Background:Interleukin 13 receptor subunit alpha 2(IL13RA2)plays an essential role in the progression of many cancers.However,the role of IL13RA2 in infantile haemangioma(IH)is still unknown.Materials and Methods:IL13...Background:Interleukin 13 receptor subunit alpha 2(IL13RA2)plays an essential role in the progression of many cancers.However,the role of IL13RA2 in infantile haemangioma(IH)is still unknown.Materials and Methods:IL13RA2 expression in IH tissues was analyzed using western blot,qRT-PCR,and immunofluorescence.The role of IL13RA2 in haemangioma-derived endothelial cells(HemECs)was determined following knockdown or overexpression of IL13RA2 using CCK-8,colony formation,apoptosis,wound healing,tubule formation,Transwell,and western blot.Results:IL13RA2 expression was upregulated in IH tissues.IL13RA2 overexpression promoted proliferation,migration,and invasion of HemECs and induced glycolysis,which was confirmed with a glycolysis inhibitor.Specifically,IL13RA2 interacted withβ-catenin and activated the Wnt/β-catenin pathway in HemECs,which were involved in the above-mentioned effects of IL13RA2.Conclusions:These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.展开更多
Agriculture is the foundation of the national economy.The periodicity of agricultural product output and prices,the asymmetry of information between buyers and sellers,and the inherent characteristics of small scale,h...Agriculture is the foundation of the national economy.The periodicity of agricultural product output and prices,the asymmetry of information between buyers and sellers,and the inherent characteristics of small scale,high cost,and low profit have caused slow sales,which greatly hurt the enthusiasm of farmers to develop production and endanger social stability.Constructing an informationized and commercialized trading platform and an information sharing platform through e-commerce and establishing related systems and supervision mechanisms will help to promote the rapid growth of agricultural product sales.Research has shown that in the field of agricultural circulation,e-commerce has a significant effect on increasing the scale of agricultural trade.展开更多
In process industries,the characteristics of industrial activities focus on the integrality and continuity of production process,which can contribute to excavating the appropriate features for industrial anomaly detec...In process industries,the characteristics of industrial activities focus on the integrality and continuity of production process,which can contribute to excavating the appropriate features for industrial anomaly detection.From this perspective,this paper proposes a novel state-based control feature extraction approach,which regards the finite control operations as different states.Furthermore,the procedure of state transition can adequately express the change of successive control operations,and the statistical information between different states can be used to calculate the feature values.Additionally,OCSVM(One Class Support Vector Machine)and BPNN(BP Neural Network),which are optimized by PSO(Particle Swarm Optimization)and GA(Genetic Algorithm)respectively,are introduced as alternative detection engines to match with our feature extraction approach.All experimental results clearly show that the proposed feature extraction approach can effectively coordinate with the optimized classification algorithms,and the optimized GA-BPNN classifier is suggested as a more applicable detection engine by comparing its average detection accuracies with the ones of PSO-OCSVM classifier.展开更多
Dear Editor,Coronavirus disease 2019(COVID-19)is a type of novel coronavirus and no specific treatment is currently available.Apart from damages to the lung,COVID-19 is also able to trigger liver injury.Numerous obser...Dear Editor,Coronavirus disease 2019(COVID-19)is a type of novel coronavirus and no specific treatment is currently available.Apart from damages to the lung,COVID-19 is also able to trigger liver injury.Numerous observational studies have revealed that elevation of liver enzymes,including alanine aminotransferase(ALT)and aspartate aminotransferase(AST),was detected in some COVID-19 patients,especially in severe cases.1 Unfortunately,the underlying mechanisms and risk factors of COVID-19-induced liver damage have not been completely elucidated.Therefore,identification of novel risk factors in liver injury of COVID-19 patients is essential for the prevention and treatment of liver damage.In this study,192 patients with COVID-19 hospitalized in Chongqing Public Health Center were recruited to identify the risk factors in COVID-19 patients with liver injury.展开更多
Cerebral ischemia is a major cause of mortality and long-term morbidity worldwide.NDRG4 has been shown to protect against cerebral ischemia,although the underlying mechanisms remain largely unclear.Here we found that ...Cerebral ischemia is a major cause of mortality and long-term morbidity worldwide.NDRG4 has been shown to protect against cerebral ischemia,although the underlying mechanisms remain largely unclear.Here we found that NDRG4 expression was decreased in the brain tissues of ischemia/reperfusion(IR)rats,indicating increased apoptosis rates among cerebral cells.NDRG4 restoration via an adenovirus significantly attenuated cerebral infarct sizes and impairments in IR rats.Furthermore,adenovirus-mediated NDRG4 inhibited cell apoptosis in the brains of IR rats and regulated the expression of Bcl-2,Bax,caspase-3,and c-Fos.Moreover,we found that NDRG4 increased expression of BDNF,which is strongly related to cerebral ischemia and cellular apoptosis.Altogether,our findings demonstrate that NDRG4 protects cerebral IR injury by inhibiting cell apoptosis and regulates cerebral cell apoptosis by increasing BDNF expression.These results suggest that NDRG4 may be a therapeutic target for IR treatment.展开更多
The yellow SrSi2O2N2：Eu2＋ phosphor has been synthesized by using a simple solid-state reaction method with Sr2SiO4：Eu2＋ as the precursor. It shows a broad excitation band extending from 250 to 520 nm and an asymme...The yellow SrSi2O2N2：Eu2＋ phosphor has been synthesized by using a simple solid-state reaction method with Sr2SiO4：Eu2＋ as the precursor. It shows a broad excitation band extending from 250 to 520 nm and an asymmetric emission band with a main peak at about 550 nm. The emission intensity of the SrSi202N2：Eu2＋ is about 1.2 times higher than the commercial yellow phosphor YAG：Ce3＋ （P46-Y3）. The temperature- dependent luminescence characteristic of SrSi202N2：Eu2＋ has been investigated in this paper. With increasing temperature, the emission band of SrSi202N2：Eu2＋ shows anomalous blue-shift along with decreasing emission intensity and the broadening full width at half maximum （FWHM）. Particularly, compared with YAG：Ce3＋ （P46-Y3）, the yellow SrSi202N2：Eu2＋ phosphors exhibit higher thermal stability due to their weaker electron-phonon coupling strength （1.1）, lower stokes shift （0.0576 eV） and larger activation energy （0.288 eV）. All these results indicate that SrSi202N2：Eu2＋ yellow phosphors have potential application for white light-emitting diodes （LEDs）, What＇s more, an energy level scheme is constructed to explain the anomalous blue-shift phenomenon.展开更多
文摘Background:Interleukin 13 receptor subunit alpha 2(IL13RA2)plays an essential role in the progression of many cancers.However,the role of IL13RA2 in infantile haemangioma(IH)is still unknown.Materials and Methods:IL13RA2 expression in IH tissues was analyzed using western blot,qRT-PCR,and immunofluorescence.The role of IL13RA2 in haemangioma-derived endothelial cells(HemECs)was determined following knockdown or overexpression of IL13RA2 using CCK-8,colony formation,apoptosis,wound healing,tubule formation,Transwell,and western blot.Results:IL13RA2 expression was upregulated in IH tissues.IL13RA2 overexpression promoted proliferation,migration,and invasion of HemECs and induced glycolysis,which was confirmed with a glycolysis inhibitor.Specifically,IL13RA2 interacted withβ-catenin and activated the Wnt/β-catenin pathway in HemECs,which were involved in the above-mentioned effects of IL13RA2.Conclusions:These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.
基金Supported by Guangxi Young and Middle-aged University Teachers’Scientific Research Ability Enhancement Project(2017KY0644).
文摘Agriculture is the foundation of the national economy.The periodicity of agricultural product output and prices,the asymmetry of information between buyers and sellers,and the inherent characteristics of small scale,high cost,and low profit have caused slow sales,which greatly hurt the enthusiasm of farmers to develop production and endanger social stability.Constructing an informationized and commercialized trading platform and an information sharing platform through e-commerce and establishing related systems and supervision mechanisms will help to promote the rapid growth of agricultural product sales.Research has shown that in the field of agricultural circulation,e-commerce has a significant effect on increasing the scale of agricultural trade.
基金This work is supported by the Program of Hainan Association for Science and Technology Plans to Youth R&D Innovation(Grant No.QCXM201910)the Natural Science Foundation of Liaoning Province(Grant No.2019-MS-149),the Social Science Planning Foundation of Liaoning Province(Grant No.L18AGL007)+1 种基金the National Natural Science Foundation of China(Grant Nos.61802092,51704138 and 61501447)the Scientific Research Setup Fund of Hainan University(Grant No.KYQD(ZR)1837).
文摘In process industries,the characteristics of industrial activities focus on the integrality and continuity of production process,which can contribute to excavating the appropriate features for industrial anomaly detection.From this perspective,this paper proposes a novel state-based control feature extraction approach,which regards the finite control operations as different states.Furthermore,the procedure of state transition can adequately express the change of successive control operations,and the statistical information between different states can be used to calculate the feature values.Additionally,OCSVM(One Class Support Vector Machine)and BPNN(BP Neural Network),which are optimized by PSO(Particle Swarm Optimization)and GA(Genetic Algorithm)respectively,are introduced as alternative detection engines to match with our feature extraction approach.All experimental results clearly show that the proposed feature extraction approach can effectively coordinate with the optimized classification algorithms,and the optimized GA-BPNN classifier is suggested as a more applicable detection engine by comparing its average detection accuracies with the ones of PSO-OCSVM classifier.
基金supported by the Chongqing Special Research Project for Prevention and Control of Novel Coronavirus Pneumonia(No.cstc2020jscx-fyzx0103).
文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a type of novel coronavirus and no specific treatment is currently available.Apart from damages to the lung,COVID-19 is also able to trigger liver injury.Numerous observational studies have revealed that elevation of liver enzymes,including alanine aminotransferase(ALT)and aspartate aminotransferase(AST),was detected in some COVID-19 patients,especially in severe cases.1 Unfortunately,the underlying mechanisms and risk factors of COVID-19-induced liver damage have not been completely elucidated.Therefore,identification of novel risk factors in liver injury of COVID-19 patients is essential for the prevention and treatment of liver damage.In this study,192 patients with COVID-19 hospitalized in Chongqing Public Health Center were recruited to identify the risk factors in COVID-19 patients with liver injury.
基金Funding:This work was supported by the National Natural Science Foundation of China[No.81271306].
文摘Cerebral ischemia is a major cause of mortality and long-term morbidity worldwide.NDRG4 has been shown to protect against cerebral ischemia,although the underlying mechanisms remain largely unclear.Here we found that NDRG4 expression was decreased in the brain tissues of ischemia/reperfusion(IR)rats,indicating increased apoptosis rates among cerebral cells.NDRG4 restoration via an adenovirus significantly attenuated cerebral infarct sizes and impairments in IR rats.Furthermore,adenovirus-mediated NDRG4 inhibited cell apoptosis in the brains of IR rats and regulated the expression of Bcl-2,Bax,caspase-3,and c-Fos.Moreover,we found that NDRG4 increased expression of BDNF,which is strongly related to cerebral ischemia and cellular apoptosis.Altogether,our findings demonstrate that NDRG4 protects cerebral IR injury by inhibiting cell apoptosis and regulates cerebral cell apoptosis by increasing BDNF expression.These results suggest that NDRG4 may be a therapeutic target for IR treatment.
基金the financial supports of the National Natural Science Foundations of China (Nos.50903038, 21171071, 51203053, and 21071063)the project sponsored by SRF for ROCS, SEM (No. [2011] 1139)the project of the combination of Industry and Research by the Ministry of Education and Guangdong Province (No. 2012B091100181)
文摘The yellow SrSi2O2N2：Eu2＋ phosphor has been synthesized by using a simple solid-state reaction method with Sr2SiO4：Eu2＋ as the precursor. It shows a broad excitation band extending from 250 to 520 nm and an asymmetric emission band with a main peak at about 550 nm. The emission intensity of the SrSi202N2：Eu2＋ is about 1.2 times higher than the commercial yellow phosphor YAG：Ce3＋ （P46-Y3）. The temperature- dependent luminescence characteristic of SrSi202N2：Eu2＋ has been investigated in this paper. With increasing temperature, the emission band of SrSi202N2：Eu2＋ shows anomalous blue-shift along with decreasing emission intensity and the broadening full width at half maximum （FWHM）. Particularly, compared with YAG：Ce3＋ （P46-Y3）, the yellow SrSi202N2：Eu2＋ phosphors exhibit higher thermal stability due to their weaker electron-phonon coupling strength （1.1）, lower stokes shift （0.0576 eV） and larger activation energy （0.288 eV）. All these results indicate that SrSi202N2：Eu2＋ yellow phosphors have potential application for white light-emitting diodes （LEDs）, What＇s more, an energy level scheme is constructed to explain the anomalous blue-shift phenomenon.
