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Research and Practice of Blending Teaching Based on “MOOC + SPOC + Flipped Classroom” for Software Engineering 被引量:15
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作者 Ce Zhang Dianhui Chu +4 位作者 Songlin Gu Xiaofei Xu jianan jiang Zheng Wang Hua Zhang 《计算机教育》 2018年第12期108-113,共6页
Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and pra... Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and practice innovatively. Firstly, the process of MOOC development in China is introduced. The distinguishing feature and effect of MOOC teaching are analyzed, followed by the comparison with traditional class. The online Plus offline blending teaching pattern is the combination of online self-study on MOOC before class, seminar study of flipped classroom in class and the summary after class. With the demonstration of a typical case, a progressive strategy is given to implement blending teaching. Finally, the blending teaching pattern is assessed from multiple perspectives, of which both advantages and disadvantages are dissected. Through primary exploration, introducing online study and flipped classroom, blending teaching plays a positive role in software engineering teaching, which means traditional teaching pattern is changed. Meanwhile, students' innovative consciousness and practical ability are inspired. Nevertheless, new problems arise, so that intensive practice and improvement are necessary. 展开更多
关键词 software engineering MOOC SPOC Flipped CLASSROOM online plus OFFLINE BLENDING teaching
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A One-pot Approach to Ethyl 1,4,5-Triaryl-lH-pyrazole-3- carboxylates via an Improved Claisen Condensation- Knorr Reaction Sequence 被引量:1
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作者 Jiaojiao Zhai Chunhui Gu +5 位作者 jianan jiang Shunli Zhang Daohua Liao Lei Wang Dunru Zhu Yafei Ji 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2013年第12期1526-1538,共13页
A one-pot approach to ethyl 1,4,5-triaryl-lH-pyrazole-3-carboxylates has been developed in moderate to high yields. The tert-BuOLi-mediated Claisen condensation of 1,2-diarylethanones and ethyl oxalyl chloride efficie... A one-pot approach to ethyl 1,4,5-triaryl-lH-pyrazole-3-carboxylates has been developed in moderate to high yields. The tert-BuOLi-mediated Claisen condensation of 1,2-diarylethanones and ethyl oxalyl chloride efficiently provided the enolized lithium salts of ethyl 2,4-dioxo-3,4-diarylbutanoates, which in situ reacted with arylhydrazine hydrochlorides via a hydrochloric acid-promoted Knorr reaction to produce the exquisite triarylpyrazole-3- carboxylates. The procedure promises a convenient access to this highly crowded framework for drug discovery. 展开更多
关键词 one-pot approach 2 4-dioxo-3 4-diarylbutanoates Claisen condensation Knorr reaction triarylpyrazole-3-carboxylates
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An Efficient One-pot Synthesis of Aryl-substituted 1-(Thiazol-2-yl)-1H-pyrazole-3-carboxylates via a Hantzsch Synthesis-Knorr Reaction Sequence
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作者 Chunhui Gu Jiaojiao Zhai +4 位作者 jianan jiang Hongwei Liu Lei Wang Dunru Zhu Yafei Ji 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2014年第2期179-190,共12页
The treatment ofα-bromoalkyl aryl ketones and 2-(propan-2-ylidene)hydrazine carbothioamide afforded 4-aryl-2-(2-(propan-2-ylidene)hydrazinyl)thiazoles via a Hantzsch-thiazole synthesis,which reacted with 4-aryl-2,4-d... The treatment ofα-bromoalkyl aryl ketones and 2-(propan-2-ylidene)hydrazine carbothioamide afforded 4-aryl-2-(2-(propan-2-ylidene)hydrazinyl)thiazoles via a Hantzsch-thiazole synthesis,which reacted with 4-aryl-2,4-diketoesters via a sequential Knorr-pyrazole reaction to deliver a variety of aryl-substituted ethyl 1-(thiazol-2-yl)-1Hpyrazole-3-carboxylates in a one-pot fashion with moderate to high yields.The key intermediates 4-aryl-2,4-diketoesters,existing as its enolic lithium salt,were synthesized in situ by a high-yield tert-BuOLi-mediated Claisen condensation of alkylphenones and diethyl oxalate.This class of elegant molecule comprises aryl groups on the two different heterocyclic cores,and the configurations of two representative molecules were determined by single crystal X-ray crystallography. 展开更多
关键词 one-pot synthesis Claisen condensation Hantzsch synthesis Knorr reaction 1-(thiazol-2-yl)pyrazole-3-carboxylates
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