Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 16...Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively analyzed.The patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood EOS.The quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA%)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA%)of grade 3 to 8 bronchi were compared between groups.Spearman correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS level.Results LAA%of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LD grade 4,middle lobe of right lung WT grade 5,upper lobe of right lung WA grade 4,middle lobe of right lung WA grade 5 and lower lobe of left lung WA grade 3 in low EOS group were all higher than those in high EOS group(all P<0.05).Except for the upper lobe of right lung LD grade 4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P<0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA%,a part of WT and WA were all weakly negatively correlated with blood EOS level.展开更多
目的分析外周血嗜酸性粒细胞(EOS)≥300/μl和<300/μl的慢性阻塞性肺疾病急性加重期(AECOPD)患者临床、炎症标记物、传统肺功能、脉冲振荡阻力测定(IOS)参数及容积CT参数特征,观察其特征差异。方法纳入357例AECOPD,其中EOS≥300/μl...目的分析外周血嗜酸性粒细胞(EOS)≥300/μl和<300/μl的慢性阻塞性肺疾病急性加重期(AECOPD)患者临床、炎症标记物、传统肺功能、脉冲振荡阻力测定(IOS)参数及容积CT参数特征,观察其特征差异。方法纳入357例AECOPD,其中EOS≥300/μl组(研究组)41例,EOS<300/μl组(对照组)316例,比较2组慢性阻塞性肺疾病(COPD)评估测试(CAT)评分、医学研究委员会呼吸困难量表(mMRC)评定等临床指标、炎症指标以及传统肺功能、IOS指标、肺容积、肺气肿指数及肺气肿密度等影像学参数的差异。结果①研究组中性粒细胞比率低于对照组(64.70%vs 73.00%,P<0.001),纤维蛋白原(3.59 vs 3.97,P=0.031)及C反应蛋白减低(3.30 mg/L vs 8.63 mg/L,P=0.012),吸烟量亦相对较低(25包/年vs 40包/年,P=0.009);②研究组RV/TLC低于对照组(51.91%vs 57.44%,P=0.041),而R5(0.56 vs 0.49,P=0.036)和R5%pred(178.65%vs 155.70%,P=0.027)较高;③研究组全肺、右肺和左肺肺气肿平均密度和PD 15均高于对照组(P均<0.05),提示肺实质破坏更严重。结论EOS≥300/μl的AECOPD患者气道阻力增加更明显,而肺气肿损害程度较EOS<300/μl者轻微。展开更多
目的利用定量CT研究成人起病型嗜酸性哮喘患者的气道参数,并分析其与肺功能的相关性。方法收集2015年3月至2016年11月“数字肺”多研究中心健康体检被试及哮喘患者94例,其中正常被试30例,嗜酸性哮喘患者33例(EA组),非嗜酸性哮喘患者31例...目的利用定量CT研究成人起病型嗜酸性哮喘患者的气道参数,并分析其与肺功能的相关性。方法收集2015年3月至2016年11月“数字肺”多研究中心健康体检被试及哮喘患者94例,其中正常被试30例,嗜酸性哮喘患者33例(EA组),非嗜酸性哮喘患者31例(NEA组)。测量并记录右肺上叶尖段(RB1)、左肺上叶尖后段(LB1+2)、右肺下叶后基底段(RB10)、左肺下叶后基底段(LB10)的管腔面积(LA)、支气管壁厚(WT)、支气管壁面积(WA)、壁面积百分比(WA%),及吸气相小于−950 HU像素占全肺体积的百分比(IN_(-950))、吸气相平均肺密度(mean lung density of inspiratory,MLDin)和吸气相肺体积(lung volume of inspiratory,V_(in))。利用Pearson或Spearman相关性分析各支气管参数与肺功能指标的相关性。结果EA组、NEA组及正常被试组间支气管参数LA/BSA、WT/√BSA、WA/BSA差异具有统计学意义(P<0.05)。FEV1%与IN_(-950)和MLDin具有良好的相关性(P<0.01),FEV1/FVC与V_(in)、IN_(-950)和MLDin具有良好的相关性(P<0.01)。EOS与IN_(-950)呈正相关(r=0.343,P=0.011),EOS与肺功能指标FEV1%呈负相关(r=−0.343,P=0.015)。结论随着嗜酸性粒细胞水平的升高,哮喘患者的气道腔狭窄程度逐渐增大,气流受限程度逐渐加重。肺气肿参数IN_(-950)可能是评价EA患者小气道病变较为敏感的影像学指标。展开更多
文摘Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively analyzed.The patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood EOS.The quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA%)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA%)of grade 3 to 8 bronchi were compared between groups.Spearman correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS level.Results LAA%of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LD grade 4,middle lobe of right lung WT grade 5,upper lobe of right lung WA grade 4,middle lobe of right lung WA grade 5 and lower lobe of left lung WA grade 3 in low EOS group were all higher than those in high EOS group(all P<0.05).Except for the upper lobe of right lung LD grade 4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P<0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA%,a part of WT and WA were all weakly negatively correlated with blood EOS level.
文摘目的分析外周血嗜酸性粒细胞(EOS)≥300/μl和<300/μl的慢性阻塞性肺疾病急性加重期(AECOPD)患者临床、炎症标记物、传统肺功能、脉冲振荡阻力测定(IOS)参数及容积CT参数特征,观察其特征差异。方法纳入357例AECOPD,其中EOS≥300/μl组(研究组)41例,EOS<300/μl组(对照组)316例,比较2组慢性阻塞性肺疾病(COPD)评估测试(CAT)评分、医学研究委员会呼吸困难量表(mMRC)评定等临床指标、炎症指标以及传统肺功能、IOS指标、肺容积、肺气肿指数及肺气肿密度等影像学参数的差异。结果①研究组中性粒细胞比率低于对照组(64.70%vs 73.00%,P<0.001),纤维蛋白原(3.59 vs 3.97,P=0.031)及C反应蛋白减低(3.30 mg/L vs 8.63 mg/L,P=0.012),吸烟量亦相对较低(25包/年vs 40包/年,P=0.009);②研究组RV/TLC低于对照组(51.91%vs 57.44%,P=0.041),而R5(0.56 vs 0.49,P=0.036)和R5%pred(178.65%vs 155.70%,P=0.027)较高;③研究组全肺、右肺和左肺肺气肿平均密度和PD 15均高于对照组(P均<0.05),提示肺实质破坏更严重。结论EOS≥300/μl的AECOPD患者气道阻力增加更明显,而肺气肿损害程度较EOS<300/μl者轻微。
文摘目的利用定量CT研究成人起病型嗜酸性哮喘患者的气道参数,并分析其与肺功能的相关性。方法收集2015年3月至2016年11月“数字肺”多研究中心健康体检被试及哮喘患者94例,其中正常被试30例,嗜酸性哮喘患者33例(EA组),非嗜酸性哮喘患者31例(NEA组)。测量并记录右肺上叶尖段(RB1)、左肺上叶尖后段(LB1+2)、右肺下叶后基底段(RB10)、左肺下叶后基底段(LB10)的管腔面积(LA)、支气管壁厚(WT)、支气管壁面积(WA)、壁面积百分比(WA%),及吸气相小于−950 HU像素占全肺体积的百分比(IN_(-950))、吸气相平均肺密度(mean lung density of inspiratory,MLDin)和吸气相肺体积(lung volume of inspiratory,V_(in))。利用Pearson或Spearman相关性分析各支气管参数与肺功能指标的相关性。结果EA组、NEA组及正常被试组间支气管参数LA/BSA、WT/√BSA、WA/BSA差异具有统计学意义(P<0.05)。FEV1%与IN_(-950)和MLDin具有良好的相关性(P<0.01),FEV1/FVC与V_(in)、IN_(-950)和MLDin具有良好的相关性(P<0.01)。EOS与IN_(-950)呈正相关(r=0.343,P=0.011),EOS与肺功能指标FEV1%呈负相关(r=−0.343,P=0.015)。结论随着嗜酸性粒细胞水平的升高,哮喘患者的气道腔狭窄程度逐渐增大,气流受限程度逐渐加重。肺气肿参数IN_(-950)可能是评价EA患者小气道病变较为敏感的影像学指标。
