AIM： To investigate the mechanisms of sulfasalazine （SASP） in the treatment of ulcerative colitis （UC）.METHODS： Changes of pathological signs and histological grading of 106 patients with active UC were observed...AIM： To investigate the mechanisms of sulfasalazine （SASP） in the treatment of ulcerative colitis （UC）.METHODS： Changes of pathological signs and histological grading of 106 patients with active UC were observed before and after the treatment with SASP, 1 g, thrice daily for 6 wk.RESULTS： The effect of SASP on the vasculitis in lamina propria was 48.2% and 17.4% in the mild active UC （P〈0.001） and 68% and 26.7% in the moderate active UC （P〈0.001） before and after treatment, Fibroid necrosis of vessel wail was found in one case of mild UC and two cases of moderate UC before treatment and was not found after treatment, No thrombosis was found in mild UC before and after treatment, while thrombosis was found in one case of moderate UC before treatment, The effect on mucosal glandular abnormality was 30.4% and 13.0% in mild UC （P〈0.05）, and 42% and 40% in moderate UC （P〉0.05） before and after treatment, The rate of eosinophil infiltration was 98.2% and 80,4% in mild UC （P〈0.01）,and 100% and 91,1% in moderate UC （P〈0.05） before and after treatment, The effect on crypt abscess was 21.4% and 4.4% in mild UC （P〈0.05）, and 48% and 13.3% in moderate UC （P〈0.001） before and after treatment. The effect on mucosal pathohistological grading was 2.00±0.84 and 0.91±0.46 in mild UC （P〈0.001）, and 2.49±0.84 and 1.31±0.75 in moderate UC （P〈0.001） before and after treatment.CONCLUSION： SASP can improve small vessel lesions and crypt abscesses and reduce neutrophilic and eosinophilic leukocyte infiltration in inflammatory mucosa of UC.展开更多
A new compound, 3S-hydroxy-7 melleine was isolated from the endophytic fungus Xylariasp No.2508 from the mangrove tree on the South China Sea coast. It was the first time that this kind of compound was isolated from m...A new compound, 3S-hydroxy-7 melleine was isolated from the endophytic fungus Xylariasp No.2508 from the mangrove tree on the South China Sea coast. It was the first time that this kind of compound was isolated from marine fungus. The structure was elucidated by NMR data, infrared spectrum （IR） and mass spectrometry （MS）. In addition, its structure was determined by the single-crystal X-ray diffraction analysis. It crystallized in monoclinic, space group P21 with a=10.8884（19） A, b=7.2284（13） A, c=13.398（2） A,β=104.217（3）°, C10H10O4·H2O, Mr=212.20, V=1022.2（3） A^3, Z=4, Dc=1.379 mg/m^3, F（000）=448, μ=0.112 mm^-1, the final R=0.0498, wR=0.101 for 2407 observed reflections （I〉2σ（I））. The molecular backbone of the compound includes a benzopyran ring. By comparing with the melting point and the optical rotation of the known 3R-hydroxy-7 melleine in literature, the absolute configuration of the compound was determined as 3S. It didn＇t exhibit antibacterial activity against Gram-positive bacterium Staphylococcus aureus at 200 μg/disk in the preliminary test.展开更多
文摘AIM： To investigate the mechanisms of sulfasalazine （SASP） in the treatment of ulcerative colitis （UC）.METHODS： Changes of pathological signs and histological grading of 106 patients with active UC were observed before and after the treatment with SASP, 1 g, thrice daily for 6 wk.RESULTS： The effect of SASP on the vasculitis in lamina propria was 48.2% and 17.4% in the mild active UC （P〈0.001） and 68% and 26.7% in the moderate active UC （P〈0.001） before and after treatment, Fibroid necrosis of vessel wail was found in one case of mild UC and two cases of moderate UC before treatment and was not found after treatment, No thrombosis was found in mild UC before and after treatment, while thrombosis was found in one case of moderate UC before treatment, The effect on mucosal glandular abnormality was 30.4% and 13.0% in mild UC （P〈0.05）, and 42% and 40% in moderate UC （P〉0.05） before and after treatment, The rate of eosinophil infiltration was 98.2% and 80,4% in mild UC （P〈0.01）,and 100% and 91,1% in moderate UC （P〈0.05） before and after treatment, The effect on crypt abscess was 21.4% and 4.4% in mild UC （P〈0.05）, and 48% and 13.3% in moderate UC （P〈0.001） before and after treatment. The effect on mucosal pathohistological grading was 2.00±0.84 and 0.91±0.46 in mild UC （P〈0.001）, and 2.49±0.84 and 1.31±0.75 in moderate UC （P〈0.001） before and after treatment.CONCLUSION： SASP can improve small vessel lesions and crypt abscesses and reduce neutrophilic and eosinophilic leukocyte infiltration in inflammatory mucosa of UC.
文摘A new compound, 3S-hydroxy-7 melleine was isolated from the endophytic fungus Xylariasp No.2508 from the mangrove tree on the South China Sea coast. It was the first time that this kind of compound was isolated from marine fungus. The structure was elucidated by NMR data, infrared spectrum （IR） and mass spectrometry （MS）. In addition, its structure was determined by the single-crystal X-ray diffraction analysis. It crystallized in monoclinic, space group P21 with a=10.8884（19） A, b=7.2284（13） A, c=13.398（2） A,β=104.217（3）°, C10H10O4·H2O, Mr=212.20, V=1022.2（3） A^3, Z=4, Dc=1.379 mg/m^3, F（000）=448, μ=0.112 mm^-1, the final R=0.0498, wR=0.101 for 2407 observed reflections （I〉2σ（I））. The molecular backbone of the compound includes a benzopyran ring. By comparing with the melting point and the optical rotation of the known 3R-hydroxy-7 melleine in literature, the absolute configuration of the compound was determined as 3S. It didn＇t exhibit antibacterial activity against Gram-positive bacterium Staphylococcus aureus at 200 μg/disk in the preliminary test.
