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Research status and hotspots of tight junctions and colorectal cancer:A bibliometric and visualization analysis
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作者 hui-min li Yin liu +5 位作者 Meng-Di Hao Xiao-Qing liang Da-Jin Yuan Wen-Bin Huang Wen-Jie li Lei Ding 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第8期3705-3715,共11页
BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related death.Over the past two decades,numerous researchers have provided important evidence regarding... BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related death.Over the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of CRC.The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed.Despite the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed.AIM To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research directions.METHODS We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023.We used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and references.Co-authorship,co-citation,and co-occurrence analyses were the main methods of analysis.CiteSpace and VOSviewer were used to visualize the results.RESULTS A total of 205 studies were ultimately identified.The number of publications on this topic has steadily increased since 2007.China and the United States have made the largest contributions to this field.Anticancer Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this field.Co-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this field.CONCLUSION This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between the two.It is recommended to focus on emerging research hotspots,such as the correlations among intestinal microbiota,inflammatory bowel disease,TJ protein expression,and CRC. 展开更多
关键词 Colorectal cancer Tight junctions Bibliometric analysis Research trends Hot spots
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Synthesis Methods and Property Control of Two-Dimensional Magnetic Materials
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作者 李明爽 李惠敏 刘松 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第2期112-121,共10页
Two-dimensional(2D)magnetic materials have been demonstrated to have excellent chemical,optical,electrical,and magnetic properties,particularly in the development of multifunctional electronic and spin electronic devi... Two-dimensional(2D)magnetic materials have been demonstrated to have excellent chemical,optical,electrical,and magnetic properties,particularly in the development of multifunctional electronic and spin electronic devices,showcasing tremendous potential.Therefore,corresponding synthesis techniques for 2D magnetic materials that offer high quality,high yield,low cost,time-saving,and simplicity are highly desired.This review provides a comprehensive overview of recent research advances in preparation of magnetic 2D materials,with a particular focus on the preparation methods employed.Moreover,the characteristics and applications of these magnetic materials are also discussed.Finally,the challenges and prospects of synthesis methods for magnetic 2D materials are briefly addressed.This review serves as a guiding reference for the controlled synthesis of 2D magnetic materials. 展开更多
关键词 SYNTHESIS PREPARATION SIMPLICITY
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The deformation and failure mechanism of cylindrical shell and square plate with pre-formed holes under blast loading
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作者 Wei li Peng Wang +3 位作者 Gao-peng Feng Yong-gang Lu Jun-zheng Yue hui-min li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第4期1143-1159,共17页
The deformation and failure mechanism of cylindrical shells and square plate with pre-formed holes under blast loading were investigated numerically by employing the Ansys 17.0 and Ls-Dyna 971.To calibrate the numeric... The deformation and failure mechanism of cylindrical shells and square plate with pre-formed holes under blast loading were investigated numerically by employing the Ansys 17.0 and Ls-Dyna 971.To calibrate the numerical model,the experiments of square plates with pre-formed circle holes were modeled and the numerical results have a good agreement with the experiment data.The calibrated numerical model was used to study the deformation and failure mechanism of cylindrical shells with pre-formed circle holes subjected to blast loading.The structure response and stress field changing process has been divided into four specific stages and the deformation mechanism has been discussed systematically.The local and global deformation curves,degree of damage,change of stress status and failure modes of cylindrical shell and square plate with pre-formed circular holes are obtained,compared and analyzed,it can be concluded as:(1)The transition of tensile stress fields is due to the geometrical characteristic of pre-formed holes and cylindrical shell with arch configuration;(2)The existence of preformed holes not only lead to the increasing of stress concentration around the holes,but also release the stress concentration during whole response process;(3)There are three and two kinds of failure modes for square plate and cylindrical shell with pre-formed holes,respectively.and the standoff distance has a key influence on the forming location of the crack initiating point and the locus of crack propagation;(4)The square plate with pre-formed holes has a better performance than cylindrical shell on blast-resistant capability at a smaller standoff distance,while the influence of pre-formed holes on the reduction of blast-resistant capability of square plate is bigger than that of cylindrical shell. 展开更多
关键词 Pre-formed holes Cylindrical shell and square plate Deformation mechanism Failure mechanism
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超宽禁带半导体NaYO_(2)的光电性质的第性原理研究 被引量:1
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作者 Nisar Muhammad M.U.Muzaffar +1 位作者 李会民 丁泽军 《Chinese Journal of Chemical Physics》 SCIE EI CAS CSCD 2023年第2期186-192,I0055,共8页
超宽禁带半导体在发展电子器件的性能方面具有巨大潜力.本文利用密度泛函理论和精确的屏蔽杂化泛函计算了两种不同相的NaYO_(2)的电子和光学性质.电子结构计算结果表明,NaYO_(2)的单斜相和三方相都表现为直接带隙,大小分别5.6 eV和5.4 ... 超宽禁带半导体在发展电子器件的性能方面具有巨大潜力.本文利用密度泛函理论和精确的屏蔽杂化泛函计算了两种不同相的NaYO_(2)的电子和光学性质.电子结构计算结果表明,NaYO_(2)的单斜相和三方相都表现为直接带隙,大小分别5.6 eV和5.4 eV,超越了公认的金刚石和GaN半导体材料,为半导体行业提供了一个物理上现实的材料平台.研究了NaYO_(2)两相的光学性质,发现它们在红外和可见光区都是透明的.因此,NaYO_(2)可被用作红外窗口材料. 展开更多
关键词 NaYO_(2) 第一性原理计算 电子结构 光学性质
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经肛门全直肠系膜切除术在中低位直肠癌中的疗效及安全性的系统评价和Meta分析 被引量:18
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作者 靳鹏辉 胡立冬 +4 位作者 李小飞 李惠民 刘文涵 郭天康 马云涛 《中国内镜杂志》 2019年第6期25-33,共9页
目的系统评价经肛门全直肠系膜切除术(TaTME)在低位直肠癌中的疗效及安全性。方法计算机检索各数据库The Cochrane Library、Pubmed、Embase、Web of Science、维普、万方、知网和中国生物医学文献数据库(CBM),收集所有关于对比TaTME与... 目的系统评价经肛门全直肠系膜切除术(TaTME)在低位直肠癌中的疗效及安全性。方法计算机检索各数据库The Cochrane Library、Pubmed、Embase、Web of Science、维普、万方、知网和中国生物医学文献数据库(CBM),收集所有关于对比TaTME与腹腔镜全直肠系膜切除术(LaTME)治疗中低位直肠癌疗效的相关研究。对于纳入文献依据NOS量表进行质量评价,采用Review Manager 5.3版软件进行数据合并。结果共纳入13篇符合该研究的文献,共859例直肠癌患者。在疗效方面,Meta分析结果显示,与LaTME相比,TaTME提高了肿瘤完全切除的概率,减少了环周切缘阳性(CRM)的发生风险(OR=1.75,95%CI=1.02~3.01,P=0.040;OR=0.43,95%CI=0.22~0.82,P=0.010)。在安全性方面,Meta分析结果显示,两者的术后并发症相似,发生肠梗阻和吻合口漏的风险差异无统计学意义(OR=0.91,95%CI=0.46~1.78,P=0.780;OR=0.79,95%CI=0.45~1.38,P=0.400)。结论 TaTME在治疗中低位直肠癌患者的疗效方面比LaTME好,有效降低了肿瘤的CRM的发生率。但在安全性方面,两者没有较大的差异,其真实性还需大量高质量的研究进一步验证。 展开更多
关键词 直肠癌 经肛门 腹腔镜 全直肠系膜切除术 META分析
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类风湿关节炎合并骨质疏松的发病机制和治疗进展 被引量:13
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作者 于晶晶 李慧敏 +2 位作者 马瑞瑞 吴天进 应振华 《中国现代医学杂志》 CAS 2020年第24期51-56,共6页
随着我国人口老龄化日益加重,骨质疏松的患者也愈来愈多,并且呈逐渐年轻化的趋势。性激素、钙吸收下降、炎症因子等多种因素均可能引起骨质疏松。继发性原因导致的骨质疏松占绝大多数,在风湿免疫疾病中,部分疾病如类风湿关节炎、强直性... 随着我国人口老龄化日益加重,骨质疏松的患者也愈来愈多,并且呈逐渐年轻化的趋势。性激素、钙吸收下降、炎症因子等多种因素均可能引起骨质疏松。继发性原因导致的骨质疏松占绝大多数,在风湿免疫疾病中,部分疾病如类风湿关节炎、强直性脊柱炎、骨关节炎等均可导致骨质疏松,其原因可能与肿瘤坏死因子、白细胞介素等炎症因子相关。该文对类风湿关节炎合并骨质疏松的发病机制和治疗进展进行综述。 展开更多
关键词 关节炎 类风湿 骨质疏松 发病机制 治疗
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Prediction model for surface layer microhardness of processed TC17 via high energy shot peening 被引量:2
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作者 li-xing SUN Miao-quan li hui-min li 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2017年第9期1956-1963,共8页
The bulk TC17was subjected to the high energy shot peening(HESP)at the air pressures ranging from0.35to0.55MPa and processing durations ranging from15to60min.The microhardness(HV0.02)from topmost surface to matrix of ... The bulk TC17was subjected to the high energy shot peening(HESP)at the air pressures ranging from0.35to0.55MPa and processing durations ranging from15to60min.The microhardness(HV0.02)from topmost surface to matrix of the HESP processed TC17was measured,which generally decreases with the increase of depth from topmost surface to matrix and presents different variation with air pressure and processing duration at different depths.A fuzzy neural network(FNN)model was established to predict the surface layer microhardness of the HESP processed TC17,where the maximum and average difference between the measured and the predicted microhardness were respectively8.5%and3.2%.Applying the FNN model,the effects of the air pressure and processing duration on the microhardness at different depths were analyzed,revealing the significant interaction between the refined layer shelling and the continuous grain refinement. 展开更多
关键词 TC17 high energy shot peening MICROHARDNESS fuzzy neural network MODEL
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Fabrication and application of arrays related to two-dimensional materials 被引量:4
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作者 Hui-li Jiang Jia Pan +2 位作者 Wei Zhou hui-min li Song liu 《Rare Metals》 SCIE EI CAS CSCD 2022年第1期262-286,共25页
In recent years,two-dimensional(2D)materials have attracted extensive attention from researchers for their unique structures and electrical properties.2D materials have been widely applied in field effect transistors,... In recent years,two-dimensional(2D)materials have attracted extensive attention from researchers for their unique structures and electrical properties.2D materials have been widely applied in field effect transistors,sensors,and photodetectors.Integration is extremely important for practical applications in devices,which requires both minimal crosstalk and high performance.The fabrication of patterned arrays of 2D materials can realize high-density fabrication.In addition,the properties of 2D materials can be also adjusted by the patterned nanostructures.In this review,we summarize the emerging researches related to 2D materials and arrays.Firstly,the preparation strategies of different arrays have been introduced.Then,the applications of arrays have been investigated,such as physical unclonable functions,sensors,energy consumption,photoluminescence enhancement,quantum emitters and photodetectors.Finally,the prospects and existing challenges have been proposed. 展开更多
关键词 2D materials 2D material arrays Sensors Quantum emitters PHOTODETECTORS
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Thermal error modeling based on BiLSTM deep learning for CNC machine tool 被引量:4
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作者 Pu-ling liu Zheng-Chun Du +3 位作者 hui-min li Ming Deng Xiao-Bing Feng Jian-Guo Yang 《Advances in Manufacturing》 SCIE EI CAS CSCD 2021年第2期235-249,共15页
The machining accuracy of computer numerical control machine tools has always been a focus of the manufacturing industry.Among all errors,thermal error affects the machining accuracy considerably.Because of the signif... The machining accuracy of computer numerical control machine tools has always been a focus of the manufacturing industry.Among all errors,thermal error affects the machining accuracy considerably.Because of the significant impact of Industry 4.0 on machine tools,existing thermal error modeling methods have encountered unprecedented challenges in terms of model complexity and capability of dealing with a large number of time series data.A thermal error modeling method is proposed based on bidirectional long short-term memory(BiLSTM)deep learning,which has good learning ability and a strong capability to handle a large group of dynamic data.A four-layer model framework that includes BiLSTM,a feedforward neural network,and the max pooling is constructed.An elaborately designed algorithm is proposed for better and faster model training.The window length of the input sequence is selected based on the phase space reconstruction of the time series.The model prediction accuracy and model robustness were verified experimentally by three validation tests in which thermal errors predicted by the proposed model were compensated for real workpiece cutting.The average depth variation of the workpiece was reduced from approximately 50μm to less than 2μm after compensation.The reduction in maximum depth variation was more than 85%.The proposed model was proved to be feasible and effective for improving machining accuracy significantly. 展开更多
关键词 Thermal error Error modeling Bidirectional long short-term memory(BiLSTM) Phase space reconstruction Computer numerical control(CNC)machine tool
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Towards a global One Health index: a potential assessment tool for One Health performance 被引量:6
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作者 Xiao-Xi Zhang Jing-Shu liu +35 位作者 Le-Fei Han Shang Xia Shi-Zhu li Odel Yli Kokouvi Kassegne Min li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie hui-min li Jin Chen Zhao-Yu Guo Jia-Xin Feng lin Ai Jing-Bo Xue Qian Ye liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou 《Infectious Diseases of Poverty》 SCIE 2022年第3期12-26,共15页
Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, ani... Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. 展开更多
关键词 Antimicrobial resistance Cell-like framework Climate change Food security Global One Health index(GOHI) Global performance assessment GOVERNANCE Zoonotic diseases
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Sesquiterpene lactones of Aucklandia lappa: Pharmacology,pharmacokinetics, toxicity, and structure–activity relationship 被引量:2
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作者 Xin-nan liu hui-min li +2 位作者 Shu-ping Wang Jing-ze Zhang Dai-lin liu 《Chinese Herbal Medicines》 CAS 2021年第2期167-176,共10页
The medicinal part of Aucklandia lappa(Asteraceae) is its dried root,which is one of the commonly used Chinese medicinal materials.Here we reviewed sesquiterpene lactones isolated from A.lappa over the past ten years ... The medicinal part of Aucklandia lappa(Asteraceae) is its dried root,which is one of the commonly used Chinese medicinal materials.Here we reviewed sesquiterpene lactones isolated from A.lappa over the past ten years in the following aspects of pharmacological activities,pharmacokinetics,toxicology,structure-activity relationship.Pharmacological activities consist of anti-cancer,anti-inflammatory activity,anti-immunity activity,anti-oxidant activity,antimicrobial activity,spasmolytic activity and so on.The extractive,showing similar pharmacokinetics parameters,may exert their various biological activities by the interaction of their α-methylene-γ-butyrolactone moiety with the thiol groups of biomacromolecules through Michael-addition.However,the poor aqueous solubility,non-selective binding as a Michael acceptor at undesired targets limited clinical translation of this class.In order to evaluate the potential effect of the extractive applied in clinical trial,the present review outlines information on pharmacological activities,pharmacokinetics,toxicology,and structure-activity relationship,as well as the future research directions of the extractive for further development and utilization of A.lappa. 展开更多
关键词 Aucklandia lappa Dence PHARMACOKINETIC pharmacological activities sesquiterpene lactones structure–activity relationship
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Complete mitochondrial genome of Ampittia dioscorides (Lepidoptera: Hesperiidae) and its phylogenetic analysis
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作者 Xin-Min Qin Xiao-Wen Yang +1 位作者 li-Xia Hou hui-min li 《Frontiers in Biology》 CAS CSCD 2017年第1期71-81,共11页
The complete mitochondrial genome of Ampittia dioscorides (Lepidoptera: Hesperiidae) was determined. The sequenced genome is a circular molecule of 15313 bp, containing 13 protein-coding genes (PCGs), 22 tRNA gen... The complete mitochondrial genome of Ampittia dioscorides (Lepidoptera: Hesperiidae) was determined. The sequenced genome is a circular molecule of 15313 bp, containing 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, and an A + T-rich region. The gene arrangements and transcribing directions are identical to those in most of the reported lepidopteran mitogenomes. The base composition of the whole genome and genes or regions are also similar to those in other lepidopteran species. All the PCGs are initiated by typical ATN codons; the exception being CO1, which begins with a CGA codon. Eight genes (ND2, ATPase8, ATPase6, COIII, ND5, ND4L, ND6, and Cytb) end with a TAA stop codon, and two genes (ND1 and ND3) end with TAG. The remaining three genes (CO1 and COIl, which end with TA-, and ND4, which ends with T-) have incomplete stop codons. All tRNAs have the typical clover-leaf structure of mitochondrial tRNAs, with the exception of tRNAser(AGY). On the basis of the concatenated nucleotide and amino acid sequences of the 13 PCGs and wingless gene of 22 butterfly species, maximum parsimony (MP) and Bayesian inference (BI) trees were constructed, respectively. Both MP and BI trees had the same topological structure: ((((Nymphalidae + Danaidae) + Lycaenidae) + Pieridae) + Papilionidae) + Hesperiidae). The results provide support for Hesperiidae as a superfamily-level taxon. 展开更多
关键词 Ampittia dioscorides mitochondrial genome PHYLOGENY
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