Objective:To evaluate the clinical efficacy of sinew-regulating bone-setting manipulations plus exercise therapy in treating chronic non-specific low back pain(CNLBP).Methods:A total of 65 CNLBP patients were divided ...Objective:To evaluate the clinical efficacy of sinew-regulating bone-setting manipulations plus exercise therapy in treating chronic non-specific low back pain(CNLBP).Methods:A total of 65 CNLBP patients were divided into two groups by the random number table method.Thirty-three cases in the treatment group were intervened by sinew-regulating bone-setting manipulations plus exercise therapy;32 cases in the control group were intervened by medium-frequency electrotherapy plus exercise therapy.Before and after treatment,visual analog scale(VAS),dynamic and static muscle endurance of low back,median frequency(MF)of surface electromyography(sEMG)and Oswestry disability index(ODI)were used to evaluate the low back function.The therapeutic efficacy was estimated after treatment.Results:The two groups each had 2 dropouts during the study.The total effective rate was 90.3%in the treatment group versus 66.7%in the control group,and the between-group difference was statistically significant(P<0.05).After treatment,the VAS score,dynamic and static muscle endurance of low back,MF of sEMG and ODI score all changed significantly in both groups(all P<0.05);all the items in the treatment group were significantly different from those in the control group(all P<0.05).Conclusion:Sinew-regulating bone-setting manipulations plus exercise therapy can effectively release pain in CNLBP patients,increase muscle endurance of the low back and improve the quality of life,and its therapeutic efficacy is more significant than that of medium-frequency electrotherapy plus exercise therapy.展开更多
Objective To observe the therapeutic effect of sinew-regulating bone-setting manipulations for knee osteoarthritis(KOA)model rabbits and its impacts on the chondrocyte apoptosis rate and the levels of interleukin(IL)-...Objective To observe the therapeutic effect of sinew-regulating bone-setting manipulations for knee osteoarthritis(KOA)model rabbits and its impacts on the chondrocyte apoptosis rate and the levels of interleukin(IL)-1βand nitric oxide(NO).Methods According to the random number table method,30 New Zealand white rabbits were divided into a normal group(n=9)and a modeling group(n=21).Rabbits in the modeling group were used to establish KOA models with the modified Hulth method.At the 8th week,three rabbits were sacrificed to verify the model and the remaining 18 rabbits were randomly divided into a model group(n=9)and an intervention group(n=9).Rabbits in the normal group and model group were bred routinely without any intervention.Rabbits in the intervention group were treated with the sinew-regulating bone-setting manipulations,10 min/time,once every other day for a total of 20 times.The Lequesne MG knee function rating was used to evaluate the behavioral differences of the rabbits in each group.The Pelletier score was used to evaluate the general changes of the rabbits.The Mankin score was used to evaluate the pathology of knee cartilages.The enzyme-linked immunosorbent assay and nitrate reductase methods were used to determine the levels of IL-1βand NO in serum and synovial fluid of each group,respectively.In situ terminal deoxynucleotidyl transferase-mediated nick and labeling method was used to determine the apoptosis of chondrocytes in each group.Results Compared with the normal group,the scores of Lequesne MG,Pelletier and Mankin,and the levels of IL-1βand NO in the model group were increased(P<0.05),which indirectly indicated the success of the model.Compared with the model group,the scores of Lequesne MG,Pelletier and Mankin,IL-1βand NO levels,and chondrocyte apoptosis rate of the intervention group were decreased,and the differences were statistically significant(P<0.05).Conclusion The sinew-regulating bone-setting manipulations can reduce the levels of IL-1β,NO,and chondrocyte apoptosis rate,and delay the articular cartilage degeneration,therefore,having a good therapeutic effect on KOA.展开更多
文摘Objective:To evaluate the clinical efficacy of sinew-regulating bone-setting manipulations plus exercise therapy in treating chronic non-specific low back pain(CNLBP).Methods:A total of 65 CNLBP patients were divided into two groups by the random number table method.Thirty-three cases in the treatment group were intervened by sinew-regulating bone-setting manipulations plus exercise therapy;32 cases in the control group were intervened by medium-frequency electrotherapy plus exercise therapy.Before and after treatment,visual analog scale(VAS),dynamic and static muscle endurance of low back,median frequency(MF)of surface electromyography(sEMG)and Oswestry disability index(ODI)were used to evaluate the low back function.The therapeutic efficacy was estimated after treatment.Results:The two groups each had 2 dropouts during the study.The total effective rate was 90.3%in the treatment group versus 66.7%in the control group,and the between-group difference was statistically significant(P<0.05).After treatment,the VAS score,dynamic and static muscle endurance of low back,MF of sEMG and ODI score all changed significantly in both groups(all P<0.05);all the items in the treatment group were significantly different from those in the control group(all P<0.05).Conclusion:Sinew-regulating bone-setting manipulations plus exercise therapy can effectively release pain in CNLBP patients,increase muscle endurance of the low back and improve the quality of life,and its therapeutic efficacy is more significant than that of medium-frequency electrotherapy plus exercise therapy.
文摘Objective To observe the therapeutic effect of sinew-regulating bone-setting manipulations for knee osteoarthritis(KOA)model rabbits and its impacts on the chondrocyte apoptosis rate and the levels of interleukin(IL)-1βand nitric oxide(NO).Methods According to the random number table method,30 New Zealand white rabbits were divided into a normal group(n=9)and a modeling group(n=21).Rabbits in the modeling group were used to establish KOA models with the modified Hulth method.At the 8th week,three rabbits were sacrificed to verify the model and the remaining 18 rabbits were randomly divided into a model group(n=9)and an intervention group(n=9).Rabbits in the normal group and model group were bred routinely without any intervention.Rabbits in the intervention group were treated with the sinew-regulating bone-setting manipulations,10 min/time,once every other day for a total of 20 times.The Lequesne MG knee function rating was used to evaluate the behavioral differences of the rabbits in each group.The Pelletier score was used to evaluate the general changes of the rabbits.The Mankin score was used to evaluate the pathology of knee cartilages.The enzyme-linked immunosorbent assay and nitrate reductase methods were used to determine the levels of IL-1βand NO in serum and synovial fluid of each group,respectively.In situ terminal deoxynucleotidyl transferase-mediated nick and labeling method was used to determine the apoptosis of chondrocytes in each group.Results Compared with the normal group,the scores of Lequesne MG,Pelletier and Mankin,and the levels of IL-1βand NO in the model group were increased(P<0.05),which indirectly indicated the success of the model.Compared with the model group,the scores of Lequesne MG,Pelletier and Mankin,IL-1βand NO levels,and chondrocyte apoptosis rate of the intervention group were decreased,and the differences were statistically significant(P<0.05).Conclusion The sinew-regulating bone-setting manipulations can reduce the levels of IL-1β,NO,and chondrocyte apoptosis rate,and delay the articular cartilage degeneration,therefore,having a good therapeutic effect on KOA.
