Western Altun in Xinjiang is an important area,where lithium(Li)-bearing pegmatites have been found in recent years.However,the complex terrain and harsh environment of western Altun exacerbates in prospecting for Li-...Western Altun in Xinjiang is an important area,where lithium(Li)-bearing pegmatites have been found in recent years.However,the complex terrain and harsh environment of western Altun exacerbates in prospecting for Li-bearing pegmatites.Therefore,remote-sensing techniques can be an effective means for prospecting Li-bearing pegmatites.In this study,the fault information and lithologyical information in the region were obtained using the median-resolution remotesensing image Landsat-8,the radar image Sentinel-1 and hyperspectral data GF-5.Using Landsat-8 data,the hydroxyl alteration information closely related to pegmatite in the region was extracted by principal component analysis,pseudoanomaly processing and other methods.The high spatial resolution remote-sensing data WorldView-2 and WorldView-3 short-wave infrared images were used and analyzed by principal component analysis(PCA),the band ratio method and multi-class machine learning(ML),combined with conventional thresholds specified the algorithms used to automatically extract Li-bearing pegmatite information.Finally,the Li-bearing pegmatite exploration area was determined,based on a comprehensive analysis of the faults,hydroxyl alteration lithology and Li-bearing pegmatite information.Field investigations have verified that the distribution of pegmatites in the central part of the study area is consistent with that of Li-bearing pegmatites extracted in this study.This study provides a new technique for prospecting Li-bearing pegmatites,which shows that remote-sensing technology possesses great potential for identifying lithium-bearing pegmatites,especially in areas that are not readily accessible.展开更多
目的探索胃癌发生过程的风险miRNAs,为上消化道机会性筛查中早期胃癌识别提供依据。方法纳入2021年6月至2023年8月在广西医科大学附属肿瘤医院、右江民族医学院附属医院、桂林市人民医院3个中心进行上消化道癌机会性筛查的人群。选取健...目的探索胃癌发生过程的风险miRNAs,为上消化道机会性筛查中早期胃癌识别提供依据。方法纳入2021年6月至2023年8月在广西医科大学附属肿瘤医院、右江民族医学院附属医院、桂林市人民医院3个中心进行上消化道癌机会性筛查的人群。选取健康体检者107例、早期胃癌患者71例、进展期胃癌患者97例。首先采用转录组测序筛选差异表达miRNAs,然后在3组前瞻性人群的血浆样本中通过RT‐qPCR验证差异表达的miRNAs,最后采用受试者工作特征(receiver operating characteristic,ROC)曲线评估miRNAs的诊断效能。结果转录组测序的差异基因分析共筛选出胃癌发生过程中的6个差异表达miRNAs,包括miR‐3176、miR‐885‐5p、miR‐203a‐3p、miR‐452‐5p、miR‐223‐3p、miR‐219a‐2‐3p。RT‐qPCR结果显示,miR‐452‐5p在早期胃癌及进展期胃癌患者中表达上调(均P<0.001)。ROC曲线显示,miR‐452‐5p诊断早期胃癌和进展期胃癌的曲线下面积(area under the curve,AUC)分别为0.900、0.975。区分早期胃癌与进展期胃癌的AUC为0.843。结论miR‐452‐5p在早期胃癌中具有良好的诊断效能,可能作为液体活检诊断早期胃癌的潜在生物标志物。展开更多
基金supported by the National Key Research and Development Program of the China Geological Survey(DD20190173)the Fundamental Research Funds for the Institute of Mineral Resources,the Chinese Academy of Geological Sciences(KK2102)+1 种基金the National Natural Science Foundation of China(42172332)the Chinese Geological Survey Project(DD20190379)。
文摘Western Altun in Xinjiang is an important area,where lithium(Li)-bearing pegmatites have been found in recent years.However,the complex terrain and harsh environment of western Altun exacerbates in prospecting for Li-bearing pegmatites.Therefore,remote-sensing techniques can be an effective means for prospecting Li-bearing pegmatites.In this study,the fault information and lithologyical information in the region were obtained using the median-resolution remotesensing image Landsat-8,the radar image Sentinel-1 and hyperspectral data GF-5.Using Landsat-8 data,the hydroxyl alteration information closely related to pegmatite in the region was extracted by principal component analysis,pseudoanomaly processing and other methods.The high spatial resolution remote-sensing data WorldView-2 and WorldView-3 short-wave infrared images were used and analyzed by principal component analysis(PCA),the band ratio method and multi-class machine learning(ML),combined with conventional thresholds specified the algorithms used to automatically extract Li-bearing pegmatite information.Finally,the Li-bearing pegmatite exploration area was determined,based on a comprehensive analysis of the faults,hydroxyl alteration lithology and Li-bearing pegmatite information.Field investigations have verified that the distribution of pegmatites in the central part of the study area is consistent with that of Li-bearing pegmatites extracted in this study.This study provides a new technique for prospecting Li-bearing pegmatites,which shows that remote-sensing technology possesses great potential for identifying lithium-bearing pegmatites,especially in areas that are not readily accessible.
文摘目的探索胃癌发生过程的风险miRNAs,为上消化道机会性筛查中早期胃癌识别提供依据。方法纳入2021年6月至2023年8月在广西医科大学附属肿瘤医院、右江民族医学院附属医院、桂林市人民医院3个中心进行上消化道癌机会性筛查的人群。选取健康体检者107例、早期胃癌患者71例、进展期胃癌患者97例。首先采用转录组测序筛选差异表达miRNAs,然后在3组前瞻性人群的血浆样本中通过RT‐qPCR验证差异表达的miRNAs,最后采用受试者工作特征(receiver operating characteristic,ROC)曲线评估miRNAs的诊断效能。结果转录组测序的差异基因分析共筛选出胃癌发生过程中的6个差异表达miRNAs,包括miR‐3176、miR‐885‐5p、miR‐203a‐3p、miR‐452‐5p、miR‐223‐3p、miR‐219a‐2‐3p。RT‐qPCR结果显示,miR‐452‐5p在早期胃癌及进展期胃癌患者中表达上调(均P<0.001)。ROC曲线显示,miR‐452‐5p诊断早期胃癌和进展期胃癌的曲线下面积(area under the curve,AUC)分别为0.900、0.975。区分早期胃癌与进展期胃癌的AUC为0.843。结论miR‐452‐5p在早期胃癌中具有良好的诊断效能,可能作为液体活检诊断早期胃癌的潜在生物标志物。
