Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliograp...Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliographic database of Chinese medicine were searched by computer to collect randomized controlled trials of Urinary Kallidinogenase's treatment of acute cerebral infarction.The time limit was set up until September 2019.At the same time,the references and grey literature in the literature were manually screened.Two independent researchers were screened,evaluated and extracted according to inclusion and exclusion criteria.Meta-analysis was carried out by RevMan 5.3 software.Results:A total of 17 randomized controlled trials involving 2,066 patients,including 1,033 in the experimental group,and 1,033 in the control group.meta-analysis results showed that compared with the conventional treatment,Urinary Kallidinogenase had better effect in the treatment of acute cerebral infarction[OR=3.26,95%CI(2.56,4.16),P<0.00001];the national institule of Health Stroke Scale of the Urinary Kallidinogenase group was significantly better than that of the control group.Urinary Kallidinogenase group activity of daily living scale was better than the control group[OR=21.33,95%CI(6.64,36.01),P=0.004];a total of 7 articles reported adverse reactions,including 19 cases in the trial group and 21 cases in the control group,the main adverse reactions were blood pressure drop,other symptoms were chest tightness,facial redness,dizziness fever,nausea and vomiting,arrhythmia,and no other serious adverse reactions.It can recover itself.Conclusion:the available evidence shows that Urinary Kallidinogenase can effectively improve the symptoms of neurological deficits and improve the ability of daily living in patients with acute cerebral infarction,and is safe.However,the quality of the study is limited.展开更多
Mechanofluorochromic materials that render sensitive fluorescence color/pattern change upon mechanical stimuli have drawn extensive attention.However,traditional mechanofluorochromism relies on the chemical transforma...Mechanofluorochromic materials that render sensitive fluorescence color/pattern change upon mechanical stimuli have drawn extensive attention.However,traditional mechanofluorochromism relies on the chemical transformations of mechanophores,but their types are quite few.It remains challenging to develop mechanofluorochromic materials with customized fluorescence color changing response.Herein,a generally applicable strategy is proposed to present a class of double-layer mechanofluorochromic hydrogels based on the facile integration of two different-colored fluorescent hydrogels.Due to the UV transmittance change of top layer under Poisson’s effect,the emission intensity ratio of the upper and lower hydrogels exhibits a strain-dependent change,resulting in a force-triggered overlapping color variation.Both the UV transmittance of top layer and the fluorescence emission of bottom layer can be readily modulated to enrich the variety of mechanofluorochromism.Besides,the bottom layer is available to be printed by ion inks to fabricate patterned double-layer fluorescent hydrogel,holding great potential to design flexible mechanofluorochromic platforms for smart display and information encryption.展开更多
文摘Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliographic database of Chinese medicine were searched by computer to collect randomized controlled trials of Urinary Kallidinogenase's treatment of acute cerebral infarction.The time limit was set up until September 2019.At the same time,the references and grey literature in the literature were manually screened.Two independent researchers were screened,evaluated and extracted according to inclusion and exclusion criteria.Meta-analysis was carried out by RevMan 5.3 software.Results:A total of 17 randomized controlled trials involving 2,066 patients,including 1,033 in the experimental group,and 1,033 in the control group.meta-analysis results showed that compared with the conventional treatment,Urinary Kallidinogenase had better effect in the treatment of acute cerebral infarction[OR=3.26,95%CI(2.56,4.16),P<0.00001];the national institule of Health Stroke Scale of the Urinary Kallidinogenase group was significantly better than that of the control group.Urinary Kallidinogenase group activity of daily living scale was better than the control group[OR=21.33,95%CI(6.64,36.01),P=0.004];a total of 7 articles reported adverse reactions,including 19 cases in the trial group and 21 cases in the control group,the main adverse reactions were blood pressure drop,other symptoms were chest tightness,facial redness,dizziness fever,nausea and vomiting,arrhythmia,and no other serious adverse reactions.It can recover itself.Conclusion:the available evidence shows that Urinary Kallidinogenase can effectively improve the symptoms of neurological deficits and improve the ability of daily living in patients with acute cerebral infarction,and is safe.However,the quality of the study is limited.
基金the National Natural Science Foundation of China(No.52073297)Sino-German Mobility Program(No.M-0424)+2 种基金the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019297)Ningbo Natural Science Foundation(No.2021J194)K.C.Wong Education Foundation(No.GJTD-2019-13).
文摘Mechanofluorochromic materials that render sensitive fluorescence color/pattern change upon mechanical stimuli have drawn extensive attention.However,traditional mechanofluorochromism relies on the chemical transformations of mechanophores,but their types are quite few.It remains challenging to develop mechanofluorochromic materials with customized fluorescence color changing response.Herein,a generally applicable strategy is proposed to present a class of double-layer mechanofluorochromic hydrogels based on the facile integration of two different-colored fluorescent hydrogels.Due to the UV transmittance change of top layer under Poisson’s effect,the emission intensity ratio of the upper and lower hydrogels exhibits a strain-dependent change,resulting in a force-triggered overlapping color variation.Both the UV transmittance of top layer and the fluorescence emission of bottom layer can be readily modulated to enrich the variety of mechanofluorochromism.Besides,the bottom layer is available to be printed by ion inks to fabricate patterned double-layer fluorescent hydrogel,holding great potential to design flexible mechanofluorochromic platforms for smart display and information encryption.
