Photodynamic therapy(PDT)is a promising cancer treatment.This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-tr...Photodynamic therapy(PDT)is a promising cancer treatment.This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin(DTP)mediated PDT(DTP-PDT).Cell viability,reactive oxygen species(ROS),and apoptosis were measured with a Cell Counting Kit-8 assay,DCFH-DA fluorescent probe,and Hoechst staining,respectively.Cell apoptosis-and autophagy-related proteins were examined using western blotting.RNA sequencing was used to screen differentially expressed mRNAs(DERs),and bioinformatic analysis was performed to identify the major biological events after DTP-PDT.Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901 cells.The ROS scavenger N-acetyl-L-cysteine(NAC)and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced cytotoxicity.DTP-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2,which could also be inhibited by NAC or SB203580.The level of LC3B-Ⅱ,a marker of autophagy,was increased by DTP-PDT.A total of 3496 DERs were obtained after DTP-PDT.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes,the nuclear lumen,protein binding,cell cycle,protein targeting to the endoplasmic reticulum,and ribosomal DNA replication.Disease Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle checkpoints.Protein-protein interaction results demonstrated that cdk1 and rps27a ranked in the top 10 interacting genes.Therefore,DTP-PDT could inhibit cell growth and induce cell apoptosis and autophagy,partly through ROS and the P38 MAPK signaling pathway.Genes associated with the cell cycle,ribosomes,DNA replication,and protein binding may be the key changes in DTP-PDT-mediated cytotoxicity.展开更多
N-doped carbons as one of the most prominent anode materials to replace standard graphite exhibit outstanding Li+storage performance.However,N-doped carbon anodes still suffer from low N-doping levels and low initial ...N-doped carbons as one of the most prominent anode materials to replace standard graphite exhibit outstanding Li+storage performance.However,N-doped carbon anodes still suffer from low N-doping levels and low initial Coulombic efficiency(ICE).In this study,high N-doped and low graphitic-N carbons(LGNCs)with enhanced ICE were synthesized by taking advantage of a denitrification strategy for graphitic carbon nitride(g-C_(3)N_(4)).In brief,more than 14.5 at%of N from g-C_(3)N_(4)(55.1 at%N)was retained by reacting graphitic-N with lithium,which was subsequently removed.As graphitic-N is largely responsible for the irreversible capacity,the anode's performance was significantly increased.Compared to general N-doped carbons with high graphitic-N proportion(>50%)and low N content(<15 at%),LGNCs delivered a low proportion of 10.8%-17.2% within the high N-doping content of 14.5-42.7 at%,leading to an enhanced specific capacity of 1499.9mAh g^(-1) at an ICE of 93.7% for the optimal sample of LGNC(4:1).This study provides a facile strategy to control the N content and speciation,achieving both high Li+storage capacity and high ICE,and thus promoting research and application of N-doped carbon materials.展开更多
A solid-state sodium metal battery has cut a striking figure in next-generation large-scale energy storage technology on account of high safety,high energy density,and low cost.Nevertheless,the large interfacial resis...A solid-state sodium metal battery has cut a striking figure in next-generation large-scale energy storage technology on account of high safety,high energy density,and low cost.Nevertheless,the large interfacial resistance and sodium dendrite growth originating from the poor interface contact seriously hinder its practical application.Herein,a modified ultrasound welding was proposed to atomically bond Na anodes and Au-metalized Na_(3)Zr_(2)Si_(2)PO_(12) electrolytes associated with the in situ formation of Na–Au alloy interlayers.Thereupon,intimate Na_(3)Zr_(2)Si_(2)PO_(12)-Au/Na interfaces with a low interfacial resistance(~23Ωcm^(2))and a strong dendrite inhibition ability were constructed.The optimized Na symmetric battery can cycle steadily for more than 900 h at 0.3 mA cm^(-2) under a low overpotential(<50 mV)of Na electroplating/stripping and deliver a high critical current density of 0.8 mAcm^(-2) at room temperature.By incorporating the above interface into the solid-state Na metal battery,taking three-dimensional Na_(3)V_(2)(PO_(4))_(3) as the cathode,the full battery offers a high energy density of 291 Wh kg^(-1) at a high power density of 1860Wkg^(-1).A pouch-type solid-state sodium metal full battery based on a ceramic electrolyte was assembled for the first time,and it lit a 3 V LED lamp.Such a strategy of the ultrasound welding metalized solid-state electrolyte/Na interface by engineering the Na-Au interlayer would pave a new pathway to engineer a low-resistance and highly stable interface for high-energy/density solid-state sodium metal batteries.展开更多
Viscous behavior is important for the process design, especially for the non-Newtonian fluid. In this study, the viscous behaviors of slurry, i.e., 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)im ide([Hmim]...Viscous behavior is important for the process design, especially for the non-Newtonian fluid. In this study, the viscous behaviors of slurry, i.e., 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)im ide([Hmim][NTf_(2)])/titanium dioxide(TiO_(2))-polyethylene glycol(PEG200), were determined experimentally and systematically. The pressure drop was estimated when [Hmim][NTf_(2)]/TiO_(2)-PEG200 was used as the solvent in the absorption/desorption towers. The results show that the slurry belongs to the non-Newtonian fluid with shear-thinning behavior. High temperature and low solid content are beneficial to reduce the viscosity of [Hmim][NTf_(2)]/TiO_(2)-PEG200, and the presence of [Hmim][NTf_(2)] can effectively reduce the viscosity of the slurry. In addition, high temperature is preferable for reducing the pressure drop, and the pressure drop of slurry with the solid content value of 8.0%(mass) can reduce by 28.0%when the temperature increases from 313 to 333 K.展开更多
Catalytic epoxidation of alkenes is an important type of organic reaction in chemical industry,and the deep insight into catalyst deactivation will help to develop new epoxidation process.In this work,series of quater...Catalytic epoxidation of alkenes is an important type of organic reaction in chemical industry,and the deep insight into catalyst deactivation will help to develop new epoxidation process.In this work,series of quaternary ammoniums bearing different cationic sizes,i.e.MTOA+(methyltrioctylammonium,[(C_(8)H_(17))_(3)CH_(3)N]+),HTMA+(hexadecyltrimethylammonium,[(C_(16)H_(33))(CH_(3))_(3)N]+) and DMDOA+(dimethyldioctadecylammonium,[(C_(18)H_(37))_(2)(CH_(3))_(2)N]+) were incorporated with polyoxometalate (POM) anions to prepare phase transfer catalysts (PTCs),which were used in the styrene epoxidations.Among them,(MTOA)_(3)PW_(4)O_(24)exhibits the best catalytic performance judged from the highest styrene conversion rate(52%) and styrene oxide selectivity (93%),during which the styrene epoxidation conditions were optimized.Meanwhile,the deactivation mechanism of this kind of PTCs was proposed firstly,i.e.in the case of low H_(2)O_(2) content,the oxidant can only be used in the styrene epoxidation,in which the catalyst can transform into stable Keggin-type POM.But when the content of H_(2)O_(2) is higher,the excess H_(2)O_(2) can reactivate the Keggin-type POM into active (PW_(4)O_(24))_(3)-anions,which can trigger the ring-opening polymerization of styrene oxide.Consequently,the catalyst is deactivated by adhered poly(styrene oxide)irreversibly,which was determined by NMR spectra.In this situation,the active moiety{PO_(4)[WO(O_(2))_(2)]_(4)}_(3)-in phase-transfer catalytic system can break into some unidentified species with low W/P ratio with the presence of epoxides.This work will be beneficial for the design of new PTCs in alkene epoxidation in fine chemical industry.展开更多
Traffic prediction is a necessary function in intelligent transporta-tion systems to alleviate traffic congestion.Graph learning methods mainly focus on the spatiotemporal dimension,but ignore the nonlinear movement o...Traffic prediction is a necessary function in intelligent transporta-tion systems to alleviate traffic congestion.Graph learning methods mainly focus on the spatiotemporal dimension,but ignore the nonlinear movement of traffic prediction and the high-order relationships among various kinds of road segments.There exist two issues:1)deep integration of the spatiotempo-ral information and 2)global spatial dependencies for structural properties.To address these issues,we propose a nonlinear spatiotemporal optimization method,which introduces hypergraph convolution networks(HGCN).The method utilizes the higher-order spatial features of the road network captured by HGCN,and dynamically integrates them with the historical data to weigh the influence of spatiotemporal dependencies.On this basis,an extended Kalman filter is used to improve the accuracy of traffic prediction.In this study,a set of experiments were conducted on the real-world dataset in Chengdu,China.The result showed that the proposed method is feasible and accurate by two different time steps.Especially at the 15-minute time step,compared with the second-best method,the proposed method achieved 3.0%,11.7%,and 9.0%improvements in RMSE,MAE,and MAPE,respectively.展开更多
Objective: Dysphagia is a frequent symptom caused by cerebral infarction. This study investigated the effect evaluation and safety of electroacupuncture combined with balloon dilatation on dysphagia after cerebral inf...Objective: Dysphagia is a frequent symptom caused by cerebral infarction. This study investigated the effect evaluation and safety of electroacupuncture combined with balloon dilatation on dysphagia after cerebral infarction. Methods: Totally 100 patients with dysphagia after cerebral infarction were enrolled as study subjects and assigned into the control group (treated with balloon dilatation) and the observation group (treated with electroacupuncture and balloon dilatation), with 50 cases in each group. The general data of participants were recorded. Before or after treatment, swallowing function was assessed by water swallow test, standardized swallowing function assessment (SSA), videofluoroscopic swallow study (VFSS), and functional oral intake scale (FOIS). The cerebral hemodynamics, serological indicators, neurological impairment, quality of life (QOL) score were analyzed. Additionally, the occurrence of complications and adverse reactions after treatment was assessed. Results: There was no significant difference in gender, age, BMI, course of disease, and grade of dysphagia between the two groups. Balloon dilatation alone and electroacupuncture combined with balloon dilatation decreased the water swallow test, SSA, and VFSS scores, increased FOIS score, and improved the swallowing function, cerebral hemodynamic parameters, serological indicators, neurological function and QOL, with the better efficacy in the combined therapy. Moreover, combined therapy had lower incidences of complications and adverse reactions than balloon dilatation therapy alone. Conclusion: Electroacupuncture intervention combined with balloon dilatation therapy ameliorates swallowing function, cerebral hemodynamics, serological indicators, neurological function and QOL, and reduces complications and adverse reactions in dysphagia after cerebral infarction.展开更多
Pediatric ophthalmic test requires meticulous observation and precise measurement..However, children are unable to actively cooperate with the test...If they were forced to receive the examinations,.it is difficult to...Pediatric ophthalmic test requires meticulous observation and precise measurement..However, children are unable to actively cooperate with the test...If they were forced to receive the examinations,.it is difficult to deliver accurate diagnosis and treatment, and cause negative influence upon physical and mental health. Consequently, sedation technique plays an extremely vital role in pediatric eye examinations..This study was designed to summarize the application of chloral hydrate in pediatric eye examination and propose different methods of medicine administration for children of varying ages, aiming to improve the effect of sedation. In addition, the feasibility of use of dexmedetomidine,.which had been proven to be effective in pediatric sedation examination,.into pediatric ophthalmic sedation examination was evaluated,.thereby offering more options for the development of pediatric ocular sedation test.展开更多
Supply Chain Finance(SCF)refers to the financial service in which banks rely on core enterprises to manage the capital flow and logistics of upstream and downstream enterprises.SCF adopts a self-testing and closed-loo...Supply Chain Finance(SCF)refers to the financial service in which banks rely on core enterprises to manage the capital flow and logistics of upstream and downstream enterprises.SCF adopts a self-testing and closed-loop credit model to control funds and risks.The key factor in a successful SCF service is the deployment of SCF businessoriented information systems that allow businesses to form partnerships efficiently and expedite cash flows throughout the supply chain.Blockchain Technology(BCT),featuring decentralization,tamper-proofing,traceability,which is usually paired with the Internet of Things(IoT)in real-world contexts,has been widely adopted in the field of finance and is perfectly positioned to facilitate innovative collaborations among participants in supply chain networks.In this paper,we propose a BCT and IoT-based information management framework(named BC4Regu),which works as the regulatory to improve the information transparency in the business process of SCF.With BC4Regu,the operation cost of the whole supply chain can be significantly reduced through the coordination and integration of capital flow,information flow,logistics and trade flow in the supply chain.The contributions in this paper include:(1)proposing a novel information management framework which leverages Blockchain and IoT to solve the problem of information asymmetry in the trade of SCF;(2)proposing the technical design of BC4Regu,including the Blockchain infrastructure,distributed ledger-based integrated data flow service,and reshaped SCF process;and(3)applying BC4Regu to a group of scenarios and conducting theoretical analysis by introducing the principal-agent model to validate the BC4Regu.展开更多
Organic active units often transform into radical intermediates during the redox processes but exhibit poor cycling stability due to the uncontrollable redox of the radicals. Herein, we report a facile and efficient s...Organic active units often transform into radical intermediates during the redox processes but exhibit poor cycling stability due to the uncontrollable redox of the radicals. Herein, we report a facile and efficient strategy to modulate the molecular orbital energies, charge transport capacities, and spin electron densities of the active units in covalent organic frameworks(COFs) via regulating the conjugated unit size to optimize the redox activity and stability of the organic radicals. COFs based on different imide conjugated units exhibit tunable discharge voltages, rate performance and cycling stabilities. Detailed characterizations and theoretical calculation reveal that imide radicals are the important active intermediates during the redox processes of these COFs. Specifically, increasing the size of the imide conjugated units could effectively delocalize the radical electrons and improve the stability of the COFs electrodes. This study offers a very effective strategy to modulate the redox chemistry of organic materials for electrochemical energy storage.展开更多
The objective of this research was to study the precipitation of Sb and the stability of Sb2S3 during treatment of synthetic Sb(V)wastewater by sulfate-reducing bacteria(SRB).We investigated the transformation and pre...The objective of this research was to study the precipitation of Sb and the stability of Sb2S3 during treatment of synthetic Sb(V)wastewater by sulfate-reducing bacteria(SRB).We investigated the transformation and precipitation of Sb,as well as the re-dissolution of Sb2S3 under different pH and carbon sources.The results showed that the precipitation of aqueous Sb and the re-dissolution of Sb2S3 depend on the conversion between Sb(Ⅲ)-S(-Ⅱ)complexes and Sb2S3 precipitates.These processes were highly pH-dependent,and a decrease in pH enhanced reduction of Sb(Ⅴ)and precipitation of Sb2S3 were observed.The newly formed Sb2S3 was found to be unstable and could re-dissolve through complexation with H2 S due to the increase in pH.When pH decreased to approximately 6.5,Sb was almost completely transformed into Sb2S3 precipitates,and the Sb2S3 precipitates were relatively stable.Compared with lactate as a carbon source,ethanol resulted in a comparable H2 S yield and a relatively low pH and was,therefore,more conducive to the removal of Sb(Ⅴ).The results of this study suggest that when removing Sb(Ⅴ)in wastewater by SRB,it is important to control the pH at a relatively low level.展开更多
The Kuroshio extension(KE)exhibits interdecadal variability,oscillating from a stable state to an unstable state.In this paper,ERA-Interim reanalysis data are used to discuss the possible reasons for the asymmetric re...The Kuroshio extension(KE)exhibits interdecadal variability,oscillating from a stable state to an unstable state.In this paper,ERA-Interim reanalysis data are used to discuss the possible reasons for the asymmetric response of the atmosphere to symmetric sea surface temperature anomaly(SSTA)during periods of differential KE states.The analysis has the following results:the SSTA presents a nearly symmetrical distribution with opposite signs during the KE stable and unstable periods.During the KE stable period,the storm track is located north of 40°N and is significantly enhanced in the northeast Pacific Ocean.The atmospheric response is similar to the West Pacific/North Pacific Oscillation teleconnection(WP/NPO like pattern)and presents a barotropic structure.The inversion results of the potential vorticity equation show that the feedback of transient eddy vorticity manifests a WP/NPO like pattern and presents a barotropic structure,which is the main reason for bringing about the response of the WP/NPO like pattern.The magnitude of the feedbacks of both diabatic heating and transient eddy heating is small,which can offset one another.During the KE unstable period,the main body of the storm track is located to the south of 40°N,and there is no significant response signal in the atmosphere,except near the west coast of North America.Compared with the KE stable period,the asymmetry of response of the transient eddy vorticity is the main reason for the asymmetric response of the atmosphere.展开更多
Relative to the power grid, the short-capacity system has smaller inertia and weaker ability to bear disturbance. As a result, the synchronous generator in short-capacity system will be greatly influenced by harmonic....Relative to the power grid, the short-capacity system has smaller inertia and weaker ability to bear disturbance. As a result, the synchronous generator in short-capacity system will be greatly influenced by harmonic. To reveal how harmonic influence the generator, this article analyzed how harmonic current will influence the output voltage. Deduced a formula that can describe the electromagnetic torque pulsation brought by the theory of Instantaneous Power, which can explain why generator’s shaft vibrates. Then this article evaluated the applicability of current filtering methods in view of characteristics of the small capacity of the system. As a result, it was demonstrated that active filtering method is best suited for small capacity system. At last, it conducted the experiment that diesel generator set supply power to non-liner load to demonstrate the conclusion of theoretical analysis.展开更多
Visual electrophysiology is widely used in clinical ophthalmology. It is also of significant value in the objective assessment of visual function in adult and pediatric cataract patients and for the diagnosis of and r...Visual electrophysiology is widely used in clinical ophthalmology. It is also of significant value in the objective assessment of visual function in adult and pediatric cataract patients and for the diagnosis of and research on retinal and visual pathway diseases. This article systematically reviews visual electrophysiology techniques, their applications in the diagnosis and treatment of adult and pediatric cataracts, and factors influencing the application of visual electrophysiology during surgical treatment for cataracts.展开更多
Hydrogen as a clean energy source is made full use, this paper researches the electrical model of PEMFC generator, analyzes the harmonic trend and its hazards when the generator operates with linear load and nonlinear...Hydrogen as a clean energy source is made full use, this paper researches the electrical model of PEMFC generator, analyzes the harmonic trend and its hazards when the generator operates with linear load and nonlinear load running synchronously, comparatively analyzes the commonly used harmonic suppression technology. Simulate and analyze the filter performance when APF is used. The results illustrate that as a filter device, APF can absorb the harmonic properly in PEMFC power system.展开更多
Frequency control technology can achieve the purpose of energy saving of power equipment, but also bring problems of harmonic loss formula. The relationship between the loss rate and load rate is constituted by formul...Frequency control technology can achieve the purpose of energy saving of power equipment, but also bring problems of harmonic loss formula. The relationship between the loss rate and load rate is constituted by formula derivation, and calculate the load rate when the loss rate is the minimum and the total power of power-consuming devices. Then design the digital PID controller and research the power-saving optimization feedback algorithms and design the software process. Finally, carry out the inverter switching algorithm based on ABB ACS510 low voltage inverter.展开更多
Owing to their limited accuracy and narrow applicability,current antimicrobial peptide(AMP)prediction models face obstacles in industrial application.To address these limitations,we developed and improved an AMP predi...Owing to their limited accuracy and narrow applicability,current antimicrobial peptide(AMP)prediction models face obstacles in industrial application.To address these limitations,we developed and improved an AMP prediction model using Comparing and Optimizing Multiple DEep Learning(COMDEL)algorithms,coupled with high-throughput AMP screening method,finally reaching an accuracy of 94.8%in test and 88%in experiment verification,surpassing other state-of-the-art models.In conjunction with COMDEL,we employed the phage-assisted evolution method to screen Sortase in vivo and developed a cell-free AMP synthesis system in vitro,ultimately increasing AMPs yields to a range of 0.5-2.1 g/L within hours.Moreover,by multi-omics analysis using COMDEL,we identified Lactobacillus plantarum as the most promising candidate for AMP generation among 35 edible probiotics.Following this,we developed a microdroplet sorting approach and successfully screened three L.plantarum mutants,each showing a twofold increase in antimicrobial ability,underscoring their substantial industrial application values.展开更多
Relapsing fever is an acute infectious disease caused by a variety of relapsing fever-associated spirochetes,for which no optimal treatment has been developed.The purposes of this study were to compare the efficacy an...Relapsing fever is an acute infectious disease caused by a variety of relapsing fever-associated spirochetes,for which no optimal treatment has been developed.The purposes of this study were to compare the efficacy and safety of commonly used antibiotics for the treatment of relapsing fever using a network meta-analysis approach and to explore the advantages of each drug based on the current evidence.This study examined nine published studies involving 1416 patients with relapsing fever treated with penicillin,erythromycin,tetracycline,doxycycline,minocycline or chloramphenicol.The odds ratio(OR)and 95% confidence interval(CI)were used as influence indices for discontinuous data,and the efficacy and safety of drugs were ranked by the surface under the cumulative ranking(SUCRA)curve.The primary outcomes of this study were mortality and cure rates,and the secondary outcomes were the rates of Jarisch-Herxheimer reaction and relapse.Erythromycin(SUCRA,84.5%)was the most effective antibiotic for reducing mortality,whereas tetracycline was the most effective antibiotic for improving the cure rate(SUCRA,69.3%)and reducing the relapse rate(SUCRA,79.7%),and minocycline(SUCRA,66.4%)was the most effective antibiotic for reducing Jarisch-Herxheimer reactions.In addition,our network meta-analysis showed that tetracycline is superior to penicillin for improving the cure rate(OR,5.91;95%CI,2.21-15.81)and reducing the relapse rate(OR,0.16;95%CI,0.04-0.67).展开更多
基金supported by the Applied Basic Research Project of Shanxi Province(201901D211470)Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(201802093)The National Natural Science Foundation of China(No.81773765).
文摘Photodynamic therapy(PDT)is a promising cancer treatment.This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin(DTP)mediated PDT(DTP-PDT).Cell viability,reactive oxygen species(ROS),and apoptosis were measured with a Cell Counting Kit-8 assay,DCFH-DA fluorescent probe,and Hoechst staining,respectively.Cell apoptosis-and autophagy-related proteins were examined using western blotting.RNA sequencing was used to screen differentially expressed mRNAs(DERs),and bioinformatic analysis was performed to identify the major biological events after DTP-PDT.Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901 cells.The ROS scavenger N-acetyl-L-cysteine(NAC)and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced cytotoxicity.DTP-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2,which could also be inhibited by NAC or SB203580.The level of LC3B-Ⅱ,a marker of autophagy,was increased by DTP-PDT.A total of 3496 DERs were obtained after DTP-PDT.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes,the nuclear lumen,protein binding,cell cycle,protein targeting to the endoplasmic reticulum,and ribosomal DNA replication.Disease Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle checkpoints.Protein-protein interaction results demonstrated that cdk1 and rps27a ranked in the top 10 interacting genes.Therefore,DTP-PDT could inhibit cell growth and induce cell apoptosis and autophagy,partly through ROS and the P38 MAPK signaling pathway.Genes associated with the cell cycle,ribosomes,DNA replication,and protein binding may be the key changes in DTP-PDT-mediated cytotoxicity.
基金National Natural Science Foundation of China,Grant/Award Number:51777138Deutsche Forschungsgemeinschaft(DFG,German Research Foundation),Grant/Award Number:491183248Open Access Publishing Fund of the University of Bayreuth。
文摘N-doped carbons as one of the most prominent anode materials to replace standard graphite exhibit outstanding Li+storage performance.However,N-doped carbon anodes still suffer from low N-doping levels and low initial Coulombic efficiency(ICE).In this study,high N-doped and low graphitic-N carbons(LGNCs)with enhanced ICE were synthesized by taking advantage of a denitrification strategy for graphitic carbon nitride(g-C_(3)N_(4)).In brief,more than 14.5 at%of N from g-C_(3)N_(4)(55.1 at%N)was retained by reacting graphitic-N with lithium,which was subsequently removed.As graphitic-N is largely responsible for the irreversible capacity,the anode's performance was significantly increased.Compared to general N-doped carbons with high graphitic-N proportion(>50%)and low N content(<15 at%),LGNCs delivered a low proportion of 10.8%-17.2% within the high N-doping content of 14.5-42.7 at%,leading to an enhanced specific capacity of 1499.9mAh g^(-1) at an ICE of 93.7% for the optimal sample of LGNC(4:1).This study provides a facile strategy to control the N content and speciation,achieving both high Li+storage capacity and high ICE,and thus promoting research and application of N-doped carbon materials.
基金Scientific Developing Foundation of Tianjin Education Commission,Grant/Award Number:2018ZD09National Natural Science Foundation of China,Grant/Award Numbers:51777138,52202282。
文摘A solid-state sodium metal battery has cut a striking figure in next-generation large-scale energy storage technology on account of high safety,high energy density,and low cost.Nevertheless,the large interfacial resistance and sodium dendrite growth originating from the poor interface contact seriously hinder its practical application.Herein,a modified ultrasound welding was proposed to atomically bond Na anodes and Au-metalized Na_(3)Zr_(2)Si_(2)PO_(12) electrolytes associated with the in situ formation of Na–Au alloy interlayers.Thereupon,intimate Na_(3)Zr_(2)Si_(2)PO_(12)-Au/Na interfaces with a low interfacial resistance(~23Ωcm^(2))and a strong dendrite inhibition ability were constructed.The optimized Na symmetric battery can cycle steadily for more than 900 h at 0.3 mA cm^(-2) under a low overpotential(<50 mV)of Na electroplating/stripping and deliver a high critical current density of 0.8 mAcm^(-2) at room temperature.By incorporating the above interface into the solid-state Na metal battery,taking three-dimensional Na_(3)V_(2)(PO_(4))_(3) as the cathode,the full battery offers a high energy density of 291 Wh kg^(-1) at a high power density of 1860Wkg^(-1).A pouch-type solid-state sodium metal full battery based on a ceramic electrolyte was assembled for the first time,and it lit a 3 V LED lamp.Such a strategy of the ultrasound welding metalized solid-state electrolyte/Na interface by engineering the Na-Au interlayer would pave a new pathway to engineer a low-resistance and highly stable interface for high-energy/density solid-state sodium metal batteries.
基金the National Natural Science Foundation of China (22108115, 21838004)Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao Young Scholars (21729601)+1 种基金China Postdoctoral Science Foundation funded project (2021M691554)Kempe foundation (SMK21-0020) in Sweden。
文摘Viscous behavior is important for the process design, especially for the non-Newtonian fluid. In this study, the viscous behaviors of slurry, i.e., 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)im ide([Hmim][NTf_(2)])/titanium dioxide(TiO_(2))-polyethylene glycol(PEG200), were determined experimentally and systematically. The pressure drop was estimated when [Hmim][NTf_(2)]/TiO_(2)-PEG200 was used as the solvent in the absorption/desorption towers. The results show that the slurry belongs to the non-Newtonian fluid with shear-thinning behavior. High temperature and low solid content are beneficial to reduce the viscosity of [Hmim][NTf_(2)]/TiO_(2)-PEG200, and the presence of [Hmim][NTf_(2)] can effectively reduce the viscosity of the slurry. In addition, high temperature is preferable for reducing the pressure drop, and the pressure drop of slurry with the solid content value of 8.0%(mass) can reduce by 28.0%when the temperature increases from 313 to 333 K.
基金financial supported by the National Natural Science Foundation of China (22078065)Key Program of Qingyuan Innovation Laboratory (00221001)Quanzhou City Science & Technology Program of China (2020C008R)。
文摘Catalytic epoxidation of alkenes is an important type of organic reaction in chemical industry,and the deep insight into catalyst deactivation will help to develop new epoxidation process.In this work,series of quaternary ammoniums bearing different cationic sizes,i.e.MTOA+(methyltrioctylammonium,[(C_(8)H_(17))_(3)CH_(3)N]+),HTMA+(hexadecyltrimethylammonium,[(C_(16)H_(33))(CH_(3))_(3)N]+) and DMDOA+(dimethyldioctadecylammonium,[(C_(18)H_(37))_(2)(CH_(3))_(2)N]+) were incorporated with polyoxometalate (POM) anions to prepare phase transfer catalysts (PTCs),which were used in the styrene epoxidations.Among them,(MTOA)_(3)PW_(4)O_(24)exhibits the best catalytic performance judged from the highest styrene conversion rate(52%) and styrene oxide selectivity (93%),during which the styrene epoxidation conditions were optimized.Meanwhile,the deactivation mechanism of this kind of PTCs was proposed firstly,i.e.in the case of low H_(2)O_(2) content,the oxidant can only be used in the styrene epoxidation,in which the catalyst can transform into stable Keggin-type POM.But when the content of H_(2)O_(2) is higher,the excess H_(2)O_(2) can reactivate the Keggin-type POM into active (PW_(4)O_(24))_(3)-anions,which can trigger the ring-opening polymerization of styrene oxide.Consequently,the catalyst is deactivated by adhered poly(styrene oxide)irreversibly,which was determined by NMR spectra.In this situation,the active moiety{PO_(4)[WO(O_(2))_(2)]_(4)}_(3)-in phase-transfer catalytic system can break into some unidentified species with low W/P ratio with the presence of epoxides.This work will be beneficial for the design of new PTCs in alkene epoxidation in fine chemical industry.
文摘Traffic prediction is a necessary function in intelligent transporta-tion systems to alleviate traffic congestion.Graph learning methods mainly focus on the spatiotemporal dimension,but ignore the nonlinear movement of traffic prediction and the high-order relationships among various kinds of road segments.There exist two issues:1)deep integration of the spatiotempo-ral information and 2)global spatial dependencies for structural properties.To address these issues,we propose a nonlinear spatiotemporal optimization method,which introduces hypergraph convolution networks(HGCN).The method utilizes the higher-order spatial features of the road network captured by HGCN,and dynamically integrates them with the historical data to weigh the influence of spatiotemporal dependencies.On this basis,an extended Kalman filter is used to improve the accuracy of traffic prediction.In this study,a set of experiments were conducted on the real-world dataset in Chengdu,China.The result showed that the proposed method is feasible and accurate by two different time steps.Especially at the 15-minute time step,compared with the second-best method,the proposed method achieved 3.0%,11.7%,and 9.0%improvements in RMSE,MAE,and MAPE,respectively.
文摘Objective: Dysphagia is a frequent symptom caused by cerebral infarction. This study investigated the effect evaluation and safety of electroacupuncture combined with balloon dilatation on dysphagia after cerebral infarction. Methods: Totally 100 patients with dysphagia after cerebral infarction were enrolled as study subjects and assigned into the control group (treated with balloon dilatation) and the observation group (treated with electroacupuncture and balloon dilatation), with 50 cases in each group. The general data of participants were recorded. Before or after treatment, swallowing function was assessed by water swallow test, standardized swallowing function assessment (SSA), videofluoroscopic swallow study (VFSS), and functional oral intake scale (FOIS). The cerebral hemodynamics, serological indicators, neurological impairment, quality of life (QOL) score were analyzed. Additionally, the occurrence of complications and adverse reactions after treatment was assessed. Results: There was no significant difference in gender, age, BMI, course of disease, and grade of dysphagia between the two groups. Balloon dilatation alone and electroacupuncture combined with balloon dilatation decreased the water swallow test, SSA, and VFSS scores, increased FOIS score, and improved the swallowing function, cerebral hemodynamic parameters, serological indicators, neurological function and QOL, with the better efficacy in the combined therapy. Moreover, combined therapy had lower incidences of complications and adverse reactions than balloon dilatation therapy alone. Conclusion: Electroacupuncture intervention combined with balloon dilatation therapy ameliorates swallowing function, cerebral hemodynamics, serological indicators, neurological function and QOL, and reduces complications and adverse reactions in dysphagia after cerebral infarction.
文摘Pediatric ophthalmic test requires meticulous observation and precise measurement..However, children are unable to actively cooperate with the test...If they were forced to receive the examinations,.it is difficult to deliver accurate diagnosis and treatment, and cause negative influence upon physical and mental health. Consequently, sedation technique plays an extremely vital role in pediatric eye examinations..This study was designed to summarize the application of chloral hydrate in pediatric eye examination and propose different methods of medicine administration for children of varying ages, aiming to improve the effect of sedation. In addition, the feasibility of use of dexmedetomidine,.which had been proven to be effective in pediatric sedation examination,.into pediatric ophthalmic sedation examination was evaluated,.thereby offering more options for the development of pediatric ocular sedation test.
基金supported by the Educational Commission of Zhejiang Province of China under Grant No.Y202147553.
文摘Supply Chain Finance(SCF)refers to the financial service in which banks rely on core enterprises to manage the capital flow and logistics of upstream and downstream enterprises.SCF adopts a self-testing and closed-loop credit model to control funds and risks.The key factor in a successful SCF service is the deployment of SCF businessoriented information systems that allow businesses to form partnerships efficiently and expedite cash flows throughout the supply chain.Blockchain Technology(BCT),featuring decentralization,tamper-proofing,traceability,which is usually paired with the Internet of Things(IoT)in real-world contexts,has been widely adopted in the field of finance and is perfectly positioned to facilitate innovative collaborations among participants in supply chain networks.In this paper,we propose a BCT and IoT-based information management framework(named BC4Regu),which works as the regulatory to improve the information transparency in the business process of SCF.With BC4Regu,the operation cost of the whole supply chain can be significantly reduced through the coordination and integration of capital flow,information flow,logistics and trade flow in the supply chain.The contributions in this paper include:(1)proposing a novel information management framework which leverages Blockchain and IoT to solve the problem of information asymmetry in the trade of SCF;(2)proposing the technical design of BC4Regu,including the Blockchain infrastructure,distributed ledger-based integrated data flow service,and reshaped SCF process;and(3)applying BC4Regu to a group of scenarios and conducting theoretical analysis by introducing the principal-agent model to validate the BC4Regu.
基金supports from the Basic Research Project of the Science and Technology Innovation Commission of Shenzhen (No. JCYJ20200109141640095)the Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials (No. ZDSYS20200421111401738)+3 种基金the Leading Talents of Guangdong Province Program (No. 2016LJ06C536)the GuangdongHong Kong-Macao Joint Laboratory (No. 2019B121205001)the National Natural Science Foundation of China (No. 21875097)the support from the Hong Kong Research Grants Council (Project number CityU 11218420)。
文摘Organic active units often transform into radical intermediates during the redox processes but exhibit poor cycling stability due to the uncontrollable redox of the radicals. Herein, we report a facile and efficient strategy to modulate the molecular orbital energies, charge transport capacities, and spin electron densities of the active units in covalent organic frameworks(COFs) via regulating the conjugated unit size to optimize the redox activity and stability of the organic radicals. COFs based on different imide conjugated units exhibit tunable discharge voltages, rate performance and cycling stabilities. Detailed characterizations and theoretical calculation reveal that imide radicals are the important active intermediates during the redox processes of these COFs. Specifically, increasing the size of the imide conjugated units could effectively delocalize the radical electrons and improve the stability of the COFs electrodes. This study offers a very effective strategy to modulate the redox chemistry of organic materials for electrochemical energy storage.
基金financially supported by the China National Natural Science Foundation(No.U1612442)the China National Key Research and Development Program(No.2017YFD0801000)。
文摘The objective of this research was to study the precipitation of Sb and the stability of Sb2S3 during treatment of synthetic Sb(V)wastewater by sulfate-reducing bacteria(SRB).We investigated the transformation and precipitation of Sb,as well as the re-dissolution of Sb2S3 under different pH and carbon sources.The results showed that the precipitation of aqueous Sb and the re-dissolution of Sb2S3 depend on the conversion between Sb(Ⅲ)-S(-Ⅱ)complexes and Sb2S3 precipitates.These processes were highly pH-dependent,and a decrease in pH enhanced reduction of Sb(Ⅴ)and precipitation of Sb2S3 were observed.The newly formed Sb2S3 was found to be unstable and could re-dissolve through complexation with H2 S due to the increase in pH.When pH decreased to approximately 6.5,Sb was almost completely transformed into Sb2S3 precipitates,and the Sb2S3 precipitates were relatively stable.Compared with lactate as a carbon source,ethanol resulted in a comparable H2 S yield and a relatively low pH and was,therefore,more conducive to the removal of Sb(Ⅴ).The results of this study suggest that when removing Sb(Ⅴ)in wastewater by SRB,it is important to control the pH at a relatively low level.
基金the National Natural Science Foundation of China(Grant No.41490642).
文摘The Kuroshio extension(KE)exhibits interdecadal variability,oscillating from a stable state to an unstable state.In this paper,ERA-Interim reanalysis data are used to discuss the possible reasons for the asymmetric response of the atmosphere to symmetric sea surface temperature anomaly(SSTA)during periods of differential KE states.The analysis has the following results:the SSTA presents a nearly symmetrical distribution with opposite signs during the KE stable and unstable periods.During the KE stable period,the storm track is located north of 40°N and is significantly enhanced in the northeast Pacific Ocean.The atmospheric response is similar to the West Pacific/North Pacific Oscillation teleconnection(WP/NPO like pattern)and presents a barotropic structure.The inversion results of the potential vorticity equation show that the feedback of transient eddy vorticity manifests a WP/NPO like pattern and presents a barotropic structure,which is the main reason for bringing about the response of the WP/NPO like pattern.The magnitude of the feedbacks of both diabatic heating and transient eddy heating is small,which can offset one another.During the KE unstable period,the main body of the storm track is located to the south of 40°N,and there is no significant response signal in the atmosphere,except near the west coast of North America.Compared with the KE stable period,the asymmetry of response of the transient eddy vorticity is the main reason for the asymmetric response of the atmosphere.
文摘Relative to the power grid, the short-capacity system has smaller inertia and weaker ability to bear disturbance. As a result, the synchronous generator in short-capacity system will be greatly influenced by harmonic. To reveal how harmonic influence the generator, this article analyzed how harmonic current will influence the output voltage. Deduced a formula that can describe the electromagnetic torque pulsation brought by the theory of Instantaneous Power, which can explain why generator’s shaft vibrates. Then this article evaluated the applicability of current filtering methods in view of characteristics of the small capacity of the system. As a result, it was demonstrated that active filtering method is best suited for small capacity system. At last, it conducted the experiment that diesel generator set supply power to non-liner load to demonstrate the conclusion of theoretical analysis.
基金supported by the Cultivation Projects For Young Teaching Staff of Sun Yat-sen University (12ykpy61)the Pearl River Science and Technology New Star Project of Guangzhou City (Grant No.2014J2200060)the Guangdong Provincial Natural Science Foundation for Distinguished Young Scholars of China (Grant No.2014A030306030)
文摘Visual electrophysiology is widely used in clinical ophthalmology. It is also of significant value in the objective assessment of visual function in adult and pediatric cataract patients and for the diagnosis of and research on retinal and visual pathway diseases. This article systematically reviews visual electrophysiology techniques, their applications in the diagnosis and treatment of adult and pediatric cataracts, and factors influencing the application of visual electrophysiology during surgical treatment for cataracts.
文摘Hydrogen as a clean energy source is made full use, this paper researches the electrical model of PEMFC generator, analyzes the harmonic trend and its hazards when the generator operates with linear load and nonlinear load running synchronously, comparatively analyzes the commonly used harmonic suppression technology. Simulate and analyze the filter performance when APF is used. The results illustrate that as a filter device, APF can absorb the harmonic properly in PEMFC power system.
文摘Frequency control technology can achieve the purpose of energy saving of power equipment, but also bring problems of harmonic loss formula. The relationship between the loss rate and load rate is constituted by formula derivation, and calculate the load rate when the loss rate is the minimum and the total power of power-consuming devices. Then design the digital PID controller and research the power-saving optimization feedback algorithms and design the software process. Finally, carry out the inverter switching algorithm based on ABB ACS510 low voltage inverter.
基金supported by a grant from the Hubei University of Science and Technology Program(No.BK202417,China)Doctoral Special Research Fund Launch Project of Jiamusi University(JMSUBZ2021-12,China)Youth Innovative Talent Cultivation Support Plan of Jiamusi University(JMSUQP2022016,China)。
文摘Owing to their limited accuracy and narrow applicability,current antimicrobial peptide(AMP)prediction models face obstacles in industrial application.To address these limitations,we developed and improved an AMP prediction model using Comparing and Optimizing Multiple DEep Learning(COMDEL)algorithms,coupled with high-throughput AMP screening method,finally reaching an accuracy of 94.8%in test and 88%in experiment verification,surpassing other state-of-the-art models.In conjunction with COMDEL,we employed the phage-assisted evolution method to screen Sortase in vivo and developed a cell-free AMP synthesis system in vitro,ultimately increasing AMPs yields to a range of 0.5-2.1 g/L within hours.Moreover,by multi-omics analysis using COMDEL,we identified Lactobacillus plantarum as the most promising candidate for AMP generation among 35 edible probiotics.Following this,we developed a microdroplet sorting approach and successfully screened three L.plantarum mutants,each showing a twofold increase in antimicrobial ability,underscoring their substantial industrial application values.
基金supported by the National Natural Science Foundation of China(32060180,82160304,81560596,81860644 and 31560051)the Natural Foundation of Yunnan Province(2017FE467-001 and 2019FE001-002)the Scientific Research Fund Project of the Yunnan Education Department(2022Y208).
文摘Relapsing fever is an acute infectious disease caused by a variety of relapsing fever-associated spirochetes,for which no optimal treatment has been developed.The purposes of this study were to compare the efficacy and safety of commonly used antibiotics for the treatment of relapsing fever using a network meta-analysis approach and to explore the advantages of each drug based on the current evidence.This study examined nine published studies involving 1416 patients with relapsing fever treated with penicillin,erythromycin,tetracycline,doxycycline,minocycline or chloramphenicol.The odds ratio(OR)and 95% confidence interval(CI)were used as influence indices for discontinuous data,and the efficacy and safety of drugs were ranked by the surface under the cumulative ranking(SUCRA)curve.The primary outcomes of this study were mortality and cure rates,and the secondary outcomes were the rates of Jarisch-Herxheimer reaction and relapse.Erythromycin(SUCRA,84.5%)was the most effective antibiotic for reducing mortality,whereas tetracycline was the most effective antibiotic for improving the cure rate(SUCRA,69.3%)and reducing the relapse rate(SUCRA,79.7%),and minocycline(SUCRA,66.4%)was the most effective antibiotic for reducing Jarisch-Herxheimer reactions.In addition,our network meta-analysis showed that tetracycline is superior to penicillin for improving the cure rate(OR,5.91;95%CI,2.21-15.81)and reducing the relapse rate(OR,0.16;95%CI,0.04-0.67).
