Objective:To study the correlation of serum complements C3 and C4 as well as immunoglobulins IgM, IgA and IgG contents with inflammatory stress response in children with mycoplasma pneumoniae pneumonia.Methods: The ch...Objective:To study the correlation of serum complements C3 and C4 as well as immunoglobulins IgM, IgA and IgG contents with inflammatory stress response in children with mycoplasma pneumoniae pneumonia.Methods: The children who were diagnosed with Mycoplasma pneumoniae pneumonia in Xiangyang No. 1 People's Hospital, Hubei University of Medicine between February 2015 and January 2018 were selected as the MPP group, and healthy children who received physical examination during the same period were selected as the control group. The contents of complements, immunoglobulins and inflammatory stress mediators in serum as well as the expression of inflammatory stress molecules in peripheral blood were measured.Results: Serum C3, C4, IgM, sICAM-1, CD40L, HMGB1, Cor and MDA levels as well as peripheral blood TLR2, TLR4, CD11b, CD18, MPO and NOX2 expression intensity of MPP group were significantly higher than those of control group, IgA level was significantly lower than that of control group, and IgG level was not different from that of control group;serum C3, C4 and IgM levels of MPP group were positively correlated with serum sICAM-1, CD40L, HMGB1, Cor and MDA levels as well as peripheral blood TLR2, TLR4, CD11b, CD18, MPO and NOX2 expression intensity, and serum IgA level was negatively correlated with serum sICAM-1, CD40L, HMGB1, Cor and MDA levels as well as peripheral blood TLR2, TLR4, CD11b, CD18, MPO and NOX2 expression intensity. Conclusion: The changes of serum complements and immunoglobulins in children with Mycoplasma pneumoniae pneumonia are related to the excessive activation of inflammatory stress response in the course of disease.展开更多
Rare earth catalysts possessing characteristics of cation-anion ion pair show advantages of adjusting electronegativity and steric hindrance of metal active sites, which can control the catalytic performance and stere...Rare earth catalysts possessing characteristics of cation-anion ion pair show advantages of adjusting electronegativity and steric hindrance of metal active sites, which can control the catalytic performance and stereoselectivity better than those of traditional metallocene and Ziegler-Natta catalysts in diene polymerization. In this work, a series of neodymium organic sulfonate complexes,Nd(CF_3SO_3)_3·x H_2O·y L(x, y: the coordination number; L refers to an organic electron donating ligand, such as acetylacetone(acac), isooctyl alcohol(IAOH), tributyl phosphate(TBP), etc.), have been synthesized to form the cationic active species in the presence of alkylaluminum such as Al(i-Bu)_3, AlEt_3, and Al(i-Bu)_2H, which display high activities and distinguishing cis-1,4 selectivities(up to99.9%) for the polymerization of butadiene. The microstructures, yield, molecular weight, and molecular weight distribution of the resulting polymer are well controlled by adjusting electronegativity/steric hindrance of the complexes. In addition, the kinetics, active species, and the possible process of polymerization are also discussed in this article.展开更多
文摘Objective:To study the correlation of serum complements C3 and C4 as well as immunoglobulins IgM, IgA and IgG contents with inflammatory stress response in children with mycoplasma pneumoniae pneumonia.Methods: The children who were diagnosed with Mycoplasma pneumoniae pneumonia in Xiangyang No. 1 People's Hospital, Hubei University of Medicine between February 2015 and January 2018 were selected as the MPP group, and healthy children who received physical examination during the same period were selected as the control group. The contents of complements, immunoglobulins and inflammatory stress mediators in serum as well as the expression of inflammatory stress molecules in peripheral blood were measured.Results: Serum C3, C4, IgM, sICAM-1, CD40L, HMGB1, Cor and MDA levels as well as peripheral blood TLR2, TLR4, CD11b, CD18, MPO and NOX2 expression intensity of MPP group were significantly higher than those of control group, IgA level was significantly lower than that of control group, and IgG level was not different from that of control group;serum C3, C4 and IgM levels of MPP group were positively correlated with serum sICAM-1, CD40L, HMGB1, Cor and MDA levels as well as peripheral blood TLR2, TLR4, CD11b, CD18, MPO and NOX2 expression intensity, and serum IgA level was negatively correlated with serum sICAM-1, CD40L, HMGB1, Cor and MDA levels as well as peripheral blood TLR2, TLR4, CD11b, CD18, MPO and NOX2 expression intensity. Conclusion: The changes of serum complements and immunoglobulins in children with Mycoplasma pneumoniae pneumonia are related to the excessive activation of inflammatory stress response in the course of disease.
基金the National Natural Science Foundation of China(Nos.51473156 and 51873203)Key Projects of Jilin Province Science and Technology Development Plan(Nos.2018020108GX and 20160204028GX)
文摘Rare earth catalysts possessing characteristics of cation-anion ion pair show advantages of adjusting electronegativity and steric hindrance of metal active sites, which can control the catalytic performance and stereoselectivity better than those of traditional metallocene and Ziegler-Natta catalysts in diene polymerization. In this work, a series of neodymium organic sulfonate complexes,Nd(CF_3SO_3)_3·x H_2O·y L(x, y: the coordination number; L refers to an organic electron donating ligand, such as acetylacetone(acac), isooctyl alcohol(IAOH), tributyl phosphate(TBP), etc.), have been synthesized to form the cationic active species in the presence of alkylaluminum such as Al(i-Bu)_3, AlEt_3, and Al(i-Bu)_2H, which display high activities and distinguishing cis-1,4 selectivities(up to99.9%) for the polymerization of butadiene. The microstructures, yield, molecular weight, and molecular weight distribution of the resulting polymer are well controlled by adjusting electronegativity/steric hindrance of the complexes. In addition, the kinetics, active species, and the possible process of polymerization are also discussed in this article.
