Obesity,caused by excessive energy,leads to body weight gain and various diseases,including cognitive impairment.Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial f...Obesity,caused by excessive energy,leads to body weight gain and various diseases,including cognitive impairment.Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity.However,further exploration is needed to understand the specific mechanisms of high fat diet(HFD)-induced cognitive decline in obesity.In the present study,4-month-old mice were subjected to HFD feeding for 18 weeks,followed by aerobic exercise and high-intensity intermittent exercise,regular diet feeding,and intermittent fasting for 8 weeks,and then used to evaluate cognitive capacity,inflammation,compromised insulin signaling pathway,and apoptosis in hippocampal tissue,as well as AMPK/SIRT1 and TLR4 signal pathways.Obese mice revealed impaired cognitive capacity as compared with mice fed with regular diets.In contrast,aerobic exercise,high-intensity intermittent exercise,regular diet,and intermittent fasting could inhibit apoptosis caused by inflammation-mediated compromised insulin signaling pathway in hippocampal tissues through activating the AMPK/SIRT1 signal pathway and suppressing the TLR4 signal pathway,thereby rescuing the cognitive impairment of obese mice.Therefore,diet restriction and exercise interventions may play a positive role in reverting obesity-induced cognitive impairment.展开更多
The allometric scaling laws of metabolism in 447 animal and 1200 plant species showed convex and concave curvatures between mass and metabolic rate,respectively.The objective of the study is to explain the difference ...The allometric scaling laws of metabolism in 447 animal and 1200 plant species showed convex and concave curvatures between mass and metabolic rate,respectively.The objective of the study is to explain the difference of curvatures between animals and plants based on fractal models.Several intraspecific scaling laws were derived from an asymmetric vascular tree with the fractal dimension(i.e.,a in k^(a)_(1)+k^(a)_(2)+…-=1,where k_(i)refers to the ratio of daughter to mother diameters).Based on the intraspecific scaling laws,the allometric scaling exponent of metabolism(i.e.,an interspecific scaling law)was shown to be equal to one-third of fractal dimension.Moreover,a novel piecewise-defined function in conjunction with the intraspecific scaling laws was proposed to explain the diverse metabolic scaling in animals and plants.The intraspecific and interspecific scaling laws showed good agreement with morphometric measurements.The experimentally-validated scaling models predict the diversity of intraspecific and interspecific scaling seen in nature.To our knowledge,this is the first study to use fractal models to explain the convex and concave forms of metabolic scaling in animals and plants.The study resolves the long-term controversies to use the resource-transport network models for explanation of the allometric scaling law of metabolism.展开更多
As the emerging member of zero-dimension transition metal dichalcogenide,WSe2 quantum dots(QDs)have been applied to memristors and exhibited better resistance switching characteristics and miniaturization size.However...As the emerging member of zero-dimension transition metal dichalcogenide,WSe2 quantum dots(QDs)have been applied to memristors and exhibited better resistance switching characteristics and miniaturization size.However,low power consumption and high reliability are still challenges for WSe_(2) QDs-based memristors as synaptic devices.展开更多
基金supported by the National Natural Science Foundation of China(32471186,31771318)the 14th Five-Year-Plan Advantageous and Characteristic Disciplines(Groups)of Colleges and Universities in Hubei Province for Exercise and Brain Science from Hubei Provincial Department of Education,and the Leading Talent Program Foundation from Wuhan Sports University to Ning Chen+3 种基金and the National Natural Science Foundation of China(81701391)the Natural Science Foundation of Hubei Province(2023AFB700)Key Project of Scientific Research of Education Department of Hubei Province(D20234101)Young and Middle aged Scientific Research Team Project of Wuhan Sports University(21KT08)to Jingjing Fan.
文摘Obesity,caused by excessive energy,leads to body weight gain and various diseases,including cognitive impairment.Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity.However,further exploration is needed to understand the specific mechanisms of high fat diet(HFD)-induced cognitive decline in obesity.In the present study,4-month-old mice were subjected to HFD feeding for 18 weeks,followed by aerobic exercise and high-intensity intermittent exercise,regular diet feeding,and intermittent fasting for 8 weeks,and then used to evaluate cognitive capacity,inflammation,compromised insulin signaling pathway,and apoptosis in hippocampal tissue,as well as AMPK/SIRT1 and TLR4 signal pathways.Obese mice revealed impaired cognitive capacity as compared with mice fed with regular diets.In contrast,aerobic exercise,high-intensity intermittent exercise,regular diet,and intermittent fasting could inhibit apoptosis caused by inflammation-mediated compromised insulin signaling pathway in hippocampal tissues through activating the AMPK/SIRT1 signal pathway and suppressing the TLR4 signal pathway,thereby rescuing the cognitive impairment of obese mice.Therefore,diet restriction and exercise interventions may play a positive role in reverting obesity-induced cognitive impairment.
基金This research is supported in part by the National Natural Science Foundation of China(Grant 11672006(Y.Huo)and 11732001(W.Tan))Shenzhen Science and Technology R&D(Grant KQTD20180411143400981(W.Tan and Y.Huo))Leading Talents of Guangdong Province Program(Grant 2016LJ06S686(W.Tan)).
文摘The allometric scaling laws of metabolism in 447 animal and 1200 plant species showed convex and concave curvatures between mass and metabolic rate,respectively.The objective of the study is to explain the difference of curvatures between animals and plants based on fractal models.Several intraspecific scaling laws were derived from an asymmetric vascular tree with the fractal dimension(i.e.,a in k^(a)_(1)+k^(a)_(2)+…-=1,where k_(i)refers to the ratio of daughter to mother diameters).Based on the intraspecific scaling laws,the allometric scaling exponent of metabolism(i.e.,an interspecific scaling law)was shown to be equal to one-third of fractal dimension.Moreover,a novel piecewise-defined function in conjunction with the intraspecific scaling laws was proposed to explain the diverse metabolic scaling in animals and plants.The intraspecific and interspecific scaling laws showed good agreement with morphometric measurements.The experimentally-validated scaling models predict the diversity of intraspecific and interspecific scaling seen in nature.To our knowledge,this is the first study to use fractal models to explain the convex and concave forms of metabolic scaling in animals and plants.The study resolves the long-term controversies to use the resource-transport network models for explanation of the allometric scaling law of metabolism.
基金This work was financially supported by the National Natural Science Foundation of China(No.62104058)the Natural Science Foundation of Hebei Province(No.F2021201022)+14 种基金the Science and Technology Project of Hebei Education Department(No.QN2020178)the Advanced Talents Incubation Program of the Hebei University(No.521000981363)This work was also supported by the National Key R&D Plan“Nano Frontier”Key Special Project(No.2021YFA1200502)Cultivation Projects of National Major R&D Project(No.92164109)National Natural Science Foundation of China(Nos.61874158 and 62004056)Special Project of Strategic Leading Science and Technology of Chinese Academy of Sciences(No.XDB44000000-7)HebeiBasic Research Special KeyProject(No.F2021201045)the Support Program for the Top Young Talents of Hebei Province(No.70280011807)the Supporting Plan for 100 Excellent Innovative Talents in Colleges and Universities of Hebei Province(No.SLRC2019018)Outstanding Young Scientific Research and Innovation Team of Hebei University(No.605020521001)Special Support Funds for National High Level Talents(No.041500120001)High-level Talent Research Startup Project of Hebei University(No.521000981426)the Science and Technology Project of Hebei Education Department(No.QN2021026)the Advanced Talents Incubation Program of the Hebei University(No.521000981426)the Natural Science Foundation of Hebei Province(No.F2021201009).
文摘As the emerging member of zero-dimension transition metal dichalcogenide,WSe2 quantum dots(QDs)have been applied to memristors and exhibited better resistance switching characteristics and miniaturization size.However,low power consumption and high reliability are still challenges for WSe_(2) QDs-based memristors as synaptic devices.
