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柯萨奇-腺病毒受体在肾癌组织中的表达及意义 被引量:6
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作者 张林琳 贺大林 +4 位作者 李翔 李磊 罗勇 于琳华 hsieh jt 《中国肿瘤临床》 CAS CSCD 北大核心 2005年第20期1141-1143,共3页
目的:研究柯萨奇-腺病毒受体(CAR)在肾癌组织中的表达及意义。方法:应用免疫组化SP法检测12例癌旁正常肾组织和48例肾细胞癌组织中CAR的表达。结果:12例正常肾组织全部表达CAR,48例肾细胞癌组织中31例无CAR表达。不同分级CAR表达率分别... 目的:研究柯萨奇-腺病毒受体(CAR)在肾癌组织中的表达及意义。方法:应用免疫组化SP法检测12例癌旁正常肾组织和48例肾细胞癌组织中CAR的表达。结果:12例正常肾组织全部表达CAR,48例肾细胞癌组织中31例无CAR表达。不同分级CAR表达率分别为Ⅰ级54.5%(12/22)、Ⅱ级23.5%(4/17)、Ⅲ级11.1%(1/9);不同分期CAR表达率分别为Ⅰ期57.9%(11/19)、Ⅱ期30.8%(4/13)、Ⅲ期18.2%(2/11)、Ⅳ期0(0/5)。结论:在多数肾细胞癌组织中CAR基因表达丧失;CAR表达变化与肾癌的分级、分期相关,可以作为肾癌分化、转移的重要生物学指标。 展开更多
关键词 肾细胞癌 柯萨奇-腺病毒受体 免疫组织化学
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Expression and Significance of Coxsackie and Adenovirus Receptor in Renal-Cell Carcinoma
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作者 Linlin Zhang Dalin He +4 位作者 Xiang Li Lei Li Yong Luo Linhua Yu hsieh jt 《Chinese Journal of Clinical Oncology》 CSCD 2005年第5期787-790,共4页
OBJECTIVE To investigate the expression of Coxsackie and Adenovirus receptor (CAR) in renal-cell carcinoma and the relationship of the CAR to the biological behavior of the carcinomas. METHODS The immunohistochemica... OBJECTIVE To investigate the expression of Coxsackie and Adenovirus receptor (CAR) in renal-cell carcinoma and the relationship of the CAR to the biological behavior of the carcinomas. METHODS The immunohistochemical SP method was used to detect the expression of Coxsackie and Adenovirus receptor in 48 cases of renal- cell carcinoma and in 12 cases of normal renal tissue 2 cm away from the tumor tissue. RESULTS The positive rates of CAR were 100% in 12 cases of para-tumor normal renal tissue and 35.4% in 48 cases of renal-cell carcinoma respectively. The difference of CAR expression between them was significant (P〈0.05). The grades of the tumor were as follows: 22 in Grade Ⅰ, 17 in Grade Ⅱ and 9 in Grade Ⅲ with the CAR positive rate being 54.5%, 23.5% and 11.1%, respectively. There was a negative correlation between CAR expression and tumor grading (P〈0.05). In addition, the number of the cases in stages I to IV were 19, 13, 11 and 5 respectively, with the respective positive rates being 57.9%, 30.8%, 18.2% and 0.0%, i.e. there also was a negative relationship between CAR expression and the stage (P〈0.05). CONCLUSION CAR expression is down-regulated in renal-cell carcinoma compared with normal tissue. The level of CAR may be a sensitive predictor of differentiation, invasion and metastasis. Loss of CAR expression correlates with the invasive phenotype in our analysis of renal-cell carcinoma. 展开更多
关键词 renal-cell carcinoma Coxsackie and Adenovirus receptor immunohistochemistry.
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