AIM： To evaluate the features and outcome of management of malignant conjunctival squamous tumors in King Hussein Cancer Center（a referral tertiary cancer center in the Middle East）. METHODS： Retrospective case se...AIM： To evaluate the features and outcome of management of malignant conjunctival squamous tumors in King Hussein Cancer Center（a referral tertiary cancer center in the Middle East）. METHODS： Retrospective case series of 31 eyes for 31 patients with conjunctival squamous neoplasia. Main outcome measures included： age, gender, laterality, tumor location, pathological features, tumor stage, treatment modality, and outcome. RESULTS： Twenty（65%） patients were males and median age was 58 y. Twenty-two（71%） eyes had the tumor in the nasal quadrant. Tumor invasion to nearby structures was seen in 19（61%） eyes, including the cornea, fornix, eyelid, and orbit in 17（55%）, 1（3%）, 2（6%）, and 3（10%） eyes, respectively. Eye salvage was achieved by surgical excision with cryotherapy followed by topical chemotherapy in 28（90%） eyes, and orbital exenteration was necessary in 3（10%） eyes due to orbital tumor invasion. Tumor recurrence was seen in 7（23%） eyes, and the significant predictive factors for recurrence were tumor extension onto the nearby structures（P=0.04）, tumor invasiveness（P=0.038）, and tumor TNM stage（P=0.031）. No significant change in visual acuity was seen, and disease related mortality was 6%（2 patients, both had orbital invasion by invasive squamous carcinoma）. CONCLUSION： Conjunctival squamous carcinoma is more common in males. Advanced American Joint Committee on Cancer（AJCC） T-stage, tumor local invasion, more pathologically aggressive tumors, and surgical treatment alone（without adjuvant therapy） are associated with higher risk for recurrence, and orbital invasion is the most important poor prognostic factor for metastasis and death. Treatment strategies should be affected by tumor characteristics at presentation.展开更多
In this paper we are interested in investigating the physical shape-changed propagations to the generalized Equal-Width equation through studying the explicit solutions of Wazwaz-Benjamin-Bona-Mahony model.Both models...In this paper we are interested in investigating the physical shape-changed propagations to the generalized Equal-Width equation through studying the explicit solutions of Wazwaz-Benjamin-Bona-Mahony model.Both models are of considerable importance in many disciplines of research,including ocean engineering and science,and describe the propagation of equally-width waves.We highlight the effect of the coefficients of both nonlinearity and dispersion terms on changing the physical shape of both models by implementing the new exponential-expansion scheme.2D and 3D graphical plots are provided to validate the findings of the paper.展开更多
文摘AIM： To evaluate the features and outcome of management of malignant conjunctival squamous tumors in King Hussein Cancer Center（a referral tertiary cancer center in the Middle East）. METHODS： Retrospective case series of 31 eyes for 31 patients with conjunctival squamous neoplasia. Main outcome measures included： age, gender, laterality, tumor location, pathological features, tumor stage, treatment modality, and outcome. RESULTS： Twenty（65%） patients were males and median age was 58 y. Twenty-two（71%） eyes had the tumor in the nasal quadrant. Tumor invasion to nearby structures was seen in 19（61%） eyes, including the cornea, fornix, eyelid, and orbit in 17（55%）, 1（3%）, 2（6%）, and 3（10%） eyes, respectively. Eye salvage was achieved by surgical excision with cryotherapy followed by topical chemotherapy in 28（90%） eyes, and orbital exenteration was necessary in 3（10%） eyes due to orbital tumor invasion. Tumor recurrence was seen in 7（23%） eyes, and the significant predictive factors for recurrence were tumor extension onto the nearby structures（P=0.04）, tumor invasiveness（P=0.038）, and tumor TNM stage（P=0.031）. No significant change in visual acuity was seen, and disease related mortality was 6%（2 patients, both had orbital invasion by invasive squamous carcinoma）. CONCLUSION： Conjunctival squamous carcinoma is more common in males. Advanced American Joint Committee on Cancer（AJCC） T-stage, tumor local invasion, more pathologically aggressive tumors, and surgical treatment alone（without adjuvant therapy） are associated with higher risk for recurrence, and orbital invasion is the most important poor prognostic factor for metastasis and death. Treatment strategies should be affected by tumor characteristics at presentation.
文摘In this paper we are interested in investigating the physical shape-changed propagations to the generalized Equal-Width equation through studying the explicit solutions of Wazwaz-Benjamin-Bona-Mahony model.Both models are of considerable importance in many disciplines of research,including ocean engineering and science,and describe the propagation of equally-width waves.We highlight the effect of the coefficients of both nonlinearity and dispersion terms on changing the physical shape of both models by implementing the new exponential-expansion scheme.2D and 3D graphical plots are provided to validate the findings of the paper.
