Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume respon...Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored functionality.Conversely,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various technologies.Advancements in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in mice.Nevertheless,there remain issues that hinder improving reprogramming efficiency and maturity.Thus,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming strategies.This review describes recent progress in relatively successful Müller glia reprogramming strategies.It also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.展开更多
In naval direct current(DC)microgrids,pulsed power loads(PPLs)are becoming more prominent.A solar sys-tem,an energy storage system,and a pulse load coupled directly to the DC bus compose a DC microgrid in this study.F...In naval direct current(DC)microgrids,pulsed power loads(PPLs)are becoming more prominent.A solar sys-tem,an energy storage system,and a pulse load coupled directly to the DC bus compose a DC microgrid in this study.For DC mi-crogrids equipped with sonar,radar,and other sensors,pulse load research is crucial.Due to high pulse loads,there is a possibility of severe power pulsation and voltage loss.The original contribution of this paper is that we are able to address the nonlinear problem by applying the Takagi-Sugeno(TS)model formulation for naval DC microgrids.Additionally,we provide a nonlinear power observer for estimating major disturbances affecting DC microgrids.To demonstrate the TS-potential,we examine three approaches for mitigating their negative effects:instantaneous power control(IPC)control,model predictive control(MPC)formulation,and TS-MPC approach with compensated PPLs.The results reveal that the TS-MPC approach with adjusted PPLs effectively shares power and regulates bus voltage under a variety of load conditions,while greatly decreasing detrimental impacts of the pulse load.Additionally,the comparison confirmed the efficiency of this technique.Index Terms-DC microgrids(MG),model predictive control(MPC),pulsed power loads(PPLs),nonlinear power observer,Takagi-Sugeno(TS)fuzzy model.展开更多
Intensifying human activity in the Yangtze River Basin(YRB) has substantially increased nutrient concentrations in the Yangtze River Estuary,leading to degradation of the coastal environment.Analysis of nutrient deter...Intensifying human activity in the Yangtze River Basin(YRB) has substantially increased nutrient concentrations in the Yangtze River Estuary,leading to degradation of the coastal environment.Analysis of nutrient determinations published over the past 50 years reveals a gradual decreasing trend in the concentrations and fluxes of dissolved silicate(DSi).However,both dissolved inorganic nitrogen(DIN) and dissolved inorganic phosphate(DIP) concentrations have increased significantly since the 1970 s.The frequency and area covered by red tide outbreaks have increased greatly during this period,mainly due to changes in nutrient supply ratios [i.e.,N/P(DIN/DIP),N/Si(DIN/DSi),P/Si(DIP/DSi)].A strong correlation was found between the riverine DIN fluxes and the estimated DIN inputs from the major N sources,particularly fertilizers and atmospheric deposition.The data provide a comprehensive assessment of nutrients in the YRB and their ecological impacts and indicate a potentially significant influence of atmospheric deposition on DIN loadings and fluxes.展开更多
基金supported by the National Natural Science Foundation of China,No.31930068National Key Research and Development Program of China,Nos.2018YFA0107302 and 2021YFA1101203(all to HX).
文摘Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored functionality.Conversely,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various technologies.Advancements in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in mice.Nevertheless,there remain issues that hinder improving reprogramming efficiency and maturity.Thus,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming strategies.This review describes recent progress in relatively successful Müller glia reprogramming strategies.It also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.
基金supported in part by the National Key Research and Development Program of China(Grant No.2019YFE0118000)in part by the research funding of Guangxi University(No.A3020051008)。
文摘In naval direct current(DC)microgrids,pulsed power loads(PPLs)are becoming more prominent.A solar sys-tem,an energy storage system,and a pulse load coupled directly to the DC bus compose a DC microgrid in this study.For DC mi-crogrids equipped with sonar,radar,and other sensors,pulse load research is crucial.Due to high pulse loads,there is a possibility of severe power pulsation and voltage loss.The original contribution of this paper is that we are able to address the nonlinear problem by applying the Takagi-Sugeno(TS)model formulation for naval DC microgrids.Additionally,we provide a nonlinear power observer for estimating major disturbances affecting DC microgrids.To demonstrate the TS-potential,we examine three approaches for mitigating their negative effects:instantaneous power control(IPC)control,model predictive control(MPC)formulation,and TS-MPC approach with compensated PPLs.The results reveal that the TS-MPC approach with adjusted PPLs effectively shares power and regulates bus voltage under a variety of load conditions,while greatly decreasing detrimental impacts of the pulse load.Additionally,the comparison confirmed the efficiency of this technique.Index Terms-DC microgrids(MG),model predictive control(MPC),pulsed power loads(PPLs),nonlinear power observer,Takagi-Sugeno(TS)fuzzy model.
基金supported by the National Natural Science Foundation of China(42175137,41705130,41922037,and 71961137011)the National Key Research and Development Program of China(2021YFD1700902)+6 种基金the Chinese State Key Special Program on Severe Air Pollution Mitigation“Agricultural Emission Status and Enhanced Control Plan”(DQGG0208)the Shandong Provincial Natural Science Foundation(2022HWYQ-066)the Global International Nitrogen Management System(INMS)the High-level Team Project of China Agricultural Universitythe Beijing Advanced Discipline Fundingwas supported by the Fonds de la Recherche Scientifique(F.R.S.-FNRS)the Belgian State Federal Office for Scientific,Technical and Cultural Affairs(Prodex arrangement IASI.FLOW)。
基金supported by the National Natural Science Foundation of China (41705130)China Postdoctoral Science Foundation (2019T120156, 2018M641531)Beijing Advanced Discipline。
文摘Intensifying human activity in the Yangtze River Basin(YRB) has substantially increased nutrient concentrations in the Yangtze River Estuary,leading to degradation of the coastal environment.Analysis of nutrient determinations published over the past 50 years reveals a gradual decreasing trend in the concentrations and fluxes of dissolved silicate(DSi).However,both dissolved inorganic nitrogen(DIN) and dissolved inorganic phosphate(DIP) concentrations have increased significantly since the 1970 s.The frequency and area covered by red tide outbreaks have increased greatly during this period,mainly due to changes in nutrient supply ratios [i.e.,N/P(DIN/DIP),N/Si(DIN/DSi),P/Si(DIP/DSi)].A strong correlation was found between the riverine DIN fluxes and the estimated DIN inputs from the major N sources,particularly fertilizers and atmospheric deposition.The data provide a comprehensive assessment of nutrients in the YRB and their ecological impacts and indicate a potentially significant influence of atmospheric deposition on DIN loadings and fluxes.
