A sensitive,fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae(SZS)standard decoction with characterization of its chemical components was developed and validated.UPLC-Q/TOF-MS/MS syste...A sensitive,fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae(SZS)standard decoction with characterization of its chemical components was developed and validated.UPLC-Q/TOF-MS/MS system was used to identify thirty-six chemical components of SZS standard decoction which included nucleosides,phenolic acids,alkaloids,and flavonoids.Furthermore,a UPLC-PDA method was validated to simultaneously determine adenosine,protocatechuic acid,magnoflorine,catechin,protocatechin,vicenin II,spinosin,kaempferol-3-rutinoside,and 6'''-feruloylspinosin which represent four species of characteristic compounds.The qualitative method had been validated according to Chinese Pharmacopoeia(2015 edition)in terms of lineary,repeatability,recovery and stability for all analytes,with the results showing good precision,accuracy and stability.In conclusion,the method using UPLC combined with MS and PDA provided a novel way for the standardization and identification of SZS standard decoction,and also offered a basis for qualitative analysis and quality assessment of the preparations for SZS standard decoction.展开更多
In the context of frequent occurrences of disasters worldwide,disaster-coping capability is imperative for risk reduction and contemporary emergency management.The global COVID-19 pandemic since 2020 has further highl...In the context of frequent occurrences of disasters worldwide,disaster-coping capability is imperative for risk reduction and contemporary emergency management.The global COVID-19 pandemic since 2020 has further highlighted the significance of resilience construction at different geographical scales.Overall,the conceptual cognition of resilience in disaster management covers multiple elements and has diverse yielding on regional assessment.This study assesses the local resilience to the public health disaster in the prefecture-level cities,focusing on two dimensions consisting of vulnerability and capability in the targeted provincial region of Jiangsu in China.To this end,based on the vulnerability-capability framework,the Rough Analytic Hierarchy Process(Rough AHP)method was applied to the resilience assessment.Drawing upon the criteria derived from literature,the criteria weights were determined with the RAHP method and we assessed urban resilience with census data.In addition,the hierarchical factors contributing to urban resilience were determined using robustness analysis.This research provides constructive ideas for regional disaster reduction and contributes to the government’s capability to improve urban resilience.展开更多
基金financially supported by the National Key Scientific Project for China New Drug Discovery and Twelfth Five-Year Plan-preclinical study on Suanzaoren granules(No.2014ZX09304306)the Key Technologies of Common Quality Evaluation of New Drugs(Grant no.2015010201)
文摘A sensitive,fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae(SZS)standard decoction with characterization of its chemical components was developed and validated.UPLC-Q/TOF-MS/MS system was used to identify thirty-six chemical components of SZS standard decoction which included nucleosides,phenolic acids,alkaloids,and flavonoids.Furthermore,a UPLC-PDA method was validated to simultaneously determine adenosine,protocatechuic acid,magnoflorine,catechin,protocatechin,vicenin II,spinosin,kaempferol-3-rutinoside,and 6'''-feruloylspinosin which represent four species of characteristic compounds.The qualitative method had been validated according to Chinese Pharmacopoeia(2015 edition)in terms of lineary,repeatability,recovery and stability for all analytes,with the results showing good precision,accuracy and stability.In conclusion,the method using UPLC combined with MS and PDA provided a novel way for the standardization and identification of SZS standard decoction,and also offered a basis for qualitative analysis and quality assessment of the preparations for SZS standard decoction.
基金National Social Science Fund of China(17BZZ039)China’s Postdoctoral Science Foundation(2021M691503)the Graduate Research&Practical Innovation Project in Jiangsu Province(KYCX21-2544).
文摘In the context of frequent occurrences of disasters worldwide,disaster-coping capability is imperative for risk reduction and contemporary emergency management.The global COVID-19 pandemic since 2020 has further highlighted the significance of resilience construction at different geographical scales.Overall,the conceptual cognition of resilience in disaster management covers multiple elements and has diverse yielding on regional assessment.This study assesses the local resilience to the public health disaster in the prefecture-level cities,focusing on two dimensions consisting of vulnerability and capability in the targeted provincial region of Jiangsu in China.To this end,based on the vulnerability-capability framework,the Rough Analytic Hierarchy Process(Rough AHP)method was applied to the resilience assessment.Drawing upon the criteria derived from literature,the criteria weights were determined with the RAHP method and we assessed urban resilience with census data.In addition,the hierarchical factors contributing to urban resilience were determined using robustness analysis.This research provides constructive ideas for regional disaster reduction and contributes to the government’s capability to improve urban resilience.
