Background:Pulmonary arterial hypertension(PAH)is a chronic and progressive disease that is strongly associated with dysregulation of glucose metabolism.Alterations in nuclear receptor subfamily 4 group A member 1(NR4...Background:Pulmonary arterial hypertension(PAH)is a chronic and progressive disease that is strongly associated with dysregulation of glucose metabolism.Alterations in nuclear receptor subfamily 4 group A member 1(NR4A1)activity alter the outcome of PAH.This study aimed to investigate the effects of NR4A1 on glycolysis in PAH and its underlying mechanisms.Methods:This study included twenty healthy volunteers and twenty-three PAH patients,and plasma samples were collected from the participants.To mimic the conditions of PAH in vitro,a hypoxia-induced model of pulmonary artery smooth muscle cell(PASMC)model was established.The proliferation of PASMCs was assessed using CCK8 assays.Results:Levels of NR4A1,hypoxia-inducible factor-1α(HIF-1α),and various glycolysis-related enzymes were measured.In addition,extracellular glucose and lactate production were assessed.The interaction between NR4A1 and HIF-1αwas evaluated by co-immunoprecipitation assays.Levels of NR4A1 and HIF-1αwas increased in PAH patients,and exposure to hypoxia resulted in increased levels of NR4A1 and HIF-1αin PASMCs.NR4A1 interacted with HIF-1α.NR4A1 overexpression enhanced hypoxia-induced expression of HIF-1α,GLUT1,PKM2,HK2,and CD36,decreased glucose levels,increased lactate levels and promoted hypoxic PASMC viability.Conversely,silencing NR4A1 decreased hypoxia-induced expression of HIF-1α,GLUT1,PKM2,HK2,and CD36,promoted glucose production,reduced lactate levels and inhibited hypoxic PASMC viability.Furthermore,overexpression of HIF-1αreversed the regulation of glycolysis caused by NR4A1 knockdown.Conclusion:NR4A1 enhances glycolysis in hypoxia-induced PASMCs by upregulating HIF-1α.Our findings indicate that the management of NR4A1 activity may be a promising strategy for PAH therapy.展开更多
BACKGROUND Temporomandibular joint(TMJ)disorders are closely related to high-angle and skeletal Class II malocclusion.Sometimes pathological changes in the mandibular condyle can cause open bite to occur after growth ...BACKGROUND Temporomandibular joint(TMJ)disorders are closely related to high-angle and skeletal Class II malocclusion.Sometimes pathological changes in the mandibular condyle can cause open bite to occur after growth is complete.CASE SUMMARY This article is about the treatment of an adult male patient with a severe hyperdivergent skeletal Class II base,an unusual and gradually occurring open bite and an abnormal mandibular condyle anterior displacement.Because the patient refused surgery,four second molars with cavities and root canal therapy were extracted,and four mini-screws were used for intrusion of the posterior teeth.The treatment duration was 22 mo,and after the treatment,the open bite was corrected and the displaced mandibular condyles were seated back to the articular fossa as shown by cone-beam computed tomography(CBCT).Based on the patient’s open bite history,the result of clinical examinations and CBCT comparisons,we believe it is possible that the occlusion interference was eliminated after the four second molars were extracted and the posterior teeth were intruded,and the patient's condyle spontaneously returned to its physiologic position.Finally,a normal overbite was established,and stable occlusion was achieved.CONCLUSION This case report suggested that identifying the cause of open bite is essential,and the TMJ factors for hyperdivergent skeletal Class II cases should be particularly examined.For these cases,intruding posterior teeth may place the condyle in a more appropriate position and provide an environment suitable for TMJ recovery.展开更多
The monomer agglomeration of nonmetallic inclusions was simulated with a diffusion limited aggregation (DLA) model of thefractal theory. The simulation study with a random two-dimensional diffusion was carried out. Th...The monomer agglomeration of nonmetallic inclusions was simulated with a diffusion limited aggregation (DLA) model of thefractal theory. The simulation study with a random two-dimensional diffusion was carried out. The results indicate that the DLA model canbe used for the simulation of agglomeration behavior of the cluster-type inclusions. The morphology of clusters was observed with SEMand compared with the simulated agglomerates. The modelling procedure of the DLA model is applicable for the agglomeration process.The uncertainty of agglomeration process and the persuasive average agglomerative ratio was analyzed. The factors about the agglomera-tive ratio with the collision path distance and the size of particles or seed were discussed. The adherence of the nonmetallic inclusions onthe dam, the weir and the walls of a tundish, and the absorption of inclusions by stopper or nozzle were also discussed .展开更多
Certain pseudogenes may regulate their protein-coding cousins by competing for miRNAs and play an active biological role in cancer.However,few studies have focused on the association of genetic variations in pseudogen...Certain pseudogenes may regulate their protein-coding cousins by competing for miRNAs and play an active biological role in cancer.However,few studies have focused on the association of genetic variations in pseudogenes with cancer prognosis.We selected six potentially functional single nucleotide polymorphisms(SNPs) in cancerrelated pseudogenes,and performed a case-only study to assess the association between those SNPs and the prognosis of hepatocellular carcinoma(HCC) in 331 HBV-positive HCC patients without surgical treatment.Log-rank test and Cox proportional hazard models were used for survival analysis.We found that the A allele of rs9909601 in E2F3P1was significantly associated with a better prognosis compared with the G allele[adjusted hazard ratio(HR) = 0.69,95%confidence interval(CI) = 0.56-0.86,P = 0.001].Additionally,this protective effect was more predominant for patients without chemotherapy and transcatheter hepatic arterial chemoembolization(TACE) treatment.Interestingly,we also detected a statistically significant multiplicative interaction between genotypes of rs9909601 and chemotherapy or TACE status on HCC survival(P for multiplicative interaction < 0.001).These findings indicate that rs9909601 in the pseudogene E2F3P1 may be a genetic marker for HCC prognosis in Chinese.展开更多
Recent studies showed that pseudogenes can regulate the expression of their coding gene partners by competing for miRNAs. The E2F family plays a crucial role in the control of cell cycle checkpoint. E2F3P1 is a pseudo...Recent studies showed that pseudogenes can regulate the expression of their coding gene partners by competing for miRNAs. The E2F family plays a crucial role in the control of cell cycle checkpoint. E2F3P1 is a pseudogene of E2F3. Few studies focused on genetic variations on pseudogenes. In this study, we performed a case-control study to assess the association between single nucleotide polymorphisms (SNPs) in E2F3P1 and hepatocellular carcinoma (HCC) risk in 1050 hepatitis B virus (HBV)-positive HCC cases and 1050 chronic HBV carriers. Logistic regression analysis was applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and HCC risk. We found that the variant CT/TT genotypes of rs1838149 were associated with a significantly decreased risk of HCC (adjusted OR=0.66, 95% CIs=0.51-0.86, P=0.002) compared to those with wildtype CC homozygote. Furthermore, the AA genotype of rs9909601 had an increased HCC risk with an adjusted OR of 1.41 (95% CIs=1.07-1.86), and the A allele of rs9909601 was significantly associated with HCC risk compared to those with the G allele (adjusted OR=1.17, 95% CIs=1.03-1.33, P=0.017). These results indicate that genetic variations in the pseudogene E2F3P1 may confer HCC risk.展开更多
In this paper,we first propose a new stabilized finite element method for the Stokes eigenvalue problem.This new method is based on multiscale enrichment,and is derived from the Stokes eigenvalue problem itself.The co...In this paper,we first propose a new stabilized finite element method for the Stokes eigenvalue problem.This new method is based on multiscale enrichment,and is derived from the Stokes eigenvalue problem itself.The convergence of this new stabilized method is proved and the optimal priori error estimates for the eigenfunctions and eigenvalues are also obtained.Moreover,we combine this new stabilized finite element method with the two-level method to give a new two-level stabilized finite element method for the Stokes eigenvalue problem.Furthermore,we have proved a priori error estimates for this new two-level stabilized method.Finally,numerical examples confirm our theoretical analysis and validate the high effectiveness of the new methods.展开更多
Scheduling schemes assign limited resources to appropriate users,which are critical for wireless network performance.Most current schemes have been designed based on saturated traffic,i.e.,assuming users in networks a...Scheduling schemes assign limited resources to appropriate users,which are critical for wireless network performance.Most current schemes have been designed based on saturated traffic,i.e.,assuming users in networks always have data to transmit.However,the user buffer may sometimes be empty in actual network.Therefore,these algorithms will allocate resources to users having no data to transmit,which results in resource waste.In view of this,we propose new scheduling schemes for onehop and two-hop link scenario with unsaturated traffic.Furthermore,this paper analyzes their key network performance indicators,including the average queue length,average throughput,average delay and outage probability.The two scheduling algorithms avoid scheduling the links whose buffers are empty and thus improve the network resource utilization.For the one-hop link scenario,network provides differentiated services via adjusting the scheduling probabilities of the destination nodes(DNs)with different priorities.Among the DNs with same priority,the node with higher data arrival rate has larger scheduling probability.For the two-hop link scenario,we prioritize the scheduling of relay-to-destination(R-D)link and dynamically adjust the transmission probability of source-to-relay(S-R)link,according to the length of remaining buffer.The experiment results show the effectiveness and advantage of the proposed algorithms.展开更多
BACKGROUND Adult patients presenting with Angle Class II division 1 malocclusions that have a strong skeletal etiology can be challenging for clinicians,particularly if accompanied by retrognathia of the mandible and ...BACKGROUND Adult patients presenting with Angle Class II division 1 malocclusions that have a strong skeletal etiology can be challenging for clinicians,particularly if accompanied by retrognathia of the mandible and a dolichofacial growth pattern.CASE SUMMARY In this case report,we describe the successful orthodontic and surgical management of a 20-year-old woman with an Angle Class II malocclusion with a severe anteroposterior skeletal discrepancy characterized by mandibular deficiency.She had incompetent lips,dental and skeletal Class II malocclusion,high mandibular plane angle,mild mandibular crowding,and two missing maxillary first molars.The treatment plan comprised:(1)Extraction of two mandibular second premolars to decompensate and retract mandibular incisors;(2)pre-surgical alignment,leveling,and space closure of the teeth in both arches,and protraction of the second maxillary molars to close the maxillary space;(3)surgical treatment including a LeFort I osteotomy for maxillary retraction and rotation,a bilateral sagittal split osteotomy for mandibular advancement and rotation,and a genioplasty for correctting the skeletal deformities;and(4)post-surgical correction of the malocclusion.CONCLUSION The patient’s facial esthetics was significantly improved and a desirable occlusion was achieved after 16 mo treatment.Follow-up records after 2 years showed stable esthetics and function.展开更多
Catalytic reduction of molecular dinitrogen(N_(2))to ammonia(NH_(3))is one of the most important and challenging industrial reactions.Electrochemical reduction is considered as an energy-saving technology for artifici...Catalytic reduction of molecular dinitrogen(N_(2))to ammonia(NH_(3))is one of the most important and challenging industrial reactions.Electrochemical reduction is considered as an energy-saving technology for artificial ambient nitrogen fixation,which is emerging as an optimal potential sustainable strategy to substitute for the Haber–Bosch process.However,this process demands efficient catalysts for the N_(2)reduction reaction(NRR).Here,by means of first-principles calculations,we systematically explored the potential electrocatalytic performance of single transition metal atoms(Pd,Ag,Rh,Cu,Ti,Mo,Mn,Zn,Fe,Co,Ru,and Pt)embedded in monolayer defective boron phosphide(TMs/BP)monolayer with a phosphorus monovacancy for ambient NH_(3)production.Among them,the Mo/BP exhibits the best catalytic performance for ambient reduction of N_(2)through the typical enzymatic and consecutive reaction pathways with an activation barrier of 0.68 e V,indicating that Mo/BP is an efficient catalyst for N_(2)fixation.We believe that this work could provide a new avenue of ambient NH_(3)synthesis by using the designed single-atom electrocatalysts.展开更多
Layered double hydroxides(LDHs)have received extensive attention in many fields such as catalysis,environmental management and medical applications.Typically,expensive soluble metal salts are commonly used as the star...Layered double hydroxides(LDHs)have received extensive attention in many fields such as catalysis,environmental management and medical applications.Typically,expensive soluble metal salts are commonly used as the starting materials for the synthesis of LDHs.Here,we report a novel synthesis route for Mg/Al-LDH by using inexpensive basic magnesium carbonate as the starting material.X-ray diffraction(XRD)and solid-state nuclear magnetic resonance(ssNMR)data show that LDHs with rich defects are formed rapidly at room temperature and good crystallinity can be obtained after further hydrothermal treatment.These results provide a simple,rapid and green preparation method for LDHs.展开更多
As a new branch of efficient and low-cost mechanical energy conversion technology,triboelectric nanogenerator(TENG)is a potential solution to provide a long-term power supply for the Internet of Things(IoT)sensors and...As a new branch of efficient and low-cost mechanical energy conversion technology,triboelectric nanogenerator(TENG)is a potential solution to provide a long-term power supply for the Internet of Things(IoT)sensors and portable electronic devices.However,due to inherent working properties of TENG itself such as extremely high internal impedance,pulse,and alternating current(AC)output,TENG can not directly supply power to loads such as batteries efficiently.Based on these,we describe TENG’s performance from a new perspective of powering ability.It consists of two aspects:the ability to transport charge effectively and the ability to output high power quality current steadily.In order to push forward the developments and applications of TENG,it is necessary to improve its power supply capacity from different perspectives.Fortunately,in recent years,a variety of output signal’s management strategies aiming at effectively managing the generated electricity and significantly improving powering ability of TENG have obtained significantly progress.Herein,this paper discusses the working mechanisms and different load characteristics of TENG at first to clarify the electric performance of TENG.Then,on basis of theoretical analysis,the output signal’s management strategies are elaborated from four aspects:improving the cycle output electricity of TENG,increasing the surface charge density of TENG,improving the power quality of TENG-based energy harvesting system,promoting the application of TENG through integrated circuit(IC)technology and TENG network,and the relevant principles and applications are discussed systematically.Finally,the advantages and disadvantages of the above output signal’s management strategies are summarized and discussed,and the future development of the output signal’s management strategies for TENG is prospected.展开更多
Wolbachia 是感染大量节肢动物和丝虫的线虫的细胞内部的共生者。蚜虫从事与他们的 endosymbionts 的多样、复杂的关系。Wolbachia 的四超群(A， B， M 和 N ) 以前在蚜虫和超群 M 被检测， N 仅仅在蚜虫被发现。在这研究，我们在中国...Wolbachia 是感染大量节肢动物和丝虫的线虫的细胞内部的共生者。蚜虫从事与他们的 endosymbionts 的多样、复杂的关系。Wolbachia 的四超群(A， B， M 和 N ) 以前在蚜虫和超群 M 被检测， N 仅仅在蚜虫被发现。在这研究，我们在中国在蚜虫的自然人口检测了并且描述 Wolbachia 感染。三超群(A， B 和 M ) 在检验蚜虫种类被发现。超群 M 是优势的，而超群 A 和 B 仅仅在某些种类被检测。超群 N 没在这研究被发现。也就是，有在蚜虫的 Wolbachia 的四个感染模式有超群 M 的感染独自一个，有超群 A 和 M，有超群 B 和 M 的合作感染，和有超群 A， B 和 M 的合作感染的合作感染。仅仅有超群 M 的感染的模式是通用的并且在所有评估亚科被发现。仅仅二个亚科， Aphidinae 和 Lachninae，表明了介绍所有四个感染模式。三个模式在 Calaphidinae 被观察(M， A&M， B&M ) 并且 Eriosomatinae (M， B&M， A&B&M ) 。二个模式在 Anoeciinae 被观察(M， A&M ) 并且 Greenideinae (M， B&M ) ，并且一仅仅模式(M) 在 Aphidoidea 的留下的家庭或亚科被观察。这些结果显示在中国蚜虫的 Wolbachia 感染是普遍的。种系发生的分析建议超群 M 在中国在蚜虫的所有主人种类之中很快并且最近散布了的那 Wolbachia。为这传播和它的机制的原因在他们的蚜虫主人上与 Wolbachia 的可能的效果一起被讨论。展开更多
To the Editor:Livedoid vasculopathy(LV)is a thromboocclusive disorder involving superficial and mid-dermis vessels,characterized by painful erythematous or purpuric macules or papules,small crusted ulcers,and porcelai...To the Editor:Livedoid vasculopathy(LV)is a thromboocclusive disorder involving superficial and mid-dermis vessels,characterized by painful erythematous or purpuric macules or papules,small crusted ulcers,and porcelainwhite atrophic scars that remain after several months.[1,2]Dermoscopy is a non-invasive and effective image analysis technology[3]that can aid dermatologists in visualization of the pigmentation pattern and vascular structure,as well as other morphologic features of the epidermis and dermis.This study was performed to identify the clinical and dermoscopic features of LV in patients with LV who were treated in our hospital from October 2017 to August 2018.The study was approved by the Ethical Committee of the First Affiliated Hospital of Zhengzhou University(No.2018-YB-05).The study was performed in accordance with the established guidelines and regulations.We have obtained all appropriate patient consent forms.In the form,the patients have given their consents for their images and other clinical information to be reported in the journal.展开更多
基金supported by the National Natural Science Foundation of China(No.82000300).
文摘Background:Pulmonary arterial hypertension(PAH)is a chronic and progressive disease that is strongly associated with dysregulation of glucose metabolism.Alterations in nuclear receptor subfamily 4 group A member 1(NR4A1)activity alter the outcome of PAH.This study aimed to investigate the effects of NR4A1 on glycolysis in PAH and its underlying mechanisms.Methods:This study included twenty healthy volunteers and twenty-three PAH patients,and plasma samples were collected from the participants.To mimic the conditions of PAH in vitro,a hypoxia-induced model of pulmonary artery smooth muscle cell(PASMC)model was established.The proliferation of PASMCs was assessed using CCK8 assays.Results:Levels of NR4A1,hypoxia-inducible factor-1α(HIF-1α),and various glycolysis-related enzymes were measured.In addition,extracellular glucose and lactate production were assessed.The interaction between NR4A1 and HIF-1αwas evaluated by co-immunoprecipitation assays.Levels of NR4A1 and HIF-1αwas increased in PAH patients,and exposure to hypoxia resulted in increased levels of NR4A1 and HIF-1αin PASMCs.NR4A1 interacted with HIF-1α.NR4A1 overexpression enhanced hypoxia-induced expression of HIF-1α,GLUT1,PKM2,HK2,and CD36,decreased glucose levels,increased lactate levels and promoted hypoxic PASMC viability.Conversely,silencing NR4A1 decreased hypoxia-induced expression of HIF-1α,GLUT1,PKM2,HK2,and CD36,promoted glucose production,reduced lactate levels and inhibited hypoxic PASMC viability.Furthermore,overexpression of HIF-1αreversed the regulation of glycolysis caused by NR4A1 knockdown.Conclusion:NR4A1 enhances glycolysis in hypoxia-induced PASMCs by upregulating HIF-1α.Our findings indicate that the management of NR4A1 activity may be a promising strategy for PAH therapy.
文摘BACKGROUND Temporomandibular joint(TMJ)disorders are closely related to high-angle and skeletal Class II malocclusion.Sometimes pathological changes in the mandibular condyle can cause open bite to occur after growth is complete.CASE SUMMARY This article is about the treatment of an adult male patient with a severe hyperdivergent skeletal Class II base,an unusual and gradually occurring open bite and an abnormal mandibular condyle anterior displacement.Because the patient refused surgery,four second molars with cavities and root canal therapy were extracted,and four mini-screws were used for intrusion of the posterior teeth.The treatment duration was 22 mo,and after the treatment,the open bite was corrected and the displaced mandibular condyles were seated back to the articular fossa as shown by cone-beam computed tomography(CBCT).Based on the patient’s open bite history,the result of clinical examinations and CBCT comparisons,we believe it is possible that the occlusion interference was eliminated after the four second molars were extracted and the posterior teeth were intruded,and the patient's condyle spontaneously returned to its physiologic position.Finally,a normal overbite was established,and stable occlusion was achieved.CONCLUSION This case report suggested that identifying the cause of open bite is essential,and the TMJ factors for hyperdivergent skeletal Class II cases should be particularly examined.For these cases,intruding posterior teeth may place the condyle in a more appropriate position and provide an environment suitable for TMJ recovery.
基金The researches described in this article were partially supported by grants from the National Natural Science Foundation of China （No. 81570271 and 81400357） and NIH （UL1 RR024996）. We are very grateful to John R Lee （Assistant Professor of Medicine, Weill Comell Medical College, New York）, and Jeff J Zhu （Research Manager, Weill Comell Medical College, New York） for critical review of the article. The authors have nothing to disclosure.
文摘The monomer agglomeration of nonmetallic inclusions was simulated with a diffusion limited aggregation (DLA) model of thefractal theory. The simulation study with a random two-dimensional diffusion was carried out. The results indicate that the DLA model canbe used for the simulation of agglomeration behavior of the cluster-type inclusions. The morphology of clusters was observed with SEMand compared with the simulated agglomerates. The modelling procedure of the DLA model is applicable for the agglomeration process.The uncertainty of agglomeration process and the persuasive average agglomerative ratio was analyzed. The factors about the agglomera-tive ratio with the collision path distance and the size of particles or seed were discussed. The adherence of the nonmetallic inclusions onthe dam, the weir and the walls of a tundish, and the absorption of inclusions by stopper or nozzle were also discussed .
基金funded by the National Natural Science Foundation of China(81372606 and 81072344)supported by the National Key Basic Research Program Grant(2013CB911400)+6 种基金the project supportedby the National Science Foundation for Distinguished Young Scholarsof China(81225020)Foundation of Jiangsu Province for Distinguished Young Scholars(BK2012042)Foundation for the Program for NewCentury Excellent Talents in University(NCET-10-0178)the Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions(122031)Young Tip-top Talents Support Program by the Organization Department of the CPC Central Committee,the Author of National Excellent Doctoral Dissertation(201081)Jiangsu Province Clinical Science and Technology Projects(BL2012008)the Priority Academic Program for the Development of Jiangsu Higher Education Institutions(Public Health and PreventiveMedicine)
文摘Certain pseudogenes may regulate their protein-coding cousins by competing for miRNAs and play an active biological role in cancer.However,few studies have focused on the association of genetic variations in pseudogenes with cancer prognosis.We selected six potentially functional single nucleotide polymorphisms(SNPs) in cancerrelated pseudogenes,and performed a case-only study to assess the association between those SNPs and the prognosis of hepatocellular carcinoma(HCC) in 331 HBV-positive HCC patients without surgical treatment.Log-rank test and Cox proportional hazard models were used for survival analysis.We found that the A allele of rs9909601 in E2F3P1was significantly associated with a better prognosis compared with the G allele[adjusted hazard ratio(HR) = 0.69,95%confidence interval(CI) = 0.56-0.86,P = 0.001].Additionally,this protective effect was more predominant for patients without chemotherapy and transcatheter hepatic arterial chemoembolization(TACE) treatment.Interestingly,we also detected a statistically significant multiplicative interaction between genotypes of rs9909601 and chemotherapy or TACE status on HCC survival(P for multiplicative interaction < 0.001).These findings indicate that rs9909601 in the pseudogene E2F3P1 may be a genetic marker for HCC prognosis in Chinese.
基金funded by the National Key Basic Research Program (2013CB911400)the Foundation for the Program for New Century Excellent Talents in University (NCET-10-0178)+5 种基金the Author of National Excellent Doctoral Dissertation (201081)the National Natural Science Foundation of China (30800946 and 81072344)the State Key Infectious Disease Project of China (2012ZX10002010, 2012ZX10002016)the National Major S&T Projects 2011ZX10004902)the National Science Fund for Creative Research Groups (30921006)the Priority Academic Program for the Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine)
文摘Recent studies showed that pseudogenes can regulate the expression of their coding gene partners by competing for miRNAs. The E2F family plays a crucial role in the control of cell cycle checkpoint. E2F3P1 is a pseudogene of E2F3. Few studies focused on genetic variations on pseudogenes. In this study, we performed a case-control study to assess the association between single nucleotide polymorphisms (SNPs) in E2F3P1 and hepatocellular carcinoma (HCC) risk in 1050 hepatitis B virus (HBV)-positive HCC cases and 1050 chronic HBV carriers. Logistic regression analysis was applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and HCC risk. We found that the variant CT/TT genotypes of rs1838149 were associated with a significantly decreased risk of HCC (adjusted OR=0.66, 95% CIs=0.51-0.86, P=0.002) compared to those with wildtype CC homozygote. Furthermore, the AA genotype of rs9909601 had an increased HCC risk with an adjusted OR of 1.41 (95% CIs=1.07-1.86), and the A allele of rs9909601 was significantly associated with HCC risk compared to those with the G allele (adjusted OR=1.17, 95% CIs=1.03-1.33, P=0.017). These results indicate that genetic variations in the pseudogene E2F3P1 may confer HCC risk.
基金supported by the National Key R&D Program of China(2018YFB1501001)the NSF of China(11771348)China Postdoctoral Science Foundation(2019M653579)。
文摘In this paper,we first propose a new stabilized finite element method for the Stokes eigenvalue problem.This new method is based on multiscale enrichment,and is derived from the Stokes eigenvalue problem itself.The convergence of this new stabilized method is proved and the optimal priori error estimates for the eigenfunctions and eigenvalues are also obtained.Moreover,we combine this new stabilized finite element method with the two-level method to give a new two-level stabilized finite element method for the Stokes eigenvalue problem.Furthermore,we have proved a priori error estimates for this new two-level stabilized method.Finally,numerical examples confirm our theoretical analysis and validate the high effectiveness of the new methods.
基金This work was supported in part by the Natural Science Foundation of China under Grant 61725103,Grant 91638202,Grant 61801361 and Grant U19B2025,and was supported by“the Fundamental Research Funds for the Central Universities”.
文摘Scheduling schemes assign limited resources to appropriate users,which are critical for wireless network performance.Most current schemes have been designed based on saturated traffic,i.e.,assuming users in networks always have data to transmit.However,the user buffer may sometimes be empty in actual network.Therefore,these algorithms will allocate resources to users having no data to transmit,which results in resource waste.In view of this,we propose new scheduling schemes for onehop and two-hop link scenario with unsaturated traffic.Furthermore,this paper analyzes their key network performance indicators,including the average queue length,average throughput,average delay and outage probability.The two scheduling algorithms avoid scheduling the links whose buffers are empty and thus improve the network resource utilization.For the one-hop link scenario,network provides differentiated services via adjusting the scheduling probabilities of the destination nodes(DNs)with different priorities.Among the DNs with same priority,the node with higher data arrival rate has larger scheduling probability.For the two-hop link scenario,we prioritize the scheduling of relay-to-destination(R-D)link and dynamically adjust the transmission probability of source-to-relay(S-R)link,according to the length of remaining buffer.The experiment results show the effectiveness and advantage of the proposed algorithms.
基金Supported by the Natural Science Foundation of Jiangsu,No. SBK2021021787Nanjing Key Project Foundation,No. ZKX20048
文摘BACKGROUND Adult patients presenting with Angle Class II division 1 malocclusions that have a strong skeletal etiology can be challenging for clinicians,particularly if accompanied by retrognathia of the mandible and a dolichofacial growth pattern.CASE SUMMARY In this case report,we describe the successful orthodontic and surgical management of a 20-year-old woman with an Angle Class II malocclusion with a severe anteroposterior skeletal discrepancy characterized by mandibular deficiency.She had incompetent lips,dental and skeletal Class II malocclusion,high mandibular plane angle,mild mandibular crowding,and two missing maxillary first molars.The treatment plan comprised:(1)Extraction of two mandibular second premolars to decompensate and retract mandibular incisors;(2)pre-surgical alignment,leveling,and space closure of the teeth in both arches,and protraction of the second maxillary molars to close the maxillary space;(3)surgical treatment including a LeFort I osteotomy for maxillary retraction and rotation,a bilateral sagittal split osteotomy for mandibular advancement and rotation,and a genioplasty for correctting the skeletal deformities;and(4)post-surgical correction of the malocclusion.CONCLUSION The patient’s facial esthetics was significantly improved and a desirable occlusion was achieved after 16 mo treatment.Follow-up records after 2 years showed stable esthetics and function.
基金supported by the National Natural Science Foundation of China(51425301,U1601214,51573013,51773092 and 51772147,21475041,21675050,20405142,21305041)Research Foundation of State Key Lab(ZK201805)the Hunan Provincial Innovation Foundation for Postgraduate(Grant No.CX2018B294)
文摘Catalytic reduction of molecular dinitrogen(N_(2))to ammonia(NH_(3))is one of the most important and challenging industrial reactions.Electrochemical reduction is considered as an energy-saving technology for artificial ambient nitrogen fixation,which is emerging as an optimal potential sustainable strategy to substitute for the Haber–Bosch process.However,this process demands efficient catalysts for the N_(2)reduction reaction(NRR).Here,by means of first-principles calculations,we systematically explored the potential electrocatalytic performance of single transition metal atoms(Pd,Ag,Rh,Cu,Ti,Mo,Mn,Zn,Fe,Co,Ru,and Pt)embedded in monolayer defective boron phosphide(TMs/BP)monolayer with a phosphorus monovacancy for ambient NH_(3)production.Among them,the Mo/BP exhibits the best catalytic performance for ambient reduction of N_(2)through the typical enzymatic and consecutive reaction pathways with an activation barrier of 0.68 e V,indicating that Mo/BP is an efficient catalyst for N_(2)fixation.We believe that this work could provide a new avenue of ambient NH_(3)synthesis by using the designed single-atom electrocatalysts.
基金supported by National Key R&D Program of China(2021YFA1502803)the National Natural Science Foundation of China(NSFC)(21972066 and 91745202)+3 种基金NSFC-Royal Society Joint Program(21661130149)Luming Peng thanks the Royal Society and Newton Fund for a Royal Society-Newton Advanced Fellowshipsupported by the Research Funds for the Frontiers Science Center for Critical Earth Material Cycling,Nanjing Universitya Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Layered double hydroxides(LDHs)have received extensive attention in many fields such as catalysis,environmental management and medical applications.Typically,expensive soluble metal salts are commonly used as the starting materials for the synthesis of LDHs.Here,we report a novel synthesis route for Mg/Al-LDH by using inexpensive basic magnesium carbonate as the starting material.X-ray diffraction(XRD)and solid-state nuclear magnetic resonance(ssNMR)data show that LDHs with rich defects are formed rapidly at room temperature and good crystallinity can be obtained after further hydrothermal treatment.These results provide a simple,rapid and green preparation method for LDHs.
基金funded by the National Key R&D Project from Minister of Science and Technology(No.2021YFA1201602)the National Natural Science Foundation of China(Nos.52172203 and U21A20175).
文摘As a new branch of efficient and low-cost mechanical energy conversion technology,triboelectric nanogenerator(TENG)is a potential solution to provide a long-term power supply for the Internet of Things(IoT)sensors and portable electronic devices.However,due to inherent working properties of TENG itself such as extremely high internal impedance,pulse,and alternating current(AC)output,TENG can not directly supply power to loads such as batteries efficiently.Based on these,we describe TENG’s performance from a new perspective of powering ability.It consists of two aspects:the ability to transport charge effectively and the ability to output high power quality current steadily.In order to push forward the developments and applications of TENG,it is necessary to improve its power supply capacity from different perspectives.Fortunately,in recent years,a variety of output signal’s management strategies aiming at effectively managing the generated electricity and significantly improving powering ability of TENG have obtained significantly progress.Herein,this paper discusses the working mechanisms and different load characteristics of TENG at first to clarify the electric performance of TENG.Then,on basis of theoretical analysis,the output signal’s management strategies are elaborated from four aspects:improving the cycle output electricity of TENG,increasing the surface charge density of TENG,improving the power quality of TENG-based energy harvesting system,promoting the application of TENG through integrated circuit(IC)technology and TENG network,and the relevant principles and applications are discussed systematically.Finally,the advantages and disadvantages of the above output signal’s management strategies are summarized and discussed,and the future development of the output signal’s management strategies for TENG is prospected.
文摘Wolbachia 是感染大量节肢动物和丝虫的线虫的细胞内部的共生者。蚜虫从事与他们的 endosymbionts 的多样、复杂的关系。Wolbachia 的四超群(A， B， M 和 N ) 以前在蚜虫和超群 M 被检测， N 仅仅在蚜虫被发现。在这研究，我们在中国在蚜虫的自然人口检测了并且描述 Wolbachia 感染。三超群(A， B 和 M ) 在检验蚜虫种类被发现。超群 M 是优势的，而超群 A 和 B 仅仅在某些种类被检测。超群 N 没在这研究被发现。也就是，有在蚜虫的 Wolbachia 的四个感染模式有超群 M 的感染独自一个，有超群 A 和 M，有超群 B 和 M 的合作感染，和有超群 A， B 和 M 的合作感染的合作感染。仅仅有超群 M 的感染的模式是通用的并且在所有评估亚科被发现。仅仅二个亚科， Aphidinae 和 Lachninae，表明了介绍所有四个感染模式。三个模式在 Calaphidinae 被观察(M， A&M， B&M ) 并且 Eriosomatinae (M， B&M， A&B&M ) 。二个模式在 Anoeciinae 被观察(M， A&M ) 并且 Greenideinae (M， B&M ) ，并且一仅仅模式(M) 在 Aphidoidea 的留下的家庭或亚科被观察。这些结果显示在中国蚜虫的 Wolbachia 感染是普遍的。种系发生的分析建议超群 M 在中国在蚜虫的所有主人种类之中很快并且最近散布了的那 Wolbachia。为这传播和它的机制的原因在他们的蚜虫主人上与 Wolbachia 的可能的效果一起被讨论。
文摘To the Editor:Livedoid vasculopathy(LV)is a thromboocclusive disorder involving superficial and mid-dermis vessels,characterized by painful erythematous or purpuric macules or papules,small crusted ulcers,and porcelainwhite atrophic scars that remain after several months.[1,2]Dermoscopy is a non-invasive and effective image analysis technology[3]that can aid dermatologists in visualization of the pigmentation pattern and vascular structure,as well as other morphologic features of the epidermis and dermis.This study was performed to identify the clinical and dermoscopic features of LV in patients with LV who were treated in our hospital from October 2017 to August 2018.The study was approved by the Ethical Committee of the First Affiliated Hospital of Zhengzhou University(No.2018-YB-05).The study was performed in accordance with the established guidelines and regulations.We have obtained all appropriate patient consent forms.In the form,the patients have given their consents for their images and other clinical information to be reported in the journal.
