The Zengmu Basin located in the shallow water area of the southern South China Sea,is rich in oil and gas resources,within which faults and mud-diapir are developed,but it is unknown whether oil and gas migrate to the...The Zengmu Basin located in the shallow water area of the southern South China Sea,is rich in oil and gas resources,within which faults and mud-diapir are developed,but it is unknown whether oil and gas migrate to the seafloor surface.The newly collected multibeam data across the Zengmu Basin reveal a large number of depressions,with depths of 2-4 m,widths of several tens of meters,large distribution range of 1.8-8 km along survey line,up to~50 km,and their backscatter intensity(-26 dB)is much greater than that of the surrounding area(-38 dB).Combined with the developed mud-diapir and fracture structures,and abundant oil and gas resources within this basin,these depressions are presumed to be pockmarks.Furthermore,more than 110 mono-sized small circular pockmarks,with a depth of less than 1 m and a width of 5 m,are observed in an area of less than 0.03 km2,which are not obliterated by sediment infilling with high sedimentation rate,implying an existence of unit-pockmarks that are or recently were active.In addition,seismic profiles across the Zengmu Basin show characterization of upward migration of hydrocarbons,expressed as mud-diapir structures,bright spots in the shallow formation with characteristics of“low frequency increase and high frequency attenuation”.The subbottom profiles show the mud-diapir structures,as well as the gas-bearing blank zones beneath the seafloor.These features suggest large gas leaking and occurrence of large amounts of carbonate nodules on the seafloor.This indicates the complex and variable substrate type in the Zengmu Basin,while the area was once thought to be mainly silty sand and find sand.This is the first report on the discovery of pockmarks in the Zengmu Basin;it will provide basic information for submarine stability and marine engineering in China’s maritime boundaries.展开更多
The southwestern depression of the Qiongdongnan Basin(QDNB)hosts thick Cenozoic sediments and awaits major hydrocarbon discovery.Multichannel seismic(MCS)profile CFT2011 across the southwestern QDNB reveals a~60-km-wi...The southwestern depression of the Qiongdongnan Basin(QDNB)hosts thick Cenozoic sediments and awaits major hydrocarbon discovery.Multichannel seismic(MCS)profile CFT2011 across the southwestern QDNB reveals a~60-km-wide fuzzy reflection zone(FRZ)within the sediments,but its origin and distribution remain unclear.Here ocean bottom seismometer(OBS)data of Line CFT2011 are processed with focus on the velocity structures by traveltime tomography inversion and analyzed together with the coincident and adjacent MCS profiles.The OBS velocity results show that the giant FRZ features lower velocity with difference up to 1.5 km/s and smaller vertical velocity gradient than the surrounding sedimentary sequences at the same depth,likely resulting from enhanced fluid infilling.The MCS profile exhibits that the giant FRZ is about 3-9-km thick and extends from the Paleogene strata rich in organic matters upward to the lower Pleistocene sediments.Within the shallow overlying sediments,multiple bright spots with reverse polarity are imaged and their reflection amplitudes increase with offset,consistent with the features of gas-charged sediments.They are probably shallow gas reservoirs with gases sourced from the deep FRZ.Therefore,the FRZ is proposed to be a giant gas-charged zone,which probably contains lots of hydrocarbon gases migrated vertically from the deep Paleogene source rocks through the boundary faults of the depressions and the minor fractures generated under overpressure.This FRZ is also imaged on the adjacent MCS profiles MCS-L1 and MCS-L2 with the width of about 40 km and 68 km,respectively.It is roughly estimated to cover an area of~1900 km2 and host a volume of~11400 km3 assuming an average thickness of 6 km,implying huge natural gas potential in the sedimentary depression of the southwestern QDNB of the South China Sea.展开更多
Angiogenesis plays a significant role in the occurrence and development of inflammatory bowel disease(IBD).The aim of this study is to explore potential angiogenesis related genes(ARGs)in IBD through bioinformatics an...Angiogenesis plays a significant role in the occurrence and development of inflammatory bowel disease(IBD).The aim of this study is to explore potential angiogenesis related genes(ARGs)in IBD through bioinformatics analysis and in vivo experiments.Methods:GSE57945,GSE87466,and GSE36807 were obtained from the Gene Expression Omnibus database.GSE57945 was used as the training set,while GSE87466 and GSE36807 were used as the validation set.The key ARGs associated with IBD were identified using the least absolute shrinkage and selection operator(LASSO)and random forest methods.These identified ARGs were then utilized to construct a diagnostic model for IBD.The Single-Sample Genome Enrichment Analysis,Cibersort,and Xcell methods were used to evaluate the immune infiltration.Expression of amyloid beta precursor protein(APP)was verified in the IBD mouse model induced by dextran sulfate sodium using immunohistochemistry(IHC).Results:The receiver operating curve area of GSE57945 was 0.948.Two distinct clusters were identified using consensus clustering and non-negative matrix factorization clustering.Subsequent analyses revealed significant differences in immune levels and functional enrichment between the two clusters.The successful construction of the animal model for the IBD was evident by hematoxylin and eosin staining,while IHC results showed a high expression of APP in IBD and a low expression in normal tissues.Conclusion:Our findings provide new insights into the diagnosis of IBD by ARGs,and APP could be a potential novel biomarker for IBD and promising therapeutic targets.展开更多
基金Supported by the Special Support Program for Cultivating High-level Talents in Guangdong Province(No.2019BT02H594)the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0104)+3 种基金the National Natural Science Foundation of China(Nos.41876052,42076218,U1901217,91855101,41773039)the Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515011836,2021A1515110851)the Science and Technology Planning Project of Guangzhou(No.202201010230)the Special Research Assistant Program of Chinese Academy of Sciences to Junhui YU。
文摘The Zengmu Basin located in the shallow water area of the southern South China Sea,is rich in oil and gas resources,within which faults and mud-diapir are developed,but it is unknown whether oil and gas migrate to the seafloor surface.The newly collected multibeam data across the Zengmu Basin reveal a large number of depressions,with depths of 2-4 m,widths of several tens of meters,large distribution range of 1.8-8 km along survey line,up to~50 km,and their backscatter intensity(-26 dB)is much greater than that of the surrounding area(-38 dB).Combined with the developed mud-diapir and fracture structures,and abundant oil and gas resources within this basin,these depressions are presumed to be pockmarks.Furthermore,more than 110 mono-sized small circular pockmarks,with a depth of less than 1 m and a width of 5 m,are observed in an area of less than 0.03 km2,which are not obliterated by sediment infilling with high sedimentation rate,implying an existence of unit-pockmarks that are or recently were active.In addition,seismic profiles across the Zengmu Basin show characterization of upward migration of hydrocarbons,expressed as mud-diapir structures,bright spots in the shallow formation with characteristics of“low frequency increase and high frequency attenuation”.The subbottom profiles show the mud-diapir structures,as well as the gas-bearing blank zones beneath the seafloor.These features suggest large gas leaking and occurrence of large amounts of carbonate nodules on the seafloor.This indicates the complex and variable substrate type in the Zengmu Basin,while the area was once thought to be mainly silty sand and find sand.This is the first report on the discovery of pockmarks in the Zengmu Basin;it will provide basic information for submarine stability and marine engineering in China’s maritime boundaries.
基金Supported by the Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515011836,2021A1515110851)the Science and Technology Planning Project of Guangzhou(No.202201010230)+5 种基金the Special Support Program for Cultivating High-Level Talents in Guangdong Province(No.2019BT02H594)the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0104)the Open Fund of Key Laboratory of Marine Geology and EnvironmentChinese Academy of Sciences(CAS)(No.MGE2020KG01)the National Natural Science Foundation of China(Nos.U1901217,91855101,41876052,42076218)Dr.Junhui YU is funded by the Special Research Assistant Funding Program of CAS。
文摘The southwestern depression of the Qiongdongnan Basin(QDNB)hosts thick Cenozoic sediments and awaits major hydrocarbon discovery.Multichannel seismic(MCS)profile CFT2011 across the southwestern QDNB reveals a~60-km-wide fuzzy reflection zone(FRZ)within the sediments,but its origin and distribution remain unclear.Here ocean bottom seismometer(OBS)data of Line CFT2011 are processed with focus on the velocity structures by traveltime tomography inversion and analyzed together with the coincident and adjacent MCS profiles.The OBS velocity results show that the giant FRZ features lower velocity with difference up to 1.5 km/s and smaller vertical velocity gradient than the surrounding sedimentary sequences at the same depth,likely resulting from enhanced fluid infilling.The MCS profile exhibits that the giant FRZ is about 3-9-km thick and extends from the Paleogene strata rich in organic matters upward to the lower Pleistocene sediments.Within the shallow overlying sediments,multiple bright spots with reverse polarity are imaged and their reflection amplitudes increase with offset,consistent with the features of gas-charged sediments.They are probably shallow gas reservoirs with gases sourced from the deep FRZ.Therefore,the FRZ is proposed to be a giant gas-charged zone,which probably contains lots of hydrocarbon gases migrated vertically from the deep Paleogene source rocks through the boundary faults of the depressions and the minor fractures generated under overpressure.This FRZ is also imaged on the adjacent MCS profiles MCS-L1 and MCS-L2 with the width of about 40 km and 68 km,respectively.It is roughly estimated to cover an area of~1900 km2 and host a volume of~11400 km3 assuming an average thickness of 6 km,implying huge natural gas potential in the sedimentary depression of the southwestern QDNB of the South China Sea.
基金funded by the Nanjing Tianqing Research Fund Project(Grant Serial Number:HX202334)the Institute Fund from First Affliated Hospital of Xi’an Jiaotong University(Grant Serial Number:2022MS-17).
文摘Angiogenesis plays a significant role in the occurrence and development of inflammatory bowel disease(IBD).The aim of this study is to explore potential angiogenesis related genes(ARGs)in IBD through bioinformatics analysis and in vivo experiments.Methods:GSE57945,GSE87466,and GSE36807 were obtained from the Gene Expression Omnibus database.GSE57945 was used as the training set,while GSE87466 and GSE36807 were used as the validation set.The key ARGs associated with IBD were identified using the least absolute shrinkage and selection operator(LASSO)and random forest methods.These identified ARGs were then utilized to construct a diagnostic model for IBD.The Single-Sample Genome Enrichment Analysis,Cibersort,and Xcell methods were used to evaluate the immune infiltration.Expression of amyloid beta precursor protein(APP)was verified in the IBD mouse model induced by dextran sulfate sodium using immunohistochemistry(IHC).Results:The receiver operating curve area of GSE57945 was 0.948.Two distinct clusters were identified using consensus clustering and non-negative matrix factorization clustering.Subsequent analyses revealed significant differences in immune levels and functional enrichment between the two clusters.The successful construction of the animal model for the IBD was evident by hematoxylin and eosin staining,while IHC results showed a high expression of APP in IBD and a low expression in normal tissues.Conclusion:Our findings provide new insights into the diagnosis of IBD by ARGs,and APP could be a potential novel biomarker for IBD and promising therapeutic targets.
