physical properties of MGs.The physical properties of MGs are inherited from the specific element with the largest coefficient of electronic specific heat(γ_(i)),which dominates the value of the EDOS at E_(F).This work not only contributes to the understanding of property inheritances but also guides the design of novel MGs with specific properties based on material genetic engineering.展开更多
Compared with the traditional power grid,smart grid involves many advanced technologies and applications.However,due to the rapid development of various network technologies,smart grid is facing the challenges of bala...Compared with the traditional power grid,smart grid involves many advanced technologies and applications.However,due to the rapid development of various network technologies,smart grid is facing the challenges of balancing privacy,security,efficiency,and functionality.In the proposed scheme,we design a privacy protection scheme for outsourcing smart grid aided by fog computing,which supports fine-grained privacy-protected data aggregation based on user characteristics.The fog server matches the encrypted characteristics in the received message with the encrypted aggregation rules issued by the service provider.Therefore,the service provider can get more fine-grained analysis data based on user characteristics.Different from the existing outsourcing smart grid schemes,the proposed scheme can achieve real-time pricing on the premise of protecting user privacy and achieving system fault tolerance.Finally,experiment analyses demonstrate that the proposed scheme has less computation overhead and lower transmission delay than existing schemes.展开更多
The development of high-intensity ultrafast laser facilities provides the possibility to create novel physical phenomena and matter states.The timing fluctuation of the laser pulses is crucial for pump–probe experime...The development of high-intensity ultrafast laser facilities provides the possibility to create novel physical phenomena and matter states.The timing fluctuation of the laser pulses is crucial for pump–probe experiments,which is one of the vital means to observe the ultrafast dynamics driven by intense laser pulses.In this paper,we demonstrate the timing fluctuation characterization and control of the front end of a 100-PW laser that is composed of a high-contrast optical parametric amplifier(seed)and a 200-TW optical parametric chirped pulse amplifier(preamplifier).By combining the timing jitter measurement with a feedback system,the laser seed and preamplifier are synchronized to the reference with timing fluctuations of 1.82 and 4.48 fs,respectively.The timing system will be a key prerequisite for the stable operation of 100-PW laser facilities and provide the basis for potential pump–probe experiments performed on the laser.展开更多
文摘Ecological livability is one of the important tasks and objectives of the rural revitalization strategy proposed at the 19 th National Congress of the CPC.The most precious wealth of the countryside is the excellent ecological environment,and China must unswervingly follow the route of green agricultural development.Based on current research on the relationship between ecological livable and agricultural green development,comprehensive policy documents,journal literature and related reports,this paper explored the background and connotation of ecological livable,the current situation of agricultural green development and existing problems,and profoundly analyzed ecological livable and the internal connection between agricultural green development,aiming to provide theoretical reference and scientific reference for the final realization of ecological livable goal.
文摘<strong>Objective:</strong> To investigate the value of the number of circulating tumor cells (CTC) in peripheral blood in the prognosis and coagulation-related indicators of patients with renal cancer. <strong>Methods:</strong> 65 patients with renal cell carcinoma (RCC) confirmed pathologically were divided into CTC positive group and CTC negative group according to the CTC count (5 pcs/3.5 ml). Compare the age, gender, tumor location, TNM (clinical stage), pathological grade, tissue type, lymph node metastasis, distant metastasis, prognosis and prothrombin time (PT), fibrinogen (FIB), partial coagulation of the two groups of patients The correlation between the results of zymogen time (APTT) and D-dimer (DD) and the number of CTC. <strong>Results:</strong> There were significant differences in TNM, lymph node metastasis, and distant metastasis between the two groups (P < 0.05). The number of CTC in patients was correlated with FIB and D-D levels (P < 0.05). <strong>Conclusion:</strong> The number of CTC in patients with renal cell carcinoma is correlated with some clinical phenotypes (TNM, lymph node metastasis, distant metastasis) and some coagulation indexes (FIB, D-D), and can jointly predict the prognosis of renal cancer.
文摘</span><b><span style="font-family:Verdana;">Objective</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> To investigate the value of CTC clinical features and blood-related test indicators in renal cancer patients by detecting the number of circulating tumor cells (CTC) in patients with renal cancer. <b></span><b><span style="font-family:Verdana;">Methods</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> To analyze 59 patients with renal cell carcinoma (RCC) admitted to the Department of Urology, Affiliated Hospital of Chengde Medical College from May 2018 to October 2019. According to the CTC count (5 pcs/3.5</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ml), they were divided into CTC positive group and CTC negative group. The age, gender, tumor location, tumor size, hematuria, CEC (circulating endothelial cells), CTC Cluster (aggregate), gene mutation, platelet (PLT), albumin (ALB), hemoglobin (HB), alkaline phosphatase (AKP), lactate dehydrogenase (LDH) were compared between the two groups of patients and the correlation of the number of CTCs.</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><b></span><b><span style="font-family:Verdana;">Results</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> There were significant differences in tumor size, CEC, and gene mutations between the two groups (P</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">< 0.05). The number of CTC in patients was correlated with the levels of HB, PLT and LDH (P</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">< 0.05). </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><b></span><b><span style="font-family:Verdana;">C</span><span style="font-family:Verdana;">onclusion</span></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">:</span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"></b></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> The number of CTC in RCC patients is correlated with some clinical features (tumor size, CEC, gene mutation) and some related test indicators (HB, PLT, LDH), and can be combined with the above related indicators to predict the occurrence, metastasis and prognosis of renal cancer.
基金supported in part by the National Key Research and Development Program of China(2018AAA0101502,2018YFB1702300)the National Natural Science Foundation of China(61722312,61533019,U1811463,61533017)。
文摘In this paper,a new parallel controller is developed for continuous-time linear systems.The main contribution of the method is to establish a new parallel control law,where both state and control are considered as the input.The structure of the parallel control is provided,and the relationship between the parallel control and traditional feedback controls is presented.Considering the situations that the systems are controllable and incompletely controllable,the properties of the parallel control law are analyzed.The parallel controller design algorithms are given under the conditions that the systems are controllable and incompletely controllable.Finally,numerical simulations are carried out to demonstrate the effectiveness and applicability of the present method.Index Terms-Continuous-time linear systems,digital twin,parallel controller,parallel intelligence,parallel systems.
文摘Nature education is the trend of the current social development.By gradually improving the awareness of ecological civilization among the whole people,the achievements in ecological civilization are jointly built and shared by the whole people.Yancheng Yellow Sea Wetland is a characteristic natural resource and the name card of Yancheng City,and also an important part of the natural education of teenagers in Yancheng.As one of the main resources of nature education in Yancheng,the Yellow Sea Wetland World Natural Heritage resources play a more important role in the cultivation of youth ecological civilization values and legal awareness of environmental protection.Based on the protection and utilization of the Yellow Sea Wetland World Natural Heritage resources,this paper explores the methods and approaches of nature education for teenagers in Yancheng.
文摘<strong>Objective:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> T</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">he </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">objective </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">is to </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">explore the effects of different surgical methods-retroperitoneal</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> laparoscopic radical nephrectomy (RLRN) and open radical </span><span><span style="font-family:Verdana;">nephrectomy (ORN) on the number of circulating tumor cells (CTC) in the peripheral blood of patients with renal cancer. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The clinical data of</span></span><span style="font-family:Verdana;"> 63 patients in the Department of Urology, Affiliated Hospital of Chengde Medical College who underwent radical surgery for renal cancer were divided into CTC positive group (18 cases of open surgery and 16 cases of minimally invasive surgery) and CTC negative group (14 cases of open surgery), 15 cases of minimally invasive surgery), overall group (32 cases of open surgery, 31 cases of minimally invasive surgery). Observe the changes in the number of CTC 1 week before operation and 1 week after operation. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> In the positive group, whether it was open surgery or minimally invasive surgery, the postoperative CTC level of patients was significantly reduced (P < 0.05). In the negative group, the CTC decreased significantly after open surgery (P > 0.05), and the CTC level decreased significantly after minimally invasive surgery (P < 0.01). In the overall group, both open and minimally invasive surgery CTC decreased significantly, and the difference was statistically significant (P < 0.05). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The two different surgical methods can reduce the level of CTC, but compared with ORN, RLRN can significantly reduce the number of postoperative CTC. Patients in the CTC-negative group may be less suitable for open surgery. CTC levels have certain potential in the selection and guidance of treatment modes for patients with renal cell carcinoma (RCC).</span></span></span></span>
基金Supported by the National Natural Science Foundation of China(No.81503258,No.81373980)Youth Natural Science Foundation of Jiangsu Province(No.BK20151005)Science and Technology Project of Jiangsu Traditional Chinese Medicine Administration(No.YB2015009)
文摘With the rapid increase of water contamination,membrane separation technology and their corresponding molecular weight cut-off(MWCO) evaluation method become more necessary.In this study,Panax notoginseng saponins was used as a new standard marker to determinate ultrafiltration(UF) membrane MWCOs,series of Millipore membranes were selected as control group to analyze and calculate the relationship between retention rate and MWCOs with exponential or logarithmic equation.A new and convenient method was provided for determining the membrane MWCO by modeling analysis retention rate with MWCOs,and the regression coefficients >0.990.The feasibility and practicability of established method was verified by different manufactures' membrane and dextrans.In the detection progress,as the main ingredient of Panax notoginseng saponins,Notoginsenoside R_1,Ginsenoside Rg_1,Ginsenoside Rb_1 and Ginsenoside Rd with different surface activity,the MWCO range of UF membranes can be divided into two zones mainly due to the retention rate difference among Notoginsenoside R_1,Ginsenoside Rg_1,Ginsenoside Rb_1 and Ginsenoside Rd.Zone 1,1000-10000;and Zone II,10000-100000.Thus,the new method would be helpful to improve the applicability of UF membrane in separation technology.
基金This work is supported by the National Natural Science Foundation under grant No.59975021,which was gratefully acknowledged.At the same time,the author also thanks Prof.P.Zeng of Tsinghua University for his kind assistance which is also indispensble in the accomplishment of this paper.
文摘Purpose:.To analyze clinical features and main causes of multiple sclerosis-related optic neuritis(MS-ON), providing evidence for the differential diagnosis of MS-ON.Methods: Clinical data were collected from 527 patients, 123 males and 404 females, diagnosed with MS-ON between June2008 and June 2013. Visual acuity, optometry, visual field,slit-lamp microscopy, indirect ophthalmoscopy(20D), optical coherence tomography(OCT) and magnetic resonance imaging(MRI) were performed. Venous blood was sampled for detection of autoimmune antibodies and Aquaporin(AQP-4).Results:.Fifty nine cases were diagnosed with neuromyelitis optica-related optic neuritis.(NMO-ON),.27 Sjogren's syndrome-related optic neuropathy,.22 tumors,.21 anterior ischemic optic neuropathy, 15 radiation-induced optic neuropathy, 14 optic neuropathy-related infection, 17 genetic eye diseases and 10 open angle glaucoma. Among168 MS-ON patients undergoing optic nerve MRI,90 cases(53.57%) had a lesion < 15 mm in size, 15-30 mm in 76(45.24%) and > 30 mm in two(1.19%).Conclusion:.MS-ON is more commonly misdiagnosed with NMO-ON and Sjogren's syndrome, when compared to optic neuropathy, tumors and ischemic optic neuropathy.
基金supported by the National Science and Technology Major Project(Grant No.2017ZX02101007-003)the National Natural Science Foundation of China(Grant No.61965005)+4 种基金the National Natural Science Foundation of China(Grant No.62105187)the Natural Science Foundation of Guangxi Province(Grant No.2019GXNSFDA185010)Guangxi Distinguished Expert Project,Foundation of Guangxi Key Laboratory of Optoelectronic Information Processing(Grant No.GD20104)the Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QF010)the Innovation Project of Guang Xi Graduate Education(Grant No.YCSW2020158)。
文摘We numerically demonstrate a photo-excited plasmon-induced transparency(PIT)effect in hybrid terahertz(THz)metamaterials.The proposed metamaterials are regular arrays of hybrid unit cells composed of a metallic cut wire and four metallic split-ring resonators(SRRs)whose gaps are filled with photosensitive semiconductor gallium arsenide(GaAs)patches.We simulate the PIT effect controlled by external infrared light intensity to change the conductivity of GaAs.In the absence of photo excitation,the conductivity of Ga As is 0,thus the SRR gaps are disconnected,and the PIT effect is not observed since the dark resonator(supported by the hybrid SRRs)cannot be stimulated.When the conductivity of GaAs is increased via photo excitation,the conductivity of Ga As can increase rapidly from 0 S/m to 1×10^(6)S/m and GaAs can connect the metal aluminum SRR gaps,and the dark resonator is excited through coupling with the bright resonator(supported by the cut wire),which leads to the PIT effect.Therefore,the PIT effect can be dynamically tuned between the on and off states by controlling the intensity of the external infrared light.We also discuss couplings between one bright mode(CW)and several dark modes(SRRs)with different sizes.The interference analytically described by the coupled Lorentz oscillator model elucidates the coupling mechanism between one bright mode and two dark modes.The phenomenon can be considered the result of linear superposition of the coupling between the bright mode and each dark mode.The proposed metamaterials are promising for application in the fields of THz communications,optical storage,optical display,and imaging.
基金This study was supported by the National Natural Science Foundation of China(21318261 and 3201101202 to JC)National Natural Science Foundation of China(82000943 to YG)+1 种基金the Joint Fund of Basic and Applied Basic Research Fund of Guangdong Province(2019A1515110355 to YG)the Project funded by China Postdoctoral Science Foundation(2019M663391 and 2021T140273 to YG).
文摘Human adipose stem cells(hADSCs)are reliable sources for cell therapy.However,the clinical applications are limited by the decrease in activity during in vitro culture.We used a knockout serum replacement(KSR)medium,Eppendorf(EP)tube culture,and a simulated microgravity(SMG)culture system to establish hADSC spheroids.We found that hADSCs aggregated and formed spheroids in the KSR culture medium.The EP tube culture method revealed many biological cell characteristics,such as good cell viabilities,rough surfaces,polar growth,fusion phenomenon,and injectability.The findings show its advantages for hADSCs spherical cultures.When cultured in SMG,hADSC spheroids produced large-scale spheroids.Additionally,confocal examination and viability assays revealed that SMG-cultured hADSC spheroids had higher cell viabilities and looser spherical structures,relative to those cultured in EP tubes.hADSC spheroids in static EP tube culture had tighter structures and more dead cells with rough and irregular surfaces,while hADSC spheroids in dynamic SMG condition exhibited looser structures and better cell viabilities with flat and regular surfaces.Therefore,the KSR media promotes spherical formation by hADSCs,which showed polar growth,fusion,and injectability in vitro.The dynamic SMG culture enhances the formation of a looser structure and better cell viabilities for hADSC spheroids.
基金Supported by Natural Science Foundation of Hainan Province(317205)Key Research and Development Project of Hainan Province(ZDYF2016065)
文摘The origin,introduction,cultivation,active ingredients,use and advances in propagation methods of Adansonia digitata are reviewed in this paper,with focus on the rapid propagation techniques of plant tissues,to provide theoretical basis for seedling breeding and promotion of A.digitata.
基金Tabs paper is financially suPPorted by the NationalNatural Science Foundation of China (No. 59975021).
文摘The influence of loading path on tube hydroforming process is discussed in this paper with finiteelement simulation. Four different loading paths are utilized in simulating the forming process of square tubular component with hydroforming and the result of different loading path is presented. Among the result. the thickness distribution of bilinear loading path is the most uniform one. It shows that the increase of punch displacement in the stage of high pressure is beneficial to the forming of component for optimized Stress condition.
基金financially supported by the National Natural Science Foundation of China (No. 22109072)the Natural Science Foundation of Jiangsu Province (No. BK20210349)+2 种基金the China Postdoctoral Science Foundation (No. 2021M691586)the Postdoctoral Research Funding Scheme of Jiangsu Province (No. 2021K446C)the Shuangchuang (Mass Innovation and Entrepreneurship) Program of Jiangsu Province (No. JSSCBS20210208)。
文摘Herein, a bidirectional polarization strategy is proposed for hosting efficient and durable lithium-sulfur battery(Li-S) electrochemistry. By co-doping electronegative N and electropositive B in graphene matrix(BNrGO), the bidirectional electron redistribution enables a higher polysulfide affinity over its monodoped counterparts, contributing to strong sulfur immobilization and fast conversion kinetics. As a result,BNrGO as the cathode host matrix realizes excellent cycling stability over 1000 cycles with a minimum capacity fading of 0.027% per cycle, and superb rate capability up to 10 C. Meanwhile, decent areal capacity(6.46 m Ah/cm^(2)) and cyclability(300 cycles) are also achievable under high sulfur loading and limited electrolyte. This work provides instructive insights into the interaction between doping engineering and sulfur electrochemistry for pursuing superior Li-S batteries.
文摘New helium isotopic data of ores and rocks from the Altay orogenic zone, Xinjiang,China are reported, which show that the pegmatites from No. 3 vein in the Keketuohai area have high <sup>3</sup>He/<sup>4</sup>He ratios up to 1 .795 x 10<sup>-6</sup> and 2.54 x 10<sup>-6</sup>. Such a result suggests that the metallogenic process of rare metal deposits in the Altay orogenic zone might be related to mantle degassing.
基金supported by the National Natural Science Foundation of China(Nos.51871237 and 52171165)Additional support was provided through the European Research Council under the Advanced Grant‘INTELHYB—Next Generation of Complex Metallic Materials in Intelligent Hybrid Structures’(No.ERC-2013-ADG-340025).
文摘Material genetic engineering can significantly accelerate the development of new materials.As an important topic in material science and condensed matter physics,the development of metallic glasses(MGs)with specific properties has largely been the result of trial and error since their discovery in 1960.Yet,property design based on the physical parameters of constituent elements of MGs remains a huge challenge owing to the lack of an understanding of the property inheritance from constitute elements to the resultant alloys.In this work,we report the inherent relationships of the yield strengthσ_(y),Young’s modulus E,and shear Modulus G with the valence electron density.More importantly,we reveal that the electronic density of states(EDOSs)at the Fermi surface(E_(F))is an inheritance factor for the physical properties of MGs.The physical properties of MGs are inherited from the specific element with the largest coefficient of electronic specific heat(γ_(i)),which dominates the value of the EDOS at E_(F).This work not only contributes to the understanding of property inheritances but also guides the design of novel MGs with specific properties based on material genetic engineering.
基金This work was supported in part by the National Natural Science Foundation of China(Grant Nos.62125205,62072361 and 61872449)。
文摘Compared with the traditional power grid,smart grid involves many advanced technologies and applications.However,due to the rapid development of various network technologies,smart grid is facing the challenges of balancing privacy,security,efficiency,and functionality.In the proposed scheme,we design a privacy protection scheme for outsourcing smart grid aided by fog computing,which supports fine-grained privacy-protected data aggregation based on user characteristics.The fog server matches the encrypted characteristics in the received message with the encrypted aggregation rules issued by the service provider.Therefore,the service provider can get more fine-grained analysis data based on user characteristics.Different from the existing outsourcing smart grid schemes,the proposed scheme can achieve real-time pricing on the premise of protecting user privacy and achieving system fault tolerance.Finally,experiment analyses demonstrate that the proposed scheme has less computation overhead and lower transmission delay than existing schemes.
基金supported by the Shanghai High Repetition Rate XFEL and Extreme Light Facility (SHINE) projectthe National Natural Science Foundation of China (62105346)+2 种基金the CAS Project for Young Scientists in Basic Research(YSBR-059)the 100 Talents Program of CASthe Basic Research Project of the Shanghai Science and Technology Innovation Action Plan (20JC1416000)
文摘The development of high-intensity ultrafast laser facilities provides the possibility to create novel physical phenomena and matter states.The timing fluctuation of the laser pulses is crucial for pump–probe experiments,which is one of the vital means to observe the ultrafast dynamics driven by intense laser pulses.In this paper,we demonstrate the timing fluctuation characterization and control of the front end of a 100-PW laser that is composed of a high-contrast optical parametric amplifier(seed)and a 200-TW optical parametric chirped pulse amplifier(preamplifier).By combining the timing jitter measurement with a feedback system,the laser seed and preamplifier are synchronized to the reference with timing fluctuations of 1.82 and 4.48 fs,respectively.The timing system will be a key prerequisite for the stable operation of 100-PW laser facilities and provide the basis for potential pump–probe experiments performed on the laser.
