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奥洛他定联合卡介菌多糖核酸对慢性荨麻疹患者的免疫应答机制探讨 被引量:18
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作者 罗文峰 程喜平 +1 位作者 王继辉 许德清 《中国现代医学杂志》 CAS 2018年第12期113-117,共5页
目的研究奥洛他定联合卡介菌多糖核酸治疗前后慢性荨麻疹患者Toll样受体2(TLR2)表达量的变化及其与免疫球蛋白E(IgE)、补体C3、补体C4、细胞因子含量的相关性。方法选取2016年1月-2016年11月在佛山市中医院接受奥洛他定联合卡介菌多糖... 目的研究奥洛他定联合卡介菌多糖核酸治疗前后慢性荨麻疹患者Toll样受体2(TLR2)表达量的变化及其与免疫球蛋白E(IgE)、补体C3、补体C4、细胞因子含量的相关性。方法选取2016年1月-2016年11月在佛山市中医院接受奥洛他定联合卡介菌多糖核酸治疗的慢性荨麻疹患者作为研究对象。治疗前和治疗后2、4及6周时,采集外周血并测定TLR2、TLR4、TLR7、TLR9的表达量,采集血清并测定IgE、C3、C4、Th1、Th2细胞因子的含量。结果治疗后2、4及6周时,外周血单个核细胞中TLR2的mRNA含量均低于治疗前,TLR4、TLR7及TLR9的mRNA含量与治疗前比较,差异无统计学意义(P>0.05);血清中IgE、白细胞介素4(IL-4)、白细胞介素10(IL-10)的含量均低于治疗前,C3、C4、IFN-γ、白细胞介素2(IL-2)的含量高于治疗前;外周血中TLR2的表达量与血清中IgE、IL-4、IL-10的含量呈正相关,与C3、C4、IFN-γ、IL-2的含量呈负相关。结论奥洛他定联合卡介菌多糖核酸治疗可能通过TLR2通路调节慢性荨麻疹患者体内的免疫应答。 展开更多
关键词 慢性荨麻疹 奥洛他定 卡介菌多糖核酸 TOLL样受体 免疫应答
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Gut microbiota in obesity 被引量:24
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作者 Bing-Nan Liu Xiao-Tong Liu +1 位作者 Zi-Han Liang ji-hui wang 《World Journal of Gastroenterology》 SCIE CAS 2021年第25期3837-3850,共14页
Obesity is a major global health problem determined by heredity and environment,and its incidence is increasing yearly.In recent years,increasing evidence linking obesity to the gut microbiota has been reported.Gut mi... Obesity is a major global health problem determined by heredity and environment,and its incidence is increasing yearly.In recent years,increasing evidence linking obesity to the gut microbiota has been reported.Gut microbiota management has become a new method of obesity treatment.However,the complex interactions among genetics,environment,the gut microbiota,and obesity remain poorly understood.In this review,we summarize the characteristics of the gut microbiota in obesity,the mechanism of obesity induced by the gut microbiota,and the influence of genetic and environmental factors on the gut microbiota and obesity to provide support for understanding the complex relationship between obesity and microbiota.At the same time,the prospect of obesity research related to the gut microbiota is proposed. 展开更多
关键词 Gut microbiota OBESITY DYSBIOSIS GENETICS ECOLOGY
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Elastic Characteristic Extraction Method of Underwater Target Based on Adaptive Filtering
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作者 Zhen-Shan wang Yun-Fei Chen +1 位作者 Gui-Juan Li ji-hui wang 《Journal of Electronic Science and Technology》 CAS 2012年第2期149-152,共4页
In this paper, a kind of elastic characteristic extraction method of underwater targets based on adaptive filtering is introduced. The kernel of the method is the recursive least square (RLS) algorithm. Firstly, the... In this paper, a kind of elastic characteristic extraction method of underwater targets based on adaptive filtering is introduced. The kernel of the method is the recursive least square (RLS) algorithm. Firstly, the geometric scattering signal is fit by using the echo signal and the incident signal. Then, the frequency spectrum of the echo signal and the geometric scattering signal are calculated. At last, the frequency spectrum of the elastic scattering signal is obtained. The research of the simulation and lake experiment is carried on. As the results show, the formants of the elastic signal frequency spectrum can be precisely extracted by the algorithm, and the extraction algorithm can apply to extracting the elastic characteristic from the echo signal in a real underwater acoustics environment. 展开更多
关键词 Adaptive characteristic elastic scattering scattering signal. filtering SIGNAL elastic geometric
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Effect of Deep Sea Pressures on the Corrosion Behavior of X65 Steel in the Artificial Seawater 被引量:5
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作者 Qiu-Shi Li Shun-Zhong Luo +4 位作者 Xu-Teng Xing Jing Yuan Xin Liu ji-hui wang Wen-Bin Hu 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2019年第8期972-980,共9页
The corrosion behaviors of X65 steel in the artificial seawater at different hydrostatic pressures are investigated by potentiodynamic polarization measurements, electrochemical impedance spectroscopy measurements and... The corrosion behaviors of X65 steel in the artificial seawater at different hydrostatic pressures are investigated by potentiodynamic polarization measurements, electrochemical impedance spectroscopy measurements and weight loss measurements.The corroded morphologies and the corrosion products are also investigated by scanning electron microscopy, X-ray diffraction analysis and Raman analysis.The results show that the corrosion current increases as the hydrostatic pressure increases.The charge transfer resistance decreases as the hydrostatic pressure increases.The corrosion products are mainly composed of γ-FeOOH and Fe3O4 at the atmospheric pressure, while the main components are γ-FeOOH, Fe3O4, and γ-Fe2O3 at the high pressure.The hydrostatic pressure accelerates the corrosion of X65 steel due to its effect on the chemical and physical properties of corrosion products, including the promoted reduction of γ-FeOOH and the wider and deeper cracks on the corrosion products layer. 展开更多
关键词 X65 steel DEEP SEA pressures ELECTROCHEMICAL measurements CORROSION
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