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陕北地区中深层同轴地埋管取热性能影响因素分析及优化 被引量:1
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作者 邹海江 李永鹏 +4 位作者 张林 惠鹏 刘厚宁 申芳 王沣浩 《煤田地质与勘探》 EI CAS CSCD 北大核心 2024年第1期152-158,共7页
中深层同轴地埋管地热供热技术在我国北方城镇供热领域兴起并广泛应用。陕北地区地热资源丰富,但地温梯度略低且岩土热物性参数特性不同,地质参数影响中深层同轴地埋管的取热性能。采用OpenGeoSys开源数值模拟平台建立三维中深层同轴地... 中深层同轴地埋管地热供热技术在我国北方城镇供热领域兴起并广泛应用。陕北地区地热资源丰富,但地温梯度略低且岩土热物性参数特性不同,地质参数影响中深层同轴地埋管的取热性能。采用OpenGeoSys开源数值模拟平台建立三维中深层同轴地埋管耦合地层传热计算模型,并基于陕北地区典型地质参数,研究不同设计参数对中深层同轴地埋管取热性能的影响及全生命周期技术经济性,优选出地热工程最佳工艺参数。结果表明,中深层同轴地埋管的外管径与埋深增大均能提升取热能力。相较于外管径,埋深对取热能力的提升效果更为显著,埋深从2 500 m增加到3 500 m,取热量增加了77.3%。依据工程实践,当外管外径×厚度大于177.80 mm×9.19 mm时所对应的平均能源成本因其钻井成本陡增而增大。在给定工况参数下,推荐中深层同轴地埋管的最佳外管外径×厚度为177.80 mm×9.19 mm,埋深为3 200 m,此时平均能源成本为0.524元/(kW·h),经济效益最优。 展开更多
关键词 中深层 同轴地埋管 取热性能 数值模拟 经济性 埋深 管径 OPENGEOSYS
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PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging
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作者 Lingqi Xie Yalun Cheng +6 位作者 Biao Hu Xin Chen Yuze An Zhuying Xia Guangping Cai Changjun Li hui peng 《Bone Research》 SCIE CAS CSCD 2024年第3期595-610,共16页
Bone marrow adipocytes(BMAds)affect bone homeostasis,but the mechanism remains unclear.Here,we showed that exercise inhibited PCNA clamp-associated factor(PCLAF)secretion from the bone marrow macrophages to inhibit BM... Bone marrow adipocytes(BMAds)affect bone homeostasis,but the mechanism remains unclear.Here,we showed that exercise inhibited PCNA clamp-associated factor(PCLAF)secretion from the bone marrow macrophages to inhibit BMAds senescence and thus alleviated skeletal aging. 展开更多
关键词 SKELETAL inhibited HOMEOSTASIS
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Multi-Level Parallel Network for Brain Tumor Segmentation
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作者 Juhong Tie hui peng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第4期741-757,共17页
Accurate automatic segmentation of gliomas in various sub-regions,including peritumoral edema,necrotic core,and enhancing and non-enhancing tumor core from 3D multimodal MRI images,is challenging because of its highly... Accurate automatic segmentation of gliomas in various sub-regions,including peritumoral edema,necrotic core,and enhancing and non-enhancing tumor core from 3D multimodal MRI images,is challenging because of its highly heterogeneous appearance and shape.Deep convolution neural networks(CNNs)have recently improved glioma segmentation performance.However,extensive down-sampling such as pooling or stridden convolution in CNNs significantly decreases the initial image resolution,resulting in the loss of accurate spatial and object parts information,especially information on the small sub-region tumors,affecting segmentation performance.Hence,this paper proposes a novel multi-level parallel network comprising three different level parallel subnetworks to fully use low-level,mid-level,and high-level information and improve the performance of brain tumor segmentation.We also introduce the Combo loss function to address input class imbalance and false positives and negatives imbalance in deep learning.The proposed method is trained and validated on the BraTS 2020 training and validation dataset.On the validation dataset,ourmethod achieved a mean Dice score of 0.907,0.830,and 0.787 for the whole tumor,tumor core,and enhancing tumor core,respectively.Compared with state-of-the-art methods,the multi-level parallel network has achieved competitive results on the validation dataset. 展开更多
关键词 Convolution neural network brain tumor segmentation parallel network
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Will partial splenic embolization followed by splenectomy increase intraoperative bleeding?
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作者 Long Huang Qing-Lin Li +4 位作者 Qing-Sheng Yu hui peng Zhou Zhen Yi Shen Qi Zhang 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第2期318-330,共13页
BACKGROUND Partial splenic embolization(PSE)has been suggested as an alternative to splenectomy in the treatment of hypersplenism.However,some patients may experience recurrence of hypersplenism after PSE and require ... BACKGROUND Partial splenic embolization(PSE)has been suggested as an alternative to splenectomy in the treatment of hypersplenism.However,some patients may experience recurrence of hypersplenism after PSE and require splenectomy.Currently,there is a lack of evidence-based medical support regarding whether preoperative PSE followed by splenectomy can reduce the incidence of complications.AIM To investigate the safety and therapeutic efficacy of preoperative PSE followed by splenectomy in patients with cirrhosis and hypersplenism.METHODS Between January 2010 and December 2021,321 consecutive patients with cirrhosis and hypersplenism underwent splenectomy at our department.Based on whether PSE was performed prior to splenectomy,the patients were divided into two groups:PSE group(n=40)and non-PSE group(n=281).Patient characteristics,postoperative complications,and follow-up data were compared between groups.Propensity score matching(PSM)was conducted,and univariable and multivariable analyses were used to establish a nomogram predictive model for intraoperative bleeding(IB).The receiver operating characteristic curve,Hosmer-Lemeshow goodness-of-fit test,and decision curve analysis(DCA)were employed to evaluate the differentiation,calibration,and clinical performance of the model.RESULTS After PSM,the non-PSE group showed significant reductions in hospital stay,intraoperative blood loss,and operation time(all P=0.00).Multivariate analysis revealed that spleen length,portal vein diameter,splenic vein diameter,and history of PSE were independent predictive factors for IB.A nomogram predictive model of IB was constructed,and DCA demonstrated the clinical utility of this model.Both groups exhibited similar results in terms of overall survival during the follow-up period.CONCLUSION Preoperative PSE followed by splenectomy may increase the incidence of IB and a nomogram-based prediction model can predict the occurrence of IB. 展开更多
关键词 Partial splenic embolization SPLENECTOMY Hypertension Portal Liver Cirrhosis Intraoperative bleeding
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Extramedullary plasmacytoma with the uvula as first affected site:A case report
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作者 Jing Yang hui peng +2 位作者 Sheng-Ke Tu Min Li Kui Song 《World Journal of Clinical Oncology》 2025年第1期53-58,共6页
BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the body.The majority of EMP cases are predomina... BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the body.The majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal tract.While there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly uncommon.Furthermore,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of cancers.In this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected site.This case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment outcomes.In addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar situations.CASE SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the neck.The soft tissue mass was diagnosed as plasmacytoma by immunohistochemical analysis.Monoclonal immunoglobulins and bone marrow biopsy showed normal results.Therefore,we diagnosed that as EMP of the uvula.After four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass in the oropharynx and the cervical lymph nodes.Afterwards,the λ light chain returned to normal levels.There was no evidence of evolution to multiple myeloma.CONCLUSION We have reported a rare case of extramedullary plasmacytoma with the uvula as the first affected site and the relevant literature is reviewed to improve clinicians'awareness of such rare comorbidities. 展开更多
关键词 Extramedullary plasmacytoma PLASMACYTOMA UVULA Multiple myeloma Case report
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针状刀开窗术在急性梗阻化脓性胆管炎患者中的应用效果
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作者 张小宾 焦振东 +2 位作者 赵少琪 惠鹏 金上博 《临床医学研究与实践》 2024年第24期62-65,共4页
目的比较针状刀开窗术与弓状刀预切开术在内镜逆行性胰胆管造影术(ERCP)治疗急性梗阻化脓性胆管炎(AOSC)患者的临床效果。方法回顾性分析2016年12月至2021年12月宝鸡市人民医院肝胆胰脾外科收治的42例AOSC行ERCP遭遇困难插管患者的临床... 目的比较针状刀开窗术与弓状刀预切开术在内镜逆行性胰胆管造影术(ERCP)治疗急性梗阻化脓性胆管炎(AOSC)患者的临床效果。方法回顾性分析2016年12月至2021年12月宝鸡市人民医院肝胆胰脾外科收治的42例AOSC行ERCP遭遇困难插管患者的临床资料,将18例行针状刀开窗术患者纳入针状刀组,24例行弓状刀预切开术患者纳入弓状刀组。比较两组的术中相关指标(插管成功率、插管时间、手术时间)、临床相关指标(治疗费用、住院天数)、术后并发症发生情况。结果AOSC患者插管总成功率为92.86%。两组的插管成功率比较,差异无统计学意义(P>0.05);针状刀组的插管时间、手术时间短于弓状刀组,差异具有统计学意义(P<0.05)。针状刀组的治疗费用少于弓状刀组,差异具有统计学意义(P<0.05);针状刀组的住院天数虽短于弓状刀组,但差异无统计学意义(P>0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。结论针状刀开窗术在AOSC行ERCP遭遇困难插管患者中的应用效果显著,值得推广。 展开更多
关键词 急性梗阻化脓性胆管炎 内镜逆行性胰胆管造影术 针状刀开窗术 弓状刀预切开术 困难插管 十二指肠乳头括约肌预切开术
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多元逐步回归分析法在煤层含气量预测中的应用——以胡家河井田4号煤层为例
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作者 惠鹏 郭燕珩 陈小军 《中国煤层气》 CAS 2024年第3期33-37,共5页
煤层含气量是煤层气选区评价的重要指标,也是煤层气储量计算的重要参数。本文以胡家河井田4号煤层为例,依据井田煤层气井钻孔测试资料,通过进行单因素分析从诸多影响含气量因素中筛选出主控因素,优选运用多元逐步回归法结合主控因素建立... 煤层含气量是煤层气选区评价的重要指标,也是煤层气储量计算的重要参数。本文以胡家河井田4号煤层为例,依据井田煤层气井钻孔测试资料,通过进行单因素分析从诸多影响含气量因素中筛选出主控因素,优选运用多元逐步回归法结合主控因素建立了4号煤层含气量的预测模型,结果表明,胡家河4号煤层含气量主导收到煤层埋深和煤层厚度的影响,经计算其预测值与实测值基本相符,为研究区煤层气资源评价和开发选区提供了重要的指导。 展开更多
关键词 煤层含气量 单因素分析 多元逐步回归分析 预测模型 胡家河井田
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宣肺利气法针刺联合经空肠营养管中药泵入在腹腔镜胰十二指肠切除术加速康复外科中的应用
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作者 惠鹏 焦振东 金上博 《中医肿瘤学杂志》 2024年第1期31-36,共6页
目的宣肺利气法针刺联合经空肠营养管中药泵入在腹腔镜胰十二指肠切除术加速康复外科中的应用。方法回顾性分析宝鸡市人民医院肝胆外科2018年12月至2022年12月完全腹腔镜下胰十二指肠切除术62例,其中32例围手术期应用加速康复外科策略,... 目的宣肺利气法针刺联合经空肠营养管中药泵入在腹腔镜胰十二指肠切除术加速康复外科中的应用。方法回顾性分析宝鸡市人民医院肝胆外科2018年12月至2022年12月完全腹腔镜下胰十二指肠切除术62例,其中32例围手术期应用加速康复外科策略,并应用宣肺利气法针刺联合经空肠营养管中药泵入治疗,对照组30例使用加速康复外科策略。比较两组患者术后住院天数,术后并发症发生率,治疗总费用,术后肛门首次排气时间,术后下床活动时间,术后24小时应激与炎性反应指标。结果两组均成功完成LPD,两组一般资料差异无统计学意义(P>0.05),观察组在术后住院天数,术后并发症发生率,治疗总费用,术后肛门首次排气时间,术后下床活动时间,术后应激与炎性反应指标均明显优于对照组(P<0.05),其手术时间及术中出血量无差异(P>0.05)。结论宣肺利气法针刺联合经空肠营养管中药泵入可明显促进腹腔镜胰十二指肠切除术后患者恢复。 展开更多
关键词 加速康复外科 腹腔镜胰十二指肠切除术 应激与炎性反应 术后并发症
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中低煤阶镜煤/暗煤大分子结构及对甲烷吸附的影响 被引量:3
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作者 惠鹏 马东民 +6 位作者 陈跃 王丽雅 李卫波 滕金祥 李国富 杨甫 郑超 《煤炭转化》 CAS CSCD 北大核心 2023年第3期25-38,共14页
为研究中低阶煤不同宏观煤岩组分微观结构及对甲烷吸附的影响,采集黄陇煤田郭家河、大佛寺、园子沟及黄陵矿区的四种不同煤样,手工剥离不同宏观煤岩成分(镜煤和暗煤),通过傅立叶红外光谱(FTIR)分析、X射线衍射(XRD)分析和等温吸附实验... 为研究中低阶煤不同宏观煤岩组分微观结构及对甲烷吸附的影响,采集黄陇煤田郭家河、大佛寺、园子沟及黄陵矿区的四种不同煤样,手工剥离不同宏观煤岩成分(镜煤和暗煤),通过傅立叶红外光谱(FTIR)分析、X射线衍射(XRD)分析和等温吸附实验探究中低阶煤分子结构特征及其对甲烷吸附能力的影响。结果表明:同一煤样中镜煤的水分和挥发分产率高于暗煤的水分和挥发分产率,而暗煤的灰分产率和固定碳含量高于镜煤的灰分产率和固定碳含量。镜煤的显微组分中镜质组含量较大、惰质组含量较低,暗煤则相反。红外光谱分析结果表明,同一煤层的镜煤和暗煤红外光谱吸收峰形态相似,官能团类型和含量接近。煤分子结构中主要含氧官能团按含量由高到低依次为C—O,COOH,C=O,脂肪侧链按含量由高到低依次为CH_(2),CH_(3),CH。对比煤的准晶体结构发现,中低阶煤煤化程度低,γ带的峰面积整体较大。受煤化作用和压实作用影响,暗煤的堆砌度和堆砌层数大于镜煤的堆砌度和堆砌层数。分子结构特征对甲烷吸附量的影响显著。镜煤的最大甲烷吸附量与芳碳率和缩合度均呈正相关,暗煤的最大甲烷吸附量与芳碳率和缩合度均呈负相关。镜煤和暗煤的最大甲烷吸附量随羟基相对含量增加而减小,碳氧双键(羰基和羧基)相对含量对甲烷吸附量的影响有限。 展开更多
关键词 黄陇煤田 镜煤/暗煤 分子结构 准晶体结构 吸附能力
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挠率对自旋粒子的作用
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作者 惠鹏 薛迅 《华东师范大学学报(自然科学版)》 CAS CSCD 北大核心 2023年第4期164-176,共13页
有挠引力理论表明挠率–自旋耦合会影响自旋粒子在挠率场中的传播.根据有挠弯曲时空中挠率耦合的狄拉克(Dirac)作用量,将几何–流体动力学方法,从闵氏度规的黎曼(Riemann)平时空推广到宇宙学时空的情形,得到了描述在宇宙学Robertson-Wal... 有挠引力理论表明挠率–自旋耦合会影响自旋粒子在挠率场中的传播.根据有挠弯曲时空中挠率耦合的狄拉克(Dirac)作用量,将几何–流体动力学方法,从闵氏度规的黎曼(Riemann)平时空推广到宇宙学时空的情形,得到了描述在宇宙学Robertson-Walker度规和挠率背景场中,运动的自旋1/2粒子行为的半经典流守恒方程、动力学方程、自旋演化方程,以及挠率–自旋作用一般会使自旋粒子在时空中的传播路径偏离测地线;对确定宇宙学挠率时空中自旋粒子的传播,求出了其运动方程的解;发现挠率使自旋粒子绕无挠情形的传播路径做螺旋进动,这可以用来检验建立在有挠引力基础上的宇宙学模型. 展开更多
关键词 自旋挠率耦合 矢量挠率 轴矢量挠率 几何–流体动力学
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Comprehensive analysis of distal-less homeobox family gene expression in colon cancer 被引量:1
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作者 Yong-Cheng Chen Dong-Bing Li +1 位作者 Dong-Liang Wang hui peng 《World Journal of Gastrointestinal Oncology》 SCIE 2023年第6期1019-1035,共17页
BACKGROUND The distal-less homeobox(DLX)gene family plays an important role in the development of several tumors.However,the expression pattern,prognostic and diagnostic value,possible regulatory mechanisms,and the re... BACKGROUND The distal-less homeobox(DLX)gene family plays an important role in the development of several tumors.However,the expression pattern,prognostic and diagnostic value,possible regulatory mechanisms,and the relationship between DLX family genes and immune infiltration in colon cancer have not been systematically reported.AIM We aimed to comprehensively analyze the biological role of the DLX gene family in the pathogenesis of colon cancer.METHODS Colon cancer tissue and normal colon tissue samples were collected from the Cancer Genome Atlas and Gene Expression Omnibus databases.Wilcoxon rank sum test and t-test were used to assess DLX gene family expression between colon cancer tissue and unpaired normal colon tissue.cBioPortal was used to analyze DLX gene family variants.R software was used to analyze DLX gene expression in colon cancer and the relationship between DLX gene family expression and clinical features and correlation heat map.The survival package and Cox regression module were used to assess the prognostic value of the DLX gene family.The pROC package was used to analyze the diagnostic value of the DLX gene family.R software was used to analyze the possible regulatory mechanisms of DLX gene family members and related genes.The GSVA package was used to analyze the relationship between the DLX gene family and immune infiltration.The ggplot2,the survminer package,and the clusterProfiler package were used for visualization.RESULTS DLX1/2/3/4/5 were significantly aberrantly expressed in colon cancer patients.The expression of DLX genes were associated with M stage,pathologic stage,primary therapy outcome,residual tumor,lymphatic invasion,T stage,N stage,age,perineural invasion,and history of colon polyps.DLX5 was independently correlated with the prognosis of colon cancer in multivariate analysis.DLX1/2/3/4/5/6 were involved in the development and progression of colon cancer by participating in immune infiltration and associated pathways,including the Hippo signaling pathway,the Wnt signaling pathway,several signaling pathways regulating the pluripotency of stem cells,and Staphylococcus aureus infection.CONCLUSION The results of this study suggest a possible role for the DLX gene family as potential diagnostic or prognostic biomarkers and therapeutic targets in colon cancer. 展开更多
关键词 Colon cancer The Cancer Genome Atlas Distal-less homeobox genes Prognosis Immune infiltration
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胆道支架和鼻胆管引流在腹腔镜胆总管探查术后一期缝合中的应用 被引量:1
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作者 惠鹏 张小宾 +1 位作者 焦振东 金上博 《中国内镜杂志》 2023年第8期33-39,共7页
目的对比胆道支架和鼻胆管引流在腹腔镜胆总管探查术(LCBDE)后一期缝合中的临床疗效。方法回顾性分析2016年8月-2021年1月在该院行内镜逆行胰胆管造影术(ERCP)取石失败的74例患者的临床资料,分为支架引流组(n=38)和鼻胆管引流组(n=36)... 目的对比胆道支架和鼻胆管引流在腹腔镜胆总管探查术(LCBDE)后一期缝合中的临床疗效。方法回顾性分析2016年8月-2021年1月在该院行内镜逆行胰胆管造影术(ERCP)取石失败的74例患者的临床资料,分为支架引流组(n=38)和鼻胆管引流组(n=36)。支架引流组ERCP取石失败后放置胆道支架引流,鼻胆管引流组ERCP取石失败后放置鼻胆管引流,两组患者均行腹腔镜胆总管切开取石一期缝合术。比较两组患者手术时间、术后住院时间、术后并发症发生率、术后肠道功能恢复时间、术后胆总管结石复发率和住院时间。结果两组患者胆管缝合方式、手术时间、术中出血量、术后并发症总发生率和住院费用比较,差异均无统计学意义(P>0.05)。鼻胆管引流组术后胆瘘发生率明显低于支架引流组,住院时间明显短于支架引流组,术后肠道功能恢复时间明显长于支架引流组,术后总补液量多于支架引流组,差异均有统计学意义(P<0.05)。结论ERCP取石失败后放置鼻胆管引流,可降低LCBDE术后一期缝合的胆瘘发生率,缩短住院时间,但放置胆道支架引流患者肠道功能恢复更快,补液量更少。因此,在临床操作中,应根据患者具体情况,选择相应的个体化引流方式。 展开更多
关键词 鼻胆管引流 胆道内支架引流 腹腔镜胆总管探查术 胆总管一期缝合
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数字技术与中小制造企业绩效:信息共享的中介作用 被引量:1
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作者 张善亮 惠朋 李晔 《科学与管理》 2023年第3期21-30,共10页
数字技术赋能已成为我国中小制造企业高质量发展的重要选项,从数字技术赋能视角,构建了“数字技术-信息共享-绩效提升”的理论模型,基于210家中小制造企业的数字化调查问卷,采用回归分析方法验证研究假设。结果表明:数字技术对中小制造... 数字技术赋能已成为我国中小制造企业高质量发展的重要选项,从数字技术赋能视角,构建了“数字技术-信息共享-绩效提升”的理论模型,基于210家中小制造企业的数字化调查问卷,采用回归分析方法验证研究假设。结果表明:数字技术对中小制造企业绩效提升有显著正向影响,信息共享在数字技术与中小制造企业绩效之间起积极中介作用,并且数字技术与中小制造企业绩效关系还受到数字化政策感知的正向调节作用。结论丰富了数据作为生产要素方面的研究,也可为中小企业成长提供理论参考。 展开更多
关键词 数字技术 中小制造企业 企业绩效 信息共享 数字化政策感知
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Classification of Principal Wood Species in China Based on the Physiomechanical Properties
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作者 Jianyi Zhu hui peng +2 位作者 Xiaoning Lu Jianxiong Lyu Tianyi Zhan 《Journal of Renewable Materials》 SCIE EI 2023年第3期1425-1437,共13页
Many tree species are planted in China with variable properties and usage.Toward exploring the structure-properties relationships of wood and classifying the species more reasonably,the physiomechanical properties of ... Many tree species are planted in China with variable properties and usage.Toward exploring the structure-properties relationships of wood and classifying the species more reasonably,the physiomechanical properties of the domestic wood species in China were analyzed statistically.According to the correlation analysis,the mechanical properties were closely related to the wood density.Except impact toughness and cleavage strength,the correlation coefficients between mechanical properties and densities were more than 0.8.However,shrinkage properties showed fewer correlations with densities,and the coefficient was no more than 0.7.Primary component analysis was proved to be feasible to explore the information of the physiomechanical properties.Two principal components(PC1 and PC2)could account for most of the information.PC1 and PC2 were designated as density-dominated and shrinkage-associated factors,respectively.The domestic wood species in China could be classified into 4 clusters based on their physiomechanical properties.According to the cluster results,reasonable grading was proposed for air-dried density,volume shrinkage,modulus of rupture,compression strength parallel to grain and hardness in cross section.The statistical results brought insights into analyzing the physiomechanical properties of domestic Chinese wood species,which was helpful for developing strategies of tree breeding and technologies of wood processing. 展开更多
关键词 Chinese wood species physiomechanical properties primary component analysis cluster analysis GRADING
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Hidrotic ectodermal dysplasia in a Chinese pedigree:A case report
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作者 Ming-Yi Liao hui peng +3 位作者 Long-Nian Li Tao Yang Shi-Yin Xiong Xiao-Ying Ye 《World Journal of Clinical Cases》 SCIE 2023年第6期1403-1409,共7页
BACKGROUND We report on a large family of Chinese Han individuals with hidrotic ectodermal dysplasia(HED)with a variation in GJB6(c.31G>A).The patients in the family had a triad of clinical manifestations of varyin... BACKGROUND We report on a large family of Chinese Han individuals with hidrotic ectodermal dysplasia(HED)with a variation in GJB6(c.31G>A).The patients in the family had a triad of clinical manifestations of varying degrees.Although the same variation locus have been reported,the clinical manifestations of this family were difficult to distinguish from those of congenital thick nail disorder,palmoplantar keratosis,and congenital hypotrichosis.CASE SUMMARY This investigation involved a large Chinese family of 46 members across five generations and included 12 patients with HED.The proband(IV4)was a male patient with normal sweat gland function and dental development,no skeletal dysplasia,no cognitive disability,and no hearing impairments.His parents were not consanguineously married.Physical examination of the proband revealed thinning hair and thickened grayish-yellow nails and toenails with some longit-udinal ridges,in addition to mild bilateral palmoplantar hyperkeratosis.GJB6,GJB2,and GJA1 have been reported to be the causative genes of HED;therefore,we subjected the patient’s samples to Sanger sequencing of these three genes.In this family,the variation locus was at GJB6(c.31G>A,p.Gly11Arg).Overex-pression vectors of wild-type GJB6 and its variants were established and transfected into HaCaT cell models,and the related mRNA and protein expression changes were determined using real-time reverse transcriptase-polymerase chain reaction and Western blot,respectively.CONCLUSION We report another HED phenotype associated with GJB6 variations,which can help clinicians to diagnose HED despite its varying presentations. 展开更多
关键词 Hidrotic ectodermal dysplasia GJB6 CONNEXIN Gene sequencing Cell transfection Case report
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催眠治疗改善癌症患者疼痛的临床研究和问卷调查 被引量:3
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作者 彭慧 郭秋云 +3 位作者 戴宇翃 庄亮 邱红 于世英 《中国肿瘤临床》 CAS CSCD 北大核心 2022年第9期455-459,共5页
目的:研究催眠疗法治疗癌痛的有效性,了解医护人员和患者对催眠疗法治疗癌痛临床应用的认知与需求。方法:回顾性选取2020年1月至2020年12月于华中科技大学同济医学院附属同济医院招募罹患癌症且伴有疼痛的患者120例,进行8周的认知催眠... 目的:研究催眠疗法治疗癌痛的有效性,了解医护人员和患者对催眠疗法治疗癌痛临床应用的认知与需求。方法:回顾性选取2020年1月至2020年12月于华中科技大学同济医学院附属同济医院招募罹患癌症且伴有疼痛的患者120例,进行8周的认知催眠治疗。比较癌痛患者接受催眠治疗2、4、8周后疼痛数字评分(NRS)、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分及睡眠量表(MOS-SS)评分的变化;设计《催眠疗法治疗癌痛认知与需求调查问卷》,对2020年6月至2020年9月住院的354例癌痛患者和301名肿瘤科医护人员展开调查。结果:120例癌痛患者参与了催眠治疗并完成了2周的评估,109例(90.8%)完成8周的治疗评估。催眠治疗2、4、8周后,NRS评分显著下降(P<0.05);催眠治疗4、8周后,HAMA、HAMD评分显著下降(P<0.05),MOS-SS评分显著升高(P<0.05)。84.1%的医护人员认为有必要常规开展认知催眠治疗;64.4%的癌痛患者能接受催眠治疗。结论:催眠疗法可以减轻癌痛,同时降低癌痛患者的焦虑、抑郁情绪,改善患者睡眠状况;加强医护人员和患者的宣传教育对催眠疗法的临床应用具有重要意义。 展开更多
关键词 催眠 癌症疼痛 有效性 临床应用
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糖尿病分型的免疫遗传学标志物 被引量:1
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作者 李霞 hui peng +1 位作者 周智广 William Hagopian 《中国糖尿病杂志》 CAS CSCD 北大核心 2006年第4期301-302,共2页
关键词 糖尿病 免疫学 遗传学
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锂离子电池高镍三元正极材料LiNi1-x-yCoxMnyO2的改性研究进展 被引量:2
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作者 邓七九 田聪聪 +4 位作者 凤帅帅 惠鹏 燕映霖 杨蓉 许云华 《电源学报》 CSCD 北大核心 2019年第5期153-161,共9页
新能源产业的快速发展对储能材料与器件的综合性能提出了更高的要求。锂离子电池正极材料,尤其是高镍三元材料(LiNi1-x-yCoxMnyO2)具有高能量密度、高工作电压及优异的化学稳定性等特点,因而被认为是下一代动力电池商业化正极材料的优... 新能源产业的快速发展对储能材料与器件的综合性能提出了更高的要求。锂离子电池正极材料,尤其是高镍三元材料(LiNi1-x-yCoxMnyO2)具有高能量密度、高工作电压及优异的化学稳定性等特点,因而被认为是下一代动力电池商业化正极材料的优越选择。系统总结了高镍三元材料LiNi1-x-yCoxMnyO2的优势并指出了其亟待解决的问题;在此基础上,综述了其各类改性方法,包括各类阴阳离子掺杂、表面包覆、浓度梯度材料设计以及石墨烯复合等方法;最后对其发展方向及商业化应用进行了展望。 展开更多
关键词 锂离子电池 正极材料 高镍三元材料 改性
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光引发点击化学接枝聚合制备多壁碳纳米管接枝聚(N-异丙基丙烯酰胺)及对聚偏氟乙烯超滤膜性能的影响 被引量:4
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作者 彭辉 杨海存 +2 位作者 马文中 刘春林 龚方红 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2021年第4期75-83,共9页
以紫外光引发的巯基-炔基绿色点击化学反应接枝聚合制备多壁碳纳米管接枝聚(N-异丙基丙烯酰胺)(MWCNTs-g-PNIPAM),通过改变接枝时间得到了不同接枝率的MWCNTs-g-PNIPAM,并通过非溶剂致相分离法(NIPS)制备了聚偏氟乙烯(PVDF)/MWCNTs-g-PN... 以紫外光引发的巯基-炔基绿色点击化学反应接枝聚合制备多壁碳纳米管接枝聚(N-异丙基丙烯酰胺)(MWCNTs-g-PNIPAM),通过改变接枝时间得到了不同接枝率的MWCNTs-g-PNIPAM,并通过非溶剂致相分离法(NIPS)制备了聚偏氟乙烯(PVDF)/MWCNTs-g-PNIPAM复合超滤膜。通过差示扫描量热分析和红外光谱、水接触角和水通量、场发射电子显微镜和机械拉伸试验研究了MWCNTs对PVDF超滤膜的结晶度和β相结晶含量、亲水性能、表面和断面形貌、拉伸强度和断裂伸长率的影响。结果表明,无金属催化剂的光引发点击化学在接枝时间为3 h时,PNIPAM的最大接枝率为9.76%,改善了碳纳米管与PVDF的界面结合力,使碳纳米管能够满足亲水性的同时还能在PVDF基体中良好分散。其中,β相结晶含量由纯PVDF膜的68.64%提升至95.32%,结晶度由46.30%提升至57.95%,拉伸强度与断裂伸长率分别由5.37 MPa和53.2%提升至7.85 MPa和54.32%,水接触角由95°降至69.75°,水通量由3.18 LMH提升至21.68 LMH。 展开更多
关键词 光引发 点击化学 聚偏氟乙烯超滤膜 碳纳米管 聚(N-异丙基丙烯酰胺)
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先天性颅底凹陷症的细化分型及临床分析(附139例报告) 被引量:4
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作者 邱军 高峰 +2 位作者 惠鹏 黄启平 范涛 《中国微侵袭神经外科杂志》 CAS 2019年第6期271-273,共3页
目的探讨先天性颅底凹陷症的细化分型及临床特征。方法回顾性分析139例行手术治疗的颅底凹陷症病人的临床资料,均行颈椎MRI、MRI-Cine及颅颈交界区三维CT重建检查,在Goel分型基础上根据是否合并脊髓空洞症将其进一步分为4型:BIa+0型31例... 目的探讨先天性颅底凹陷症的细化分型及临床特征。方法回顾性分析139例行手术治疗的颅底凹陷症病人的临床资料,均行颈椎MRI、MRI-Cine及颅颈交界区三维CT重建检查,在Goel分型基础上根据是否合并脊髓空洞症将其进一步分为4型:BIa+0型31例,BIa+S型45例,BIb+0型21例,BIb+S型42例。采用日本骨科协会(JOA)评分评价手术疗效。结果随访6~24个月,平均12个月。术后2周、1年JOA评分平均改善率分别为:BIa+0型30.78%、58.29%,BIa+S型35.09%、60.64%,BIb+0型36.57%、62.73%,BIb+S型31.92%、57.48%。4型病人中,术后2周、1年的JOA评分均较术前明显升高(P <0.01)。结论颈椎MRI、MRI-Cine及颅颈交界区三维CT重建检查可清晰显示颅颈交界区病变及解剖结构,细化分型可准确反映复杂先天性颅底凹陷症的临床特征,为手术创造良好条件,有很好的应用价值。 展开更多
关键词 颅底凹陷症 先天性 脊髓空洞症 寰齿间距
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