Background and objectives:Lung cancer(LC)is the leading cause of cancer death.Patients treated with chemotherapy are at risk of developing chemotherapy-induced febrile neutropenia(FN),a potentially life-threatening co...Background and objectives:Lung cancer(LC)is the leading cause of cancer death.Patients treated with chemotherapy are at risk of developing chemotherapy-induced febrile neutropenia(FN),a potentially life-threatening complication.The aims of this study were(1)to characterize FN admissions of patients with LC in a pulmonology department,and(2)to determine associations between patient profiles,first-line antibiotic failure(FLAF)and mortality.Methods:Retrospective observational case-series,based on the analysis of medical records of LC patients that required hospitalization due to chemotherapy-induced FN.Results:A total of 42 cases of FN were revised,corresponding to 36 patients,of which 86.1%were male,with a mean age of 66.71±9.83 years.Most patients had a performance status(PS)equal or less than 1,and metastatic disease was present in 40.5%(n=17).Respiratory tract infections accounted for 42.9%(n=18)of FN cases,and multidrug-resistant Staphylococcus aureus was the most isolated agent.The mortality rate was 16.7%(n=7),and the FLAF was 26.2%(n=11).Mortality was associated with a PS≥2(P=0.011),infection by a Gram-negative agent(P=0.001)and severe anemia(P=0.048).FLAF was associated with longer hospitalizations(P=0.020),PS≥2(P=0.049),respiratory infections(P=0.024),and infection by a Gram-negative(P=0.003)or multidrug-resistant agent(P=0.014).Conclusions:Lower PS,severe anemia,and infections by Gram-negative or multi-resistant agents seem to be associated with worse outcomes in FN patients.展开更多
This paper reflects the results of a short experiment conducted in parallel with a larger trial which aimed to test the assumption that ’consumption of feed by broiler chickens during periods of darkness is largely n...This paper reflects the results of a short experiment conducted in parallel with a larger trial which aimed to test the assumption that ’consumption of feed by broiler chickens during periods of darkness is largely negligible’. To that effect, on d 31, feeders of birds raised under intermittent lighting(IL), i.e. 1 h of light[1L]:3 h of dark(3D):1L:3D:1L:3D:1L:3D:2L:6D, were weighed at the onset and at the end of each period of darkness(or scotoperiod). Moreover, in order to compare the feeding behavior of IL birds with that of broilers raised under continuous lighting(CL, i.e, 18L:6D), their feeders were weighed in parallel and at the same time points. On d 31, feed intake of IL birds during scotoperiods represented 45% of their 24 h feed intake. Both CL and IL birds presented anticipatory feed intake prior to the long nocturnal period of darkness(6D), as well as higher feed intake right at the onset of lighting at 06:00. Feed intake of CL birds during the 6D nocturnal scotoperiod was negligible at around 2% of their total feed intake. Intermittent lighting birds exhibited excitement at the start of each hour-length scotoperiod and, within that time,ingested around 2.5 times the amount of feed ingested by CL birds. Although short, this study revealed several interesting observations which might be worth further exploring in a larger, lengthier, behaviorfocused experiment. Amongst other factors, it might be interesting to understand whether the high feed intake observed during scotoperiods for IL birds in reflective of the whole flock or rather a coping mechanism developed mainly by hierarchically lower-ranking birds to achieve their daily feed intakes requirements.展开更多
文摘Background and objectives:Lung cancer(LC)is the leading cause of cancer death.Patients treated with chemotherapy are at risk of developing chemotherapy-induced febrile neutropenia(FN),a potentially life-threatening complication.The aims of this study were(1)to characterize FN admissions of patients with LC in a pulmonology department,and(2)to determine associations between patient profiles,first-line antibiotic failure(FLAF)and mortality.Methods:Retrospective observational case-series,based on the analysis of medical records of LC patients that required hospitalization due to chemotherapy-induced FN.Results:A total of 42 cases of FN were revised,corresponding to 36 patients,of which 86.1%were male,with a mean age of 66.71±9.83 years.Most patients had a performance status(PS)equal or less than 1,and metastatic disease was present in 40.5%(n=17).Respiratory tract infections accounted for 42.9%(n=18)of FN cases,and multidrug-resistant Staphylococcus aureus was the most isolated agent.The mortality rate was 16.7%(n=7),and the FLAF was 26.2%(n=11).Mortality was associated with a PS≥2(P=0.011),infection by a Gram-negative agent(P=0.001)and severe anemia(P=0.048).FLAF was associated with longer hospitalizations(P=0.020),PS≥2(P=0.049),respiratory infections(P=0.024),and infection by a Gram-negative(P=0.003)or multidrug-resistant agent(P=0.014).Conclusions:Lower PS,severe anemia,and infections by Gram-negative or multi-resistant agents seem to be associated with worse outcomes in FN patients.
文摘This paper reflects the results of a short experiment conducted in parallel with a larger trial which aimed to test the assumption that ’consumption of feed by broiler chickens during periods of darkness is largely negligible’. To that effect, on d 31, feeders of birds raised under intermittent lighting(IL), i.e. 1 h of light[1L]:3 h of dark(3D):1L:3D:1L:3D:1L:3D:2L:6D, were weighed at the onset and at the end of each period of darkness(or scotoperiod). Moreover, in order to compare the feeding behavior of IL birds with that of broilers raised under continuous lighting(CL, i.e, 18L:6D), their feeders were weighed in parallel and at the same time points. On d 31, feed intake of IL birds during scotoperiods represented 45% of their 24 h feed intake. Both CL and IL birds presented anticipatory feed intake prior to the long nocturnal period of darkness(6D), as well as higher feed intake right at the onset of lighting at 06:00. Feed intake of CL birds during the 6D nocturnal scotoperiod was negligible at around 2% of their total feed intake. Intermittent lighting birds exhibited excitement at the start of each hour-length scotoperiod and, within that time,ingested around 2.5 times the amount of feed ingested by CL birds. Although short, this study revealed several interesting observations which might be worth further exploring in a larger, lengthier, behaviorfocused experiment. Amongst other factors, it might be interesting to understand whether the high feed intake observed during scotoperiods for IL birds in reflective of the whole flock or rather a coping mechanism developed mainly by hierarchically lower-ranking birds to achieve their daily feed intakes requirements.
