Dopamine has demonstrated promise as a stress-relief substance.However,the function of dopamine in Cd tolerance and its mechanism remains largely unknown.The current study was performed to investigate the mechanism of...Dopamine has demonstrated promise as a stress-relief substance.However,the function of dopamine in Cd tolerance and its mechanism remains largely unknown.The current study was performed to investigate the mechanism of dopamine on alleviating apple Cd stress through regular application of CdCl2 and dopamine solution to potting soil.The results indicated that dopamine significantly reduced reactive oxygen species(ROS)and Cd accumulation and alleviated the inhibitory effect of Cd stress on the growth of apple plants through activation of the antioxidant system,enhancement of photosynthetic capacity,and regulation of gene expression related to Cd absorption and detoxification.The richness of the rhizosphere microbial community increased,and community composition and assembly were affected by dopamine treatment.Network analysis of microbial communities showed that the numbers of nodes and total links increased significantly after dopamine treatment,while the keystone species shifted.Linear discriminant analysis effect size indicated that some biomarkers were significantly enriched after dopamine treatment,suggesting that dopamine induced plants to recruit potentially beneficial microorganisms(Pseudoxanthomonas,Aeromicrobium,Bradyrhizobium,Frankia,Saccharimonadales,Novosphingobium,and Streptomyces)to resist Cd stress.The co-occurrence network showed several metabolites that were positively correlated with relative growth rate and negatively correlated with Cd accumulation,suggesting that potentially beneficial microorganisms may be attracted by several metabolites(L-threonic acid,profenamine,juniperic acid and(3β,5ξ,9ξ)-3,6,19-trihydroxyurs-12-en-28-oic acid).Our results demonstrate that dopamine alleviates Cd stress in apple trees by recruiting beneficial microorganisms to enhance the physiological resilience revealed.This study provides an effective means to reduce the harm to agricultural production caused by heavy metals.展开更多
2023年7月,阿尔茨海默病协会国际会议(Alzheimer's Association International Conference,AAIC)在荷兰召开。近10000名世界各地的研究者汇聚阿姆斯特丹,共话阿尔茨海默病(Alzheimer's Disease,AD)和痴呆症研究领域最新研究成...2023年7月,阿尔茨海默病协会国际会议(Alzheimer's Association International Conference,AAIC)在荷兰召开。近10000名世界各地的研究者汇聚阿姆斯特丹,共话阿尔茨海默病(Alzheimer's Disease,AD)和痴呆症研究领域最新研究成果。大会持续五天,呈现了超过3000个学术报告,通过专题研讨、壁报展示等活动,促进全球研究者深入开展交流研讨,探索AD创新发展新格局。本报告结合AAIC面向全球发布的《Advancements In Treatment,Diagnosis and Risk Reduction Strategies Highlighted at AAIC》,对2023年AAIC亮点进行整合。展开更多
Introduction:High-resolution data is essential for understanding the complexity of the relationship between the spread of coronavirus disease 2019(COVID-19),resident behavior,and interventions,which could be used to i...Introduction:High-resolution data is essential for understanding the complexity of the relationship between the spread of coronavirus disease 2019(COVID-19),resident behavior,and interventions,which could be used to inform policy responses for future prevention and control.Methods:We obtained high-resolution human mobility data and epidemiological data at the community level.We propose a metapopulation Susceptible-Exposed-Presymptomatic-Infectious-Removal(SEPIR)compartment model to utilize the available data and explore the internal driving forces of COVID-19 transmission dynamics in the city of Wuhan.Additionally,we will assess the effectiveness of the interventions implemented in the smallest administrative units(subdistricts)during the lockdown.Results:In the Wuhan epidemic of March 2020,intra-subdistrict transmission caused 7.6 times more infections than inter-subdistrict transmission.After the city was closed,this ratio increased to 199 times.The main transmission path was dominated by population activity during peak evening hours.Discussion:Restricting the movement of people within cities is an essential measure for controlling the spread of COVID-19.However,it is difficult to contain intra-street transmission solely through citywide mobility restriction policies.This can only be accomplished by quarantining communities or buildings with confirmed cases,and conducting mass nucleic acid testing and enforcing strict isolation protocols for close contacts.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.31901964)the Science and Technology Project of Hebei Education Department(No.BJK2022012)the Earmarked fund for the China Agricultural Research System(No.CARS-27).
文摘Dopamine has demonstrated promise as a stress-relief substance.However,the function of dopamine in Cd tolerance and its mechanism remains largely unknown.The current study was performed to investigate the mechanism of dopamine on alleviating apple Cd stress through regular application of CdCl2 and dopamine solution to potting soil.The results indicated that dopamine significantly reduced reactive oxygen species(ROS)and Cd accumulation and alleviated the inhibitory effect of Cd stress on the growth of apple plants through activation of the antioxidant system,enhancement of photosynthetic capacity,and regulation of gene expression related to Cd absorption and detoxification.The richness of the rhizosphere microbial community increased,and community composition and assembly were affected by dopamine treatment.Network analysis of microbial communities showed that the numbers of nodes and total links increased significantly after dopamine treatment,while the keystone species shifted.Linear discriminant analysis effect size indicated that some biomarkers were significantly enriched after dopamine treatment,suggesting that dopamine induced plants to recruit potentially beneficial microorganisms(Pseudoxanthomonas,Aeromicrobium,Bradyrhizobium,Frankia,Saccharimonadales,Novosphingobium,and Streptomyces)to resist Cd stress.The co-occurrence network showed several metabolites that were positively correlated with relative growth rate and negatively correlated with Cd accumulation,suggesting that potentially beneficial microorganisms may be attracted by several metabolites(L-threonic acid,profenamine,juniperic acid and(3β,5ξ,9ξ)-3,6,19-trihydroxyurs-12-en-28-oic acid).Our results demonstrate that dopamine alleviates Cd stress in apple trees by recruiting beneficial microorganisms to enhance the physiological resilience revealed.This study provides an effective means to reduce the harm to agricultural production caused by heavy metals.
文摘2023年7月,阿尔茨海默病协会国际会议(Alzheimer's Association International Conference,AAIC)在荷兰召开。近10000名世界各地的研究者汇聚阿姆斯特丹,共话阿尔茨海默病(Alzheimer's Disease,AD)和痴呆症研究领域最新研究成果。大会持续五天,呈现了超过3000个学术报告,通过专题研讨、壁报展示等活动,促进全球研究者深入开展交流研讨,探索AD创新发展新格局。本报告结合AAIC面向全球发布的《Advancements In Treatment,Diagnosis and Risk Reduction Strategies Highlighted at AAIC》,对2023年AAIC亮点进行整合。
基金Supported by the National Key R&D Program of China(2021ZD0111201)National Natural Science Foundation of China(No.82161148011,72222022,72171013).
文摘Introduction:High-resolution data is essential for understanding the complexity of the relationship between the spread of coronavirus disease 2019(COVID-19),resident behavior,and interventions,which could be used to inform policy responses for future prevention and control.Methods:We obtained high-resolution human mobility data and epidemiological data at the community level.We propose a metapopulation Susceptible-Exposed-Presymptomatic-Infectious-Removal(SEPIR)compartment model to utilize the available data and explore the internal driving forces of COVID-19 transmission dynamics in the city of Wuhan.Additionally,we will assess the effectiveness of the interventions implemented in the smallest administrative units(subdistricts)during the lockdown.Results:In the Wuhan epidemic of March 2020,intra-subdistrict transmission caused 7.6 times more infections than inter-subdistrict transmission.After the city was closed,this ratio increased to 199 times.The main transmission path was dominated by population activity during peak evening hours.Discussion:Restricting the movement of people within cities is an essential measure for controlling the spread of COVID-19.However,it is difficult to contain intra-street transmission solely through citywide mobility restriction policies.This can only be accomplished by quarantining communities or buildings with confirmed cases,and conducting mass nucleic acid testing and enforcing strict isolation protocols for close contacts.
