AIM:To examine the integrity of the ocular surfaces of subjects with and without diabetes with no conjunctival and dry eye signs and symptoms and compare conjunctival impression cytology findings in diabetics with non...AIM:To examine the integrity of the ocular surfaces of subjects with and without diabetes with no conjunctival and dry eye signs and symptoms and compare conjunctival impression cytology findings in diabetics with non-proliferative and proliferative diabetic retinopathy.METHODS:Conjunctival impression cytology was performed on 43 eyes of 43 subjects with nonproliferative diabetic retinopathy(NPDR),42 eyes of 42subjects with proliferative diabetic retinopathy(PDR),and30 eyes of 30 control subjects.Impression cytology specimens of each group were graded and scored in the range 0-3 according to Nelson's method.RESULTS:There were 45(52.9%)women and 40(47.1%)men.The mean age of the patients was 59.6±9.3y(range,43-76y)in NPDR group and 58.0±8.8y(range,41-85y)in PDR group.Cases with NPDR and PDR showed statistically significant higher impression cytology scores than control group(P<0.05).There was no difference between the NPDR and PDR patients for impression cytology grading scores.CONCLUSION:It is determined that impression cytology grades are altered in patients with NPDR and PDR.Consequently,we suggest that there might be an association between the impression cytology grading scores and the severity of diabetic展开更多
Topiramate(TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spi...Topiramate(TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spinal cord injury has not been studied extensively. Thus, we evaluated effects of TPM on secondary cellular injury mechanisms in an experimental rat model of traumatic spinal cord injury(SCI). After rat models of thoracic contusive SCI were established by free weight-drop method, TPM(40 mg/kg) was given at 12-hour intervals for four times orally. Post TPM treatment, malondialdehyde and protein carbonyl levels were significantly reduced and reduced glutathione levels were increased, while immunoreactivity for endothelial nitric oxide synthase, inducible nitric oxide synthase, and apoptotic peptidase activating factor 1 was diminished in SCI rats. In addition, TPM treatment improved the functional recovery of SCI rats. This study suggests that administration of TPM exerts neuroprotective effects on SCI.展开更多
文摘AIM:To examine the integrity of the ocular surfaces of subjects with and without diabetes with no conjunctival and dry eye signs and symptoms and compare conjunctival impression cytology findings in diabetics with non-proliferative and proliferative diabetic retinopathy.METHODS:Conjunctival impression cytology was performed on 43 eyes of 43 subjects with nonproliferative diabetic retinopathy(NPDR),42 eyes of 42subjects with proliferative diabetic retinopathy(PDR),and30 eyes of 30 control subjects.Impression cytology specimens of each group were graded and scored in the range 0-3 according to Nelson's method.RESULTS:There were 45(52.9%)women and 40(47.1%)men.The mean age of the patients was 59.6±9.3y(range,43-76y)in NPDR group and 58.0±8.8y(range,41-85y)in PDR group.Cases with NPDR and PDR showed statistically significant higher impression cytology scores than control group(P<0.05).There was no difference between the NPDR and PDR patients for impression cytology grading scores.CONCLUSION:It is determined that impression cytology grades are altered in patients with NPDR and PDR.Consequently,we suggest that there might be an association between the impression cytology grading scores and the severity of diabetic
基金partly supported by Turkish Neurosurgical Society
文摘Topiramate(TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spinal cord injury has not been studied extensively. Thus, we evaluated effects of TPM on secondary cellular injury mechanisms in an experimental rat model of traumatic spinal cord injury(SCI). After rat models of thoracic contusive SCI were established by free weight-drop method, TPM(40 mg/kg) was given at 12-hour intervals for four times orally. Post TPM treatment, malondialdehyde and protein carbonyl levels were significantly reduced and reduced glutathione levels were increased, while immunoreactivity for endothelial nitric oxide synthase, inducible nitric oxide synthase, and apoptotic peptidase activating factor 1 was diminished in SCI rats. In addition, TPM treatment improved the functional recovery of SCI rats. This study suggests that administration of TPM exerts neuroprotective effects on SCI.
