After investigating the current situation of college students'employment and entrepreneurship environment and the existing problems and related policies in the Beijing-Tianjin-Hebei region under the background of ...After investigating the current situation of college students'employment and entrepreneurship environment and the existing problems and related policies in the Beijing-Tianjin-Hebei region under the background of the integration of Beijing-Tianjin-Hebei region,this project put forward some insights into the reform of university teaching.First,a questionnaire survey was conducted to understand the basic information of the respondents,the obstacles to starting a business,and the current situation of the entrepreneurial environment such as government assistance.The questionnaires were distributed in the questionnaire star.The data were summarized with Excel;reliability and validity analysis was performed with SPSS,and descriptive statistical analysis was performed with Excel;and then,one-way ANOVA and exploratory factor analysis were performed with SPSS,and confirmatory factor analysis was performed with the SEM structural equation.It was found that gender,educational background and major have a significant impact on choosing to start a business.The evaluation indexes of entrepreneurial environment were divided into two common factors:government policy assistance and government fund assistance,and eight specific influencing factors were obtained,and the model fit well.This paper analyzed the work that schools have to do in the process of college students'entrepreneurship and its impact on entrepreneurship,providing ideas for the government and schools to help college students start their own businesses in the future.展开更多
The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by w...The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by which pericytes are regulated in the damaged brain are largely unknown.Here,we show that the formation of neutrophil extracellular traps(NETs)induces the appearance of CD11b^(+)pericytes after TBI.These CD11b^(+)pericyte subsets are characterized by increased permeability and pro-inflammatory profiles compared to CD11b-pericytes.Moreover,histones from NETs by Dectin-1 facilitate CD11b induction in brain pericytes in PKC-c-Jun dependent manner,resulting in neuroinflammation and BBB dysfunction after TBI.These data indicate that neutrophil-NET-pericyte and histone-Dectin-1-CD11b are possible mechanisms for the activation and dysfunction of pericytes.Targeting NETs formation and Dectin-1 are promising means of treating TBI.展开更多
基金Supported by College Students’Innovation and Entrepreneurship Training Program of Tianjin Agricultural University (202110061151)
文摘After investigating the current situation of college students'employment and entrepreneurship environment and the existing problems and related policies in the Beijing-Tianjin-Hebei region under the background of the integration of Beijing-Tianjin-Hebei region,this project put forward some insights into the reform of university teaching.First,a questionnaire survey was conducted to understand the basic information of the respondents,the obstacles to starting a business,and the current situation of the entrepreneurial environment such as government assistance.The questionnaires were distributed in the questionnaire star.The data were summarized with Excel;reliability and validity analysis was performed with SPSS,and descriptive statistical analysis was performed with Excel;and then,one-way ANOVA and exploratory factor analysis were performed with SPSS,and confirmatory factor analysis was performed with the SEM structural equation.It was found that gender,educational background and major have a significant impact on choosing to start a business.The evaluation indexes of entrepreneurial environment were divided into two common factors:government policy assistance and government fund assistance,and eight specific influencing factors were obtained,and the model fit well.This paper analyzed the work that schools have to do in the process of college students'entrepreneurship and its impact on entrepreneurship,providing ideas for the government and schools to help college students start their own businesses in the future.
基金This work was supported by the National Natural Science Foundation of China(32000670 and 82071779)Chongqing Research Program of Basic Research and Frontier Technology(cstc2017jcyjAX0338).
文摘The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by which pericytes are regulated in the damaged brain are largely unknown.Here,we show that the formation of neutrophil extracellular traps(NETs)induces the appearance of CD11b^(+)pericytes after TBI.These CD11b^(+)pericyte subsets are characterized by increased permeability and pro-inflammatory profiles compared to CD11b-pericytes.Moreover,histones from NETs by Dectin-1 facilitate CD11b induction in brain pericytes in PKC-c-Jun dependent manner,resulting in neuroinflammation and BBB dysfunction after TBI.These data indicate that neutrophil-NET-pericyte and histone-Dectin-1-CD11b are possible mechanisms for the activation and dysfunction of pericytes.Targeting NETs formation and Dectin-1 are promising means of treating TBI.
